Do caffeine and more selective adenosine A2A receptor antagonists protect against dopaminergic neurodegeneration in Parkinson's disease?

Abstract:

:The adenosine A2A receptor is a major target of caffeine, the most widely used psychoactive substance worldwide. Large epidemiological studies have long shown caffeine consumption is a strong inverse predictor of Parkinson's disease (PD). In this review, we first examine the epidemiology of caffeine use vis-à-vis PD and follow this by looking at the evidence for adenosine A2A receptor antagonists as potential neuroprotective agents. There is a wealth of accumulating biological, epidemiological and clinical evidence to support the further investigation of selective adenosine A2A antagonists, as well as caffeine, as promising candidate therapeutics to fill the unmet need for disease modification of PD.

authors

Chen JF,Schwarzschild MA

doi

10.1016/j.parkreldis.2020.10.024

subject

Has Abstract

pub_date

2020-11-01 00:00:00

pages

S45-S53

eissn

1353-8020

issn

1873-5126

pii

S1353-8020(20)30815-4

journal_volume

80 Suppl 1

pub_type

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