Abstract:
:Monoclonal antibodies (mAbs) are in widespread use for the treatment of cancer. Their success as cancer therapeutics relies substantially on their ability to engage the immune system. Specifically, Fc-receptor-expressing immune cells mediate the killing of tumor cells by mAbs. Stimulation of these immune effector cells might therefore represent a promising strategy to enhance the therapeutic potential of mAbs. For instance, stimulation of natural killer cells, γδ T cells, macrophages, or dendritic cells can be used to enhance antibody-dependent cellular cytotoxicity, phagocytosis or even tumor vaccine effects. Here, we review several ways to improve the antitumor efficacy of mAbs by combining them with therapies that are directed against immune effector cells.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Houot R,Kohrt HE,Marabelle A,Levy Rdoi
10.1016/j.it.2011.07.003subject
Has Abstractpub_date
2011-11-01 00:00:00pages
510-6issue
11eissn
1471-4906issn
1471-4981pii
S1471-4906(11)00130-Xjournal_volume
32pub_type
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