Ischemic injury precipitates neuronal vulnerability in Parkinson's disease: Insights from PINK1 mouse model study and clinical retrospective data.

Abstract:

INTRODUCTION:Increasing evidence demonstrates the relevant association between Parkinson's disease (PD) and vascular diseases/risk factors, as well as a worse clinico-pathological progression in those patients with vascular comorbidity. The mechanisms underlying this relationship have not been clarified yet, although their comprehension is critical in a perspective of disease-modifying treatments development or prevention. METHODS:We performed an experimental protocol of ischemic injury (glucose-oxygen deprivation, OGD) on PTEN-induced kinase 1 knockout (PINK1-/-) mice, a well-established PD model, looking at both electrophysiological and morphological changes in basal ganglia. In addition, 253 PD patients were retrospectively analysed, to estimate the prevalence of vascular risk factors. RESULTS:In PINK1-/- mice, the OGD protocol induced electrophysiological (prolonged depolarization) and morphological alterations (picnotic cells, cellular loss and swelling, thickening of nuclear chromatin) in striatal medium spiny neurons and nigral dopaminergic neurons. Vascular comorbidity occurred in 75% of PD patients. CONCLUSIONS:The ischemic injury precipitates neuronal vulnerability in basal ganglia of PINK1-/- mice, probably through an impairment of mitochondrial metabolism and higher oxidative stress. These experimental data may provide a potential mechanistic explanation for both the association between vascular diseases and PD and their reciprocal interactions in determining the clinico-pathological burden of PD patients.

authors

Imbriani P,D'Angelo V,Platania P,Di Lazzaro G,Scalise S,Salimei C,El Atiallah I,Colona VL,Mercuri NB,Bonsi P,Pisani A,Schirinzi T,Martella G

doi

10.1016/j.parkreldis.2020.04.004

subject

Has Abstract

pub_date

2020-05-01 00:00:00

pages

57-63

eissn

1353-8020

issn

1873-5126

pii

S1353-8020(20)30099-7

journal_volume

74

pub_type

杂志文章
  • Rotigotine for nocturnal hypokinesia in Parkinson's disease: Quantitative analysis of efficacy from a randomized, placebo-controlled trial using an axial inertial sensor.

    abstract:BACKGROUND:Nocturnal hypokinesia is a common symptom in Parkinson's disease (PD), negatively affecting quality of life of both patients and caregivers. However, evidence-based treatment strategies are limited. OBJECTIVE:To evaluate the efficacy of rotigotine transdermal patch, using a wearable sensor, in the managemen...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.parkreldis.2017.08.010

    authors: Bhidayasiri R,Sringean J,Chaiwong S,Anan C,Penkeaw N,Leaknok A,Boonpang K,Saksornchai K,Rattanachaisit W,Thanawattano C,Jagota P

    更新日期:2017-11-01 00:00:00

  • Plantar cutaneous sensory stimulation improves single-limb support time, and EMG activation patterns among individuals with Parkinson's disease.

    abstract::Parkinson's disease is a chronic neurological disorder that results in gait and posture impairment. There is increasing evidence that these motor impairments may be partially due to deficits within the sensory system. In this study, the effects of a facilitatory insole that provides increased plantar sensory stimulati...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2009.04.004

    authors: Jenkins ME,Almeida QJ,Spaulding SJ,van Oostveen RB,Holmes JD,Johnson AM,Perry SD

    更新日期:2009-11-01 00:00:00

  • Gender and onset age-related features of non-motor symptoms of patients with Parkinson's disease--a study from Southwest China.

    abstract:BACKGROUND:Non-motor symptom (NMS) differences between male Parkinson's disease (PD) and female PD, and between early-onset PD (EOPD) and late-onset PD (LOPD) in Chinese populations remain largely unknown. METHODS:A total of 522 PD patients from Southwest China were included. Patients were assessed using the Non-Motor...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2013.06.009

    authors: Guo X,Song W,Chen K,Chen X,Zheng Z,Cao B,Huang R,Zhao B,Wu Y,Shang HF

    更新日期:2013-11-01 00:00:00

  • SNCA and MAPT genes: Independent and joint effects in Parkinson disease in the Italian population.

    abstract:BACKGROUND:Significant efforts have been focused on investigating the contribution of common variants to Parkinson disease (PD) risk. Several independent GWAS and metanalysis studies have shown a genome-wide significant association of single nucleotide polymorphisms (SNPs) in the α-synuclein (SNCA) and microtubule-asso...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2011.10.014

    authors: Trotta L,Guella I,Soldà G,Sironi F,Tesei S,Canesi M,Pezzoli G,Goldwurm S,Duga S,Asselta R

    更新日期:2012-03-01 00:00:00

  • Objective intestinal function in patients with idiopathic REM sleep behavior disorder.

    abstract:BACKGROUND:Parkinson's disease is characterized by pathological α-synuclein accumulation and cell death, which has been hypothesized to originate in peripheral nerve terminals and subsequently spread via autonomic nerves. Supporting this, most Parkinson's disease patients experience autonomic non-motor symptoms such as...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2018.08.011

    authors: Knudsen K,Fedorova TD,Hansen AK,Sommerauer M,Haase AM,Svendsen KB,Otto M,Østergaard K,Krogh K,Borghammer P

    更新日期:2019-01-01 00:00:00

  • Is there a pathogenic role for mitochondria in Parkinson's disease?

    abstract::Parkinson's disease (PD) is a common neurodegenerative disorder of unknown cause. For decades, a deficit in mitochondrial respiration was thought to be a key factor in PD neurodegeneration. However, excluding a few exceptions where a clinical picture of parkinsonism is associated with a mitochondrial DNA mutation, pre...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/S1353-8020(09)70823-5

    authors: Vives-Bauza C,de Vries RL,Tocilescu MA,Przedborski S

    更新日期:2009-12-01 00:00:00

  • Survival in Parkinson's disease in relation to striatal dopamine transporter binding.

    abstract:OBJECTIVE:To investigate whether dopamine transporter (DAT) binding, as measured with single photon emission computed tomography (SPECT), can be used to predict mortality in patients with Parkinson's disease (PD). METHODS:A total of 162 patients with PD and abnormal [I-123]FP-CIT SPECT were clinically followed for a m...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2017.06.013

    authors: Mäkinen E,Joutsa J,Vahlberg T,Kaasinen V

    更新日期:2017-09-01 00:00:00

  • EIF4G1 gene mutations are not a common cause of Parkinson's disease in the Japanese population.

    abstract::Pathogenic mutations in the EIF4G1 gene were recently reported as a cause of autosomal dominant parkinsonism. To assess the frequency of EIF4G1 mutations in the Japanese population we sequenced the entire gene coding region (31 exons) in 95 patients with an apparent autosomal dominant inherited form of Parkinson's dis...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2014.03.004

    authors: Nishioka K,Funayama M,Vilariño-Güell C,Ogaki K,Li Y,Sasaki R,Kokubo Y,Kuzuhara S,Kachergus JM,Cobb SA,Takahashi H,Mizuno Y,Farrer MJ,Ross OA,Hattori N

    更新日期:2014-06-01 00:00:00

  • Red flags phenotyping: A systematic review on clinical features in atypical parkinsonian disorders.

    abstract::To establish a clinical diagnosis of a parkinsonian disorder, physicians rely on their ability to identify relevant red flags, in addition to cardinal features, to support or refute their working diagnosis in an individual patient. The term 'red flag', was originally coined in 1989 to define the presence of non-cardin...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2018.10.009

    authors: Bhidayasiri R,Sringean J,Reich SG,Colosimo C

    更新日期:2019-02-01 00:00:00

  • Adenosine, adenosine A 2A antagonists, and Parkinson's disease.

    abstract::Adenosine derived from the degradation of ATP/AMP functions as a signalling molecule in the nervous system through the occupation of A1, A2, and A3 adenosine receptors. Adenosine A(2A) receptors have a selective localization to the basal ganglia and specifically to the indirect output pathway, and as a consequence off...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章,评审

    doi:10.1016/j.parkreldis.2008.12.006

    authors: Jenner P,Mori A,Hauser R,Morelli M,Fredholm BB,Chen JF

    更新日期:2009-07-01 00:00:00

  • Subjective perceived outcome of subthalamic deep brain stimulation in Parkinson's disease one year after surgery.

    abstract:OBJECTIVES:Dissatisfaction with subthalamic deep brain stimulation (STN-DBS) despite motor improvements has been observed in Parkinson's disease (PD). Hence, we compared patient's subjective perceived outcome 12 months after surgery (12mFU) with clinical measures to identify risk factors of dissatisfaction. METHODS:Pa...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2016.01.019

    authors: Maier F,Lewis CJ,Horstkoetter N,Eggers C,Dembek TA,Visser-Vandewalle V,Kuhn J,Zurowski M,Moro E,Woopen C,Timmermann L

    更新日期:2016-03-01 00:00:00

  • Defining delirium in idiopathic Parkinson's disease: A systematic review.

    abstract:BACKGROUND:Parkinson's disease patients may be at increased risk of delirium and developing adverse outcomes, such as cognitive decline and increased mortality. Delirium is an acute state of confusion that has overlapping symptoms with Parkinson's dementia, making it difficult to identify. This study aimed to determine...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2018.09.025

    authors: Lawson RA,McDonald C,Burn DJ

    更新日期:2019-07-01 00:00:00

  • A computerized survey of pain in Parkinson's disease patients: A pilot feasibility study.

    abstract::Approximately two thirds of Parkinson's disease (PD) patients exhibit bothersome pain symptoms that oftentimes go unrecognized. In this study, 14 patients with PD volunteered to complete a computerized version of the McGill Pain Questionnaire using the PAINReportIt interactive software to assess the feasibility of acq...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2009.07.001

    authors: Page DB,Weaver F,Wilkie DJ,Simuni T

    更新日期:2010-02-01 00:00:00

  • Correlation between changes in CSF dopamine turnover and development of dyskinesia in Parkinson's disease.

    abstract::To assess possible differences in dopamine metabolism that could parallel disease progression in Parkinson's disease (PD), we measured dopamine (DA) and its metabolites in the cerebrospinal fluid (CSF) in PD patients at different stages of disease: de novo (DEN), advanced not showing dyskinesias (ADV), and advanced wi...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2008.10.001

    authors: Lunardi G,Galati S,Tropepi D,Moschella V,Brusa L,Pierantozzi M,Stefani A,Rossi S,Fornai F,Fedele E,Stanzione P,Hainsworth AH,Pisani A

    更新日期:2009-06-01 00:00:00

  • Longitudinal changes in cognition in early Parkinson's disease patients with REM sleep behavior disorder.

    abstract:INTRODUCTION:Cognitive decline is common in Parkinson's disease (PD), and identifying patients at highest risk for it is essential. We aimed to examine the effect of possible REM sleep behavior disorder (pRBD) on rate of cognitive decline in early PD, for both global cognition and in specific cognitive domains. METHOD...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.parkreldis.2016.03.006

    authors: Chahine LM,Xie SX,Simuni T,Tran B,Postuma R,Amara A,Oertel WH,Iranzo A,Scordia C,Fullard M,Linder C,Purri R,Darin A,Rennert L,Videnovic A,Del Riva P,Weintraub D

    更新日期:2016-06-01 00:00:00

  • Factor structure of the Montreal Cognitive Assessment items in a sample with early Parkinson's disease.

    abstract:INTRODUCTION:The Montreal Cognitive Assessment (MoCA) is a frequently utilized cognitive screening tool that has attractive clinical attributes when utilized in individuals with Parkinson's disease. However, the construct validity of this instrument has not been well-characterized in Parkinson's samples. The purpose of...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2017.05.023

    authors: Benge JF,Balsis S,Madeka T,Uhlman C,Lantrip C,Soileau MJ

    更新日期:2017-08-01 00:00:00

  • Outcome of gastrostomy in parkinsonism: A retrospective study.

    abstract:OBJECTIVE:To investigate the indications and the outcomes of gastrostomy tube insertion in patients with parkinsonian syndromes. METHODS:Consecutive patients with Parkinson's disease or atypical parkinsonism, seen in two French tertiary referral movement disorders centers, that received gastrostomy tube insertion (GTI...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2017.06.012

    authors: Marois C,Amador MDM,Payan C,Lacomblez L,Bonnet AM,Degos B,Corvol JC,Vidailhet M,Le Forestier N,Mesnage V,Grabli D

    更新日期:2017-10-01 00:00:00

  • Using virtual reality to explore the role of conflict resolution and environmental salience in freezing of gait in Parkinson's disease.

    abstract:BACKGROUND:The freezing phenomenon is among the most disabling symptoms of Parkinson's disease (PD) manifesting most commonly as Freezing of Gait with a paroxysmal cessation of effective stepping. Recent studies have suggested that freezing is related to both impairments in conflict resolution as well as the processing...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.parkreldis.2013.06.002

    authors: Matar E,Shine JM,Naismith SL,Lewis SJ

    更新日期:2013-11-01 00:00:00

  • Autosomal dominant parkinsonism: its etiologies and differential diagnoses.

    abstract::Recently, several genes for parkinsonism have been identified. Among them, familial Parkinson's disease (PD) could be assigned for PARK disorders. PARK disorders consist of three different inherited modes such as autosomal recessive, autosomal dominant modes and susceptible genes. Some of them manifest not only typica...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章,评审

    doi:10.1016/S1353-8020(11)70003-7

    authors: Hattori N

    更新日期:2012-01-01 00:00:00

  • Effect of subthalamic deep brain stimulation on posture in Parkinson's disease: A blind computerized analysis.

    abstract:INTRODUCTION:We sought to assess the effect of subthalamic deep brain stimulation (STN DBS) on Parkinson's disease (PD)-associated postural abnormalities. METHODS:A computerized analysis of posture was used to quantify the thoracolumbar, thoracic, and cervical-occipital ventral angles, as well as the thoracolumbar and...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2019.01.003

    authors: Roediger J,Artusi CA,Romagnolo A,Boyne P,Zibetti M,Lopiano L,Espay AJ,Fasano A,Merola A

    更新日期:2019-05-01 00:00:00

  • Daytime somnolence in patients with Parkinson's disease.

    abstract::We studied daytime sleepiness in 160 patients with Parkinson's disease and 40 normal subjects. We compared the prevalence of daytime sleepiness in patients who were taking levodopa alone, levodopa with bromocriptine, levodopa with ropinirole, and levodopa with pramipexole. We found that (1) all these anti-Parkinson dr...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/s1353-8020(00)00076-6

    authors: Sanjiv CC,Schulzer M,Mak E,Fleming J,Martin WR,Brown T,Calne SM,Tsui J,Stoessl AJ,Lee CS,Calne DB

    更新日期:2001-10-01 00:00:00

  • Effects of intracerebral neurotrophic factor application on motor symptoms in Parkinson's disease: A systematic review and meta-analysis.

    abstract:INTRODUCTION:Neurotrophic factors (NTFs) have been evaluated for neuroprotective effects in Parkinson's disease (PD). However, clinical trials examining the efficacy of intracerebral administration of NTFs on motor symptoms in PD have produced mixed results, and are thus inconclusive. The objective of this systematic r...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.parkreldis.2017.02.011

    authors: Hegarty SV,Lee DJ,O'Keeffe GW,Sullivan AM

    更新日期:2017-05-01 00:00:00

  • A novel bedside task to tap inhibitory dysfunction and fronto-striatal atrophy in Parkinson's disease.

    abstract:BACKGROUND:Given the heterogeneity of mild cognitive deficits in non-demented Parkinson's disease (PD), sensitive and anatomically specific behavioural measures are crucial when evaluating cognition in this patient group. Inhibitory dysfunction is one such deficit increasingly being recognised in non-demented PD; howev...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2013.04.020

    authors: O'Callaghan C,Naismith SL,Shine JM,Bertoux M,Lewis SJ,Hornberger M

    更新日期:2013-09-01 00:00:00

  • Memory perception and strategy use in Parkinson's disease.

    abstract::Although there is growing support for the existence of memory deficits within Parkinson's disease (PD), little has been done to evaluate the extent to which PD patients demonstrate differences in their use of metacognitive strategies. In the present study, 79 PD patients (46 men and 33 women) and 49 age-matched health...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2004.06.005

    authors: Johnson AM,Pollard CC,Vernon PA,Tomes JL,Jog MS

    更新日期:2005-03-01 00:00:00

  • Striatal plasticity and extrapyramidal motor dysfunction.

    abstract::Knowledge of molecular events contributing to motor dysfunction in Parkinson's disease has advanced rapidly during the past decade. Studies in animal models as well as in patients afflicted by this disorder suggest that the nonphysiologic stimulation of striatal dopamine receptors, first as a result of dopaminergic de...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章,评审

    doi:10.1016/j.parkreldis.2004.02.012

    authors: Chase TN

    更新日期:2004-07-01 00:00:00

  • Significance of cerebellar Purkinje cell loss to pathogenesis of essential tremor.

    abstract:UNLABELLED:Some recent studies indicate that most essential tremor (ET) cases have cerebellar pathology characterized by Purkinje cell (PC) loss and its sequelae. OBJECTIVE:To assess the role of PC degeneration in ET symptomatology. METHODS:We studied seven ET, six tremor dominant Parkinson's disease controls and two...

    journal_title:Parkinsonism & related disorders

    pub_type: 评论,杂志文章

    doi:10.1016/j.parkreldis.2011.05.008

    authors: Rajput AH,Rajput A

    更新日期:2011-07-01 00:00:00

  • Patterns of brain atrophy in Parkinson's disease, progressive supranuclear palsy and multiple system atrophy.

    abstract:BACKGROUND AND PURPOSE:Quantitative analysis of brain atrophy may be useful in differentiating Parkinson's Disease (PD) from Progressive Supranuclear Palsy (PSP) and parkinsonian variant of Multiple System Atrophy (MSA-P); the aim of this study was to identify the volumetric differences of subcortical structures in pat...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2010.12.010

    authors: Messina D,Cerasa A,Condino F,Arabia G,Novellino F,Nicoletti G,Salsone M,Morelli M,Lanza PL,Quattrone A

    更新日期:2011-03-01 00:00:00

  • The impact of ropinirole on blood pressure and noradrenaline concentration after active orthostasis in Parkinsonian patients.

    abstract::Orthostatic hypotension is common in Parkinsonian patients. It is probably caused by reduced noradrenaline (NA) release. This effect is further enhanced by therapeutic use of ergot alkaloid dopamine agonists. In this trial we studied the impact of the non-ergot dopamine agonist ropinirole on blood pressure and noradre...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/s1353-8020(98)00014-5

    authors: Jost WH,Bellon AK,Kaiser T,Schrank B

    更新日期:1998-08-01 00:00:00

  • Mesencephalic area measured by transcranial sonography in the differential diagnosis of parkinsonism.

    abstract:BACKGROUND:Transcranial B-mode sonography (TCS) has become an important tool in the differential diagnosis of parkinsonism given that current technology enables an adequate assessment of brain structures. In this study we aimed at evaluating the usefulness of midbrain area measured by TCS in the differential diagnosis ...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.parkreldis.2013.04.010

    authors: Sastre-Bataller I,Vázquez JF,Martínez-Torres I,Sahuquillo P,Rubio-Agustí I,Burguera JA,Ferrer JM,Valero C,Tembl JI

    更新日期:2013-08-01 00:00:00

  • Levodopa and neuropathy risk in patients with Parkinson disease: Effect of COMT inhibition.

    abstract:OBJECTIVE:Our purpose was to determine whether the use of catechol-O-methyltransferase-inhibitors (ICOMT) can reduce the risk of developing levodopa (LD)-induced neuropathy in Parkinson's disease (PD) patients. METHODS:A multicentre study of 197 PD patients was performed. 144 were exposed to LD for more than three yea...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.parkreldis.2016.04.016

    authors: Cossu G,Ceravolo R,Zibetti M,Arca R,Ricchi V,Paribello A,Murgia D,Merola A,Romagnolo A,Nicoletti V,Palermo G,Mereu A,Lopiano L,Melis M,Abbruzzese G,Bonuccelli U

    更新日期:2016-06-01 00:00:00