Adult-onset primary focal foot dystonia.

abstract：INTRODUCTION:Gait and balance impairments are cardinal features of Parkinson's disease (PD) that require cognitive input. However, the extent to which specific gait and balance characteristics relate to cognition in PD is unclear. In addition, independent models of gait and balance have not been developed from the same...

journal_title：Parkinsonism & related disorders

authors： Morris R,Martini DN,Smulders K,Kelly VE,Zabetian CP,Poston K,Hiller A,Chung KA,Yang L,Hu SC,Edwards KL,Cholerton B,Grabowski TJ,Montine TJ,Quinn JF,Horak F

更新日期：2019-12-01 00:00:00

abstract：:Oxidative stress has been reported as one of the pathogeneses of Parkinson's disease (PD). Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that regulates the expression of the target genes involved in antioxidant pathway. The promoter polymorphisms of the Nrf2-encoding gene, NFE2L2, have b...

journal_title：Parkinsonism & related disorders

authors： Chen YC,Wu YR,Wu YC,Lee-Chen GJ,Chen CM

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Quantitative analysis of brain atrophy may be useful in differentiating Parkinson's Disease (PD) from Progressive Supranuclear Palsy (PSP) and parkinsonian variant of Multiple System Atrophy (MSA-P); the aim of this study was to identify the volumetric differences of subcortical structures in pat...

journal_title：Parkinsonism & related disorders

authors： Messina D,Cerasa A,Condino F,Arabia G,Novellino F,Nicoletti G,Salsone M,Morelli M,Lanza PL,Quattrone A

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Given the heterogeneity of mild cognitive deficits in non-demented Parkinson's disease (PD), sensitive and anatomically specific behavioural measures are crucial when evaluating cognition in this patient group. Inhibitory dysfunction is one such deficit increasingly being recognised in non-demented PD; howev...

journal_title：Parkinsonism & related disorders

authors： O'Callaghan C,Naismith SL,Shine JM,Bertoux M,Lewis SJ,Hornberger M

更新日期：2013-09-01 00:00:00

abstract：:Today's society is changing rapidly and individuals increasingly favor an active role in designing their own lives. Contemporary patients are no exception, but the present health care system-which is organized primarily from the provider's perspective-is not yet prepared for this development. Here, we argue that an al...

journal_title：Parkinsonism & related disorders

authors： van der Eijk M,Nijhuis FA,Faber MJ,Bloem BR

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Autosomal-dominant striatal degeneration (ADSD) is a rare neurodegenerative movement disorder caused by mutations in the Phosphodiesterase 8B (PDE8B) gene. OBJECTIVE:To summarize the clinical and imaging features of a Chinese ADSD family and determine whether mutations in PDE8B are associated with Parkinson...

journal_title：Parkinsonism & related disorders

authors： Ni J,Yi X,Liu Z,Sun W,Yuan Y,Yang J,Jiang H,Shen L,Tang B,Liu Y,Wang J

更新日期：2019-12-01 00:00:00

abstract：:A 68-year-old, normal female volunteer was scanned by positron emission tomography (PET) with [(18)F]6-L-fluorodopa (FD). Striatal FD uptake was in the high normal range. Subsequently, she developed parkinsonism 3.7 years after the scan. A repeat FD PET scan revealed a significant reduction of FD uptake by 20% over th...

journal_title：Parkinsonism & related disorders

authors： Shinotoh H,Vingerhoets FJ,Schulzer M,Snow BJ

更新日期：1996-07-01 00:00:00

abstract：BACKGROUND:Apathy is a common neuropsychiatric syndrome in Parkinson's Disease (PD) that affects quality of life. Research into apathy has been hampered by a lack of broadly accepted diagnostic criteria. Recently, diagnostic criteria for apathy in neuropsychiatric disorders have been proposed, which to date have not be...

journal_title：Parkinsonism & related disorders

authors： Drijgers RL,Dujardin K,Reijnders JS,Defebvre L,Leentjens AF

更新日期：2010-12-01 00:00:00

abstract：OBJECTIVE:To assess the association between diabetes preceding Parkinson's disease (PD) and PD. METHODS:PD individuals were matched to PD free individuals randomly selected from people in the same municipality as the cases. Occurrence of diabetes preceding PD onset among cases and controls was assessed through a struc...

journal_title：Parkinsonism & related disorders

authors： D'Amelio M,Ragonese P,Callari G,Di Benedetto N,Palmeri B,Terruso V,Salemi G,Famoso G,Aridon P,Savettieri G

更新日期：2009-11-01 00:00:00

abstract：PURPOSE:To assess optimism/pessimism and locus of control in a sample of Parkinson's disease patients and to evaluate their impact on disability and health-related quality of life. METHODS:99 patients with Parkinson's disease completed the Life Orientation Test, Multidimensional Health Locus of Control, Older American...

journal_title：Parkinsonism & related disorders

authors： Gruber-Baldini AL,Ye J,Anderson KE,Shulman LM

更新日期：2009-11-01 00:00:00

abstract：:Pathogenic mutations in the EIF4G1 gene were recently reported as a cause of autosomal dominant parkinsonism. To assess the frequency of EIF4G1 mutations in the Japanese population we sequenced the entire gene coding region (31 exons) in 95 patients with an apparent autosomal dominant inherited form of Parkinson's dis...

journal_title：Parkinsonism & related disorders

authors： Nishioka K,Funayama M,Vilariño-Güell C,Ogaki K,Li Y,Sasaki R,Kokubo Y,Kuzuhara S,Kachergus JM,Cobb SA,Takahashi H,Mizuno Y,Farrer MJ,Ross OA,Hattori N

更新日期：2014-06-01 00:00:00

abstract：:In this study we aimed to investigate the effects of bilateral STN HFS in patients with advanced Parkinson disease (PD) at long-term, with a minimum follow-up of 4 years. Twenty patients (15 men, five women) were included, with a mean age of 60.9+/-8.1 years. Surgery was performed under local anesthesia. The target wa...

journal_title：Parkinsonism & related disorders

authors： Visser-Vandewalle V,van der Linden C,Temel Y,Celik H,Ackermans L,Spincemaille G,Caemaert J

更新日期：2005-05-01 00:00:00

abstract：:This case series describes the inpatient rehabilitation of two medically complex patients with Parkinson's disease (PD) who had undergone deep brain stimulator (DBS) placement. Most patients may not require inpatient rehabilitation. However, a short rehabilitation stay might be of use to patients who need to be weaned...

journal_title：Parkinsonism & related disorders

authors： Nampiaparampil DE,Kuppy JE,Nampiaparampil GM,Salles SS

更新日期：2008-01-01 00:00:00

abstract：:Understanding of the pathophysiology of Parkinson disease (PD) has advanced rapidly over the last two decades through basic and clinical studies using modern neuroanatomical, clinical assessment, neuropathological and functional brain imaging methods. Two interacting processes determine the development of functional i...

journal_title：Parkinsonism & related disorders

authors： Moore RY

更新日期：2003-08-01 00:00:00

abstract：:The authors review some particularities of movement disorders (MDs) in the ethnically diverse population of Latin America. Although idiopathic diseases are evenly prevalent, access to treatment encounters difficulties that are worth discussing. Infectious-parasitic diseases observed throughout the continent occasional...

journal_title：Parkinsonism & related disorders

authors： Troiano AR,Micheli FE,Alarcón F,Teive HA

更新日期：2006-04-01 00:00:00

abstract：:Moclobemide, a potent reversible monoamine-oxidase A (MAO-A) inhibitor, is an effective antidepressant that does not cause impairment of cognitive function in elderly patients and might be beneficial to motor deficits in Parkinson's disease (PD). In a 12-week open-label prospective study, we administered moclobemide (...

journal_title：Parkinsonism & related disorders

authors： Giménez-Roldán S,Dobato JL,Mateo D

更新日期：1997-12-01 00:00:00

abstract：:The opsoclonus-myoclonus syndrome is a pathological condition characterized mainly by involuntary myoclonic movements involving ocular, trunk and limb muscles associated with ataxia and other neurological signs.We describe the case of a 30-year-old woman who developed this syndrome 15days after anti-Rubella vaccinatio...

journal_title：Parkinsonism & related disorders

authors： Lapenna F,Lochi L,de Mari M,Iliceto G,Lamberti P

更新日期：2000-10-01 00:00:00

abstract：OBJECTIVES:To investigate the frequency and the different types of psychiatric disturbances in PSP patients using validated psychiatric instruments. METHODS:We conducted a case-control study using the Structured Clinical Interview (SCID-I) for DSM-IV to investigate psychiatric disorders in 28 PSP patients and 28 age a...

journal_title：Parkinsonism & related disorders

authors： Bloise MC,Berardelli I,Roselli V,Pasquini M,Stirpe P,Colosimo C,Berardelli A,Fabbrini G

更新日期：2014-09-01 00:00:00

abstract：:Levodopa (LD) is the most effective drug for symptomatic control of Parkinsonism (PS). As prolonged LD therapy leads to response failure; is associated with adverse effects; may accelerate disease process, and its impact on life expectancy is controversial, delaying LD use has been recommended. We studied 934 PS cases...

journal_title：Parkinsonism & related disorders

authors： Rajput AH,Uitti RJ,Rajput AH,Offord KP

更新日期：1997-11-01 00:00:00

abstract：BACKGROUND:Though visual illusions and hallucinations are common in dementia with Lewy bodies (DLB) and Parkinson's disease (PD), they are not typically observed clinically in prodromal stages, including isolated REM sleep behavior disorder (iRBD). False-noise errors on the pareidolia test (seeing faces when none are p...

journal_title：Parkinsonism & related disorders

authors： Honeycutt L,Gagnon JF,Pelletier A,De Roy J,Montplaisir JY,Postuma RB

更新日期：2020-06-01 00:00:00

abstract：:We examined the autopsied brains of two parkinsonian patients who had malignant syndrome (MS). Neopterin and biopterin contents, and GTP cyclohydrolase I activity were measured in various region of the brain. We found relatively higher GTP cyclohydrolase I activities in the hypothalamus compared with other regions of ...

journal_title：Parkinsonism & related disorders

authors： Ichinose H,Ohye T,Shinotoh H,Arai K,Yamazaki S,Mizuta E,Kuno S,Nagatsu T

更新日期：2003-04-01 00:00:00

abstract：INTRODUCTION:Cognitive impairment and dementia are highly prevalent non-motor complications in Parkinson's disease (PD) with deleterious consequences for patients and caregivers. With no treatment currently available, finding and validating minimally-invasive biomarkers of neurodegeneration in this population represent...

journal_title：Parkinsonism & related disorders

authors： Sampedro F,Pérez-González R,Martínez-Horta S,Marín-Lahoz J,Pagonabarraga J,Kulisevsky J

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Significant efforts have been focused on investigating the contribution of common variants to Parkinson disease (PD) risk. Several independent GWAS and metanalysis studies have shown a genome-wide significant association of single nucleotide polymorphisms (SNPs) in the α-synuclein (SNCA) and microtubule-asso...

journal_title：Parkinsonism & related disorders

authors： Trotta L,Guella I,Soldà G,Sironi F,Tesei S,Canesi M,Pezzoli G,Goldwurm S,Duga S,Asselta R

更新日期：2012-03-01 00:00:00

abstract：INTRODUCTION:Our objective was to compare the relative value of elements of the motor system in predicting the physical mobility domain of health related quality of life in patients with Parkinson's disease in order to specify targets for intervention. METHODS:In this cross-sectional study, the Parkinson's disease que...

journal_title：Parkinsonism & related disorders

authors： Ellis T,Cavanaugh JT,Earhart GM,Ford MP,Foreman KB,Dibble LE

更新日期：2011-11-01 00:00:00

abstract：:Adenosine derived from the degradation of ATP/AMP functions as a signalling molecule in the nervous system through the occupation of A1, A2, and A3 adenosine receptors. Adenosine A(2A) receptors have a selective localization to the basal ganglia and specifically to the indirect output pathway, and as a consequence off...

journal_title：Parkinsonism & related disorders

authors： Jenner P,Mori A,Hauser R,Morelli M,Fredholm BB,Chen JF

更新日期：2009-07-01 00:00:00

abstract：:We report here on a Japanese family in which five members in three generations developed non-progressive adult onset cortical tremor and epilepsy. Other than tremulous movements resembling essential tremor, the neurologic findings were unremarkable. Electrophysiologic studies revealed giant somatosensory evoked potent...

journal_title：Parkinsonism & related disorders

authors： Okuma Y,Shimo Y,Hatori K,Hattori T,Tanaka S,Mizuno Y

更新日期：1997-04-01 00:00:00

abstract：:Some procedures, such as deep inspiration, increase sweat output (SSwR; sympathetic sweat response) and reduce cutaneous blood flow (SVR; skin vasomotor reflex) on the palm. We investigated SSwR, SVR, and cardiovascular function in 12 patients with progressive supranuclear palsy (PSP), 13 patients with Parkinson's dis...

journal_title：Parkinsonism & related disorders

authors： Kikkawa Y,Asahina M,Suzuki A,Hattori T

更新日期：2003-12-01 00:00:00

abstract：BACKGROUND:In late stage Parkinson patients there is an unmet need for new treatments to adequately control motor complications, especially dyskinesias. In several preliminary studies, it has been suggested that applying unilateral low-frequency repetitive transcranial magnetic stimulation (LF rTMS), delivered at the p...

journal_title：Parkinsonism & related disorders

authors： Flamez A,Cordenier A,De Raedt S,Michiels V,Smetcoren S,Van Merhaegen-Wieleman A,Parys E,De Keyser J,Baeken C

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:The Vanderbilt pilot trial of deep brain stimulation (DBS) in early Parkinson's disease (PD) enrolled patients on medications six months to four years without motor fluctuations or dyskinesias. We conducted a patient-centered analysis based on clinically important worsening of motor symptoms and complication...

journal_title：Parkinsonism & related disorders

authors： Hacker ML,Tonascia J,Turchan M,Currie A,Heusinkveld L,Konrad PE,Davis TL,Neimat JS,Phibbs FT,Hedera P,Wang L,Shi Y,Shade DM,Sternberg AL,Drye LT,Charles D

更新日期：2015-10-01 00:00:00

abstract：:Orthostatic hypotension is common in Parkinsonian patients. It is probably caused by reduced noradrenaline (NA) release. This effect is further enhanced by therapeutic use of ergot alkaloid dopamine agonists. In this trial we studied the impact of the non-ergot dopamine agonist ropinirole on blood pressure and noradre...

journal_title：Parkinsonism & related disorders

authors： Jost WH,Bellon AK,Kaiser T,Schrank B

更新日期：1998-08-01 00:00:00