当前位置： SCI文献检索 > PARKINSONISM & RELATED DISORDERS期刊下所有文献 > Long-term response to continuous duodenal infusion of levodopa/carbidopa gel in patients with advanced Parkinson disease: The Barcelona registry.

Long-term response to continuous duodenal infusion of levodopa/carbidopa gel in patients with advanced Parkinson disease: The Barcelona registry.

Abstract：

INTRODUCTION:Continuous infusion of levodopa/carbidopa intestinal gel (LCIG) is an effective treatment for patients with advanced Parkinson Disease (PD) that cannot be further improved by oral therapy. METHODS:We conducted an observational, prospective, and multicenter study to collect, in a large sample of PD treated with LCIG, long-term information about the outcome and safety of the treatment. The assessments were performed before LCIG, 1, 3, 6 months after, and ever since, every 6 months. RESULTS:We studied 72 patients with a mean observation time of 22 months and a maximum of 48 months. During follow-up 28 patients discontinued the treatment, especially for lack of efficacy or adverse events related to the drug. We obtained a significant improvement of motor and non-motor fluctuations, mean off time and some non-motor symptoms. A significant increase in the percentage of time with dyskinesias was found in patients having less than 50% of the day with dyskinesias before LCIG. However, patients having already many dyskinesias before LCIG experienced a significant decrease of the troublesome dyskinesias, meaning that outcomes might be different depending on specific clinical characteristics. Adverse effects were in general minor but one case of intestinal perforation and one of abdominal cellulite were observed. CONCLUSIONS:We confirmed that LCIG is a very effective treatment option for advanced PD; however considering the findings that dyskinesia can increase and the potential for serious side effects, we suggest the necessity for development of guidelines that better define the profile of responders.

journal_name

Parkinsonism Relat Disord

journal_title

Parkinsonism & related disorders

authors

Buongiorno M,Antonelli F,Cámara A,Puente V,de Fabregues-Nebot O,Hernandez-Vara J,Calopa M,Pascual-Sedano B,Campolongo A,Valldeoriola F,Tolosa E,Kulisevsky J,Martí MJ

doi

10.1016/j.parkreldis.2015.05.014

subject

Has Abstract

pub_date

2015-08-01 00:00:00

pages

871-6

issue

8

eissn

1353-8020

issn

1873-5126

pii

S1353-8020(15)00216-3

journal_volume

21

pub_type

杂志文章,多中心研究

相关文献

PARKINSONISM & RELATED DISORDERS文献大全
  • Stroop test performance in impulsive and non impulsive patients with Parkinson's disease.

    abstract：:Impulsive personalities are considered to have a general impairment in cognitive flexibility and cortical inhibition. To examine this hypothesis we used a trial by trial Stroop task in impulsive and non impulsive patients with Parkinson's disease (PD) and recorded errors and reaction times (RT). We tested 28 impulsive...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2010.12.014

    authors： Djamshidian A,O'Sullivan SS,Lees A,Averbeck BB

    更新日期：2011-03-01 00:00:00

  • Low frequency of the PARK2 gene mutations in Polish patients with the early-onset form of Parkinson disease.

    abstract：OBJECTIVE:Mutations in the PARK2 (Parkin) gene result in an early-onset autosomal recessive form of Parkinson Disease (EO-PD). Although the frequency of the PARK2 mutations in EO-PD patients according to several studies is high and has been reported in up to 50% in familial and 19% in sporadic cases, these data remain ...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2009.06.010

    authors： Koziorowski D,Hoffman-Zacharska D,Sławek J,Szirkowiec W,Janik P,Bal J,Friedman A

    更新日期：2010-02-01 00:00:00

  • Hypertrophic olivary degeneration: A clinico-radiologic study.

    abstract：INTRODUCTION:The frequency and causes of hypertrophic olivary degeneration (HOD) are unknown. We compared the clinical and radiological characteristics of unilateral HOD and bilateral HOD. METHODS:We performed a search of a radiologic report database for patients who were radiologically diagnosed as having HOD. This d...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2016.04.008

    authors： Konno T,Broderick DF,Tacik P,Caviness JN,Wszolek ZK

    更新日期：2016-07-01 00:00:00

  • Task-switching abilities in pre-manifest Huntington's disease subjects.

    abstract：INTRODUCTION:Huntington's Disease (HD) cognitive dysfunction occurs before unequivocal motor signs become apparent. The predominant early cognitive abnormal domains may include deficits in psychomotor speed, negative emotion recognition and executive functioning. Our study is aimed to investigate the executive control ...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2018.09.007

    authors： Migliore S,D'Aurizio G,Curcio G,Squitieri F

    更新日期：2019-03-01 00:00:00

  • A randomized, double-blind, controlled trial of add-on therapy in moderate-to-severe Parkinson's disease.

    abstract：OBJECTIVE:The primary objective was to evaluate the efficacy and safety of droxidopa as add-on therapy in improving stiffness, tremors and other motor functions and activities of daily living for moderate-to-severe Parkinson's disease (PD). METHODS:PD patients, above Hoehn-Yahr III (including Hoehn-Yahr III), were ran...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.parkreldis.2015.08.023

    authors： Zhao S,Cheng R,Zheng J,Li Q,Wang J,Fan W,Zhang L,Zhang Y,Li H,Liu S

    更新日期：2015-10-01 00:00:00

  • How to improve neuroprotection in Parkinson's disease?

    abstract：:Several factors involved in the etiology of Parkinson's disease (PD) have been proposed, including genetic and environmental factors or even a combination of both. Thus, multiple cellular hits are likely to contribute to neurodegeneration in PD. If such a mechanism happens to occur, our therapeutic intervention may pe...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,评审

    doi：10.1016/S1353-8020(08)70026-9

    authors： Hirsch EC

    更新日期：2007-01-01 00:00:00

  • The spiral axis as a clinical tool to distinguish essential tremor from dystonia cases.

    abstract：BACKGROUND:Tremor is a common feature of a variety of neurological disorders. In genetic studies of essential tremor (ET), investigators need to screen potential enrollees by mail or telephone to exclude those with other neurological conditions, especially dystonia. In clinical settings, the differentiation of ET and d...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2014.01.021

    authors： Michalec M,Hernandez N,Clark LN,Louis ED

    更新日期：2014-05-01 00:00:00

  • Imaging biomarkers in tauopathies.

    abstract：:Abnormally aggregated tau protein is central to the pathophysiology of Alzheimer's disease, frontotemporal dementia variants, progressive supranuclear palsy, corticobasal degeneration and chronic traumatic encephalopathy. The post-mortem cortical density of hyperphosphorylated tau tangles correlates with pre-morbid co...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,评审

    doi：10.1016/j.parkreldis.2015.08.011

    authors： Dani M,Edison P,Brooks DJ

    更新日期：2016-01-01 00:00:00

  • Urinary 8-hydroxydeoxyguanosine correlate with hallucinations rather than motor symptoms in Parkinson's disease.

    abstract：BACKGROUND:Oxidative stress is causally associated with the pathogenesis of Parkinson's disease (PD). Oxygen generates a large amount of reactive oxygen species (ROS). ROS including hydroxyl radicals and H(2)O(2) react with guanine residues in DNA and produce 8-hydroxydeoxyguanosine (8-OHdG). 8-OHdG serves as a biomark...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2010.11.004

    authors： Hirayama M,Nakamura T,Watanabe H,Uchida K,Hama T,Hara T,Niimi Y,Ito M,Ohno K,Sobue G

    更新日期：2011-01-01 00:00:00

  • Resting activity in visual and corticostriatal pathways in Parkinson's disease with hallucinations.

    abstract：BACKGROUND:Visual hallucinations are an important non-motor complication of Parkinson's disease (PD) and carry a negative prognosis. Their biological basis is uncertain, but may relate to the activity of resting state networks in brain. We therefore aimed to investigate functional activity of brain in patients with vis...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2014.11.020

    authors： Yao N,Pang S,Cheung C,Chang RS,Lau KK,Suckling J,Yu K,Mak HK,McAlonan G,Ho SL,Chua SE

    更新日期：2015-02-01 00:00:00

  • Treatment of acute Sydenham's chorea with methyl-prednisolone pulse-therapy.

    abstract：:Serious adverse effects with antichoreic drugs can occur in patients with acute Sydenham's chorea (SC). The response to conventional treatment in severe SC may also be poor. Thus alternative therapeutic strategies have been developed. We report on four patients with severe acute SC (two with chorea paralytica and two ...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2005.02.007

    authors： Teixeira AL Jr,Maia DP,Cardoso F

    更新日期：2005-08-01 00:00:00

  • Benign hereditary chorea: an update.

    abstract：:Benign hereditary chorea (BHC, MIM 118700) is a rare autosomal dominant disorder manifesting with chorea in conjunction with hypothyroidism and respiratory problems, a triad also named "brain-lung-thyroid syndrome". BHC is characterized by childhood onset with minimal or no progression into adult life and normal cogni...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,评审

    doi：10.1016/j.parkreldis.2011.01.002

    authors： Inzelberg R,Weinberger M,Gak E

    更新日期：2011-06-01 00:00:00

  • Factor structure of the Montreal Cognitive Assessment items in a sample with early Parkinson's disease.

    abstract：INTRODUCTION:The Montreal Cognitive Assessment (MoCA) is a frequently utilized cognitive screening tool that has attractive clinical attributes when utilized in individuals with Parkinson's disease. However, the construct validity of this instrument has not been well-characterized in Parkinson's samples. The purpose of...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2017.05.023

    authors： Benge JF,Balsis S,Madeka T,Uhlman C,Lantrip C,Soileau MJ

    更新日期：2017-08-01 00:00:00

  • Historical perspective: The pros and cons of conventional outcome measures in Parkinson's disease.

    abstract：BACKGROUND:Conventional outcome measures (COMs) in Parkinson's disease (PD) refer to rating scales, questionnaires, patient diaries and clinically-based tests that do not require specialized equipment. METHODS:It is timely at this juncture - as clinicians and researchers begin to grapple with the "invasion" of digital...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,评审

    doi：10.1016/j.parkreldis.2017.07.029

    authors： Lim SY,Tan AH

    更新日期：2018-01-01 00:00:00

  • The SCA17 phenotype can include features of MSA-C, PSP and cognitive impairment.

    abstract：:Spinocerebellar ataxia (SCA) 17 is a dominant neurodegenerative disorder characterized by ataxia, cognitive decline, dystonia, and parkinsonism. The disease is caused by unstable cytosine-adenine-guanine (CAG) trinucleotide expansion mutation coding for polyglutamine tracts in the TATA box-binding protein (TBP), a gen...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2006.04.009

    authors： Lin IS,Wu RM,Lee-Chen GJ,Shan DE,Gwinn-Hardy K

    更新日期：2007-05-01 00:00:00

  • Prevalence and diagnostic challenge of dystonia in Thailand: a service-based study in a tertiary university referral centre.

    abstract：:Although the subspeciality of movement disorders was established in neurology more than 20 years ago, it is relatively new in Thailand, and while most physicians are generally aware of Parkinson's disease, they often are not familiar with dystonia. As one of the common movement disorders seen in general practice, a nu...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2011.06.014

    authors： Bhidayasiri R,Kaewwilai L,Wannachai N,Brenden N,Truong DD,Devahastin R

    更新日期：2011-11-01 00:00:00

  • Organization of midbrain dopamine systems and the pathophysiology of Parkinson's disease.

    abstract：:Understanding of the pathophysiology of Parkinson disease (PD) has advanced rapidly over the last two decades through basic and clinical studies using modern neuroanatomical, clinical assessment, neuropathological and functional brain imaging methods. Two interacting processes determine the development of functional i...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,评审

    doi：10.1016/s1353-8020(03)00063-4

    authors： Moore RY

    更新日期：2003-08-01 00:00:00

  • 24 h Levodopa-carbidopa intestinal gel may reduce falls and "unresponsive" freezing of gait in Parkinson's disease.

    abstract：OBJECTIVE:We report a prospective, open label study of 24 h levodopa-carbidopa intestinal gel (LCIG) as treatment for levodopa "unresponsive" freezing of gait (FOG) associated with Parkinson's disease. METHOD:5 patients with disabling FOG, documented as being levodopa "unresponsive", were commenced on continuous 24 h ...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2014.12.019

    authors： Chang FC,Tsui DS,Mahant N,Wolfe N,Kim SD,Ha AD,Drury M,Griffith JM,Fung VS

    更新日期：2015-03-01 00:00:00

  • Chronic and acute LRRK2 silencing has no long-term behavioral effects, whereas wild-type and mutant LRRK2 overexpression induce motor and cognitive deficits and altered regulation of dopamine release.

    abstract：INTRODUCTION:Germline silencing of the PD-related protein LRRK2 does not alter glutamate or dopamine release in adult mice, but some exploratory abnormalities have been reported with ageing. Contrastingly, high levels of human LRRK2 cause locomotor alterations and cognitive deficits accompanied by reduced striatal dopa...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2015.07.025

    authors： Volta M,Cataldi S,Beccano-Kelly D,Munsie L,Tatarnikov I,Chou P,Bergeron S,Mitchell E,Lim R,Khinda J,Lloret A,Bennett CF,Paradiso C,Morari M,Farrer MJ,Milnerwood AJ

    更新日期：2015-10-01 00:00:00

  • Moving from physician-centered care towards patient-centered care for Parkinson's disease patients.

    abstract：:Today's society is changing rapidly and individuals increasingly favor an active role in designing their own lives. Contemporary patients are no exception, but the present health care system-which is organized primarily from the provider's perspective-is not yet prepared for this development. Here, we argue that an al...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,评审

    doi：10.1016/j.parkreldis.2013.04.022

    authors： van der Eijk M,Nijhuis FA,Faber MJ,Bloem BR

    更新日期：2013-11-01 00:00:00

  • Is there a pathogenic role for mitochondria in Parkinson's disease?

    abstract：:Parkinson's disease (PD) is a common neurodegenerative disorder of unknown cause. For decades, a deficit in mitochondrial respiration was thought to be a key factor in PD neurodegeneration. However, excluding a few exceptions where a clinical picture of parkinsonism is associated with a mitochondrial DNA mutation, pre...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/S1353-8020(09)70823-5

    authors： Vives-Bauza C,de Vries RL,Tocilescu MA,Przedborski S

    更新日期：2009-12-01 00:00:00

  • Non motor subtypes and Parkinson's disease.

    abstract：:Non motor symptoms (NMS) represent a significant burden in Parkinson's disease (PD) with numerous studies highlighting the importance of NMS both in "pre-motor" phase of PD as well as throughout the course of disease. In part this has led the international Parkinson and Movement Disorder Society (IPMDS) task force to ...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,评审

    doi：10.1016/j.parkreldis.2015.09.027

    authors： Sauerbier A,Jenner P,Todorova A,Chaudhuri KR

    更新日期：2016-01-01 00:00:00

  • Adenosine, adenosine A 2A antagonists, and Parkinson's disease.

    abstract：:Adenosine derived from the degradation of ATP/AMP functions as a signalling molecule in the nervous system through the occupation of A1, A2, and A3 adenosine receptors. Adenosine A(2A) receptors have a selective localization to the basal ganglia and specifically to the indirect output pathway, and as a consequence off...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,评审

    doi：10.1016/j.parkreldis.2008.12.006

    authors： Jenner P,Mori A,Hauser R,Morelli M,Fredholm BB,Chen JF

    更新日期：2009-07-01 00:00:00

  • Treatment of restless legs syndrome.

    abstract：:Restless legs syndrome (RLS) is a common condition characterized by an urge to move the legs, accompanied by uncomfortable or unpleasant sensations. Symptoms predominantly occur at rest in the evening or at night, and they are alleviated by moving the affected extremity or by walking. Recent European epidemiological s...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,评审

    doi：10.1016/S1353-8020(09)70838-7

    authors： Ferini-Strambi L,Manconi M

    更新日期：2009-12-01 00:00:00

  • Effects of augmented visual feedback during balance training in Parkinson's disease: a pilot randomized clinical trial.

    abstract：BACKGROUND:Balance training has been demonstrated to improve postural control in patients with Parkinson's disease (PD). The objective of this pilot randomized clinical trial was to investigate whether a balance training program using augmented visual feedback is feasible, safe, and more effective than conventional bal...

    journal_title：Parkinsonism & related disorders

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.parkreldis.2014.09.022

    authors： van den Heuvel MR,Kwakkel G,Beek PJ,Berendse HW,Daffertshofer A,van Wegen EE

    更新日期：2014-12-01 00:00:00

  • HFE gene mutations in a population of Italian Parkinson's disease patients.

    abstract：:An abnormal accumulation and distribution of brain iron are common to different neurodegenerative disorders, including Parkinson's disease (PD), and alteration of genes involved in iron metabolism cause neurodegeneration with brain iron accumulation. HFE participates in the regulation of iron metabolism, its mutations...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2007.10.011

    authors： Biasiotto G,Goldwurm S,Finazzi D,Tunesi S,Zecchinelli A,Sironi F,Pezzoli G,Arosio P

    更新日期：2008-01-01 00:00:00

  • Diagnostic accuracy of ¹²³I-FP-CIT (DaTSCAN) in dementia with Lewy bodies: a meta-analysis of published studies.

    abstract：PURPOSE:A systematic meta-analysis of published studies on the diagnostic accuracy of presynaptic dopaminergic imaging with ¹²³I-FP-CIT (DaTSCAN) in dementia with Lewy bodies (DLB). METHODS:We included (a) studies in which DaTSCAN was performed in cases of diagnostic uncertainty to differentiate between DLB and non-DL...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.parkreldis.2011.09.015

    authors： Papathanasiou ND,Boutsiadis A,Dickson J,Bomanji JB

    更新日期：2012-03-01 00:00:00

  • Neonatal iron potentiates adult MPTP-induced neurodegenerative and functional deficits.

    abstract：:The interactive effects of neonatal iron and adult MPTP treatment groups of C57 Bl/6 mice were studied through adminustration of iron (Fe(2+)) 7.5mg/kg b.w., p.o. or vehicle (saline) on days 10-12 post partum, followed at 3months of age by administration of either MPTP (2x20 or 2x40mg/kg, s.c.) or saline. Neonatal iro...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/s1353-8020(00)00028-6

    authors： Fredriksson A,Schröder N,Eriksson P,Izquierdo I,Archer T

    更新日期：2001-04-01 00:00:00

  • Glucocerebrosidase gene variants are accumulated in idiopathic REM sleep behavior disorder.

    abstract：INTRODUCTION:Glucocerebrosidase (GBA) gene variants are associated with the development of the Lewy body disorders (LBD) Parkinson disease (PD) and dementia with Lewy bodies (DLB). Idiopathic REM sleep behavior disorder (IRBD) represents prodromal LBD in most instances. We investigated whether GBA variants are overrepr...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2018.02.034

    authors： Gámez-Valero A,Iranzo A,Serradell M,Vilas D,Santamaria J,Gaig C,Álvarez R,Ariza A,Tolosa E,Beyer K

    更新日期：2018-05-01 00:00:00

  • Body mass index is reduced early in Parkinson's disease.

    abstract：:Mean body mass index (BMI) in 100 cases of idiopathic Parkinson's disease (PD) was found to be 9% reduced in comparison to that in patients with either essential tremor or no neurologic disease. A similar reduction in BMI was also discovered among the 24 cases of PD in whom retrospective BMI data were available from t...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2004.07.001

    authors： Cheshire WP Jr,Wszolek ZK

    更新日期：2005-01-01 00:00:00