当前位置： SCI文献检索 > PARKINSONISM & RELATED DISORDERS期刊下所有文献 > Diagnostic accuracy of [99mTc]TRODAT-1 SPECT imaging in early Parkinson's disease.

Diagnostic accuracy of [99mTc]TRODAT-1 SPECT imaging in early Parkinson's disease.

Abstract：

:We evaluated the diagnostic accuracy of SPECT imaging using [(99m)Tc]TRODAT-1 (TRODAT), a relatively inexpensive technetium-labeled dopamine transporter ligand, in distinguishing 29 patients with early PD from 38 healthy volunteers. Mean TRODAT uptake values were significantly decreased in the caudate (p=0.0097) and anterior and posterior putamen (p < 0.0001) of PD patients compared to controls. Using the posterior putamen as the main region of interest resulted in the greatest accuracy (sensitivity 0.79, specificity 0.92). These findings show that TRODAT imaging can accurately differentiate early PD patients from controls and has the potential to improve the diagnosis of patients with early signs of PD.

journal_name

Parkinsonism Relat Disord

journal_title

Parkinsonism & related disorders

authors

Chou KL,Hurtig HI,Stern MB,Colcher A,Ravina B,Newberg A,Mozley PD,Siderowf A

doi

10.1016/j.parkreldis.2004.04.002

subject

Has Abstract

pub_date

2004-08-01 00:00:00

pages

375-9

issue

6

eissn

1353-8020

issn

1873-5126

pii

S1353802004000689

journal_volume

10

pub_type

临床试验,杂志文章

相关文献

PARKINSONISM & RELATED DISORDERS文献大全
  • Oropharyngeal freezing and its relation to dysphagia - An analogy to freezing of gait.

    abstract：INTRODUCTION:The pathophysiology of dysphagia in Parkinson's disease (PD) is heterogeneous and poorly understood at present. This study investigated the phenotypes, prevalence and pathophysiology of oropharyngeal freezing (OPF) in PD and its relation to dysphagia. METHODS:In a prospective study, 50 PD patients were sy...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2020.05.002

    authors： Labeit B,Claus I,Muhle P,Lapa S,Suntrup-Krueger S,Dziewas R,Osada N,Warnecke T

    更新日期：2020-06-01 00:00:00

  • Magnetization transfer and adiabatic R 1ρ MRI in the brainstem of Parkinson's disease.

    abstract：BACKGROUND:In addition to classic midbrain pathology, Parkinson's disease (PD) is accompanied by changes in pontine and medullary brainstem structures. These additional abnormalities may underlie non-motor features as well as play a role in motor disability. METHODS:Using novel magnetic resonance imaging (MRI) methods...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2012.01.003

    authors： Tuite PJ,Mangia S,Tyan AE,Lee MK,Garwood M,Michaeli S

    更新日期：2012-06-01 00:00:00

  • Dystonic frowning without blepharospasm.

    abstract：:We report on two cases who presented with involuntary facial grimacing and frowning. Blepharospasm has never been documented in one, and the other case showed difficulty in lid opening only in the early phase of the disease. Botulinum toxin was effective for both. This is a hitherto unreported presentation of upper fa...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2007.12.001

    authors： Hirota N,Hirota M,Mezaki T

    更新日期：2008-11-01 00:00:00

  • High-dose treatment with pergolide in Parkinson's disease patients with motor fluctuations and dyskinesias.

    abstract：:Motor complications arising after long-term treatment with levodopa remain one of the main challenges in the treatment of patients with Parkinson's disease (PD). Monotherapy with dopamine agonists may delay the onset of motor complications or reduce their severity when added to levodopa treatment. Here, we retrospecti...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2005.03.005

    authors： Storch A,Trenkwalder C,Oehlwein C,Winkelmann J,Polzer U,Hundemer HP,Schwarz J

    更新日期：2005-09-01 00:00:00

  • How to improve neuroprotection in Parkinson's disease?

    abstract：:Several factors involved in the etiology of Parkinson's disease (PD) have been proposed, including genetic and environmental factors or even a combination of both. Thus, multiple cellular hits are likely to contribute to neurodegeneration in PD. If such a mechanism happens to occur, our therapeutic intervention may pe...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,评审

    doi：10.1016/S1353-8020(08)70026-9

    authors： Hirsch EC

    更新日期：2007-01-01 00:00:00

  • Finger dexterity deficits in Parkinson's disease and somatosensory cortical dysfunction.

    abstract：INTRODUCTION:The patho-physiological basis for finger dexterity deficits in Parkinson's disease (PD) is controversial. Previously, bradykinesia was regarded as the major mechanism. However, recent research suggested limb-kinetic apraxia as an important component of impaired fine motor skills in PD. In contrast to brady...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2014.12.025

    authors： Foki T,Pirker W,Geißler A,Haubenberger D,Hilbert M,Hoellinger I,Wurnig M,Rath J,Lehrner J,Matt E,Fischmeister F,Trattnig S,Auff E,Beisteiner R

    更新日期：2015-03-01 00:00:00

  • Long-term outcome of 50 consecutive Parkinson's disease patients treated with subthalamic deep brain stimulation.

    abstract：OBJECTIVE:To describe the long-term outcome in 50 consecutive advanced Parkinson's disease (PD) patients treated with subthalamic nucleus deep brain stimulation (STN-DBS). METHOD:Assessments were carried out at baseline, 6 months, 2 years, and 5 years postoperatively. RESULTS:Compared to baseline scores without medic...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2007.06.012

    authors： Wider C,Pollo C,Bloch J,Burkhard PR,Vingerhoets FJ

    更新日期：2008-01-01 00:00:00

  • Comparison of IPX066 with carbidopa-levodopa plus entacapone in advanced PD patients.

    abstract：BACKGROUND:IPX066, an investigational extended-release carbidopa-levodopa (CD-LD) preparation, has demonstrated a rapid attainment and prolonged maintenance of therapeutic LD plasma concentrations in advanced Parkinson's disease (PD). This phase-3 crossover study assessed its efficacy and safety vs. CD-LD plus entacapo...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.parkreldis.2014.08.004

    authors： Stocchi F,Hsu A,Khanna S,Ellenbogen A,Mahler A,Liang G,Dillmann U,Rubens R,Kell S,Gupta S

    更新日期：2014-12-01 00:00:00

  • Interoceptive processing deficit: A behavioral marker for subtyping Parkinson's disease.

    abstract：BACKGROUND:Non-motor symptoms in Parkinson's disease (PD), such as cognitive, emotional, autonomic and somatosensory alterations, are not ubiquitous but vary between the tremor dominant (TD) and postural instability/gait difficulty (PIGD) subtypes of the syndrome. Non-motor phenomena (e.g., anxiety, depression and apat...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2018.05.001

    authors： Santangelo G,Vitale C,Baiano C,D'Iorio A,Longo K,Barone P,Amboni M,Conson M

    更新日期：2018-08-01 00:00:00

  • Novel GNAL mutation with intra-familial clinical heterogeneity: Expanding the phenotype.

    abstract：INTRODUCTION:Mutations in GNAL have been associated with adult-onset cranio-cervical dystonia, but a limited number of cases have been reported so far and the clinical spectrum associated with this gene still needs to be fully characterized. METHODS:We identified an Italian family with adult-onset, dominantly-inherite...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2015.12.012

    authors： Carecchio M,Panteghini C,Reale C,Barzaghi C,Monti V,Romito L,Sasanelli F,Garavaglia B

    更新日期：2016-02-01 00:00:00

  • Olfaction in Parkinson's disease.

    abstract：:It has become increasingly apparent that Parkinson's disease (PD) can no longer be considered purely a motor disease, as numerous sensory alterations accompany this disorder either before or early in its clinical progression. Most notable among such disturbances are decrements in smell function. Such anomalies have be...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,评审

    doi：10.1016/S1353-8020(08)70006-3

    authors： Doty RL

    更新日期：2007-01-01 00:00:00

  • Effects of optimism/pessimism and locus of control on disability and quality of life in Parkinson's disease.

    abstract：PURPOSE:To assess optimism/pessimism and locus of control in a sample of Parkinson's disease patients and to evaluate their impact on disability and health-related quality of life. METHODS:99 patients with Parkinson's disease completed the Life Orientation Test, Multidimensional Health Locus of Control, Older American...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2009.03.005

    authors： Gruber-Baldini AL,Ye J,Anderson KE,Shulman LM

    更新日期：2009-11-01 00:00:00

  • Altered functional network topology correlates with clinical measures in very early-stage, drug-naïve Parkinson's disease.

    abstract：INTRODUCTION:The aim of the study was to identify abnormalities of whole-brain network functional organization and their relation to clinical measures in a well-characterized, multi-site cohort of very early-stage, drug-naïve Parkinson's Disease (PD) patients. METHODS:Functional-MRI data for 16 healthy controls and 20...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2019.02.001

    authors： Sreenivasan K,Mishra V,Bird C,Zhuang X,Yang Z,Cordes D,Walsh RR

    更新日期：2019-05-01 00:00:00

  • Hypertrophic olivary degeneration: A clinico-radiologic study.

    abstract：INTRODUCTION:The frequency and causes of hypertrophic olivary degeneration (HOD) are unknown. We compared the clinical and radiological characteristics of unilateral HOD and bilateral HOD. METHODS:We performed a search of a radiologic report database for patients who were radiologically diagnosed as having HOD. This d...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2016.04.008

    authors： Konno T,Broderick DF,Tacik P,Caviness JN,Wszolek ZK

    更新日期：2016-07-01 00:00:00

  • Stage-dependent patterns of disturbed neural synchrony in Parkinson's disease.

    abstract：:Synchronization of neuronal activity within and across distributed brain regions is a fundamental property of cortical and subcortical networks and serves a variety of functions including motor and cognitive processes. Data will be reviewed here from cross-sectional EEG and MEG studies to suggest that Parkinson's dise...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,评审

    doi：10.1016/S1353-8020(08)70046-4

    authors： Berendse HW,Stam CJ

    更新日期：2007-01-01 00:00:00

  • Benign hereditary chorea: an update.

    abstract：:Benign hereditary chorea (BHC, MIM 118700) is a rare autosomal dominant disorder manifesting with chorea in conjunction with hypothyroidism and respiratory problems, a triad also named "brain-lung-thyroid syndrome". BHC is characterized by childhood onset with minimal or no progression into adult life and normal cogni...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,评审

    doi：10.1016/j.parkreldis.2011.01.002

    authors： Inzelberg R,Weinberger M,Gak E

    更新日期：2011-06-01 00:00:00

  • Serum neurofilament light chain levels reflect cortical neurodegeneration in de novo Parkinson's disease.

    abstract：INTRODUCTION:Cognitive impairment and dementia are highly prevalent non-motor complications in Parkinson's disease (PD) with deleterious consequences for patients and caregivers. With no treatment currently available, finding and validating minimally-invasive biomarkers of neurodegeneration in this population represent...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2020.04.009

    authors： Sampedro F,Pérez-González R,Martínez-Horta S,Marín-Lahoz J,Pagonabarraga J,Kulisevsky J

    更新日期：2020-05-01 00:00:00

  • Motor outcome of dystonic camptocormia treated with pallidal neurostimulation.

    abstract：BACKGROUND:Deep brain stimulation of the internal pallidum (GPi-DBS) is effective for various types of drug-refractory primary dystonias. Rare clinical forms as dystonic camptocormia may profit but available data are scarce. METHODS:We here report on a retrospective clinical assessment of three patients with primary d...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2013.10.022

    authors： Reese R,Knudsen K,Falk D,Mehdorn HM,Deuschl G,Volkmann J

    更新日期：2014-02-01 00:00:00

  • High rates and the risk factors for emergency room visits and hospitalization in Parkinson's disease.

    abstract：BACKGROUND:Parkinson's disease (PD) patients are hospitalized more frequently than their peers as a result of falls, psychosis, infections and other medical complications. However, patient-specific risk factors for hospitalization are unclear. OBJECTIVE:To identify rates and risk factors for hospital encounters (Emerg...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.parkreldis.2013.06.006

    authors： Hassan A,Wu SS,Schmidt P,Dai Y,Simuni T,Giladi N,Bloem BR,Malaty IA,Okun MS,NPF-QII Investigators.

    更新日期：2013-11-01 00:00:00

  • The next chapter in symptomatic Parkinson disease treatments.

    abstract：:Significant advances in the symptomatic treatment of Parkinson disease (PD) have occurred since the discovery of levodopa (LD). Perhaps as a testament to its unparalleled efficacy, novel formulations aiming to optimize LD delivery to obtain better bioavailability, longer duration of effect and less plasma level fluctu...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,评审

    doi：10.1016/j.parkreldis.2019.01.002

    authors： Hengartner D,Fernandez HH

    更新日期：2019-02-01 00:00:00

  • Autosomal recessive parkinsonism.

    abstract：:Several forms of autosomal recessive parkinsonism are known. In three forms, caused by mutations in parkin (PARK2), PINK1 (PARK6), or DJ-1 (PARK7), the phenotype is usually characterized by levodopa-responsive parkinsonism without atypical features. Parkin mutations are most frequent, explaining -50% of the cases with...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,评审

    doi：10.1016/S1353-8020(11)70004-9

    authors： Bonifati V

    更新日期：2012-01-01 00:00:00

  • 24 h Levodopa-carbidopa intestinal gel may reduce falls and "unresponsive" freezing of gait in Parkinson's disease.

    abstract：OBJECTIVE:We report a prospective, open label study of 24 h levodopa-carbidopa intestinal gel (LCIG) as treatment for levodopa "unresponsive" freezing of gait (FOG) associated with Parkinson's disease. METHOD:5 patients with disabling FOG, documented as being levodopa "unresponsive", were commenced on continuous 24 h ...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2014.12.019

    authors： Chang FC,Tsui DS,Mahant N,Wolfe N,Kim SD,Ha AD,Drury M,Griffith JM,Fung VS

    更新日期：2015-03-01 00:00:00

  • Low doses of sarizotan reduce dyskinesias and maintain antiparkinsonian efficacy of L-Dopa in parkinsonian monkeys.

    abstract：:Dyskinesia is an important complication of treatment in Parkinson's disease (PD). Sarizotan, a 5-HT(1A) agonist with high affinity for D3 and D4 receptors was investigated on L-Dopa-induced dyskinesia (LID) in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) animal model of PD. Five MPTP female cynomolgus monke...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2008.11.001

    authors： Grégoire L,Samadi P,Graham J,Bédard PJ,Bartoszyk GD,Di Paolo T

    更新日期：2009-07-01 00:00:00

  • Utility of quantitative EEG in early Lewy body disease.

    abstract：INTRODUCTION:The reduction of background activity and the increase of low-frequency powers on electroencephalogram (EEG) correlate with cognitive impairment and have been suggested to be underpinned by cholinergic deficit. We aimed to investigate the ratio between α and θ band power (α/θ ratio), as a synoptic index of ...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2020.05.007

    authors： Massa F,Meli R,Grazzini M,Famà F,De Carli F,Filippi L,Arnaldi D,Pardini M,Morbelli S,Nobili F

    更新日期：2020-06-01 00:00:00

  • Wheeled and standard walkers in Parkinson's disease patients with gait freezing.

    abstract：OBJECTIVES:Compare the efficacy of two walking assistance devices (wheeled walker and standard walker) to unassisted walking for patients with PD and gait freezing. BACKGROUND:Although numerous walking devices are used clinically, their relative effects on freezing and walking speed have never been systematically test...

    journal_title：Parkinsonism & related disorders

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s1353-8020(03)00060-9

    authors： Cubo E,Moore CG,Leurgans S,Goetz CG

    更新日期：2003-10-01 00:00:00

  • SNCA and MAPT genes: Independent and joint effects in Parkinson disease in the Italian population.

    abstract：BACKGROUND:Significant efforts have been focused on investigating the contribution of common variants to Parkinson disease (PD) risk. Several independent GWAS and metanalysis studies have shown a genome-wide significant association of single nucleotide polymorphisms (SNPs) in the α-synuclein (SNCA) and microtubule-asso...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2011.10.014

    authors： Trotta L,Guella I,Soldà G,Sironi F,Tesei S,Canesi M,Pezzoli G,Goldwurm S,Duga S,Asselta R

    更新日期：2012-03-01 00:00:00

  • Electronic motor function diary for patients with Parkinson's disease: a feasibility study.

    abstract：:Parkinson's disease (PD) studies often measure daily motor function with paper diaries resulting in issues of compliance and reliability. The feasibility and compliance of PD patients using electronic diaries were examined. Twelve patients completed diaries for 7 consecutive days. Diaries recorded motor function, time...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2006.06.008

    authors： Lyons KE,Pahwa R

    更新日期：2007-07-01 00:00:00

  • Neuropsychiatric symptoms and caregiver's burden in Parkinson's disease.

    abstract：INTRODUCTION:In Parkinson's disease (PD), neuropsychiatric symptoms (NPS) can be particularly burdensome for caregivers. The main goal of this study was to assess the impact of NPS, assessed by means of a new specific scale, on caregiver burden. METHODS:A sample of 584 pairs of PD patients and their primary caregivers...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2015.03.024

    authors： Martinez-Martin P,Rodriguez-Blazquez C,Forjaz MJ,Frades-Payo B,Agüera-Ortiz L,Weintraub D,Riesco A,Kurtis MM,Chaudhuri KR

    更新日期：2015-06-01 00:00:00

  • Body mass index is reduced early in Parkinson's disease.

    abstract：:Mean body mass index (BMI) in 100 cases of idiopathic Parkinson's disease (PD) was found to be 9% reduced in comparison to that in patients with either essential tremor or no neurologic disease. A similar reduction in BMI was also discovered among the 24 cases of PD in whom retrospective BMI data were available from t...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2004.07.001

    authors： Cheshire WP Jr,Wszolek ZK

    更新日期：2005-01-01 00:00:00

  • Association between cerebral small vessel diseases and mild parkinsonian signs in the elderly with vascular risk factors.

    abstract：INTRODUCTION:The aim of this study was to examine the association between mild parkinsonian signs (MPS), cerebral small-vessel disease (SVD), and total SVD burden in patients with vascular risk factors. METHODS:We performed a cross-sectional study among 268 patients with vascular risk factors but without parkinsonism ...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2016.02.011

    authors： Hatate J,Miwa K,Matsumoto M,Sasaki T,Yagita Y,Sakaguchi M,Kitagawa K,Mochizuki H

    更新日期：2016-05-01 00:00:00