The probable REM sleep behavior disorder negatively affects health-related quality of life in Parkinson's disease with bilateral subthalamic nucleus stimulation.

Abstract:

OBJECTIVE:The aim of this study was to compare the short- and long-term outcomes of bilateral subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD) patients with and without probable REM sleep behavior disorder (RBD). METHODS:We retrospectively reviewed 127 patients who underwent bilateral STN-DBS for PD with probable RBD from September 2011 to November 2018. Motor performance, physical and mental health-related quality of life (HRQoL), cognitive function, and depressive severity were compared between with or without probable RBD at the baseline and at the 1-, 3- or 5-year follow-up. RESULTS:One hundred three PD patients (55 with RBD; 48 without RBD) were evaluated at the baseline and at the 1-year follow-up and 33 (17 with RBD, 16 without RBD) of them were examined at the 5-year follow-up. Motor performances were significantly improved in the non-RBD group compared to the RBD group at the 1-year follow-up, and there was a trend toward a greater difference in the physical HRQoL compared with the 1-year follow-up. There were also marked improvements of axial symptom and physical HRQoL in the non-RBD group compared with the RBD group from baseline to 5 years after STN-DBS. CONCLUSION:Our study showed that RBD negatively affected the short- and long-term outcomes on motor performances, especially axial symptom and HRQoL after STN-DBS in PD patients.

authors

Park S,Kim R,Shin JH,Kim HJ,Paek SH,Jeon B

doi

10.1016/j.parkreldis.2020.06.031

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

136-139

eissn

1353-8020

issn

1873-5126

pii

S1353-8020(20)30208-X

journal_volume

81

pub_type

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