Abstract:
:Senescent cells, albeit not proliferating, are metabolically and transcriptionally active, thereby capable of affecting their microenvironment, notably via the production of inflammatory mediators. These mediators maintain and propagate the senescence process to neighboring cells, and then recruit immune cells for clearing senescent cells. Among the inflammatory cues are molecules with pronounced tumor-controlling properties, both growth and invasion factors and inhibitory factors, working directly or via recruited immune cells. These senescence-inflammatory effects also prevail within tumors, mediated by the senescent tumor cells and the senescent tumor stroma. Here, we review the course and impact of senescence-associated inflammatory responses in aging and cancer. We propose that controlling senescence-associated inflammation by targeting specific inflammatory mediators may have a beneficial therapeutic effect in treatment of cancer and aging-related diseases.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Lasry A,Ben-Neriah Ydoi
10.1016/j.it.2015.02.009subject
Has Abstractpub_date
2015-04-01 00:00:00pages
217-28issue
4eissn
1471-4906issn
1471-4981pii
S1471-4906(15)00040-Xjournal_volume
36pub_type
杂志文章,评审abstract::Much attention has focused on the role of co-stimulation in dictating tolerance versus immunity to internalized antigens, with the assumption that the presentation of antigen-derived peptides by MHC molecules occurs constitutively. Here, I highlight our new appreciation for the regulated presentation of phagocytosed a...
journal_title:Trends in immunology
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doi:10.1016/j.it.2006.11.001
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abstract::Hepatitis C virus (HCV) uses complex and unique mechanisms to prevent, evade or subvert innate and adaptive immune responses and to establish persistent infection and chronic hepatitis. Recently developed experimental systems have significantly facilitated the analysis of HCV replication, virus-host interaction and pa...
journal_title:Trends in immunology
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journal_title:Trends in immunology
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abstract::One major determinant of systemic immunity during homeostasis and in certain complex multifactorial diseases (e.g. cancer and autoimmune conditions), is the gut microbiota. These commensals can shape systemic immune responses via translocation of metabolites, microbial cell wall components, and viable microbes. In the...
journal_title:Trends in immunology
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journal_title:Trends in immunology
pub_type: 新闻
doi:10.1016/s1471-4906(02)02306-2
更新日期:2002-10-01 00:00:00
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journal_title:Trends in immunology
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journal_title:Trends in immunology
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2010.12.002
更新日期:2011-03-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2011.02.006
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journal_title:Trends in immunology
pub_type: 评论,杂志文章
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2019.06.005
更新日期:2019-08-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2016.11.008
更新日期:2017-03-01 00:00:00
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journal_title:Trends in immunology
pub_type: 评论,杂志文章
doi:10.1016/j.it.2019.07.007
更新日期:2019-09-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章
doi:10.1016/j.it.2010.05.002
更新日期:2010-07-01 00:00:00
abstract::Recent advances in genome analysis have provided important insights into the genetic architecture of infectious and inflammatory diseases. The combined analysis of loci detected by genome-wide association studies (GWAS) in 22 inflammatory diseases has revealed a shared genetic core and associated biochemical pathways ...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2015.12.006
更新日期:2016-02-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/s1471-4906(00)01792-0
更新日期:2001-01-01 00:00:00
abstract::Manipulating the immune system in order to induce clinically relevant responses against cancer is a longstanding goal. Interventions to enhance tumor-specific immunity through vaccination, sustaining effector T cell activation, or increasing the numbers of tumor-specific T cells using ex vivo expansion, have all resul...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2012.08.004
更新日期:2013-02-01 00:00:00
abstract::T-bet was originally described as the key transcription factor defining type 1 T helper (Th) cells. However, it is now clear that it drives the orchestrated generation of effector and memory cells in multiple different lymphocyte lineages. In addition to Th1 cells, CD8 T cells, B cells and some innate lymphocyte popul...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2017.02.003
更新日期:2017-04-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/s1471-4906(01)01862-2
更新日期:2001-04-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2020.04.006
更新日期:2020-06-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2011.10.001
更新日期:2012-01-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2012.01.003
更新日期:2012-03-01 00:00:00
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journal_title:Trends in immunology
pub_type: 评论,杂志文章
doi:10.1016/j.it.2016.07.003
更新日期:2016-09-01 00:00:00
abstract::Immunodeficiency due to inborn errors, infections, autoimmune diseases and the toxicity of certain therapies, has become an important clinical challenge. Strategies to enhance immune function could improve the outcome for a considerable number of patients. Although myeloid growth factors have found widespread use in c...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2004.11.002
更新日期:2005-01-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章
doi:10.1016/s1471-4906(02)00014-5
更新日期:2003-01-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/s1471-4906(00)01809-3
更新日期:2001-02-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2012.11.001
更新日期:2013-05-01 00:00:00
abstract::Two recent crystal structures of membrane attack complex/perforin (MACPF) domains found in the complement and perforin families unexpectedly reveal that some proteins of the immune system share a common core fold with their bacterial targets. Although a relationship between MACPF proteins and the previously characteri...
journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2007.11.003
更新日期:2008-02-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章
doi:10.1016/j.it.2006.09.006
更新日期:2006-11-01 00:00:00
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journal_title:Trends in immunology
pub_type: 杂志文章,评审
doi:10.1016/j.it.2019.08.004
更新日期:2019-10-01 00:00:00