Comment on Akbar et al., "Valbenazine-induced parkinsonism".

abstract：INTRODUCTION:Low body weight in Parkinson's disease (PD) is poorly understood despite the associated risks of malnutrition, fractures, and death. Sarcopenia (loss of muscle bulk and strength) and frailty are geriatric syndromes that are likewise associated with adverse health outcomes, yet have received scant attention...

journal_title：Parkinsonism & related disorders

authors： Tan AH,Hew YC,Lim SY,Ramli NM,Kamaruzzaman SB,Tan MP,Grossmann M,Ang BH,Tan JY,Manap MAAA,Tay TK,Tan SL,New RP,Fadzli F,Yee EJ,Moy FM,Mahadeva S,Lang AE

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:A novel homozygous missense mutation (c.773G > A, p.Arg258Gln) in Synaptojanin 1 (SYNJ1, 21q22.2) has recently been reported in two Italian and one Iranian consanguineous families with autosomal recessive juvenile Parkinsonism (ARJP). Contribution of this synaptic gene related to Parkinsonism phenotypes in o...

journal_title：Parkinsonism & related disorders

authors： Kirola L,Behari M,Shishir C,Thelma BK

更新日期：2016-10-01 00:00:00

abstract：:Motor complications arising after long-term treatment with levodopa remain one of the main challenges in the treatment of patients with Parkinson's disease (PD). Monotherapy with dopamine agonists may delay the onset of motor complications or reduce their severity when added to levodopa treatment. Here, we retrospecti...

journal_title：Parkinsonism & related disorders

authors： Storch A,Trenkwalder C,Oehlwein C,Winkelmann J,Polzer U,Hundemer HP,Schwarz J

更新日期：2005-09-01 00:00:00

abstract：INTRODUCTION:Freezing of gait (FoG) is one of the most disabling gait disorders in Parkinson's disease (PD), reflecting motor and cognitive impairments, mainly related to dopamine deficiency. Recent studies investigating kinematic and kinetic factors affecting gait in these patients showed a postural instability charac...

journal_title：Parkinsonism & related disorders

authors： Mezzarobba S,Grassi M,Pellegrini L,Catalan M,Krüger B,Stragapede L,Manganotti P,Bernardis P

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Sleep disorders occur commonly in Parkinson's disease and are often under-recognized and under treated in clinical practice. OBJECTIVES:To determine the quality of sleep in patients with Young onset Parkinson's disease (YOPD) and to note whether there is any difference in quality of sleep from those patient...

journal_title：Parkinsonism & related disorders

authors： Mahale R,Yadav R,Pal PK

更新日期：2015-05-01 00:00:00

abstract：:Although primary focal hand dystonia has been well characterized, primary focal foot dystonia in adults has rarely been reported. Our objective was to describe the clinical phenotype and treatment outcomes in patients with primary, adult-onset focal foot dystonia. To this end we conducted a retrospective study of four...

journal_title：Parkinsonism & related disorders

authors： Singer C,Papapetropoulos S

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:Cerebellar circuits are hypothesized to play a central role in the pathogenesis of essential tremor. Rhythmic finger tapping is known to strongly engage the cerebellar motor circuitry. We characterize cerebellar and, more specifically, dentate nucleus function, and neural correlates of cerebellar output in...

journal_title：Parkinsonism & related disorders

authors： Buijink AW,Broersma M,van der Stouwe AM,van Wingen GA,Groot PF,Speelman JD,Maurits NM,van Rootselaar AF

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVE:To investigate whether dopamine transporter (DAT) binding, as measured with single photon emission computed tomography (SPECT), can be used to predict mortality in patients with Parkinson's disease (PD). METHODS:A total of 162 patients with PD and abnormal [I-123]FP-CIT SPECT were clinically followed for a m...

journal_title：Parkinsonism & related disorders

authors： Mäkinen E,Joutsa J,Vahlberg T,Kaasinen V

更新日期：2017-09-01 00:00:00

abstract：:Patients with advanced Parkinson's Disease (PD) may be eligible for Deep Brain Stimulation (DBS) in case of medication-related motor fluctuations or tremor refractory to oral medication. However, several PD symptoms are unresponsive to DBS and constitute relative contra-indications for DBS. Patients referred for DBS u...

journal_title：Parkinsonism & related disorders

authors： Geraedts VJ,Kuijf ML,van Hilten JJ,Marinus J,Oosterloo M,Contarino MF

更新日期：2019-09-01 00:00:00

abstract：INTRODUCTION:The aim of the study was to identify abnormalities of whole-brain network functional organization and their relation to clinical measures in a well-characterized, multi-site cohort of very early-stage, drug-naïve Parkinson's Disease (PD) patients. METHODS:Functional-MRI data for 16 healthy controls and 20...

journal_title：Parkinsonism & related disorders

authors： Sreenivasan K,Mishra V,Bird C,Zhuang X,Yang Z,Cordes D,Walsh RR

更新日期：2019-05-01 00:00:00

abstract：:Some procedures, such as deep inspiration, increase sweat output (SSwR; sympathetic sweat response) and reduce cutaneous blood flow (SVR; skin vasomotor reflex) on the palm. We investigated SSwR, SVR, and cardiovascular function in 12 patients with progressive supranuclear palsy (PSP), 13 patients with Parkinson's dis...

journal_title：Parkinsonism & related disorders

authors： Kikkawa Y,Asahina M,Suzuki A,Hattori T

更新日期：2003-12-01 00:00:00

abstract：BACKGROUND:Deep brain stimulation of the internal pallidum (GPi-DBS) is effective for various types of drug-refractory primary dystonias. Rare clinical forms as dystonic camptocormia may profit but available data are scarce. METHODS:We here report on a retrospective clinical assessment of three patients with primary d...

journal_title：Parkinsonism & related disorders

authors： Reese R,Knudsen K,Falk D,Mehdorn HM,Deuschl G,Volkmann J

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Multiple system atrophy (MSA) can clinically be divided into the cerebellar (MSA-C) and the parkinsonian (MSA-P) variants. It is unknown whether the variation in clinical expression is also reflected by a different underlying neurochemical profile. METHODS:We analyzed brain specific proteins and neurotransm...

journal_title：Parkinsonism & related disorders

authors： Abdo WF,van de Warrenburg BP,Kremer HP,Bloem BR,Verbeek MM

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:Hyposmia is a common non-motor symptom in Parkinson's disease (PD). However, patients with PD are sometimes unaware of their olfactory dysfunction, resulting in an under-diagnosis of this symptom. To determine whether the loss of awareness of hyposmia results from cognitive impairment in patients with PD, we...

journal_title：Parkinsonism & related disorders

authors： Kawasaki I,Baba T,Takeda A,Mori E

更新日期：2016-01-01 00:00:00

abstract：:Non motor symptoms (NMS) represent a significant burden in Parkinson's disease (PD) with numerous studies highlighting the importance of NMS both in "pre-motor" phase of PD as well as throughout the course of disease. In part this has led the international Parkinson and Movement Disorder Society (IPMDS) task force to ...

journal_title：Parkinsonism & related disorders

authors： Sauerbier A,Jenner P,Todorova A,Chaudhuri KR

更新日期：2016-01-01 00:00:00

abstract：:Autosomal recessive juvenile parkinsonism (ARJP/PARK2) is a distinct clinical and genetic entity characterized by early-onset levodopa-responsive parkinsonism, foot dystonia, sleep benefit, and hyperactive tendon reflexes. We report a patient with genetically confirmed ARJP, who showed mild sensory disturbance and dim...

journal_title：Parkinsonism & related disorders

authors： Okuma Y,Hattori N,Mizuno Y

更新日期：2003-06-01 00:00:00

abstract：INTRODUCTION:The age of diagnosis of Huntington's disease (HD) varies among individuals with the same HTT CAG-repeat expansion size. We investigated whether early-life events, like perinatal insults or neurodevelopmental disorders, influence the diagnosis age. METHODS:We used data from 13,856 participants from REGISTR...

journal_title：Parkinsonism & related disorders

authors： Barkhuizen M,Rodrigues FB,Anderson DG,Winkens B,REGISTRY Investigators of the European Huntington's Disease Network.,Wild EJ,Kramer BW,Gavilanes AWD

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Deep brain stimulation (DBS) is an effective and approved therapy for advanced Parkinson's disease (PD), and a recent study suggests efficacy in mid-stage disease. This manuscript reports the results of a pilot trial investigating preliminary safety and tolerability of DBS in early PD. METHODS:Thirty subjec...

journal_title：Parkinsonism & related disorders

authors： Charles D,Konrad PE,Neimat JS,Molinari AL,Tramontana MG,Finder SG,Gill CE,Bliton MJ,Kao C,Phibbs FT,Hedera P,Salomon RM,Cannard KR,Wang L,Song Y,Davis TL

更新日期：2014-07-01 00:00:00

abstract：INTRODUCTION:Recent evidence suggests deep brain stimulation can alter impulse control. Our objective was to prospectively evaluate the effects of subthalamic nucleus (STN) and globus pallidus internus (GPi) deep brain stimulation on impulse control disorders (ICDs) in the setting of a conservative dopamine reduction s...

journal_title：Parkinsonism & related disorders

authors： Rossi PJ,De Jesus S,Hess CW,Martinez-Ramirez D,Foote KD,Gunduz A,Okun MS

更新日期：2017-11-01 00:00:00

abstract：:This is a short report illustrating the problems of the prescribing of anti-Parkinson's disease (PD) medication in patients with PD who are admitted acutely to hospital for any reason. There were a large number of complications as a result of inappropriate or lack of anti-PD drug administration and poor understanding ...

journal_title：Parkinsonism & related disorders

authors： Magdalinou KN,Martin A,Kessel B

更新日期：2007-12-01 00:00:00

abstract：:White matter lesions (WML) and epilepsy have been occasionally seen in Wilson's disease. No cases of generalized myoclonus have been reported so far. We present a patient with psychiatric symptoms starting at age 16, followed by tremor, generalized dystonia and severe generalized myoclonus. In addition to classical fi...

journal_title：Parkinsonism & related disorders

authors： Barbosa ER,Silveira-Moriyama L,Machado AC,Bacheschi LA,Rosemberg S,Scaff M

更新日期：2007-04-01 00:00:00

abstract：:The alpha-synuclein gene (SNCA) multiplication causes autosomal dominant Parkinson Disease (PD): triplication is associated with early-onset rapidly progressing parkinsonism with a strong likelihood of developing dementia, while duplication is associated with a less severe phenotype similar to idiopathic PD. We tested...

journal_title：Parkinsonism & related disorders

authors： Sironi F,Trotta L,Antonini A,Zini M,Ciccone R,Della Mina E,Meucci N,Sacilotto G,Primignani P,Brambilla T,Coviello DA,Pezzoli G,Goldwurm S

更新日期：2010-03-01 00:00:00

abstract：:A prevalence survey of movement disorders, epilepsy, hypertension and smoking was undertaken in Vejer de la Frontera, Southern Spain in 1988. A validated screening instrument designed for door-to-door tracing of specific disorders was used. Neurological diagnoses were based on: (1) direct anamnesis and examination by ...

journal_title：Parkinsonism & related disorders

authors： Acosta-Varo J,De Pedro-Cuesta J

更新日期：1996-10-01 00:00:00

abstract：OBJECTIVE:To determine the nationwide prevalence of primary dystonia, ataxia and hereditary spastic paraplegia (HSP) in Sweden. METHODS:We extracted data on all patients who were registered in The National Patient Register (NPR) in Sweden (population 9.64 million) at least twice during five consecutive years with a di...

journal_title：Parkinsonism & related disorders

authors： Hellberg C,Alinder E,Jaraj D,Puschmann A

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:Non-motor symptoms (NMS) are common in Parkinson's disease (PD) and cause significant distress. A high rate of non-declaration of NMS by patients to healthcare providers (HCP) means that many NMS remain untreated. Current understanding of the factors preventing disclosure of NMS to HCPs is limited. The prese...

journal_title：Parkinsonism & related disorders

authors： Hurt CS,Rixon L,Chaudhuri KR,Moss-Morris R,Samuel M,Brown RG

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:In addition to the most frequent TOR1A/DYT1 mutation (c.907_909delGAG), a growing number of TOR1A sequence variants are found in dystonia patients. For most, functional characterization has demonstrated pathogenicity at different levels, implying that TOR1A genetic testing should not be limited to screening ...

journal_title：Parkinsonism & related disorders

authors： Dobričić V,Kresojević N,Žarković M,Tomić A,Marjanović A,Westenberger A,Cvetković D,Svetel M,Novaković I,Kostić VS

更新日期：2015-10-01 00:00:00

abstract：:The objective of this review is to assess the effectiveness of tai chi as a treatment option for Parkinson's disease (PD). We have searched the literature using 21 databases from their inceptions to January 2008, without language restrictions. We included all types of clinical studies regardless of their design. Their...

journal_title：Parkinsonism & related disorders

authors： Lee MS,Lam P,Ernst E

更新日期：2008-12-01 00:00:00

abstract：INTRODUCTION:Increasing evidence demonstrates the relevant association between Parkinson's disease (PD) and vascular diseases/risk factors, as well as a worse clinico-pathological progression in those patients with vascular comorbidity. The mechanisms underlying this relationship have not been clarified yet, although t...

journal_title：Parkinsonism & related disorders

authors： Imbriani P,D'Angelo V,Platania P,Di Lazzaro G,Scalise S,Salimei C,El Atiallah I,Colona VL,Mercuri NB,Bonsi P,Pisani A,Schirinzi T,Martella G

更新日期：2020-05-01 00:00:00

abstract：:The stiff-man syndrome (SMS) is characterised by rigidity and spasm of predominantly axial and proximal limb muscles. The cause of the condition is unknown but the finding of antibodies to glutamic acid decarboxylase (GAD) in approximately 60% of patients has suggested an autoimmune basis. Pathological findings are li...

journal_title：Parkinsonism & related disorders

authors： Thompson PD

更新日期：2001-10-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy of solifenacin succinate in Parkinson's disease (PD) patients suffering from overactive bladder (OAB). BACKGROUND:Urinary dysfunction is a commonly encountered non-motor feature in PD that significantly impacts patient quality of life. DESIGN/METHODS:This was a double-blind, randomi...

journal_title：Parkinsonism & related disorders

authors： Zesiewicz TA,Evatt M,Vaughan CP,Jahan I,Singer C,Ordorica R,Salemi JL,Shaw JD,Sullivan KL,Non-Motor Working Group of the Parkinson Study Group (PSG).

更新日期：2015-05-01 00:00:00