当前位置： SCI文献检索 > PARKINSONISM & RELATED DISORDERS期刊下所有文献 > Salivary alpha-synuclein in the diagnosis of Parkinson's disease and Progressive Supranuclear Palsy.

Salivary alpha-synuclein in the diagnosis of Parkinson's disease and Progressive Supranuclear Palsy.

Abstract：

INTRODUCTION:Alpha-synuclein (α-syn) aggregation is the pathological hallmark of Parkinson's Disease (PD). In this study, we measured α-syn total (α-syntotal), oligomeric α-syn (α-synolig) and α-synolig/α-syntotal ratio in the saliva of patients affected by PD and in age and sex-matched healthy subjects. We also compared salivary α-syntotal measured in PD with those detected in Progressive Supranuclear Palsy (PSP), in order to assess whether salivary α-syn can be used as a biomarker for PD and for the differential diagnosis between PD and PSP. METHODS:We studied 100 PD patients, 20 patients affected by PSP and 80 age- and sex-matched healthy subjects. ELISA analysis was performed using two commercial ELISA platforms and a specific ELISA assay for α-syn aggregates. RESULTS:We detected lower α-syntotal and higher α-synolig in PD than in healthy subjects. Conversely in PSP salivary α-syntotal concentration was comparable to that measured in healthy subjects. Receiver Operating Characteristic analyses revealed specific cut-off values able to differentiate PD patients from healthy subjects and PSP patients with high sensitivity and specificity. However, there was no significant correlation between clinical and molecular data. CONCLUSION:Salivary α-syn detection could be a promising and easily accessible biomarker for PD and for the differential diagnosis between PD and PSP.

journal_name

Parkinsonism Relat Disord

journal_title

Parkinsonism & related disorders

authors

Vivacqua G,Suppa A,Mancinelli R,Belvisi D,Fabbrini A,Costanzo M,Formica A,Onori P,Fabbrini G,Berardelli A

doi

10.1016/j.parkreldis.2019.02.014

subject

Has Abstract

pub_date

2019-06-01 00:00:00

pages

143-148

eissn

1353-8020

issn

1873-5126

pii

S1353-8020(19)30060-4

journal_volume

63

pub_type

杂志文章

相关文献

PARKINSONISM & RELATED DISORDERS文献大全
  • Imaging executive functions in Parkinson's disease: An activation likelihood estimation meta-analysis.

    abstract：INTRODUCTION:Executive dysfunction is a common and early cognitive symptom in Parkinson's disease (PD) with a detrimental effect on quality of life of patients and their care givers. Thus, a number of neuroimaging studies investigated the underlying neural correlates of such an impairment. Results of individual studies...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.parkreldis.2019.02.015

    authors： Giehl K,Tahmasian M,Eickhoff SB,van Eimeren T

    更新日期：2019-06-01 00:00:00

  • Could Mucuna pruriens be the answer to Parkinson's disease management in sub-Saharan Africa and other low-income countries worldwide?

    abstract：:Parkinson's disease (PD) is a progressive, disabling, neurodegenerative disease that requires long term care and pharmaceutical treatment. Levodopa remains the gold standard treatment for PD globally, although it is largely unavailable and unaffordable for the majority of patients in many sub-Saharan African and other...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2020.03.002

    authors： Fothergill-Misbah N,Maroo H,Cham M,Pezzoli G,Walker R,Cilia R

    更新日期：2020-04-01 00:00:00

  • Subjective perceived outcome of subthalamic deep brain stimulation in Parkinson's disease one year after surgery.

    abstract：OBJECTIVES:Dissatisfaction with subthalamic deep brain stimulation (STN-DBS) despite motor improvements has been observed in Parkinson's disease (PD). Hence, we compared patient's subjective perceived outcome 12 months after surgery (12mFU) with clinical measures to identify risk factors of dissatisfaction. METHODS:Pa...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2016.01.019

    authors： Maier F,Lewis CJ,Horstkoetter N,Eggers C,Dembek TA,Visser-Vandewalle V,Kuhn J,Zurowski M,Moro E,Woopen C,Timmermann L

    更新日期：2016-03-01 00:00:00

  • Autosomal recessive parkinsonism.

    abstract：:Several forms of autosomal recessive parkinsonism are known. In three forms, caused by mutations in parkin (PARK2), PINK1 (PARK6), or DJ-1 (PARK7), the phenotype is usually characterized by levodopa-responsive parkinsonism without atypical features. Parkin mutations are most frequent, explaining -50% of the cases with...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,评审

    doi：10.1016/S1353-8020(11)70004-9

    authors： Bonifati V

    更新日期：2012-01-01 00:00:00

  • Delayed administration of dopaminergic drugs is not associated with prolonged length of stay of hospitalized patients with Parkinson's disease.

    abstract：BACKGROUND:Punctual delivery of dopaminergic medication to Parkinson's disease (PD) patients may be important in optimizing disease control. We tested the hypothesis that prompt delivery of l-dopa medications to emergency hospital inpatients was associated with a decreased length of stay in hospital. METHODS:The study...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2016.11.004

    authors： Skelly R,Brown L,Fogarty A

    更新日期：2017-02-01 00:00:00

  • Efficacy and safety of atypical antipsychotics for psychosis in Parkinson's disease: A systematic review and Bayesian network meta-analysis.

    abstract：INTRODUCTION:We performed a systematic review and Bayesian network meta-analysis to clarify the relative efficacy and safety of pimavanserin compared to atypical antipsychotics for psychosis in Parkinson's disease (PD). METHODS:PubMed, Embase, Cochrane Central Register of Controlled Trials, and Japana Centra Revuo Med...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2020.07.021

    authors： Iketani R,Furushima D,Imai S,Yamada H

    更新日期：2020-09-01 00:00:00

  • Association of metals with the risk and clinical characteristics of Parkinson's disease.

    abstract：INTRODUCTION:While metals have been implicated in the pathophysiology of Parkinson's disease (PD), the clinical evidence is scarce. Further, the contribution of metals for the risk or clinical presentation of PD remains to be explored. METHODS:To investigate the associations between the level of metals in blood serum ...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2018.05.022

    authors： Kim MJ,Oh SB,Kim J,Kim K,Ryu HS,Kim MS,Ayton S,Bush AI,Lee JY,Chung SJ

    更新日期：2018-10-01 00:00:00

  • Levodopa and neuropathy risk in patients with Parkinson disease: Effect of COMT inhibition.

    abstract：OBJECTIVE:Our purpose was to determine whether the use of catechol-O-methyltransferase-inhibitors (ICOMT) can reduce the risk of developing levodopa (LD)-induced neuropathy in Parkinson's disease (PD) patients. METHODS:A multicentre study of 197 PD patients was performed. 144 were exposed to LD for more than three yea...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.parkreldis.2016.04.016

    authors： Cossu G,Ceravolo R,Zibetti M,Arca R,Ricchi V,Paribello A,Murgia D,Merola A,Romagnolo A,Nicoletti V,Palermo G,Mereu A,Lopiano L,Melis M,Abbruzzese G,Bonuccelli U

    更新日期：2016-06-01 00:00:00

  • Women pioneers in basal ganglia surgery.

    abstract：BACKGROUND:Stereotactic functional neurosurgery on basal ganglia has a long history and the pioneers are mostly men. We aimed at finding out if there were women who have contributed pioneering work in this field. METHODS:The literature was searched to identify women who have been first to publish innovative papers rel...

    journal_title：Parkinsonism & related disorders

    pub_type： 传,历史文章,杂志文章,评审

    doi：10.1016/j.parkreldis.2013.11.002

    authors： Hariz GM,Rehncrona S,Blomstedt P,Limousin P,Hamberg K,Hariz M

    更新日期：2014-02-01 00:00:00

  • Cardiac denervation occurs independent of orthostatic hypotension and impaired heart rate variability in Parkinson's disease.

    abstract：:Patients with idiopathic Parkinson's disease (PD) have impaired sympathetically mediated neurocirculatory innervation. Here we analyzed the correlation between cardiac (123)I-metaiodobenzylguanidine (MIBG) uptake, orthostatic hypotension and heart rate variability in treated patients with PD. Orthostatic hypotension (...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2008.04.031

    authors： Haensch CA,Lerch H,Jörg J,Isenmann S

    更新日期：2009-02-01 00:00:00

  • Ischemic injury precipitates neuronal vulnerability in Parkinson's disease: Insights from PINK1 mouse model study and clinical retrospective data.

    abstract：INTRODUCTION:Increasing evidence demonstrates the relevant association between Parkinson's disease (PD) and vascular diseases/risk factors, as well as a worse clinico-pathological progression in those patients with vascular comorbidity. The mechanisms underlying this relationship have not been clarified yet, although t...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2020.04.004

    authors： Imbriani P,D'Angelo V,Platania P,Di Lazzaro G,Scalise S,Salimei C,El Atiallah I,Colona VL,Mercuri NB,Bonsi P,Pisani A,Schirinzi T,Martella G

    更新日期：2020-05-01 00:00:00

  • Prevalence of parkin gene mutations and variations in idiopathic Parkinson's disease.

    abstract：:Mutations in the parkin gene are a common cause of autosomal recessive juvenile parkinsonism (AR-JP) but their role in idiopathic Parkinson's disease (PD) is not clear. Recent studies demonstrate that most young onset PD without family history is not due to mutations in parkin. However, there is less information about...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2005.04.003

    authors： Sinha R,Racette B,Perlmutter JS,Parsian A

    更新日期：2005-09-01 00:00:00

  • Clinical heterogeneity of LRRK2 p.I2012T mutation.

    abstract：INTRODUCTION:Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common genetic cause of Parkinson's disease (PD). However, only few cases carrying LRRK2 mutations have been reported in Taiwanese PD patients. METHODS:We used targeted next generation sequencing (NGS), covering 24 candidate genes involved in neu...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2016.09.008

    authors： Fan TS,Wu RM,Chen PL,Chen TF,Li HY,Lin YH,Chen CY,Chen ML,Tai CH,Lin HI,Lin CH

    更新日期：2016-12-01 00:00:00

  • Pareidolias and cognition in isolated REM sleep behavior disorder.

    abstract：BACKGROUND:Though visual illusions and hallucinations are common in dementia with Lewy bodies (DLB) and Parkinson's disease (PD), they are not typically observed clinically in prodromal stages, including isolated REM sleep behavior disorder (iRBD). False-noise errors on the pareidolia test (seeing faces when none are p...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2020.05.017

    authors： Honeycutt L,Gagnon JF,Pelletier A,De Roy J,Montplaisir JY,Postuma RB

    更新日期：2020-06-01 00:00:00

  • Medical decision-making in progressive supranuclear palsy: A comparison to other neurodegenerative disorders.

    abstract：INTRODUCTION:Cognitive dysfunction is common in progressive supranuclear palsy (PSP) but its effect on medical decision-making has not been well studied. To address this gap in the research literature, we compared the medical decision-making capacity of patients with PSP to groups of patients with other neurodegenerati...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2018.11.022

    authors： Gerstenecker A,Grimsley L,Otruba B,Cowden L,Marson DC,Gerstenecker KT,Martin RC,Roberson ED

    更新日期：2019-04-01 00:00:00

  • Rhythmic finger tapping reveals cerebellar dysfunction in essential tremor.

    abstract：INTRODUCTION:Cerebellar circuits are hypothesized to play a central role in the pathogenesis of essential tremor. Rhythmic finger tapping is known to strongly engage the cerebellar motor circuitry. We characterize cerebellar and, more specifically, dentate nucleus function, and neural correlates of cerebellar output in...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.parkreldis.2015.02.003

    authors： Buijink AW,Broersma M,van der Stouwe AM,van Wingen GA,Groot PF,Speelman JD,Maurits NM,van Rootselaar AF

    更新日期：2015-04-01 00:00:00

  • Treatment of acute Sydenham's chorea with methyl-prednisolone pulse-therapy.

    abstract：:Serious adverse effects with antichoreic drugs can occur in patients with acute Sydenham's chorea (SC). The response to conventional treatment in severe SC may also be poor. Thus alternative therapeutic strategies have been developed. We report on four patients with severe acute SC (two with chorea paralytica and two ...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2005.02.007

    authors： Teixeira AL Jr,Maia DP,Cardoso F

    更新日期：2005-08-01 00:00:00

  • Impaired decision-making in Parkinson's disease.

    abstract：:The present study demonstrated that individuals with Parkinson's disease display impairments in making profitable decisions, as evidenced by poorer performance on the Iowa Gambling Task relative to matched controls. The ability to make beneficial judgments solely correlates with ability to appropriately attribute inte...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2005.12.003

    authors： Mimura M,Oeda R,Kawamura M

    更新日期：2006-04-01 00:00:00

  • Hypothesis: a role for EBV-induced molecular mimicry in Parkinson's disease.

    abstract：:Current concepts regarding the pathogenesis of Parkinson's disease support a model whereby environmental factors conspire with a permissive genetic background to initiate the disease. The identity of the responsible environmental trigger has remained elusive. There is incontrovertible evidence that aggregation of the ...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,评审

    doi：10.1016/j.parkreldis.2014.02.031

    authors： Woulfe JM,Gray MT,Gray DA,Munoz DG,Middeldorp JM

    更新日期：2014-07-01 00:00:00

  • Identification of a novel homozygous mutation Arg459Pro in SYNJ1 gene of an Indian family with autosomal recessive juvenile Parkinsonism.

    abstract：BACKGROUND:A novel homozygous missense mutation (c.773G > A, p.Arg258Gln) in Synaptojanin 1 (SYNJ1, 21q22.2) has recently been reported in two Italian and one Iranian consanguineous families with autosomal recessive juvenile Parkinsonism (ARJP). Contribution of this synaptic gene related to Parkinsonism phenotypes in o...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2016.07.014

    authors： Kirola L,Behari M,Shishir C,Thelma BK

    更新日期：2016-10-01 00:00:00

  • Prevalence and clinical correlates of drooling in Parkinson disease: a study on 518 Chinese patients.

    abstract：BACKGROUND:The prevalence and clinical correlates of drooling in Chinese patients with Parkinson disease (PD) are unknown. METHODS:A cross-sectional analysis of 518 Chinese patients with PD was conducted. Assessments included Unified PD Rating Scale (UPDRS), Non-Motor Symptoms Scale (NMSS), Hamilton Depression Scale (...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2014.12.004

    authors： Ou R,Guo X,Wei Q,Cao B,Yang J,Song W,Shao N,Zhao B,Chen X,Shang H

    更新日期：2015-03-01 00:00:00

  • Involuntary movements associated with vitamin B12 deficiency.

    abstract：:Involuntary movements are not a known feature of vitamin B12 (vB12) deficiency in adults, though they are a characteristic feature of vB12 deficiency in infants. This case report presents an adult patient with vB12 deficiency in whom, myoclonus-like muscular contractions appeared soon after the initiation of vB12 and ...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/s1353-8020(03)00065-8

    authors： Celik M,Barkut IK,Oncel C,Forta H

    更新日期：2003-10-01 00:00:00

  • Reduced orexin immunoreactivity in Perry syndrome and multiple system atrophy.

    abstract：INTRODUCTION:Orexin is a neuropeptide that plays a key role in maintaining a state of arousal, and possibly associates with sleep apnea syndrome (SAS). Reduced orexin immunoreactivity has been reported in various neurologic conditions such as narcolepsy, Alzheimer's disease, Lewy body disease and multiple system atroph...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2017.06.003

    authors： Mishima T,Kasanuki K,Koga S,Castanedes-Casey M,Wszolek ZK,Tsuboi Y,Dickson DW

    更新日期：2017-09-01 00:00:00

  • Naftazone in advanced Parkinson's disease: An acute L-DOPA challenge randomized controlled trial.

    abstract：INTRODUCTION:There is an unmet need to better control motor complications in Parkinson's disease (PD). Naftazone, which exhibits glutamate release inhibition properties, has shown antiparkinsonian and antidyskinetic activity in preclinical models of PD and in a clinical proof of concept study. METHODS:We conducted a d...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.parkreldis.2018.10.005

    authors： Corvol JC,Durif F,Meissner WG,Azulay JP,Haddad R,Guimarães-Costa R,Mariani LL,Cormier-Dequaire F,Thalamas C,Galitzky M,Boraud T,Debilly B,Eusebio A,Houot M,Dellapina E,Chaigneau V,Salis A,Lacomblez L,Benel L,Rascol

    更新日期：2019-03-01 00:00:00

  • Young onset Hemifacial Spasm in patients with Chiari type I malformation.

    abstract：:Hemifacial spasm (HFS) resulting from Chiari type I malformation (CIM) is rare. We retrospectively evaluated five patients with CIM and HFS among a series of 103 subjects. The frequency of HFS associated to CIM was of 4.85%. The clinical profile did not differ from the classical primary cases except for young-onset de...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2007.04.002

    authors： Felício AC,de Godeiro C Jr,Borges V,de Azevedo Silva SM,Ferraz HB

    更新日期：2008-01-01 00:00:00

  • Gender and onset age-related features of non-motor symptoms of patients with Parkinson's disease--a study from Southwest China.

    abstract：BACKGROUND:Non-motor symptom (NMS) differences between male Parkinson's disease (PD) and female PD, and between early-onset PD (EOPD) and late-onset PD (LOPD) in Chinese populations remain largely unknown. METHODS:A total of 522 PD patients from Southwest China were included. Patients were assessed using the Non-Motor...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2013.06.009

    authors： Guo X,Song W,Chen K,Chen X,Zheng Z,Cao B,Huang R,Zhao B,Wu Y,Shang HF

    更新日期：2013-11-01 00:00:00

  • Defining delirium in idiopathic Parkinson's disease: A systematic review.

    abstract：BACKGROUND:Parkinson's disease patients may be at increased risk of delirium and developing adverse outcomes, such as cognitive decline and increased mortality. Delirium is an acute state of confusion that has overlapping symptoms with Parkinson's dementia, making it difficult to identify. This study aimed to determine...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2018.09.025

    authors： Lawson RA,McDonald C,Burn DJ

    更新日期：2019-07-01 00:00:00

  • Validation of diagnostic criteria for apathy in Parkinson's disease.

    abstract：BACKGROUND:Apathy is a common neuropsychiatric syndrome in Parkinson's Disease (PD) that affects quality of life. Research into apathy has been hampered by a lack of broadly accepted diagnostic criteria. Recently, diagnostic criteria for apathy in neuropsychiatric disorders have been proposed, which to date have not be...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2010.08.015

    authors： Drijgers RL,Dujardin K,Reijnders JS,Defebvre L,Leentjens AF

    更新日期：2010-12-01 00:00:00

  • Cognitive associations with comprehensive gait and static balance measures in Parkinson's disease.

    abstract：INTRODUCTION:Gait and balance impairments are cardinal features of Parkinson's disease (PD) that require cognitive input. However, the extent to which specific gait and balance characteristics relate to cognition in PD is unclear. In addition, independent models of gait and balance have not been developed from the same...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2019.06.014

    authors： Morris R,Martini DN,Smulders K,Kelly VE,Zabetian CP,Poston K,Hiller A,Chung KA,Yang L,Hu SC,Edwards KL,Cholerton B,Grabowski TJ,Montine TJ,Quinn JF,Horak F

    更新日期：2019-12-01 00:00:00

  • Walking ability after implantation of a pallidal stimulator: analysis of plantar force distribution in patients with Parkinson's disease.

    abstract：:This preliminary study aimed to analyse the roll-off of the foot during gait before and after implantation of a unilateral pallidal electrode in severely affected patients with Parkinson's disease (PD). Five subjects were tested in a gait laboratory during the "on" phase of the medication cycle. Spatiotemporal variabl...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/s1353-8020(98)00038-8

    authors： Nieuwboer A,De Weerdt W,Dom R,Nuttin B,Peeraer L,Pattyn A

    更新日期：1998-12-01 00:00:00