Voxel-wise analysis of diffusion tensor MRI improves the confidence of diagnosis of corticobasal degeneration non-invasively.

Abstract:

:Corticobasal degeneration (CBD) presents with symptoms that often overlap with other neurological conditions. In many cases, diagnosis, prognosis and consequent clinical management remain uncertain. Structural and functional asymmetric brain changes represent the most consistent imaging findings that may assist in CBD diagnosis. Diffusion Tensor MRI (DT-MRI) is a quantitative technique that allows microscopic tissue abnormalities to be non-invasively assessed in vivo. A single case of clinically suspected CBD with symmetric diffuse brain atrophy on conventional-MRI scans was studied using DT-MRI by voxel-wise comparison with eight healthy subjects. The lateralized distribution of DT-MRI abnormalities was consistent with clinical features providing a substantial support to the diagnosis.

authors

Bozzali M,Cercignani M,Baglio F,Scotti G,Farina E,Pugnetti L,Ashburner J,Nemni R,Falini A

doi

10.1016/j.parkreldis.2007.09.011

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

436-9

issue

5

eissn

1353-8020

issn

1873-5126

pii

S1353-8020(07)00207-6

journal_volume

14

pub_type

杂志文章
  • The impact of ropinirole on blood pressure and noradrenaline concentration after active orthostasis in Parkinsonian patients.

    abstract::Orthostatic hypotension is common in Parkinsonian patients. It is probably caused by reduced noradrenaline (NA) release. This effect is further enhanced by therapeutic use of ergot alkaloid dopamine agonists. In this trial we studied the impact of the non-ergot dopamine agonist ropinirole on blood pressure and noradre...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/s1353-8020(98)00014-5

    authors: Jost WH,Bellon AK,Kaiser T,Schrank B

    更新日期:1998-08-01 00:00:00

  • Stroke of the substance nigra and parkinsonism as first manifestation of systemic lupus erythematosus.

    abstract::The authors report one case of parkinsonism associated with systemic lupus erythematosus (SLE): a 45-year-old woman, who presented with a strategic infarct of the right substance nigra secondary to vasculitis, and contralateral symptoms. Other causes of parkinsonism were excluded. She had a partial response to therapy...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2007.08.001

    authors: Orta Daniel SJ,Ulises RO

    更新日期:2008-01-01 00:00:00

  • The next chapter in symptomatic Parkinson disease treatments.

    abstract::Significant advances in the symptomatic treatment of Parkinson disease (PD) have occurred since the discovery of levodopa (LD). Perhaps as a testament to its unparalleled efficacy, novel formulations aiming to optimize LD delivery to obtain better bioavailability, longer duration of effect and less plasma level fluctu...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章,评审

    doi:10.1016/j.parkreldis.2019.01.002

    authors: Hengartner D,Fernandez HH

    更新日期:2019-02-01 00:00:00

  • Orthostatic myoclonus after brain tumor radiation: Insights from two lesional cases.

    abstract:INTRODUCTION:Orthostatic myoclonus (OM) is a recognized syndrome of gait unsteadiness accompanied by lower limb myoclonus provoked by the assumption of an upright posture. OM typically affects the elderly and is often associated with neurodegenerative disease. We sought to review the clinical and electrophysiologic cha...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2017.04.015

    authors: Cutsforth-Gregory JK,Hammack JE,Matsumoto JY

    更新日期:2017-08-01 00:00:00

  • Dystonia and tremor secondary to a pediatric thalamic stroke.

    abstract::A previously healthy 10-year-old girl developed a right hemiparesis with sensory loss secondary to a posterolateral thalamic infarct. Despite improvement in strength, three weeks later a 4 Hz kinetic tremor appeared in the right hand accompanied by dystonia in the right upper and lower limbs. Basal ganglia vascular le...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/s1353-8020(98)00029-7

    authors: Micheli F,Cersósimo G,Palacios C,Scorticati MC,Tenembaum S,Típoli J

    更新日期:1998-10-01 00:00:00

  • Intertemporal choice in Parkinson's disease and restless legs syndrome.

    abstract:BACKGROUND:Impulse control disorders in Parkinson's disease are a potential consequence of dopaminergic therapy. Impulse control problems might be revealed by intertemporal choice tasks which entail to forgo an immediately available reward in favor of a larger but later reward. The steepness of the discounting curve ca...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2015.09.026

    authors: Al-Khaled M,Heldmann M,Bolstorff I,Hagenah J,Münte TF

    更新日期:2015-11-01 00:00:00

  • The SCA17 phenotype can include features of MSA-C, PSP and cognitive impairment.

    abstract::Spinocerebellar ataxia (SCA) 17 is a dominant neurodegenerative disorder characterized by ataxia, cognitive decline, dystonia, and parkinsonism. The disease is caused by unstable cytosine-adenine-guanine (CAG) trinucleotide expansion mutation coding for polyglutamine tracts in the TATA box-binding protein (TBP), a gen...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2006.04.009

    authors: Lin IS,Wu RM,Lee-Chen GJ,Shan DE,Gwinn-Hardy K

    更新日期:2007-05-01 00:00:00

  • Validity and reliability of the PDQ-39 and the PDQ-8 in English-speaking Parkinson's disease patients in Singapore.

    abstract::The purpose of the study was to assess the validity and reliability of the Parkinson's disease questionnaire (PDQ-39, UK English version) as well as its briefer version (the PDQ-8) among Asian patients with Parkinson's disease (PD) in Singapore. Eighty-eight patients recruited from movement disorder clinics or patient...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2004.05.007

    authors: Tan LC,Luo N,Nazri M,Li SC,Thumboo J

    更新日期:2004-12-01 00:00:00

  • Do caffeine and more selective adenosine A2A receptor antagonists protect against dopaminergic neurodegeneration in Parkinson's disease?

    abstract::The adenosine A2A receptor is a major target of caffeine, the most widely used psychoactive substance worldwide. Large epidemiological studies have long shown caffeine consumption is a strong inverse predictor of Parkinson's disease (PD). In this review, we first examine the epidemiology of caffeine use vis-à-vis PD a...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2020.10.024

    authors: Chen JF,Schwarzschild MA

    更新日期:2020-11-01 00:00:00

  • Cognitive associations with comprehensive gait and static balance measures in Parkinson's disease.

    abstract:INTRODUCTION:Gait and balance impairments are cardinal features of Parkinson's disease (PD) that require cognitive input. However, the extent to which specific gait and balance characteristics relate to cognition in PD is unclear. In addition, independent models of gait and balance have not been developed from the same...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2019.06.014

    authors: Morris R,Martini DN,Smulders K,Kelly VE,Zabetian CP,Poston K,Hiller A,Chung KA,Yang L,Hu SC,Edwards KL,Cholerton B,Grabowski TJ,Montine TJ,Quinn JF,Horak F

    更新日期:2019-12-01 00:00:00

  • Interoceptive processing deficit: A behavioral marker for subtyping Parkinson's disease.

    abstract:BACKGROUND:Non-motor symptoms in Parkinson's disease (PD), such as cognitive, emotional, autonomic and somatosensory alterations, are not ubiquitous but vary between the tremor dominant (TD) and postural instability/gait difficulty (PIGD) subtypes of the syndrome. Non-motor phenomena (e.g., anxiety, depression and apat...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2018.05.001

    authors: Santangelo G,Vitale C,Baiano C,D'Iorio A,Longo K,Barone P,Amboni M,Conson M

    更新日期:2018-08-01 00:00:00

  • Familial Behr syndrome-like phenotype with autosomal dominant inheritance.

    abstract::Behr syndrome is an autosomal recessive disease characterized by early-onset ataxia, optic atrophy and other signs such as pyramidal tract dysfunction. Autosomal dominant inheritance has also been described. In this case report we present a family pedigree of patients with an inherited autosomal dominant Behr syndrome...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2007.08.008

    authors: Felicio AC,Godeiro-Junior C,Alberto LG,Pinto AP,Sallum JM,Teive HG,Barsottini OG

    更新日期:2008-01-01 00:00:00

  • The spiral axis as a clinical tool to distinguish essential tremor from dystonia cases.

    abstract:BACKGROUND:Tremor is a common feature of a variety of neurological disorders. In genetic studies of essential tremor (ET), investigators need to screen potential enrollees by mail or telephone to exclude those with other neurological conditions, especially dystonia. In clinical settings, the differentiation of ET and d...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2014.01.021

    authors: Michalec M,Hernandez N,Clark LN,Louis ED

    更新日期:2014-05-01 00:00:00

  • Autosomal dominant parkinsonism: its etiologies and differential diagnoses.

    abstract::Recently, several genes for parkinsonism have been identified. Among them, familial Parkinson's disease (PD) could be assigned for PARK disorders. PARK disorders consist of three different inherited modes such as autosomal recessive, autosomal dominant modes and susceptible genes. Some of them manifest not only typica...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章,评审

    doi:10.1016/S1353-8020(11)70003-7

    authors: Hattori N

    更新日期:2012-01-01 00:00:00

  • Comparison of IPX066 with carbidopa-levodopa plus entacapone in advanced PD patients.

    abstract:BACKGROUND:IPX066, an investigational extended-release carbidopa-levodopa (CD-LD) preparation, has demonstrated a rapid attainment and prolonged maintenance of therapeutic LD plasma concentrations in advanced Parkinson's disease (PD). This phase-3 crossover study assessed its efficacy and safety vs. CD-LD plus entacapo...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.parkreldis.2014.08.004

    authors: Stocchi F,Hsu A,Khanna S,Ellenbogen A,Mahler A,Liang G,Dillmann U,Rubens R,Kell S,Gupta S

    更新日期:2014-12-01 00:00:00

  • Effect of deep brain stimulation of the subthalamic nucleus on non-motor fluctuations in Parkinson's disease: two-years' follow-up.

    abstract:BACKGROUND:Deep brain stimulation of the subthalamic nucleus (STN-DBS) reduces motor fluctuations in Parkinson's disease (PD) but its effect on non-motor fluctuations (NMF) is not well known. In this study we assess the efficacy of STN-DBS on NMF two years after surgery. METHODS:Autonomic, cognitive, psychiatric and s...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2013.02.001

    authors: Ortega-Cubero S,Clavero P,Irurzun C,Gonzalez-Redondo R,Guridi J,Obeso JA,Rodriguez-Oroz MC

    更新日期:2013-05-01 00:00:00

  • Patients' reluctance to undergo deep brain stimulation for Parkinson's disease.

    abstract:BACKGROUND:Many patients with advanced Parkinson's disease (PD) are reluctant to undergo the subthalamic nucleus deep brain stimulation (STN-DBS) when surgery is warranted. Reasons for this reluctance have not been examined. We undertook to establish the rate and causes of this reluctance for STN-DBS in patients with a...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2015.11.010

    authors: Kim MR,Yun JY,Jeon B,Lim YH,Kim KR,Yang HJ,Paek SH

    更新日期:2016-02-01 00:00:00

  • Alpha-synuclein multiplications with parkinsonism, dementia or progressive myoclonus?

    abstract::Duplications and triplications of the alpha-synuclein (SNCA) gene have been reported in Parkinson's disease patients belonging to the Southern Swedish "Lister family". Further genealogical research has now shown that these individuals are descended from a large kindred characterized by Herman Lundborg in 1901-1913. In...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2008.08.002

    authors: Puschmann A,Wszolek ZK,Farrer M,Gustafson L,Widner H,Nilsson C

    更新日期:2009-06-01 00:00:00

  • Barriers to reporting non-motor symptoms to health-care providers in people with Parkinson's.

    abstract:BACKGROUND:Non-motor symptoms (NMS) are common in Parkinson's disease (PD) and cause significant distress. A high rate of non-declaration of NMS by patients to healthcare providers (HCP) means that many NMS remain untreated. Current understanding of the factors preventing disclosure of NMS to HCPs is limited. The prese...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2019.04.014

    authors: Hurt CS,Rixon L,Chaudhuri KR,Moss-Morris R,Samuel M,Brown RG

    更新日期:2019-07-01 00:00:00

  • Essential tremor: Is the word "essential" really essential?

    abstract::Essential tremor (ET) is among the common movement disorders. A surge in research in recent years has considerably improved our understanding of disease etiology and pathogenesis, and its associated clinical phenomenology and natural history. With this progress have emerged a multitude of new questions and conundrums ...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2020.10.035

    authors: Lenka A,Louis ED

    更新日期:2020-12-01 00:00:00

  • Long-term effects of bilateral subthalamic nucleus stimulation in advanced Parkinson disease: a four year follow-up study.

    abstract::In this study we aimed to investigate the effects of bilateral STN HFS in patients with advanced Parkinson disease (PD) at long-term, with a minimum follow-up of 4 years. Twenty patients (15 men, five women) were included, with a mean age of 60.9+/-8.1 years. Surgery was performed under local anesthesia. The target wa...

    journal_title:Parkinsonism & related disorders

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.parkreldis.2004.10.011

    authors: Visser-Vandewalle V,van der Linden C,Temel Y,Celik H,Ackermans L,Spincemaille G,Caemaert J

    更新日期:2005-05-01 00:00:00

  • Walking ability after implantation of a pallidal stimulator: analysis of plantar force distribution in patients with Parkinson's disease.

    abstract::This preliminary study aimed to analyse the roll-off of the foot during gait before and after implantation of a unilateral pallidal electrode in severely affected patients with Parkinson's disease (PD). Five subjects were tested in a gait laboratory during the "on" phase of the medication cycle. Spatiotemporal variabl...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/s1353-8020(98)00038-8

    authors: Nieuwboer A,De Weerdt W,Dom R,Nuttin B,Peeraer L,Pattyn A

    更新日期:1998-12-01 00:00:00

  • Long-term evaluation of open-label pimavanserin safety and tolerability in Parkinson's disease psychosis.

    abstract:INTRODUCTION:Pimavanserin is a selective 5-HT2A inverse agonist/antagonist approved for treating hallucinations and delusions associated with Parkinson's disease psychosis (PDP). Results from short-term, placebo-controlled studies demonstrated a positive benefit/risk profile. This multi-year, open-label study assessed ...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2020.06.026

    authors: Ballard CG,Kreitzman DL,Isaacson S,Liu IY,Norton JC,Demos G,Fernandez HH,Ilic TV,Azulay JP,Ferreira JJ,Abler V,Stankovic S,015 Study Group.

    更新日期:2020-08-01 00:00:00

  • Bilateral pallidal stimulation improves cervical dystonia for more than a decade.

    abstract:INTRODUCTION:Deep brain stimulation (DBS) is an effective treatment in medically resistant cervical dystonia (CD) with a documented therapeutic effect. Long term outcome beyond a decade, however, has not been studied systematically. METHODS:To investigate the impact of pallidal DBS beyond 10 years in CD we followed a ...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2020.10.028

    authors: Kaelin-Lang A,You H,Burgunder JM,Lönnfors-Weitze T,Loher TJ,Taub E,Isaias IU,Krauss JK,Michael Schüpbach WM

    更新日期:2020-12-01 00:00:00

  • Non-motor extranigral signs and symptoms in Parkinson's disease.

    abstract::Clinical symptoms in Parkinson's disease (PD) comprise both motor and non-motor symptoms. In this disease, synucleinopathic-induced, nigral dopamine deficiency-related dysfunction of the basal ganglia is held responsible for the characteristic levodopa-responsive motor signs and symptoms (bradykinesia, hypokinesia, ri...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章,评审

    doi:10.1016/S1353-8020(09)70770-9

    authors: Wolters ECh

    更新日期:2009-12-01 00:00:00

  • Psychological functioning in patients with Parkinson's disease.

    abstract::Forty patients with Parkinson's disease (PD) were studied to explore the relationship between aspects of psychological functioning (depression, problems in motoric, cognitive and psychological areas) and physical illness (stage and duration of illness, functional disability, global cognitive status). Depression, motor...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/s1353-8020(00)00010-9

    authors: Gupta A,Bhatia S

    更新日期:2000-07-01 00:00:00

  • Proton magnetic resonance spectroscopy of the striatum in Parkinson's disease patients with motor response fluctuations.

    abstract::We have performed proton magnetic resonance spectroscopy centred on the putamen contralateral to the worst affected side in 10 patients with idiopathic Parkinson's disease (PD) and motor response fluctuations and seven age matched healthy controls. In PD, there was striking reduction in the N-acetylaspartate (NAA) and...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/1353-8020(96)00007-7

    authors: Chaudhuri KR,Lemmens GM,Williams SC,Ellis C,Lloyd CM,Dawson J,Simmons A,Leigh PN

    更新日期:1996-04-01 00:00:00

  • Movement disorders in cerebrotendinous xanthomatosis.

    abstract::Cerebrotendinous xanthomatosis (CTX) is an inborn error of cholesterol and bile acid metabolism, leading to neuropsychiatric and systemic manifestations. Movement disorders have rarely been reported in CTX, while a detailed appreciation of the full phenotypic spectrum is required in order to prevent underdiagnosis of ...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章,评审

    doi:10.1016/j.parkreldis.2018.07.006

    authors: Stelten BML,van de Warrenburg BPC,Wevers RA,Verrips A

    更新日期:2019-01-01 00:00:00

  • Dopaminergic polymorphisms associated with medication responsiveness of gait in Parkinson's disease.

    abstract:BACKGROUND:Gait dysfunction is a common symptom of Parkinson's disease that can cause significant disability and put patients at risk for falls. These symptoms show variable responsiveness to dopaminergic therapy. OBJECTIVE:To determine whether dopaminergic (rs1076560 DRD2 G > T and rs4680 catechole-o-methyltransphera...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2017.12.010

    authors: Miller NS,Chou KL,Bohnen NI,Müller MLTM,Seidler RD

    更新日期:2018-03-01 00:00:00

  • Pathological findings in a patient with alpha-synuclein p.A53T and familial Parkinson's disease.

    abstract::The present report documents a patient harboring an alpha-synuclein p.A53T variant from a family presenting with autosomal dominant inheritance, including four patients clinically diagnosed with Parkinson's disease (PD) and two with dementia. The alpha-synuclein p.A53T variant is linked to young- or middle-aged onset ...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2020.11.001

    authors: Nishioka K,Hashizume Y,Takanashi M,Daida K,Li Y,Yoshino H,Tambasco N,Prontera P,Hattori Y,Ueda A,Watanabe H,Hattori N

    更新日期:2020-12-01 00:00:00