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Treatment of restless legs syndrome.

Abstract：

:Restless legs syndrome (RLS) is a common condition characterized by an urge to move the legs, accompanied by uncomfortable or unpleasant sensations. Symptoms predominantly occur at rest in the evening or at night, and they are alleviated by moving the affected extremity or by walking. Recent European epidemiological studies reported an overall prevalence of RLS up to 10%, with a female preponderance. The prevalence rates reported in south-eastern Europe are lower, as are those in Asiatic populations. Although the aetiopathogenesis of RLS is still unknown, the rapid and dramatic improvement of RLS with dopaminergic compounds suggests a dopaminergic system dysfunction as the basic mechanism. Extensive data are available for l-dopa and dopamine receptor agonists, especially for pramipexole and ropinirole. Pharmacological treatment should be limited to those patients who suffer from clinically relevant RLS with impaired sleep quality or quality of life. Treatment on demand is a clinical need in RLS cases that present intermittent symptoms.

journal_name

Parkinsonism Relat Disord

journal_title

Parkinsonism & related disorders

authors

Ferini-Strambi L,Manconi M

doi

10.1016/S1353-8020(09)70838-7

subject

Has Abstract

pub_date

2009-12-01 00:00:00

pages

S65-70

eissn

1353-8020

issn

1873-5126

pii

S1353-8020(09)70838-7

journal_volume

15 Suppl 4

pub_type

杂志文章,评审

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