听力与言语-语言病理学

行为科学

医学伦理学

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  • Serum uric acid level as a putative biomarker in Parkinson's disease patients carrying GBA1 mutations: 2-Year data from the PPMI study.

    abstract:INTRODUCTION:Blood uric acid represents an important biomarker in sporadic Parkinson's disease (PD). Whether uric acid levels change in genetic forms of PD is beginning to be assessed. The aim of the present study was to evaluate differences in serum uric acid level among PD patients harboring mutations in the glucocer...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2020.12.020

    authors: Koros C,Simitsi AM,Papagiannakis N,Bougea A,Prentakis A,Papadimitriou D,Pachi I,Antonelou R,Angelopoulou E,Beratis I,Bozi M,Papageorgiou SG,Trapali XG,Stamelou M,Stefanis L

    更新日期:2021-01-20 00:00:00

  • The pattern of FP-CIT PET in pure white matter hyperintensities-related vascular parkinsonism.

    abstract:OBJECTIVES:To determine whether vascular parkinsonism (VaP) patients with visually normal dopamine transporter (DAT) scans have presynaptic dopaminergic depletion. METHODS:We enrolled 23 VaP patients who had parkinsonism, relevant diffuse subcortical white matter hyperintensities (WMH), and visually normal DAT scans, ...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2020.11.002

    authors: Lee YH,Lee S,Chung SJ,Yoo HS,Jung JH,Baik K,Ye BS,Sohn YH,Yun M,Lee PH

    更新日期:2021-01-01 00:00:00

  • SNCA-Rep1 polymorphism correlates with susceptibility and iron deficiency in restless legs syndrome.

    abstract:BACKGROUND:Brain iron disequilibrium and dopaminergic dysfunction are key pathophysiological features of Restless Legs Syndrome (RLS). Rep1 polymorphism in the promotor region of SNCA is associated with risk of Parkinson's disease, however its association with RLS and iron status is unclear. OBJECTIVE:To investigate S...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2020.09.015

    authors: Zhu XY,Wang HM,Wu TT,Liu T,Chen YJ,Li X,Chen TJ,Liu Y,Zhang XJ,Wang XX,Zhang Y,Ondo WG,Wu YC

    更新日期:2020-12-01 00:00:00

  • Pathological findings in a patient with alpha-synuclein p.A53T and familial Parkinson's disease.

    abstract::The present report documents a patient harboring an alpha-synuclein p.A53T variant from a family presenting with autosomal dominant inheritance, including four patients clinically diagnosed with Parkinson's disease (PD) and two with dementia. The alpha-synuclein p.A53T variant is linked to young- or middle-aged onset ...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2020.11.001

    authors: Nishioka K,Hashizume Y,Takanashi M,Daida K,Li Y,Yoshino H,Tambasco N,Prontera P,Hattori Y,Ueda A,Watanabe H,Hattori N

    更新日期:2020-12-01 00:00:00

  • Apolipoprotein E ε4 genotype and risk of freezing of gait in Parkinson's disease.

    abstract:OBJECTIVE:To investigate the association between Apolipoprotein E (APOE) genotype and freezing of gait (FOG) in Parkinson's disease (PD). METHODS:This cohort study included 339 early PD patients who were divided into APOE ε4-positive (n = 88) and ε4-negative (n = 251) groups. They were followed-up for up to 6 years to...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2020.10.033

    authors: Kim R,Shin JH,Park S,Kim HJ,Jeon B

    更新日期:2020-12-01 00:00:00

  • Bilateral pallidal stimulation improves cervical dystonia for more than a decade.

    abstract:INTRODUCTION:Deep brain stimulation (DBS) is an effective treatment in medically resistant cervical dystonia (CD) with a documented therapeutic effect. Long term outcome beyond a decade, however, has not been studied systematically. METHODS:To investigate the impact of pallidal DBS beyond 10 years in CD we followed a ...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2020.10.028

    authors: Kaelin-Lang A,You H,Burgunder JM,Lönnfors-Weitze T,Loher TJ,Taub E,Isaias IU,Krauss JK,Michael Schüpbach WM

    更新日期:2020-12-01 00:00:00

  • The probable REM sleep behavior disorder negatively affects health-related quality of life in Parkinson's disease with bilateral subthalamic nucleus stimulation.

    abstract:OBJECTIVE:The aim of this study was to compare the short- and long-term outcomes of bilateral subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD) patients with and without probable REM sleep behavior disorder (RBD). METHODS:We retrospectively reviewed 127 patients who underwent bilateral S...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2020.06.031

    authors: Park S,Kim R,Shin JH,Kim HJ,Paek SH,Jeon B

    更新日期:2020-12-01 00:00:00

  • Essential tremor: Is the word "essential" really essential?

    abstract::Essential tremor (ET) is among the common movement disorders. A surge in research in recent years has considerably improved our understanding of disease etiology and pathogenesis, and its associated clinical phenomenology and natural history. With this progress have emerged a multitude of new questions and conundrums ...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2020.10.035

    authors: Lenka A,Louis ED

    更新日期:2020-12-01 00:00:00

  • Prevalence and clinical associations of tau in Lewy body dementias: A systematic review and meta-analysis.

    abstract:INTRODUCTION:Alzheimer's disease neuropathologies (amyloid-β and tau) frequently co-exist to varying degrees in Lewy body dementias (LBD), which include dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD). OBJECTIVES:To investigate the prevalence of tau in DLB and PDD, and its associations with clin...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章,评审

    doi:10.1016/j.parkreldis.2020.09.030

    authors: Chin KS,Yassi N,Churilov L,Masters CL,Watson R

    更新日期:2020-11-01 00:00:00

  • Do caffeine and more selective adenosine A2A receptor antagonists protect against dopaminergic neurodegeneration in Parkinson's disease?

    abstract::The adenosine A2A receptor is a major target of caffeine, the most widely used psychoactive substance worldwide. Large epidemiological studies have long shown caffeine consumption is a strong inverse predictor of Parkinson's disease (PD). In this review, we first examine the epidemiology of caffeine use vis-à-vis PD a...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2020.10.024

    authors: Chen JF,Schwarzschild MA

    更新日期:2020-11-01 00:00:00

  • Action observation improves sit-to-walk in patients with Parkinson's disease and freezing of gait. Biomechanical analysis of performance.

    abstract:INTRODUCTION:Freezing of gait (FoG) is one of the most disabling gait disorders in Parkinson's disease (PD), reflecting motor and cognitive impairments, mainly related to dopamine deficiency. Recent studies investigating kinematic and kinetic factors affecting gait in these patients showed a postural instability charac...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2020.09.029

    authors: Mezzarobba S,Grassi M,Pellegrini L,Catalan M,Krüger B,Stragapede L,Manganotti P,Bernardis P

    更新日期:2020-11-01 00:00:00

  • Analysis of diffusion tensor parameters in spinocerebellar ataxia type 3 and type 10 patients.

    abstract:INTRODUCTION:There is a dearth of studies of spinocerebellar ataxias (SCAs) and diffusion tensor magnetic resonance imaging (DTI). OBJECTIVE:To analyze changes observed in DTI parameters and correlate these to clinical findings in SCA3 and SCA10 patients. METHODS:SCA3 (n = 19) and SCA10 (n = 18) patients were compare...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2020.06.460

    authors: Meira AT,Arruda WO,Ono SE,Franklin GL,de Carvalho Neto A,Raskin S,Ashizawa T,Camargo CHF,Teive HAG

    更新日期:2020-09-01 00:00:00

  • Diagnostic accuracy of the appearance of Nigrosome-1 on magnetic resonance imaging in Parkinson's disease: A systematic review and meta-analysis.

    abstract:INTRODUCTION:There is currently no definitive diagnostic test for Parkinson's disease (PD) and the current diagnostic procedure primarily relies on clinical manifestations. A hypointense appearance of nigrosome-1 (or absence of the "swallow tail" sign) on magnetic resonance imaging (MRI) has been proposed as a biomarke...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章,评审

    doi:10.1016/j.parkreldis.2020.07.002

    authors: Chau MT,Todd G,Wilcox R,Agzarian M,Bezak E

    更新日期:2020-09-01 00:00:00

  • Efficacy and safety of atypical antipsychotics for psychosis in Parkinson's disease: A systematic review and Bayesian network meta-analysis.

    abstract:INTRODUCTION:We performed a systematic review and Bayesian network meta-analysis to clarify the relative efficacy and safety of pimavanserin compared to atypical antipsychotics for psychosis in Parkinson's disease (PD). METHODS:PubMed, Embase, Cochrane Central Register of Controlled Trials, and Japana Centra Revuo Med...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2020.07.021

    authors: Iketani R,Furushima D,Imai S,Yamada H

    更新日期:2020-09-01 00:00:00

  • Plasma immune markers in an idiopathic REM sleep behavior disorder cohort.

    abstract:INTRODUCTION:Increasing evidence shows a strong association between idiopathic REM sleep behavior disorder (iRBD) and α-synucleinopathies. Recent studies have indicated an inflammatory mechanism in the pathogenesis of α-synucleinopathies. Whether peripheral inflammatory cytokines are altered in iRBD and can be biomarke...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2020.07.017

    authors: Zhang H,Wang T,Li Y,Mao W,Hao S,Huang Z,Chan P,Cai Y

    更新日期:2020-09-01 00:00:00

  • Long-term evaluation of open-label pimavanserin safety and tolerability in Parkinson's disease psychosis.

    abstract:INTRODUCTION:Pimavanserin is a selective 5-HT2A inverse agonist/antagonist approved for treating hallucinations and delusions associated with Parkinson's disease psychosis (PDP). Results from short-term, placebo-controlled studies demonstrated a positive benefit/risk profile. This multi-year, open-label study assessed ...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2020.06.026

    authors: Ballard CG,Kreitzman DL,Isaacson S,Liu IY,Norton JC,Demos G,Fernandez HH,Ilic TV,Azulay JP,Ferreira JJ,Abler V,Stankovic S,015 Study Group.

    更新日期:2020-08-01 00:00:00

  • Medical management of myoclonus-dystonia and implications for underlying pathophysiology.

    abstract::Myoclonus-dystonia is an early onset genetic disorder characterised by subcortical myoclonus and less prominent dystonia. Its primary causative gene is the epsilon-sarcoglycan gene but the syndrome of "myoclonic dystonia" has been shown to be a heterogeneous group of genetic disorders. The underlying pathophysiology o...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章,评审

    doi:10.1016/j.parkreldis.2020.06.016

    authors: Fearon C,Peall KJ,Vidailhet M,Fasano A

    更新日期:2020-08-01 00:00:00

  • Female, aging, difference formulations of DCI, or lower body weight increases AUC4hr of levodopa in patients with Parkinson's disease.

    abstract:INTRODUCTION:There is considerable intra- and inter-individual variability in the pharmacokinetics (PK) of levodopa after oral administration. Inter-individual variability in levodopa PK has also been demonstrated in fasting single-dose studies. We examined the factors that affect levodopa PK in patients with Parkinson...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2020.05.020

    authors: Nishikawa N,Iwaki H,Shiraishi T,Mukai Y,Takahashi Y,Murata M

    更新日期:2020-07-01 00:00:00

  • Functional correlates of cognitive slowing in Parkinson's disease.

    abstract::Although attentional impairments (particularly cognitive slowing) are frequent in Parkinson's disease (PD), the mechanisms underlying these phenomena have not been fully characterized. The MRI-compatible version of the Symbol Digit Modalities Test (SDMT) has been applied to healthy individuals but not previously to pa...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2020.05.006

    authors: Grolez G,Viard R,Lopes R,Kuchcinski G,Defebvre L,Devos D,Dujardin K,Moreau C

    更新日期:2020-07-01 00:00:00

  • A physical therapy programme for functional motor symptoms: A telemedicine pilot study.

    abstract:INTRODUCTION:for a proportion of patients with functional motor symptoms (FMS), specific physiotherapy has recently emerged as a promising treatment. Aim of the present study was to assess in a sample of patients with FMS the efficacy of a physical therapy-based telemedicine programme on the motor symptoms themselves a...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2019.05.004

    authors: Demartini B,Bombieri F,Goeta D,Gambini O,Ricciardi L,Tinazzi M

    更新日期:2020-07-01 00:00:00

  • Oropharyngeal freezing and its relation to dysphagia - An analogy to freezing of gait.

    abstract:INTRODUCTION:The pathophysiology of dysphagia in Parkinson's disease (PD) is heterogeneous and poorly understood at present. This study investigated the phenotypes, prevalence and pathophysiology of oropharyngeal freezing (OPF) in PD and its relation to dysphagia. METHODS:In a prospective study, 50 PD patients were sy...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2020.05.002

    authors: Labeit B,Claus I,Muhle P,Lapa S,Suntrup-Krueger S,Dziewas R,Osada N,Warnecke T

    更新日期:2020-06-01 00:00:00

  • The impact of supine hypertension on target organ damage and survival in patients with synucleinopathies and neurogenic orthostatic hypotension.

    abstract:INTRODUCTION:In addition to neurogenic orthostatic hypotension (nOH), patients with synucleinopathies frequently have hypertension when supine. The long-term consequences of both abnormalities are difficult to disentangle. We aimed to determine if supine hypertension is associated with target organ damage and worse sur...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2020.04.011

    authors: Palma JA,Redel-Traub G,Porciuncula A,Samaniego-Toro D,Millar Vernetti P,Lui YW,Norcliffe-Kaufmann L,Kaufmann H

    更新日期:2020-06-01 00:00:00

  • Pareidolias and cognition in isolated REM sleep behavior disorder.

    abstract:BACKGROUND:Though visual illusions and hallucinations are common in dementia with Lewy bodies (DLB) and Parkinson's disease (PD), they are not typically observed clinically in prodromal stages, including isolated REM sleep behavior disorder (iRBD). False-noise errors on the pareidolia test (seeing faces when none are p...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2020.05.017

    authors: Honeycutt L,Gagnon JF,Pelletier A,De Roy J,Montplaisir JY,Postuma RB

    更新日期:2020-06-01 00:00:00

  • Utility of quantitative EEG in early Lewy body disease.

    abstract:INTRODUCTION:The reduction of background activity and the increase of low-frequency powers on electroencephalogram (EEG) correlate with cognitive impairment and have been suggested to be underpinned by cholinergic deficit. We aimed to investigate the ratio between α and θ band power (α/θ ratio), as a synoptic index of ...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2020.05.007

    authors: Massa F,Meli R,Grazzini M,Famà F,De Carli F,Filippi L,Arnaldi D,Pardini M,Morbelli S,Nobili F

    更新日期:2020-06-01 00:00:00

  • Serum neurofilament light chain levels reflect cortical neurodegeneration in de novo Parkinson's disease.

    abstract:INTRODUCTION:Cognitive impairment and dementia are highly prevalent non-motor complications in Parkinson's disease (PD) with deleterious consequences for patients and caregivers. With no treatment currently available, finding and validating minimally-invasive biomarkers of neurodegeneration in this population represent...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2020.04.009

    authors: Sampedro F,Pérez-González R,Martínez-Horta S,Marín-Lahoz J,Pagonabarraga J,Kulisevsky J

    更新日期:2020-05-01 00:00:00

  • Ischemic injury precipitates neuronal vulnerability in Parkinson's disease: Insights from PINK1 mouse model study and clinical retrospective data.

    abstract:INTRODUCTION:Increasing evidence demonstrates the relevant association between Parkinson's disease (PD) and vascular diseases/risk factors, as well as a worse clinico-pathological progression in those patients with vascular comorbidity. The mechanisms underlying this relationship have not been clarified yet, although t...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2020.04.004

    authors: Imbriani P,D'Angelo V,Platania P,Di Lazzaro G,Scalise S,Salimei C,El Atiallah I,Colona VL,Mercuri NB,Bonsi P,Pisani A,Schirinzi T,Martella G

    更新日期:2020-05-01 00:00:00

  • Could Mucuna pruriens be the answer to Parkinson's disease management in sub-Saharan Africa and other low-income countries worldwide?

    abstract::Parkinson's disease (PD) is a progressive, disabling, neurodegenerative disease that requires long term care and pharmaceutical treatment. Levodopa remains the gold standard treatment for PD globally, although it is largely unavailable and unaffordable for the majority of patients in many sub-Saharan African and other...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2020.03.002

    authors: Fothergill-Misbah N,Maroo H,Cham M,Pezzoli G,Walker R,Cilia R

    更新日期:2020-04-01 00:00:00

  • Delivering patient-centered care in Parkinson's disease: Challenges and consensus from an international panel.

    abstract::An international panel of movement disorders specialists explored the views and perceptions of people with Parkinson's disease (PD) about their condition and its treatment, including the potential mismatch between the clinician's view of the patient's condition and their own view of what aspects of the disease most af...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2020.02.013

    authors: Bhidayasiri R,Panyakaew P,Trenkwalder C,Jeon B,Hattori N,Jagota P,Wu YR,Moro E,Lim SY,Shang H,Rosales R,Lee JY,Thit WM,Tan EK,Lim TT,Tran NT,Binh NT,Phoumindr A,Boonmongkol T,Phokaewvarangkul O,Thongchuam Y,Vora

    更新日期:2020-03-01 00:00:00

  • Diagnostic potential of automated tractography in progressive supranuclear palsy variants.

    abstract:BACKGROUND:Microstructural white matter integrity captured by diffusion-tensor imaging (DTI) is significantly more affected in progressive supranuclear palsy-Richardson's syndrome (PSP-RS) compared to PSP-parkinsonism (PSP-P). OBJECTIVES:To characterize the microstructural integrity of large fascicular bundles using s...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2020.02.007

    authors: Potrusil T,Krismer F,Beliveau V,Seppi K,Müller C,Troger F,Göbel G,Steiger R,Gizewski ER,Poewe W,Scherfler C

    更新日期:2020-03-01 00:00:00

  • Comment on Akbar et al., "Valbenazine-induced parkinsonism".

    abstract::This letter to the editor acknowledges the contribution of Akbar et al. to the field of tardive dyskinesia (TD) and provides important regulatory information about the potential for parkinson-like symptoms in patients with TD who are treated with valbenazine. ...

    journal_title:Parkinsonism & related disorders

    pub_type: 评论,信件

    doi:10.1016/j.parkreldis.2020.01.011

    authors: Shah C

    更新日期:2020-02-01 00:00:00

  • Quality of life outcomes after deep brain stimulation in dystonia: A systematic review.

    abstract::Dystonia is an incurable movement disorder which can cause not only physical but also mental problems, leading to impaired health-related quality of life (HRQoL). For patients with dystonia refractory to medical treatment, deep brain stimulation (DBS) is a well-established surgical treatment. The objective of this sys...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2019.11.016

    authors: Tsuboi T,Wong JK,Okun MS,Ramirez-Zamora A

    更新日期:2020-01-01 00:00:00

  • Evolution of neuropsychological profile in motor subtypes of multiple system atrophy.

    abstract:INTRODUCTION:Cognitive deficits and neuropsychiatric symptoms occur in parkinsonian and cerebellar subtypes of Multiple System Atrophy (MSA-P and MSA-C). These symptoms have been investigated mainly in cross-sectional studies. The present 1-year follow-up study aimed at evaluating the evolution of cognitive and neurops...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2019.12.010

    authors: Santangelo G,Cuoco S,Picillo M,Erro R,Squillante M,Volpe G,Cozzolino A,Cicarelli G,Barone P,Pellecchia MT

    更新日期:2020-01-01 00:00:00

  • Obstructive sleep apnea, CPAP therapy and Parkinson's disease motor function: A longitudinal study.

    abstract:INTRODUCTION:We aimed to assess, in patients with Parkinson's disease (PD), the association between obstructive sleep apnea (OSA), progression of motor dysfunction and the effect of OSA treatment. METHODS:Data were analysed from a prospective cohort study of idiopathic PD patients from a movement disorders clinic. Pat...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2019.12.001

    authors: Meng L,Benedetti A,Lafontaine AL,Mery V,Robinson AR,Kimoff J,Gros P,Kaminska M

    更新日期:2020-01-01 00:00:00

  • Nationwide prevalence of primary dystonia, progressive ataxia and hereditary spastic paraplegia.

    abstract:OBJECTIVE:To determine the nationwide prevalence of primary dystonia, ataxia and hereditary spastic paraplegia (HSP) in Sweden. METHODS:We extracted data on all patients who were registered in The National Patient Register (NPR) in Sweden (population 9.64 million) at least twice during five consecutive years with a di...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2019.10.028

    authors: Hellberg C,Alinder E,Jaraj D,Puschmann A

    更新日期:2019-12-01 00:00:00

  • Cognitive associations with comprehensive gait and static balance measures in Parkinson's disease.

    abstract:INTRODUCTION:Gait and balance impairments are cardinal features of Parkinson's disease (PD) that require cognitive input. However, the extent to which specific gait and balance characteristics relate to cognition in PD is unclear. In addition, independent models of gait and balance have not been developed from the same...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2019.06.014

    authors: Morris R,Martini DN,Smulders K,Kelly VE,Zabetian CP,Poston K,Hiller A,Chung KA,Yang L,Hu SC,Edwards KL,Cholerton B,Grabowski TJ,Montine TJ,Quinn JF,Horak F

    更新日期:2019-12-01 00:00:00

  • Clinical findings of autosomal-dominant striatal degeneration and PDE8B mutation screening in parkinsonism and related disorders.

    abstract:BACKGROUND:Autosomal-dominant striatal degeneration (ADSD) is a rare neurodegenerative movement disorder caused by mutations in the Phosphodiesterase 8B (PDE8B) gene. OBJECTIVE:To summarize the clinical and imaging features of a Chinese ADSD family and determine whether mutations in PDE8B are associated with Parkinson...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2019.11.002

    authors: Ni J,Yi X,Liu Z,Sun W,Yuan Y,Yang J,Jiang H,Shen L,Tang B,Liu Y,Wang J

    更新日期:2019-12-01 00:00:00

  • Increases in institutionalization, healthcare resource utilization, and mortality risk associated with Parkinson disease psychosis: Retrospective cohort study.

    abstract:INTRODUCTION:Patients with Parkinson disease (PD) often develop psychosis (P). The association of PDP with death and long-term custodial care (CC) has not been well studied. METHODS:Medicare Parts A, B, and D data, 2007-2015, were used to define cohorts of PD and PDP patients. PD was defined by ≥ 2 ICD-9-CM codes (332...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2019.10.018

    authors: Wetmore JB,Li S,Yan H,Irfan M,Rashid N,Peng Y,Gilbertson DT,Shim A

    更新日期:2019-11-01 00:00:00

  • Effect of light on blinking in patients with idiopathic isolated blepharospasm.

    abstract:OBJECTIVE:Melanopsin may be involved in the pathophysiology of photophobia in idiopathic isolated blepharospasm. We assessed the efficacy of blocking wavelengths of melanopsin absorption to reduce blinking in blepharospasm as a possible surrogate for photophobia. METHODS:Twenty-one participants (11 blepharospasm and 1...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2019.09.010

    authors: Wu Y,Cho HJ,Panyakaew P,Savant CS,Wu T,Dang N,Hallett M

    更新日期:2019-10-01 00:00:00

  • Quantifying physical activity in early Parkinson disease using a commercial activity monitor.

    abstract:INTRODUCTION:Physical inactivity in Parkinson disease (PD) has an impact on motor and non-motor symptoms of the disease. It is unclear whether this decline in physical activity occurs early in the disease, in addition to any decline due to aging, and whether commercial activity monitors can be used to self-monitor phys...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2019.08.001

    authors: Pradhan S,Kelly VE

    更新日期:2019-09-01 00:00:00

  • Selecting candidates for Deep Brain Stimulation in Parkinson's disease: the role of patients' expectations.

    abstract::Patients with advanced Parkinson's Disease (PD) may be eligible for Deep Brain Stimulation (DBS) in case of medication-related motor fluctuations or tremor refractory to oral medication. However, several PD symptoms are unresponsive to DBS and constitute relative contra-indications for DBS. Patients referred for DBS u...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.parkreldis.2019.07.011

    authors: Geraedts VJ,Kuijf ML,van Hilten JJ,Marinus J,Oosterloo M,Contarino MF

    更新日期:2019-09-01 00:00:00

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