Abstract:
OBJECTIVE:To determine the nationwide prevalence of primary dystonia, ataxia and hereditary spastic paraplegia (HSP) in Sweden. METHODS:We extracted data on all patients who were registered in The National Patient Register (NPR) in Sweden (population 9.64 million) at least twice during five consecutive years with a diagnosis of primary dystonia, ataxia or HSP. We excluded patients with an additional diagnosis possibly indicating secondary causes, and determined the proportion of wrongly diagnosed patients at our own tertiary center by patient examination or chart review. We analyzed patients' age and disorder subtypes, geographical distribution of patients within Sweden and the country of birth of all patients. RESULTS:Nationwide, we identified 4239 patients (31.6% male) with a diagnosis of primary dystonia. Of 347 patients with dystonia at our center, 20.2% may have had a different final diagnosis. Extrapolation of this uncertainty rate to the national population resulted in a prevalence for primary dystonia of 35.1/100,000. There were 672 patients (49.6% male) with ataxia in NPR, and the diagnostic uncertainty rate among 81 patients in our center was 13.6% (prevalence 6.0/100,000). HSP was diagnosed in 235 patients nationwide (52.3% male, prevalence 2.4/100,000). Patients were distributed relatively evenly throughout the country. The proportions of patients with these diagnoses who were born outside of Sweden were lower (8.0-12.7%) than the proportion of all Swedish residents born abroad (15.9%). CONCLUSIONS:In this large, nationwide study, the prevalence of dystonia was high compared to previous studies, which partly may be explained by the high coverage of NPR.
journal_name
Parkinsonism Relat Disordjournal_title
Parkinsonism & related disordersauthors
Hellberg C,Alinder E,Jaraj D,Puschmann Adoi
10.1016/j.parkreldis.2019.10.028subject
Has Abstractpub_date
2019-12-01 00:00:00pages
79-84eissn
1353-8020issn
1873-5126pii
S1353-8020(19)30471-7journal_volume
69pub_type
杂志文章abstract::Over the last decade, several autosomal dominant and recessive genes causative of Parkinson's disease (PD) have been identified. The functional studies on their protein products and the pathogenetic effect related to their mutations have greatly contributed to understand the many cellular pathways leading to neurodege...
journal_title:Parkinsonism & related disorders
pub_type: 杂志文章,评审
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journal_title:Parkinsonism & related disorders
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journal_title:Parkinsonism & related disorders
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journal_title:Parkinsonism & related disorders
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abstract::Myoclonus is a sudden and brief involuntary muscle contraction presenting with jerk-like movements that can occasionally involve the trunk muscles or the diaphragm as in the case of spinal myoclonus1. We here present an unusual case with unilateral diaphragmatic myoclonus owing to electrode dislocation of an implantab...
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journal_title:Parkinsonism & related disorders
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journal_title:Parkinsonism & related disorders
pub_type: 杂志文章
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journal_title:Parkinsonism & related disorders
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journal_title:Parkinsonism & related disorders
pub_type: 杂志文章,评审
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journal_title:Parkinsonism & related disorders
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journal_title:Parkinsonism & related disorders
pub_type: 临床试验,杂志文章
doi:10.1016/j.parkreldis.2014.05.015
更新日期:2014-09-01 00:00:00
abstract::Evidence shows that neuronal injury accompanies neuroinflammatory reactions in the brain, and well as in Parkinson's disease (PD) animal models, in which the loss of dopamine neurons is associated with the activation of microglia in the substantia nigra. Activated microglia can be illustrated in vivo using Positron em...
journal_title:Parkinsonism & related disorders
pub_type: 杂志文章,评审
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更新日期:2009-12-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Parkinsonism & related disorders
pub_type: 杂志文章,评审
doi:10.1016/S1353-8020(08)70056-7
更新日期:2007-01-01 00:00:00
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journal_title:Parkinsonism & related disorders
pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章,评审
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journal_title:Parkinsonism & related disorders
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journal_title:Parkinsonism & related disorders
pub_type: 杂志文章
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journal_title:Parkinsonism & related disorders
pub_type: 杂志文章
doi:10.1016/j.parkreldis.2009.07.011
更新日期:2010-01-01 00:00:00
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journal_title:Parkinsonism & related disorders
pub_type: 杂志文章
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journal_title:Parkinsonism & related disorders
pub_type: 杂志文章
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journal_title:Parkinsonism & related disorders
pub_type: 杂志文章
doi:10.1016/j.parkreldis.2009.01.001
更新日期:2009-08-01 00:00:00
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journal_title:Parkinsonism & related disorders
pub_type: 杂志文章,多中心研究
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更新日期:2015-08-01 00:00:00
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journal_title:Parkinsonism & related disorders
pub_type: 杂志文章,评审
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更新日期:2007-09-01 00:00:00
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journal_title:Parkinsonism & related disorders
pub_type: 杂志文章
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更新日期:2011-11-01 00:00:00
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journal_title:Parkinsonism & related disorders
pub_type: 杂志文章
doi:10.1016/j.parkreldis.2007.08.008
更新日期:2008-01-01 00:00:00
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journal_title:Parkinsonism & related disorders
pub_type: 杂志文章
doi:10.1016/j.parkreldis.2005.01.005
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journal_title:Parkinsonism & related disorders
pub_type: 杂志文章
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更新日期:2017-09-01 00:00:00