Magnetization transfer and adiabatic R 1ρ MRI in the brainstem of Parkinson's disease.

Abstract:

BACKGROUND:In addition to classic midbrain pathology, Parkinson's disease (PD) is accompanied by changes in pontine and medullary brainstem structures. These additional abnormalities may underlie non-motor features as well as play a role in motor disability. METHODS:Using novel magnetic resonance imaging (MRI) methods based on rotating frame adiabatic R(1ρ) (i.e., measurements of longitudinal relaxation during adiabatic full passage pulses) and modified magnetization transfer (MT) MRI mapping, we sought to identify brainstem alterations in nine individuals with mild-moderate PD (off medication) and ten age-matched controls at 4 T. RESULTS:We discovered significant differences in MRI parameters between midbrain and medullary brainstem structures in control subjects as compared to PD patients. CONCLUSIONS:These findings support the presence of underlying functional/structural brainstem changes in mild-moderate PD.

authors

Tuite PJ,Mangia S,Tyan AE,Lee MK,Garwood M,Michaeli S

doi

10.1016/j.parkreldis.2012.01.003

subject

Has Abstract

pub_date

2012-06-01 00:00:00

pages

623-5

issue

5

eissn

1353-8020

issn

1873-5126

pii

S1353-8020(12)00004-1

journal_volume

18

pub_type

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