abstract：:Insulin resistance (IR) is a metabolic deficiency associated with type 2 diabetes and commonly related to the pathogenesis of cardiovascular diseases, being the determining factor of the metabolic syndrome. This research aims to understand the chronotropic and inotropic effects of Propranolol in isolated atrium of rat...

journal_title：Investigacion clinica

authors： Rodríguez G,Mago N

更新日期：2017-03-01 00:00:00

abstract：:The EVESCAM (EstudioVenezolano de Salud Cardio-Metabólica) is the first national, population survey in Venezuela, designed to examine the prevalence of diabetes and cardio-metabolic risk factors and its relationship with lifestyle. It is a cross-sectional, cluster sampling study, which recruited 4454 participants aged...

journal_title：Investigacion clinica

authors： Nieto-Martínez R,Inés Marulanda M,González-Rivas JP,Ugel E,Durán M,Barengo N,Aschner P,Patiño M,López Gómez L,Monsalve P,Marcano H,Florez H

更新日期：2017-03-01 00:00:00

abstract：:The antimicrobial efficacy of the silver nanoparticles (NPsAg), incorporated into the adhesive (primer) placed in the enamel adjacent to fixed orthodontic appliances (brackets), was evaluated. An experimental study was performed on 40 premolars in vitro, which were divided into two groups with brackets, one cemented w...

journal_title：Investigacion clinica

authors： Mariel Murga H,Centeno Sanchez R,Sánchez Meraz W,González Amaro AM,Arredondo Hérnandez R,Mariel Cárdenas J,Javier Gutiérrez Cantu F

更新日期：2016-12-01 00:00:00

abstract：:Arthur Schopenhauer (1788-1860) is known as the pessimist philosopher and the psychologist of the will. He anticipated some features of cognitive neuroscience, psychoanalysis and evolutionary psychology, but he is relatively unfamiliar to most contemporary mental health professionals. Schopenhauer conceived the will a...

journal_title：Investigacion clinica

authors： Baptista T

更新日期：2016-12-01 00:00:00

abstract：:Globally, about 50% of liver cancer originates as a result of long term infection with hepatitis B virus (HBV), and some genotypes and mutations have been associated with an increased severity of infection. The aim of this study was to evaluate the genetic diversity of HBV in patients from Venezuela, with chronic infe...

journal_title：Investigacion clinica

authors： Puche ML,Kay-Valero S,Michelli P,Oropeza MD,Loureiro CL,Devesa M,Dagher L,Pujol FH

更新日期：2016-03-01 00:00:00

abstract：:In general, it has been reported that rotavirus infection was detected year round in tropical countries. However, studies in Venezuela and Brazil suggest a seasonal behavior of the infection. On the other hand, some studies link infection with climatic variables such as rainfall. This study analyzes the pattern of beh...

journal_title：Investigacion clinica

authors： González Chávez R

更新日期：2015-09-01 00:00:00

abstract：:Multiple sclerosis is the most common cause of progressive neurological disability in young adults. This disease involves damage to the myelin sheath that normally insulates the electrical activity of nerve fibers. This leads to a wide range of symptoms as specific nerves become injured and lose their function. Epidem...

journal_title：Investigacion clinica

authors： Flores-Alvarado LJ,Gabriel-Ortiz G,Pacheco-Mois FP,Bitzer-Quintero K

更新日期：2015-06-01 00:00:00

abstract：:Investigación Clínica has been published uninterruptedly for 55 years and for this reason, the University of Zulia has recognized the work of its editorial team with the imposition of the Order "Jesus Enrique Lossada". Despite some financial and structural problems we are optimistic because our journal has been includ...

journal_title：Investigacion clinica

authors： Ryder E

更新日期：2015-03-01 00:00:00

abstract：:The aim of this study was to compare the identification of clin- ically relevant yeasts by the Vitek YBC and Microscan Walk Away RYID automated methods with conventional phenotypic methods. One hundred and ninety three yeast strains isolated from clinical samples and five controls strains were used. All the yeasts wer...

journal_title：Investigacion clinica

authors： Ferrara G,Mercedes Panizol M,Mazzone M,Delia Pequeneze M,Reviakina V

更新日期：2014-12-01 00:00:00

abstract：:Congenital heart diseases are defined as any heart or large vessel structural abnormality resulting from abnormal embryonic development, usually described between the 3rd and 10th week of gestation. They comprise the second cause of death in children under a year of age in Colombia, with a prevalence of 7.5-9.5 per 1,...

journal_title：Investigacion clinica

authors： Orjuela Quintero DC,Núñez F,Caicedo V,Pachón S,Salazar Salazar M

更新日期：2014-09-01 00:00:00

abstract：:In Latin America, people have largely abandoned the practice of wearing hats and traditional clothing that provided skin protection. Sunscreen application has therefore become essential to protect against the increased sun exposure. The physician-prescribed medical-grade sunscreens provide sufficient sun protection bu...

journal_title：Investigacion clinica

authors： Castanedo-Cázares JP,Martínez-Rosales K,Hernández-Blanco D,Valdés-Rodríguez G,Torres-Alvarez B

更新日期：2014-06-01 00:00:00

abstract：:In this study we determined the prevalence of extended-spectrum beta-lactamases (ESBLs) in phylogenetic groups of uropathogenic E. coli (UPEC) isolated from patients in the community. Twenty one UPEC strains with reduced susceptibility to broad-spectrum cephalosporins were collected between January 2009 and July 2010,...

journal_title：Investigacion clinica

authors： Hernández E,Araque M,Millán Y,Millán B,Vielma S

更新日期：2014-03-01 00:00:00

abstract：:Infective endocarditis (IE) associated with permanent cardiovascular implantable electronic devices (CIEDs) is a complication of low frequency, but high mortality without adequate treatment. Progress on the knowledge of this disease and the development of therapeutic strategies such as early diagnosis, antibiotic mana...

journal_title：Investigacion clinica

authors： Pérez-Baztarrica G,Salvaggio F,Blanco N,Mazzetti H,Levin R,Botbol A,Porcile R

更新日期：2013-12-01 00:00:00

abstract：:Neuregulins (NRG) are proteins that belong to the family of epidermal growth factors. It is well established that these factors are essential for the development and maintenance of the nervous system. Due to the difficulty of purifying enough quantities of these factors and the lack of specificity from commercially av...

journal_title：Investigacion clinica

authors： Felizzola O,Martínez JC,Zerpa N,Malavé C

更新日期：2013-09-01 00:00:00

abstract：:The purpose of this research was to investigate how the knowledge and attitudes have influence in Cervical Cancer (CC) screening among Venezuelan women, by realizing a cross-sectional descriptive study based on a structured non disguised questionnaire with closed ended questions: yes/no questions and multiple choices....

journal_title：Investigacion clinica

authors： Núñez-Troconis J,Tulliani E,Gabriela Martínez M,Fernández N

更新日期：2013-03-01 00:00:00

abstract：:Metastases in the sellar region are rare and are frequently found incidentally or in necropsies. Only 7% are reported to be symptomatic. Diabetes insipidus, anterior pituitary dysfunction, visual field defects, headache/pain and ophthalmoplegia are the most commonly reported symptoms. We present the cases of two male ...

journal_title：Investigacion clinica

authors： Benaiges D,Zanui M,Chillaron JJ,Arriola E,Garrigos L,Pedro-Botet J

更新日期：2012-12-01 00:00:00

abstract：:The aim of this study was to evaluate the fracture resistance of teeth with incomplete root development and intracanal reinforcement with adhesives materials. 50 human central and lateral incisors were instrumented and prepared to simulate an immature tooth and filled apically with MTA. The samples were divided into f...

journal_title：Investigacion clinica

authors： Cabrales Salgado R,Carvajal Cabrales K,Pupo Marrugo S,Hernández González DF,Gracia Bárcenas JL

更新日期：2012-09-01 00:00:00

abstract：:The aim of this study was to determine the prevalence of cytomegalovirus (CMV) in pediatric patients with neurological disorders from Zulia State, Venezuela, during the period 2007-2008. Samples of cerebrospinal fluid (CSF) and serum were obtained from 186 patients with neurological symptoms and bacteriological negati...

journal_title：Investigacion clinica

authors： Vivolo M,Durán A,Atacho L,Porto L,Bermúdez J,Valero N

更新日期：2012-06-01 00:00:00

abstract：:HIV (human immunodeficiency virus) infection is today a very important health issue worldwide, which demands new ways and strategies for its prevention and treatment. Several studies on the innate immunity against HIV infection have shown that antimicrobial peptides are associated with increased resistance to infectio...

journal_title：Investigacion clinica

authors： Castañeda-Delgado JE,Cervantes-Villagrana AR,Rivas-Santiago B

更新日期：2012-03-01 00:00:00

abstract：:The aim of this study was to determine the presence of pesticides in drinking water from six aqueducts in a region of intense agricultural activity in the state of Merida, Venezuela. The study was conducted for four continuous weeks, between May and June 2008. Pesticide residues were analyzed by solid phase extraction...

journal_title：Investigacion clinica

authors： Flores-García ME,Molina-Morales Y,Balza-Quintero A,Benítez-Díaz PR,Miranda-Contreras L

更新日期：2011-12-01 00:00:00

abstract：:One of the phenomena that offers more questions in Immunology is: Why the embryo, behaving like a semialogenic graft, is not rejected by the mother? It is known that the mother produces an active immunological response against the fetus and, nevertheless, in normal conditions, the immunological rejection does not take...

journal_title：Investigacion clinica

authors： Barañao RI

更新日期：2011-06-01 00:00:00

abstract：:During the past two years, Investigación Clínica has undergone a substantial reduction in its funding caused by the insufficient budget allotment that the University of Zulia has received from the Venezuelan Government. The progressive increase in the number of articles contained in each issue of the journal caused it...

journal_title：Investigacion clinica

authors： Ryder E

更新日期：2011-03-01 00:00:00

abstract：:Adenosine deaminase (ADA) is an enzyme of purine metabolism which has been the subject of much interest because the congenital defect of this enzyme causes severe combined immunodeficiency syndrome. One of the three isoforms of the enzyme (ecto-ADA) is capable of binding to the glycoprotein CD26 and adenosine receptor...

journal_title：Investigacion clinica

authors： Pérez-Aguilar MC,Goncalves L,Ibarra A,Bonfante-Cabarcas R

更新日期：2010-12-01 00:00:00

abstract：:Individuals with hypertension, dyslipidemia or diabetes are at a higher risk to suffer cardiovascular disease than other people; while impaired fibrin structure/function may contribute to further raise the cardiovascular risk in the former. The purpose of this work was to study the fibrin network and fibrin degradatio...

journal_title：Investigacion clinica

authors： Marchi-Cappelletti R,Suárez-Nieto N

更新日期：2010-09-01 00:00:00

abstract：:The study was designed for evaluating immunological reactivity to various mycobacterial protein preparations using serological and cell-mediated immunological tests in patients with clinical leprosy signs, predominantly, with the multibacillary forms. All patients were adults with ages between 20 and 30 years. Fifty e...

journal_title：Investigacion clinica

authors： Rada E,Aranzazu N,Rodríguez V,Borges R,Convit J

更新日期：2010-09-01 00:00:00

abstract：:The history of Entamoeba histolytica is very confuse and shows several wrong concepts about the parasite and its relationship with the host. The poor correlation between the prevalence of asymptomatic and symptomatic amebiasis originated the proposal of three explicative hypothesis, among them was the concept of Brump...

journal_title：Investigacion clinica

authors： Chacín-Bonilla L

更新日期：2010-06-01 00:00:00

abstract：UNLABELLED:In this prospective study we evaluated the performance characteristics of a specific and sensitive antigen preparation (AgA) used in an enzyme-linked immunosorbent assay (ELISA) for the detection of anti-Trypanosoma cruzi antibodies in serum samples, for Chagas' disease diagnosis. The antigen production was ...

journal_title：Investigacion clinica

authors： Briceño L,Rodríguez EM,Medina M,Campos Y,Mosca W,Briceño A,León G

更新日期：2010-03-01 00:00:00

abstract：:The effects of prenatal expossure to paraquat (PQ) were studied on postnatal development of mouse parietal cerebral cortex, in particular, the ontogenesis of amino acid synaptic transmission. Pregnant NMRI mice were separated into two groups: the experimental group received 5 doses of 10 mg PQ/kg body weight, between ...

journal_title：Investigacion clinica

authors： Benítez-Díaz P,Miranda-Contreras L

更新日期：2009-12-01 00:00:00

abstract：:As of July 1st 2009, 90300 cases of the new Influenza A (H1N1) have been officially reported to the World Health Organization (WHO) in more than 80 countries. Venezuela does not seem to be the exception, but it was not until June 11th 2009, when the first case was reported; however, the Venezuelan sanitary authorities...

journal_title：Investigacion clinica

authors： Gotera J,Valero N

更新日期：2009-09-01 00:00:00

abstract：:Human sexual orientation is a complex trait, influenced by several genes, experiential and sociocultural factors. These elements interact and produce a typical pattern of sexual orientation towards the opposite sex. Some exceptions exist, like bisexuality and homosexuality, which seem to be more frequent in males than...

journal_title：Investigacion clinica

authors： Rodríguez-Larralde A,Paradisi I

更新日期：2009-09-01 00:00:00

abstract：:The Malassezia genus contains a group of lipophilic yeasts that form part of the normal microbiota of human and animals skins. The presence of Malassezia species was studied on healthy skin in children, who attended day care centers, located in Maracaibo, Zulia state, Venezuela. Children without skin lesions that were...

journal_title：Investigacion clinica

authors： González-Morán E,Rodríguez-Valero S,Del Monte ML,Briceño M,Sintjago S,Mesa LM,García D,Villalobos R,Pereira N

更新日期：2009-06-01 00:00:00

abstract：:Transverse myelitis (TM) is an inflammatory process involving restricted areas of the spinal cord. The usually dramatic presentation with rapidly progressive symptoms involving motor, sensory and autonomic functions makes acute TM a medical emergency. Acute TM has been cited as a rare and unusual complication of syste...

journal_title：Investigacion clinica

authors： Tristano AG

更新日期：2009-06-01 00:00:00

abstract：:The clinical case of a 6 years old boy, who presented severe right renal trauma with rupture of the pyelocaliceal system and renal injury (IV grade), is reported. Upon admittance to emergency he presented paleness, tachycardia, rapid pulse, intense pain in the right lumbar region and macroscopic hematuria. Using abdom...

journal_title：Investigacion clinica

authors： Fernández-Fernández J,Robles G,Amado-Medina L,Rincón-Márquez E,Pachano-Arenas F

更新日期：2009-03-01 00:00:00

abstract：:Chromosomal abnormalities are frequent pathologies. We must find new methods for early prenatal diagnosis. Therefore we propose to assess the effectiveness of nuchal translucency thickness and abnormal Doppler of ductus venosus as ultrasound markers of aneuploidies. We evaluated 228 high risk pregnancies between 11 an...

journal_title：Investigacion clinica

authors： Díaz V,Guevara R,Brito J

更新日期：2008-12-01 00:00:00

abstract：:Haemophilia A (HA) and B (HB) are the most common inherited bleeding diseases. HA and HB are X-linked recessive disorders caused by mutation in the factor VIII gene which maps to Xq28 and factor IX located at Xq27, respectively; resulting in absence or deficiency of these proteins. Several mutations have been reported...

journal_title：Investigacion clinica

authors： Morales-Machín A,Borjas-Fajardo L,Zabala W,Alvarez F,Fernández E,Zambrano M,Delgado W,Hernández ML,Solis-Añez E,Chacín JA

更新日期：2008-09-01 00:00:00

abstract：:Tuberculosis (TB) is one of the main causes of death by M. tuberculosis infection in humans worldwide and, it is worrying that the number of cases have been increasing in recent years, largely due to HIV infection. Since the diagnostic methods for detecting the disease are not totally effective because of their lack o...

journal_title：Investigacion clinica

authors： Araujo Z,Acosta M,Escobar H,Baños R,Fernández de Larrea C,Rivas-Santiago B

更新日期：2008-09-01 00:00:00

abstract：:The aim of this paper is to present the main clinical findings and evolution of a fatal case of Berardinelli Syndrome (congenital generalized lipodystrophy). A 15-year-old girl, followed since the age of three months in the Genetic outpatients' clinic, developed insulin resistance when she was eight years old. She had...

journal_title：Investigacion clinica

authors： Daher E,Silva Júnior G,Benevides V,Mendonça P,Bezerra H,Silva A,Fernandes V,Montenegro Júnior R,Azevedo MF

更新日期：2008-06-01 00:00:00

abstract：:The objectives of this study were first, to validate the Primary Care Evaluation of Mental Disorders (PRIME-MD) as an instrument that identifies the generalized anxiety disorder (GAD) in psychiatric consultations and second, to determine the frequency of GAD in two types of psychiatric consultation settings. To begin ...

journal_title：Investigacion clinica

authors： Mata S,González A,Lavie R,Resler G

更新日期：2008-03-01 00:00:00

abstract：:Between March-July 2003, a cross-sectional survey was conducted to investigate clinical and epidemiological data on Pediculus capitis infestation among 327 (175 males and 152 females) primary school age children of an urban sector of Coro city, from the semiarid region of Falcon state, north-western Venezuela. Childre...

journal_title：Investigacion clinica

authors： Cazorla D,Ruiz A,Acosta M

更新日期：2007-12-01 00:00:00

abstract：:To assess mercury exposure and potential risk, total mercury (THg-H) and methylmercury (MeHg-H) in hair were studied in 160 adults. The study group consisted of 60 individuals living in the north central coast of Venezuela. A section of the area was known to be contaminated with mercury from a chlor-alkali plant insta...

journal_title：Investigacion clinica

authors： Rojas M,Nakamura K,Seijas D,Squiuante G,Pieters MA,Infante S

更新日期：2007-09-01 00:00:00