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Biopterin metabolism in patients with malignant syndrome.

Abstract：

:We examined the autopsied brains of two parkinsonian patients who had malignant syndrome (MS). Neopterin and biopterin contents, and GTP cyclohydrolase I activity were measured in various region of the brain. We found relatively higher GTP cyclohydrolase I activities in the hypothalamus compared with other regions of the brain from patients with MS. This finding suggested a possible involvement of biopterin metabolism in pathophysiology of MS. This is the first report on biopterin metabolism in the brains of patients with MS.

journal_name

Parkinsonism Relat Disord

journal_title

Parkinsonism & related disorders

authors

Ichinose H,Ohye T,Shinotoh H,Arai K,Yamazaki S,Mizuta E,Kuno S,Nagatsu T

doi

10.1016/s1353-8020(02)00120-7

subject

Has Abstract

pub_date

2003-04-01 00:00:00

pages

S11-4

eissn

1353-8020

issn

1873-5126

pii

S1353802002001207

journal_volume

9 Suppl 1

pub_type

杂志文章

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