Glucocerebrosidase gene variants are accumulated in idiopathic REM sleep behavior disorder.

abstract：BACKGROUND:Oxidative stress is causally associated with the pathogenesis of Parkinson's disease (PD). Oxygen generates a large amount of reactive oxygen species (ROS). ROS including hydroxyl radicals and H(2)O(2) react with guanine residues in DNA and produce 8-hydroxydeoxyguanosine (8-OHdG). 8-OHdG serves as a biomark...

journal_title：Parkinsonism & related disorders

authors： Hirayama M,Nakamura T,Watanabe H,Uchida K,Hama T,Hara T,Niimi Y,Ito M,Ohno K,Sobue G

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:Patients with Parkinson disease (PD) and their partners may experience a worsening of their sexual life. AIM:To assess quality of sexual life (QoSL) in male and female PD patients and their partners. MATERIALS AND METHODS:Medical, demographic and clinical data was collected regarding consecutive PD patie...

journal_title：Parkinsonism & related disorders

authors： Bronner G,Cohen OS,Yahalom G,Kozlova E,Orlev Y,Molshatzki N,Strauss H,Hassin-Baer S

更新日期：2014-10-01 00:00:00

abstract：:Autosomal recessive juvenile parkinsonism (ARJP/PARK2) is a distinct clinical and genetic entity characterized by early-onset levodopa-responsive parkinsonism, foot dystonia, sleep benefit, and hyperactive tendon reflexes. We report a patient with genetically confirmed ARJP, who showed mild sensory disturbance and dim...

journal_title：Parkinsonism & related disorders

authors： Okuma Y,Hattori N,Mizuno Y

更新日期：2003-06-01 00:00:00

abstract：:We studied daytime sleepiness in 160 patients with Parkinson's disease and 40 normal subjects. We compared the prevalence of daytime sleepiness in patients who were taking levodopa alone, levodopa with bromocriptine, levodopa with ropinirole, and levodopa with pramipexole. We found that (1) all these anti-Parkinson dr...

journal_title：Parkinsonism & related disorders

authors： Sanjiv CC,Schulzer M,Mak E,Fleming J,Martin WR,Brown T,Calne SM,Tsui J,Stoessl AJ,Lee CS,Calne DB

更新日期：2001-10-01 00:00:00

abstract：:Deficiency in skilled motor activity is primarily attributed to the loss of dopaminergic neurons in the pars compacta of substantia nigra (SNc), which can be detected by performance of the rotarod test. Previous reports have demonstrated impaired skilled motor behavior in rats during the pre-motor stage of Parkinson's...

journal_title：Parkinsonism & related disorders

authors： Gambhir H,Mathur R,Behari M

更新日期：2011-07-01 00:00:00

abstract：INTRODUCTION:In Parkinson's disease (PD), neuropsychiatric symptoms (NPS) can be particularly burdensome for caregivers. The main goal of this study was to assess the impact of NPS, assessed by means of a new specific scale, on caregiver burden. METHODS:A sample of 584 pairs of PD patients and their primary caregivers...

journal_title：Parkinsonism & related disorders

authors： Martinez-Martin P,Rodriguez-Blazquez C,Forjaz MJ,Frades-Payo B,Agüera-Ortiz L,Weintraub D,Riesco A,Kurtis MM,Chaudhuri KR

更新日期：2015-06-01 00:00:00

abstract：:We report a cluster of five cases of Parkinson's disease (PD) among paper mill workers exposed to a fungicide, diphenyl. The cause of PD is still unknown, but epidemiological studies have indicated an elevated risk of developing PD after exposure to pesticides. The five cases of PD were found in a group of 255 dipheny...

journal_title：Parkinsonism & related disorders

authors： Wastensson G,Hagberg S,Andersson E,Johnels B,Barregård L

更新日期：2006-01-01 00:00:00

abstract：:Myoclonus-dystonia is an early onset genetic disorder characterised by subcortical myoclonus and less prominent dystonia. Its primary causative gene is the epsilon-sarcoglycan gene but the syndrome of "myoclonic dystonia" has been shown to be a heterogeneous group of genetic disorders. The underlying pathophysiology o...

journal_title：Parkinsonism & related disorders

authors： Fearon C,Peall KJ,Vidailhet M,Fasano A

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Non-motor symptoms in Parkinson's disease (PD), such as cognitive, emotional, autonomic and somatosensory alterations, are not ubiquitous but vary between the tremor dominant (TD) and postural instability/gait difficulty (PIGD) subtypes of the syndrome. Non-motor phenomena (e.g., anxiety, depression and apat...

journal_title：Parkinsonism & related disorders

authors： Santangelo G,Vitale C,Baiano C,D'Iorio A,Longo K,Barone P,Amboni M,Conson M

更新日期：2018-08-01 00:00:00

abstract：:Behr syndrome is an autosomal recessive disease characterized by early-onset ataxia, optic atrophy and other signs such as pyramidal tract dysfunction. Autosomal dominant inheritance has also been described. In this case report we present a family pedigree of patients with an inherited autosomal dominant Behr syndrome...

journal_title：Parkinsonism & related disorders

authors： Felicio AC,Godeiro-Junior C,Alberto LG,Pinto AP,Sallum JM,Teive HG,Barsottini OG

更新日期：2008-01-01 00:00:00

abstract：:Although primary focal hand dystonia has been well characterized, primary focal foot dystonia in adults has rarely been reported. Our objective was to describe the clinical phenotype and treatment outcomes in patients with primary, adult-onset focal foot dystonia. To this end we conducted a retrospective study of four...

journal_title：Parkinsonism & related disorders

authors： Singer C,Papapetropoulos S

更新日期：2006-01-01 00:00:00

abstract：:Several factors involved in the etiology of Parkinson's disease (PD) have been proposed, including genetic and environmental factors or even a combination of both. Thus, multiple cellular hits are likely to contribute to neurodegeneration in PD. If such a mechanism happens to occur, our therapeutic intervention may pe...

journal_title：Parkinsonism & related disorders

authors： Hirsch EC

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Traditionally the risk of Parkinson's has been considered to increase monotonically with age, although there is evidence that prevalence and incidence may decrease in the oldest old. To examine this further we estimated the national prevalence and incidence of Parkinson's in New Zealand, using drug-tracing m...

journal_title：Parkinsonism & related disorders

authors： Myall DJ,Pitcher TL,Pearson JF,Dalrymple-Alford JC,Anderson TJ,MacAskill MR

更新日期：2017-09-01 00:00:00

abstract：:Six healthy controls and eighteen patients with Parkinson's disease in different disability stages were studied with SPECT using [(123)I]beta-CIT to label the striatal dopamine transporter. The mean uptake of [(123)I]beta-CIT in the putamen was reduced to 54% of the control mean and to 65% of the average control value...

journal_title：Parkinsonism & related disorders

authors： Rinne JO,Kuikka JT,Bergström KA,Rinne UK

更新日期：1995-07-01 00:00:00

abstract：OBJECTIVE:To investigate the indications and the outcomes of gastrostomy tube insertion in patients with parkinsonian syndromes. METHODS:Consecutive patients with Parkinson's disease or atypical parkinsonism, seen in two French tertiary referral movement disorders centers, that received gastrostomy tube insertion (GTI...

journal_title：Parkinsonism & related disorders

authors： Marois C,Amador MDM,Payan C,Lacomblez L,Bonnet AM,Degos B,Corvol JC,Vidailhet M,Le Forestier N,Mesnage V,Grabli D

更新日期：2017-10-01 00:00:00

abstract：:Abnormally aggregated tau protein is central to the pathophysiology of Alzheimer's disease, frontotemporal dementia variants, progressive supranuclear palsy, corticobasal degeneration and chronic traumatic encephalopathy. The post-mortem cortical density of hyperphosphorylated tau tangles correlates with pre-morbid co...

journal_title：Parkinsonism & related disorders

authors： Dani M,Edison P,Brooks DJ

更新日期：2016-01-01 00:00:00

abstract：:Parkinson's disease (PD) is the most common neurodegenerative movement disorder. Currently, no curative treatments or treatments that interdict disease progression are available. Over the past decade, immunization strategies were developed in our laboratories to combat disease progression. These strategies were develo...

journal_title：Parkinsonism & related disorders

authors： Ha D,Stone DK,Mosley RL,Gendelman HE

更新日期：2012-01-01 00:00:00

abstract：:Cerebrospinal fluid (CSF) levels of neurofilament light protein (NFL), a marker of neuronal damage, are normal in Parkinson's disease (PD) but elevated in multiple system atrophy (MSA) and progressive supranuclear palsy (PSP). Therefore, CSF NFL can help differentiate between PD on one hand and MSA/PSP on the other. I...

journal_title：Parkinsonism & related disorders

authors： Constantinescu R,Rosengren L,Johnels B,Zetterberg H,Holmberg B

更新日期：2010-02-01 00:00:00

abstract：:This letter to the editor acknowledges the contribution of Akbar et al. to the field of tardive dyskinesia (TD) and provides important regulatory information about the potential for parkinson-like symptoms in patients with TD who are treated with valbenazine. ...

journal_title：Parkinsonism & related disorders

authors： Shah C

更新日期：2020-02-01 00:00:00

abstract：INTRODUCTION:The aim of the study was to identify abnormalities of whole-brain network functional organization and their relation to clinical measures in a well-characterized, multi-site cohort of very early-stage, drug-naïve Parkinson's Disease (PD) patients. METHODS:Functional-MRI data for 16 healthy controls and 20...

journal_title：Parkinsonism & related disorders

authors： Sreenivasan K,Mishra V,Bird C,Zhuang X,Yang Z,Cordes D,Walsh RR

更新日期：2019-05-01 00:00:00

abstract：:Cerebrotendinous xanthomatosis (CTX) is an inborn error of cholesterol and bile acid metabolism, leading to neuropsychiatric and systemic manifestations. Movement disorders have rarely been reported in CTX, while a detailed appreciation of the full phenotypic spectrum is required in order to prevent underdiagnosis of ...

journal_title：Parkinsonism & related disorders

authors： Stelten BML,van de Warrenburg BPC,Wevers RA,Verrips A

更新日期：2019-01-01 00:00:00

abstract：:In Parkinson's disease (PD), post-mortem examination reveals a loss of dopaminergic (DA) neurons in the substantia nigra (SN) associated with a massive astrogliosis and the presence of activated microglial cells. Similarly, microglial activation has also been reported to be associated with the loss of DA neurons in an...

journal_title：Parkinsonism & related disorders

authors： Hirsch EC,Hunot S,Hartmann A

更新日期：2005-06-01 00:00:00

abstract：:Synchronization of neuronal activity within and across distributed brain regions is a fundamental property of cortical and subcortical networks and serves a variety of functions including motor and cognitive processes. Data will be reviewed here from cross-sectional EEG and MEG studies to suggest that Parkinson's dise...

journal_title：Parkinsonism & related disorders

authors： Berendse HW,Stam CJ

更新日期：2007-01-01 00:00:00

abstract：:Parkinson's disease (PD) is a progressive, disabling, neurodegenerative disease that requires long term care and pharmaceutical treatment. Levodopa remains the gold standard treatment for PD globally, although it is largely unavailable and unaffordable for the majority of patients in many sub-Saharan African and other...

journal_title：Parkinsonism & related disorders

authors： Fothergill-Misbah N,Maroo H,Cham M,Pezzoli G,Walker R,Cilia R

更新日期：2020-04-01 00:00:00

abstract：:Anterograde tract-tracing and immunohistochemical methods were used to study projections from the pedunculopontine tegmental nucleus (PPN) to midbrain dopaminergic neurons in the squirrel monkey (Saimiri sciureus). The PPN harbored numerous cholinergic and glutamatergic neurons, as well as neurons that displayed both ...

journal_title：Parkinsonism & related disorders

authors： Parent A,Parent M,Charara A

更新日期：1999-12-01 00:00:00

abstract：:The present report documents a patient harboring an alpha-synuclein p.A53T variant from a family presenting with autosomal dominant inheritance, including four patients clinically diagnosed with Parkinson's disease (PD) and two with dementia. The alpha-synuclein p.A53T variant is linked to young- or middle-aged onset ...

journal_title：Parkinsonism & related disorders

authors： Nishioka K,Hashizume Y,Takanashi M,Daida K,Li Y,Yoshino H,Tambasco N,Prontera P,Hattori Y,Ueda A,Watanabe H,Hattori N

更新日期：2020-12-01 00:00:00

abstract：:This preliminary study aimed to analyse the roll-off of the foot during gait before and after implantation of a unilateral pallidal electrode in severely affected patients with Parkinson's disease (PD). Five subjects were tested in a gait laboratory during the "on" phase of the medication cycle. Spatiotemporal variabl...

journal_title：Parkinsonism & related disorders

authors： Nieuwboer A,De Weerdt W,Dom R,Nuttin B,Peeraer L,Pattyn A

更新日期：1998-12-01 00:00:00

abstract：BACKGROUND:A mean of 10 years elapse before patients with Parkinson's disease (PD) reach Hoehn & Yahr (H&Y) stage 4, and 14 years for stage 5. A small proportion of PD patients survive and are ambulatory for ≥ 20 years. We sought to identify features associated with long-duration PD (dPD). METHODS:This five-center, ca...

journal_title：Parkinsonism & related disorders

authors： Munhoz RP,Espay AJ,Morgante F,Li JY,Teive HA,Dunn E,Gallin E,Litvan I

更新日期：2013-01-01 00:00:00

abstract：:Excessive daytime sleepiness (EDS) is common in Parkinson's Disease (PD). Actigraphy uses periods of immobility as surrogate markers of nighttime sleep but there are no examples of its use in assessing EDS of PD. A commercial wrist worn system for measuring bradykinesia and dyskinesia also detects 2 min periods of imm...

journal_title：Parkinsonism & related disorders

authors： Kotschet K,Johnson W,McGregor S,Kettlewell J,Kyoong A,O'Driscoll DM,Turton AR,Griffiths RI,Horne MK

更新日期：2014-06-01 00:00:00

abstract：:Spinocerebellar ataxia (SCA) 17 is a dominant neurodegenerative disorder characterized by ataxia, cognitive decline, dystonia, and parkinsonism. The disease is caused by unstable cytosine-adenine-guanine (CAG) trinucleotide expansion mutation coding for polyglutamine tracts in the TATA box-binding protein (TBP), a gen...

journal_title：Parkinsonism & related disorders

authors： Lin IS,Wu RM,Lee-Chen GJ,Shan DE,Gwinn-Hardy K

更新日期：2007-05-01 00:00:00