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Finger dexterity deficits in Parkinson's disease and somatosensory cortical dysfunction.

Abstract：

INTRODUCTION:The patho-physiological basis for finger dexterity deficits in Parkinson's disease (PD) is controversial. Previously, bradykinesia was regarded as the major mechanism. However, recent research suggested limb-kinetic apraxia as an important component of impaired fine motor skills in PD. In contrast to bradykinesia, limb-kinetic apraxia only marginally responds to dopaminergic treatment. Here we investigate the novel hypothesis that the dexterity deficits are related to an intrinsic dysfunction of primary somatosensory cortex (S1), which is not reversible by dopaminergic medication. METHODS:Applying a standard and approved dexterity task (coin rotation), brain activation networks were investigated using functional magnetic resonance imaging in PD patients both ON and OFF medication and matched healthy controls. RESULTS:PD patients both ON and OFF medication showed impaired S1 activation relative to controls (p < 0.05; region of interest based analysis). The impaired S1 activation remained unchanged by dopaminergic medication. Despite the considerable clinical deficit, no other brain area showed impaired activation. In contrast, structures of the basal ganglia--motor cortex loop responded to dopaminergic medication. Behaviorally, dexterity performance both ON and OFF was significantly (p < 0.05) reduced relative to controls. CONCLUSIONS:Our results provide first evidence that dexterity deficits in PD are related to an S1 dysfunction which is insensitive to dopaminergic treatment.

journal_name

Parkinsonism Relat Disord

journal_title

Parkinsonism & related disorders

authors

Foki T,Pirker W,Geißler A,Haubenberger D,Hilbert M,Hoellinger I,Wurnig M,Rath J,Lehrner J,Matt E,Fischmeister F,Trattnig S,Auff E,Beisteiner R

doi

10.1016/j.parkreldis.2014.12.025

subject

Has Abstract

pub_date

2015-03-01 00:00:00

pages

259-65

issue

3

eissn

1353-8020

issn

1873-5126

pii

S1353-8020(14)00499-4

journal_volume

21

pub_type

杂志文章

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