Abstract：
:Recent advances in the understanding of medullary thymic epithelial cell biology, and especially of their promiscuous gene expression, have highlighted the indispensable role of thymic medulla in shaping a self-tolerant T-cell repertoire. Additionally, our recent results have shown that cortical thymic epithelial cells possess a unique proteasome (the so-called thymoproteasome), which seems to possess limited protein degradation capability for generating peptides that are loaded onto class I major histocompatibility complex molecules. We discuss here the unique role of thymoproteasomes in the development and repertoire formation of CD8+ T cells, focusing on the stepwise and contrasting roles of cortical epithelial cells and medullary epithelial cells. These results could offer fundamental new insights into the molecular mechanisms of T-cell repertoire selection.
journal_name
Trends Immunoljournal_title
Trends in immunologyauthors
Takahama Y,Tanaka K,Murata Sdoi
10.1016/j.it.2008.03.003subject
Has Abstractpub_date
2008-06-01 00:00:00pages
251-5issue
6eissn
1471-4906issn
1471-4981pii
S1471-4906(08)00117-8journal_volume
29pub_type
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