当前位置： SCI文献检索 > PARKINSONISM & RELATED DISORDERS期刊下所有文献 > Longitudinal changes in cognition in early Parkinson's disease patients with REM sleep behavior disorder.

Longitudinal changes in cognition in early Parkinson's disease patients with REM sleep behavior disorder.

Abstract：

INTRODUCTION:Cognitive decline is common in Parkinson's disease (PD), and identifying patients at highest risk for it is essential. We aimed to examine the effect of possible REM sleep behavior disorder (pRBD) on rate of cognitive decline in early PD, for both global cognition and in specific cognitive domains. METHODS:Parkinson's Progression Markers Initiative (PPMI) is a multi-site, international study of PD patients untreated at enrollment. pRBD was assessed with the REM sleep behavior disorder questionnaire (RBDSQ). Global cognition was assessed at baseline and annually using the Montreal Cognitive Assessment (MoCA) and a cognitive battery. Linear mixed effects models were used to examine the relationship between pRBD (RBDSQ≥6) and rate of change in cognitive variables. Age, sex, years of education, and baseline motor and cognitive scores were included as covariates. RESULTS:The baseline sample consisted of 423 individuals with PD, mean age 61.7 years and 65.5% male. Data was available on 389, 366, and 196 participants at 1-year, 2-year, and 3-year follow-up respectively. Possible RBD occurred in 108 (25.5%) at baseline. In multivariate analyses, baseline RBD was associated with greater annual rate of decline in MoCA score (β = -0.34, 95%CI -0.54, -0.13, p < 0.001), Symbol Digit Modalities Test (β = -0.69, 95%CI -1.3, -0.09, p = 0.024), and Hopkins Verbal Learning Test-Revised, delayed free recall (β = -0.21, 95%CI -0.41, -0.013, p = 0.037). CONCLUSIONS:Possible RBD is common in early PD and predicts future cognitive decline, particularly in attention and memory domains.

journal_name

Parkinsonism Relat Disord

journal_title

Parkinsonism & related disorders

authors

Chahine LM,Xie SX,Simuni T,Tran B,Postuma R,Amara A,Oertel WH,Iranzo A,Scordia C,Fullard M,Linder C,Purri R,Darin A,Rennert L,Videnovic A,Del Riva P,Weintraub D

doi

10.1016/j.parkreldis.2016.03.006

subject

Has Abstract

pub_date

2016-06-01 00:00:00

pages

102-6

eissn

1353-8020

issn

1873-5126

pii

S1353-8020(16)30060-8

journal_volume

27

pub_type

杂志文章,多中心研究

相关文献

PARKINSONISM & RELATED DISORDERS文献大全
  • Glutamatergic inputs to midbrain dopaminergic neurons in primates.

    abstract：:Anterograde tract-tracing and immunohistochemical methods were used to study projections from the pedunculopontine tegmental nucleus (PPN) to midbrain dopaminergic neurons in the squirrel monkey (Saimiri sciureus). The PPN harbored numerous cholinergic and glutamatergic neurons, as well as neurons that displayed both ...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/s1353-8020(99)00037-1

    authors： Parent A,Parent M,Charara A

    更新日期：1999-12-01 00:00:00

  • Striatal plasticity and extrapyramidal motor dysfunction.

    abstract：:Knowledge of molecular events contributing to motor dysfunction in Parkinson's disease has advanced rapidly during the past decade. Studies in animal models as well as in patients afflicted by this disorder suggest that the nonphysiologic stimulation of striatal dopamine receptors, first as a result of dopaminergic de...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,评审

    doi：10.1016/j.parkreldis.2004.02.012

    authors： Chase TN

    更新日期：2004-07-01 00:00:00

  • Using virtual reality to explore the role of conflict resolution and environmental salience in freezing of gait in Parkinson's disease.

    abstract：BACKGROUND:The freezing phenomenon is among the most disabling symptoms of Parkinson's disease (PD) manifesting most commonly as Freezing of Gait with a paroxysmal cessation of effective stepping. Recent studies have suggested that freezing is related to both impairments in conflict resolution as well as the processing...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.parkreldis.2013.06.002

    authors： Matar E,Shine JM,Naismith SL,Lewis SJ

    更新日期：2013-11-01 00:00:00

  • Memory perception and strategy use in Parkinson's disease.

    abstract：:Although there is growing support for the existence of memory deficits within Parkinson's disease (PD), little has been done to evaluate the extent to which PD patients demonstrate differences in their use of metacognitive strategies. In the present study, 79 PD patients (46 men and 33 women) and 49 age-matched health...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2004.06.005

    authors： Johnson AM,Pollard CC,Vernon PA,Tomes JL,Jog MS

    更新日期：2005-03-01 00:00:00

  • Changes in quality of life, burden and mood among spouses of Parkinson's disease patients receiving neurostimulation.

    abstract：BACKGROUND:Deep brain stimulation improves motor function and quality of life in patients with Parkinson's disease. The impact of these changes on patients' spouses is largely unknown. METHODS:Twenty-six spouses of patients undergoing surgery were evaluated before and 12 months after surgery, using the 36-Item Short F...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2011.11.008

    authors： Soulas T,Sultan S,Gurruchaga JM,Palfi S,Fénelon G

    更新日期：2012-06-01 00:00:00

  • Gaba and serotonin molecular neuroimaging in essential tremor: a clinical correlation study.

    abstract：BACKGROUND:Essential tremor is the most common movement disorder in adults, but its exact etiology and pathophysiology are still not fully understood. There is some consensus, however, about the involvement of the cerebellum and accumulating evidence points towards a dysfunction of the gabaergic system. We hypothesize ...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2012.04.024

    authors： Gironell A,Figueiras FP,Pagonabarraga J,Herance JR,Pascual-Sedano B,Trampal C,Gispert JD

    更新日期：2012-08-01 00:00:00

  • Neural correlates of minor hallucinations in non-demented patients with Parkinson's disease.

    abstract：BACKGROUND:Hallucinations are a frequent and severe complication in Parkinson's disease (PD). Minor hallucinations are generally not disturbing, but likely progress to well-structured hallucinations with loss of insight and a great impact on quality of life. Knowledge on the neural bases of minor hallucinations may hel...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2013.11.017

    authors： Pagonabarraga J,Soriano-Mas C,Llebaria G,López-Solà M,Pujol J,Kulisevsky J

    更新日期：2014-03-01 00:00:00

  • Clinical findings of autosomal-dominant striatal degeneration and PDE8B mutation screening in parkinsonism and related disorders.

    abstract：BACKGROUND:Autosomal-dominant striatal degeneration (ADSD) is a rare neurodegenerative movement disorder caused by mutations in the Phosphodiesterase 8B (PDE8B) gene. OBJECTIVE:To summarize the clinical and imaging features of a Chinese ADSD family and determine whether mutations in PDE8B are associated with Parkinson...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2019.11.002

    authors： Ni J,Yi X,Liu Z,Sun W,Yuan Y,Yang J,Jiang H,Shen L,Tang B,Liu Y,Wang J

    更新日期：2019-12-01 00:00:00

  • Adults with a history of illicit amphetamine use exhibit abnormal substantia nigra morphology and parkinsonism.

    abstract：INTRODUCTION:The sonographic appearance of the substantia nigra is abnormally bright and enlarged (hyperechogenic) in young adults with a history of illicit stimulant use. The abnormality is a risk factor for Parkinson's disease. The aim of the current study was to identify the type of illicit stimulant drug associated...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2016.02.019

    authors： Todd G,Pearson-Dennett V,Wilcox RA,Chau MT,Thoirs K,Thewlis D,Vogel AP,White JM

    更新日期：2016-04-01 00:00:00

  • Deep brain stimulation of the internal pallidum in multiple system atrophy.

    abstract：:We describe the outcome of deep brain stimulation of the internal pallidum in a 57-year old patient with multiple system atrophy. Although the prominent dystonic features of this patient were markedly attenuated post-operatively, the outcome was to be considered unfavourable. There was a severe increase in akinesia re...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2005.08.004

    authors： Santens P,Vonck K,De Letter M,Van Driessche K,Sieben A,De Reuck J,Van Roost D,Boon P

    更新日期：2006-04-01 00:00:00

  • Levodopa and neuropathy risk in patients with Parkinson disease: Effect of COMT inhibition.

    abstract：OBJECTIVE:Our purpose was to determine whether the use of catechol-O-methyltransferase-inhibitors (ICOMT) can reduce the risk of developing levodopa (LD)-induced neuropathy in Parkinson's disease (PD) patients. METHODS:A multicentre study of 197 PD patients was performed. 144 were exposed to LD for more than three yea...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.parkreldis.2016.04.016

    authors： Cossu G,Ceravolo R,Zibetti M,Arca R,Ricchi V,Paribello A,Murgia D,Merola A,Romagnolo A,Nicoletti V,Palermo G,Mereu A,Lopiano L,Melis M,Abbruzzese G,Bonuccelli U

    更新日期：2016-06-01 00:00:00

  • Involuntary emotional expression disorder (IEED) in Parkinson's disease.

    abstract：OBJECTIVE:To estimate the frequency and correlates of involuntary emotional expression disorder (IEED) in Parkinson's disease (PD) using the Center for Neurologic Study-Lability Scale (CNS-LS) and recently-proposed diagnostic criteria for IEED. BACKGROUND:IEED is characterized by uncontrollable emotional episodes, typ...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2009.01.001

    authors： Phuong L,Garg S,Duda JE,Stern MB,Weintraub D

    更新日期：2009-08-01 00:00:00

  • Do caffeine and more selective adenosine A2A receptor antagonists protect against dopaminergic neurodegeneration in Parkinson's disease?

    abstract：:The adenosine A2A receptor is a major target of caffeine, the most widely used psychoactive substance worldwide. Large epidemiological studies have long shown caffeine consumption is a strong inverse predictor of Parkinson's disease (PD). In this review, we first examine the epidemiology of caffeine use vis-à-vis PD a...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2020.10.024

    authors： Chen JF,Schwarzschild MA

    更新日期：2020-11-01 00:00:00

  • Salivary alpha-synuclein in the diagnosis of Parkinson's disease and Progressive Supranuclear Palsy.

    abstract：INTRODUCTION:Alpha-synuclein (α-syn) aggregation is the pathological hallmark of Parkinson's Disease (PD). In this study, we measured α-syn total (α-syntotal), oligomeric α-syn (α-synolig) and α-synolig/α-syntotal ratio in the saliva of patients affected by PD and in age and sex-matched healthy subjects. We also compar...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2019.02.014

    authors： Vivacqua G,Suppa A,Mancinelli R,Belvisi D,Fabbrini A,Costanzo M,Formica A,Onori P,Fabbrini G,Berardelli A

    更新日期：2019-06-01 00:00:00

  • Walking ability after implantation of a pallidal stimulator: analysis of plantar force distribution in patients with Parkinson's disease.

    abstract：:This preliminary study aimed to analyse the roll-off of the foot during gait before and after implantation of a unilateral pallidal electrode in severely affected patients with Parkinson's disease (PD). Five subjects were tested in a gait laboratory during the "on" phase of the medication cycle. Spatiotemporal variabl...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/s1353-8020(98)00038-8

    authors： Nieuwboer A,De Weerdt W,Dom R,Nuttin B,Peeraer L,Pattyn A

    更新日期：1998-12-01 00:00:00

  • Bilateral low frequency rTMS of the primary motor cortex may not be a suitable treatment for levodopa-induced dyskinesias in late stage Parkinson's disease.

    abstract：BACKGROUND:In late stage Parkinson patients there is an unmet need for new treatments to adequately control motor complications, especially dyskinesias. In several preliminary studies, it has been suggested that applying unilateral low-frequency repetitive transcranial magnetic stimulation (LF rTMS), delivered at the p...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2015.11.009

    authors： Flamez A,Cordenier A,De Raedt S,Michiels V,Smetcoren S,Van Merhaegen-Wieleman A,Parys E,De Keyser J,Baeken C

    更新日期：2016-01-01 00:00:00

  • Obstructive sleep apnea, CPAP therapy and Parkinson's disease motor function: A longitudinal study.

    abstract：INTRODUCTION:We aimed to assess, in patients with Parkinson's disease (PD), the association between obstructive sleep apnea (OSA), progression of motor dysfunction and the effect of OSA treatment. METHODS:Data were analysed from a prospective cohort study of idiopathic PD patients from a movement disorders clinic. Pat...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2019.12.001

    authors： Meng L,Benedetti A,Lafontaine AL,Mery V,Robinson AR,Kimoff J,Gros P,Kaminska M

    更新日期：2020-01-01 00:00:00

  • Inflammation and neurodegeneration in Parkinson's disease.

    abstract：:The immunohistochemical demonstration of reactive microglia and activated complement components suggests that chronic inflammation occurs in affected brain regions in Parkinson's disease (PD). Evidence from humans and monkeys exposed to MPTP indicates this inflammation may persist many years after the initial stimulus...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,评审

    doi：10.1016/j.parkreldis.2004.01.005

    authors： McGeer PL,McGeer EG

    更新日期：2004-05-01 00:00:00

  • Selecting candidates for Deep Brain Stimulation in Parkinson's disease: the role of patients' expectations.

    abstract：:Patients with advanced Parkinson's Disease (PD) may be eligible for Deep Brain Stimulation (DBS) in case of medication-related motor fluctuations or tremor refractory to oral medication. However, several PD symptoms are unresponsive to DBS and constitute relative contra-indications for DBS. Patients referred for DBS u...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.parkreldis.2019.07.011

    authors： Geraedts VJ,Kuijf ML,van Hilten JJ,Marinus J,Oosterloo M,Contarino MF

    更新日期：2019-09-01 00:00:00

  • Increases in institutionalization, healthcare resource utilization, and mortality risk associated with Parkinson disease psychosis: Retrospective cohort study.

    abstract：INTRODUCTION:Patients with Parkinson disease (PD) often develop psychosis (P). The association of PDP with death and long-term custodial care (CC) has not been well studied. METHODS:Medicare Parts A, B, and D data, 2007-2015, were used to define cohorts of PD and PDP patients. PD was defined by ≥ 2 ICD-9-CM codes (332...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2019.10.018

    authors： Wetmore JB,Li S,Yan H,Irfan M,Rashid N,Peng Y,Gilbertson DT,Shim A

    更新日期：2019-11-01 00:00:00

  • A physical therapy programme for functional motor symptoms: A telemedicine pilot study.

    abstract：INTRODUCTION:for a proportion of patients with functional motor symptoms (FMS), specific physiotherapy has recently emerged as a promising treatment. Aim of the present study was to assess in a sample of patients with FMS the efficacy of a physical therapy-based telemedicine programme on the motor symptoms themselves a...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2019.05.004

    authors： Demartini B,Bombieri F,Goeta D,Gambini O,Ricciardi L,Tinazzi M

    更新日期：2020-07-01 00:00:00

  • Acute dystonia in a young schizophrenic patient associated with ingestion of a cloperastine containing cough syrup.

    abstract：:Acute dystonic reactions are usually observed after exposure to drugs with antidopaminergic actions. We report on one patient with acute dystonia associated with ingestion of a cloperastine containing syrup, who suffered from schizophrenia but had been neuroleptic-free for 6months. Cloperastine has antihistaminic prop...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/s1353-8020(99)00042-5

    authors： Linazasoro G,Garmendia MT,Lizaso X

    更新日期：2000-01-01 00:00:00

  • Ventral striatal D(3) receptors and Parkinson's Disease.

    abstract：:Antiparkinsonian drugs are thought to act largely through the D2 receptor family that includes the D(2) and D(3) receptors. D(2) and D(3) receptors exhibit both complementary and overlapping expression at the macro and cellular level. The D(3) receptor appears to be a primary target of the mesolimbic dopamine system, ...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/s1353-8020(00)00060-2

    authors： Joyce JN,Ryoo H,Gurevich EV,Adler C,Beach T

    更新日期：2001-07-01 00:00:00

  • Familial cortical tremor with epilepsy.

    abstract：:We report here on a Japanese family in which five members in three generations developed non-progressive adult onset cortical tremor and epilepsy. Other than tremulous movements resembling essential tremor, the neurologic findings were unremarkable. Electrophysiologic studies revealed giant somatosensory evoked potent...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/s1353-8020(97)00001-1

    authors： Okuma Y,Shimo Y,Hatori K,Hattori T,Tanaka S,Mizuno Y

    更新日期：1997-04-01 00:00:00

  • Resting activity in visual and corticostriatal pathways in Parkinson's disease with hallucinations.

    abstract：BACKGROUND:Visual hallucinations are an important non-motor complication of Parkinson's disease (PD) and carry a negative prognosis. Their biological basis is uncertain, but may relate to the activity of resting state networks in brain. We therefore aimed to investigate functional activity of brain in patients with vis...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2014.11.020

    authors： Yao N,Pang S,Cheung C,Chang RS,Lau KK,Suckling J,Yu K,Mak HK,McAlonan G,Ho SL,Chua SE

    更新日期：2015-02-01 00:00:00

  • Long-term effects of bilateral subthalamic nucleus stimulation in advanced Parkinson disease: a four year follow-up study.

    abstract：:In this study we aimed to investigate the effects of bilateral STN HFS in patients with advanced Parkinson disease (PD) at long-term, with a minimum follow-up of 4 years. Twenty patients (15 men, five women) were included, with a mean age of 60.9+/-8.1 years. Surgery was performed under local anesthesia. The target wa...

    journal_title：Parkinsonism & related disorders

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.parkreldis.2004.10.011

    authors： Visser-Vandewalle V,van der Linden C,Temel Y,Celik H,Ackermans L,Spincemaille G,Caemaert J

    更新日期：2005-05-01 00:00:00

  • Ischemic injury precipitates neuronal vulnerability in Parkinson's disease: Insights from PINK1 mouse model study and clinical retrospective data.

    abstract：INTRODUCTION:Increasing evidence demonstrates the relevant association between Parkinson's disease (PD) and vascular diseases/risk factors, as well as a worse clinico-pathological progression in those patients with vascular comorbidity. The mechanisms underlying this relationship have not been clarified yet, although t...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2020.04.004

    authors： Imbriani P,D'Angelo V,Platania P,Di Lazzaro G,Scalise S,Salimei C,El Atiallah I,Colona VL,Mercuri NB,Bonsi P,Pisani A,Schirinzi T,Martella G

    更新日期：2020-05-01 00:00:00

  • Effect of deep brain stimulation of the subthalamic nucleus on non-motor fluctuations in Parkinson's disease: two-years' follow-up.

    abstract：BACKGROUND:Deep brain stimulation of the subthalamic nucleus (STN-DBS) reduces motor fluctuations in Parkinson's disease (PD) but its effect on non-motor fluctuations (NMF) is not well known. In this study we assess the efficacy of STN-DBS on NMF two years after surgery. METHODS:Autonomic, cognitive, psychiatric and s...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2013.02.001

    authors： Ortega-Cubero S,Clavero P,Irurzun C,Gonzalez-Redondo R,Guridi J,Obeso JA,Rodriguez-Oroz MC

    更新日期：2013-05-01 00:00:00

  • Treatment of restless legs syndrome.

    abstract：:Restless legs syndrome (RLS) is a common condition characterized by an urge to move the legs, accompanied by uncomfortable or unpleasant sensations. Symptoms predominantly occur at rest in the evening or at night, and they are alleviated by moving the affected extremity or by walking. Recent European epidemiological s...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,评审

    doi：10.1016/S1353-8020(09)70838-7

    authors： Ferini-Strambi L,Manconi M

    更新日期：2009-12-01 00:00:00

  • Voxel-wise analysis of diffusion tensor MRI improves the confidence of diagnosis of corticobasal degeneration non-invasively.

    abstract：:Corticobasal degeneration (CBD) presents with symptoms that often overlap with other neurological conditions. In many cases, diagnosis, prognosis and consequent clinical management remain uncertain. Structural and functional asymmetric brain changes represent the most consistent imaging findings that may assist in CBD...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2007.09.011

    authors： Bozzali M,Cercignani M,Baglio F,Scotti G,Farina E,Pugnetti L,Ashburner J,Nemni R,Falini A

    更新日期：2008-01-01 00:00:00