当前位置： SCI文献检索 > PARKINSONISM & RELATED DISORDERS期刊下所有文献 > Motor, behavioural, and cognitive correlates of fatigue in early, de novo Parkinson disease patients.

Motor, behavioural, and cognitive correlates of fatigue in early, de novo Parkinson disease patients.

Abstract：

INTRODUCTION:Fatigue is one of the most common and disabling non-motor symptoms in Parkinson's disease (PD). The objective of this study was to determine prevalence and motor, behavioural, and cognitive correlates of distressing fatigue in early, de novo PD patients. METHODS:Eighty-one consecutive de novo PD patients (64% men; mean age 65.73 ± 8.26 years) underwent a comprehensive examination, including Parkinson's disease Fatigue Scale (PFS), Epworth Sleepiness Scale (ESS), Parkinson's Disease Sleep Scale (PDSS), Beck Depression Inventory (BDI), Parkinson's Anxiety Scale (PAS), and Apathy Evaluation Scale (AES). Moreover, all patients underwent a detailed neuropsychological evaluation exploring attention and working memory, executive functions, memory, visuospatial abilities and language. Score of patients with or without distressing fatigue (defined as a PFS score ≥ 8) were compared by Student's t-test or Pearson's chi-square test. Logistic regression analyses were performed to search for motor and non-motor features independently associated with presence of distressing fatigue. RESULTS:Twelve (15%) patients presented distressing fatigue. Logistic regression identified sleepiness (p = 0.04), "episodic anxiety" subscale of PAS (p = 0.005), and "cognitive apathy" subscale of AES (p = 0.017) as the main factors associated with distressing fatigue. No significant association was found between diagnosis of Mild Cognitive Impairment and distressing fatigue (p = 0.745). CONCLUSION:In a sample of consecutive de novo PD patients, distressing fatigue is associated with episodic anxiety, cognitive apathy and sleepiness, but not with cognitive impairment. Our findings suggest possible shared pathogenic mechanisms underlying these non-motor symptoms and foster development of early combined therapeutic approaches.

journal_name

Parkinsonism Relat Disord

journal_title

Parkinsonism & related disorders

authors

Siciliano M,Trojano L,De Micco R,De Mase A,Garramone F,Russo A,Tedeschi G,Tessitore A

doi

10.1016/j.parkreldis.2017.10.004

subject

Has Abstract

pub_date

2017-12-01 00:00:00

pages

63-68

eissn

1353-8020

issn

1873-5126

pii

S1353-8020(17)30361-9

journal_volume

45

pub_type

杂志文章

相关文献

PARKINSONISM & RELATED DISORDERS文献大全
  • Red flags phenotyping: A systematic review on clinical features in atypical parkinsonian disorders.

    abstract：:To establish a clinical diagnosis of a parkinsonian disorder, physicians rely on their ability to identify relevant red flags, in addition to cardinal features, to support or refute their working diagnosis in an individual patient. The term 'red flag', was originally coined in 1989 to define the presence of non-cardin...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2018.10.009

    authors： Bhidayasiri R,Sringean J,Reich SG,Colosimo C

    更新日期：2019-02-01 00:00:00

  • Essential tremor: Is the word "essential" really essential?

    abstract：:Essential tremor (ET) is among the common movement disorders. A surge in research in recent years has considerably improved our understanding of disease etiology and pathogenesis, and its associated clinical phenomenology and natural history. With this progress have emerged a multitude of new questions and conundrums ...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2020.10.035

    authors： Lenka A,Louis ED

    更新日期：2020-12-01 00:00:00

  • Relationships among cognitive impairment, sleep, and fatigue in Parkinson's disease using the MDS-UPDRS.

    abstract：BACKGROUND:Non-motor complications of Parkinson's disease (PD), specifically cognitive impairment, sleep disturbances, and fatigue, are recognized as important contributors to poor patient outcomes and quality of life. How sleep problems and fatigue interrelate and impact cognitive function, however, has not systematic...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2014.08.001

    authors： Goldman JG,Stebbins GT,Leung V,Tilley BC,Goetz CG

    更新日期：2014-11-01 00:00:00

  • Motor impairment in normal aging, clinically possible Parkinson's disease, and clinically probable Parkinson's disease: longitudinal evaluation of a cohort of prospective brain donors.

    abstract：:This study presents data on the antemortem evaluations of a cohort of individuals registered in a brain donation program. Clinical evaluation determined that many individuals were unaware they had clinical signs of Parkinson's disease (PD) (rest tremor, bradykinesia, rigidity). Quantitative motor testing (timed tappin...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/s1353-8020(02)00012-3

    authors： Adler CH,Hentz JG,Joyce JN,Beach T,Caviness JN

    更新日期：2002-12-01 00:00:00

  • Young onset Hemifacial Spasm in patients with Chiari type I malformation.

    abstract：:Hemifacial spasm (HFS) resulting from Chiari type I malformation (CIM) is rare. We retrospectively evaluated five patients with CIM and HFS among a series of 103 subjects. The frequency of HFS associated to CIM was of 4.85%. The clinical profile did not differ from the classical primary cases except for young-onset de...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2007.04.002

    authors： Felício AC,de Godeiro C Jr,Borges V,de Azevedo Silva SM,Ferraz HB

    更新日期：2008-01-01 00:00:00

  • Adenosine, adenosine A 2A antagonists, and Parkinson's disease.

    abstract：:Adenosine derived from the degradation of ATP/AMP functions as a signalling molecule in the nervous system through the occupation of A1, A2, and A3 adenosine receptors. Adenosine A(2A) receptors have a selective localization to the basal ganglia and specifically to the indirect output pathway, and as a consequence off...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,评审

    doi：10.1016/j.parkreldis.2008.12.006

    authors： Jenner P,Mori A,Hauser R,Morelli M,Fredholm BB,Chen JF

    更新日期：2009-07-01 00:00:00

  • Quantifying physical activity in early Parkinson disease using a commercial activity monitor.

    abstract：INTRODUCTION:Physical inactivity in Parkinson disease (PD) has an impact on motor and non-motor symptoms of the disease. It is unclear whether this decline in physical activity occurs early in the disease, in addition to any decline due to aging, and whether commercial activity monitors can be used to self-monitor phys...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2019.08.001

    authors： Pradhan S,Kelly VE

    更新日期：2019-09-01 00:00:00

  • Low frequency of the PARK2 gene mutations in Polish patients with the early-onset form of Parkinson disease.

    abstract：OBJECTIVE:Mutations in the PARK2 (Parkin) gene result in an early-onset autosomal recessive form of Parkinson Disease (EO-PD). Although the frequency of the PARK2 mutations in EO-PD patients according to several studies is high and has been reported in up to 50% in familial and 19% in sporadic cases, these data remain ...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2009.06.010

    authors： Koziorowski D,Hoffman-Zacharska D,Sławek J,Szirkowiec W,Janik P,Bal J,Friedman A

    更新日期：2010-02-01 00:00:00

  • The overlap between Essential tremor and Parkinson disease.

    abstract：INTRODUCTION:Essential tremor (ET) and Parkinson's disease (PD) are common disorders especially in the aging population and can have overlapping features that can make it difficult to differentiate between the two. In addition, a possible overlap from a pathophysiological standpoint has been often advocated in the past...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,评审

    doi：10.1016/j.parkreldis.2017.07.006

    authors： Algarni M,Fasano A

    更新日期：2018-01-01 00:00:00

  • Psychological functioning in patients with Parkinson's disease.

    abstract：:Forty patients with Parkinson's disease (PD) were studied to explore the relationship between aspects of psychological functioning (depression, problems in motoric, cognitive and psychological areas) and physical illness (stage and duration of illness, functional disability, global cognitive status). Depression, motor...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/s1353-8020(00)00010-9

    authors： Gupta A,Bhatia S

    更新日期：2000-07-01 00:00:00

  • High-dose treatment with pergolide in Parkinson's disease patients with motor fluctuations and dyskinesias.

    abstract：:Motor complications arising after long-term treatment with levodopa remain one of the main challenges in the treatment of patients with Parkinson's disease (PD). Monotherapy with dopamine agonists may delay the onset of motor complications or reduce their severity when added to levodopa treatment. Here, we retrospecti...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2005.03.005

    authors： Storch A,Trenkwalder C,Oehlwein C,Winkelmann J,Polzer U,Hundemer HP,Schwarz J

    更新日期：2005-09-01 00:00:00

  • Analysis of LRRK2, SNCA, Parkin, PINK1, and DJ-1 in Zambian patients with Parkinson's disease.

    abstract：:Recent studies delineate substantial genetic components in Parkinson's disease (PD). However, very few studies were performed in Sub-Saharan African populations. Here, we explore the contribution of known PD-causing genes in patients of indigenous Zambian ancestry. We studied thirty-nine Zambian patients, thirty-eight...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2012.02.018

    authors： Yonova-Doing E,Atadzhanov M,Quadri M,Kelly P,Shawa N,Musonda ST,Simons EJ,Breedveld GJ,Oostra BA,Bonifati V

    更新日期：2012-06-01 00:00:00

  • Myasthenia gravis: an unrecognized cause of head drop in Parkinson's disease.

    abstract：:Head drop is characterized by marked anterior flexion of the cervical spine, caused by weakness of the neck extensors or by increased tone of the flexor muscles. We report a woman with Parkinson's disease and head drop not due to cervical dystonia (a common cause of antecollis in parkinsonisms). Clinical, radiological...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2007.02.009

    authors： Fasano A,Evoli A,Piano C,Tonali PA,Bentivoglio AR

    更新日期：2008-01-01 00:00:00

  • Secured web-based video repository for multicenter studies.

    abstract：BACKGROUND:We developed a novel secured web-based dystonia video repository for the Dystonia Coalition, part of the Rare Disease Clinical Research network funded by the Office of Rare Diseases Research and the National Institute of Neurological Disorders and Stroke. A critical component of phenotypic data collection fo...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2015.01.011

    authors： Yan L,Hicks M,Winslow K,Comella C,Ludlow C,Jinnah HA,Rosen AR,Wright L,Galpern WR,Perlmutter JS

    更新日期：2015-04-01 00:00:00

  • Diaphragmatic myoclonus owing to electrode dislocation of implantable cardioverter defibrillator.

    abstract：:Myoclonus is a sudden and brief involuntary muscle contraction presenting with jerk-like movements that can occasionally involve the trunk muscles or the diaphragm as in the case of spinal myoclonus1. We here present an unusual case with unilateral diaphragmatic myoclonus owing to electrode dislocation of an implantab...

    journal_title：Parkinsonism & related disorders

    pub_type： 信件

    doi：10.1016/j.parkreldis.2019.03.004

    authors： Bedarf JR,Nitsch L,Malotki R,Andrié R,Reimann J

    更新日期：2019-06-01 00:00:00

  • Quality of life in Essential Tremor Questionnaire (QUEST): development and initial validation.

    abstract：BACKGROUND/OBJECTIVE:Essential tremor (ET) can diminish functioning and quality of life (QOL) but generic QOL measures may be relatively insensitive to ET and its therapies. We sought to develop an ET-specific measure that might be more sensitive, acceptable to patients, relatively brief, and easily used. DESIGN/METHO...

    journal_title：Parkinsonism & related disorders

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.parkreldis.2005.05.009

    authors： Tröster AI,Pahwa R,Fields JA,Tanner CM,Lyons KE

    更新日期：2005-09-01 00:00:00

  • Could Mucuna pruriens be the answer to Parkinson's disease management in sub-Saharan Africa and other low-income countries worldwide?

    abstract：:Parkinson's disease (PD) is a progressive, disabling, neurodegenerative disease that requires long term care and pharmaceutical treatment. Levodopa remains the gold standard treatment for PD globally, although it is largely unavailable and unaffordable for the majority of patients in many sub-Saharan African and other...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2020.03.002

    authors： Fothergill-Misbah N,Maroo H,Cham M,Pezzoli G,Walker R,Cilia R

    更新日期：2020-04-01 00:00:00

  • Mouse models for LRRK2 Parkinson's disease.

    abstract：:Parkinson's disease (PD) is the second most common neurodegenerative disease. Mutations in Leucine-rich-repeat-kinase 2 (LRRK2), the causative gene for PARK8 type PD with autosomal dominant inheritance, are the most prevalent genetic causes of both familial and sporadic PD. Animal models are critical tools in the atte...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,评审

    doi：10.1016/S1353-8020(11)70058-X

    authors： Xu Q,Shenoy S,Li C

    更新日期：2012-01-01 00:00:00

  • Correlates of quality of sexual life in male and female patients with Parkinson disease and their partners.

    abstract：INTRODUCTION:Patients with Parkinson disease (PD) and their partners may experience a worsening of their sexual life. AIM:To assess quality of sexual life (QoSL) in male and female PD patients and their partners. MATERIALS AND METHODS:Medical, demographic and clinical data was collected regarding consecutive PD patie...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2014.07.003

    authors： Bronner G,Cohen OS,Yahalom G,Kozlova E,Orlev Y,Molshatzki N,Strauss H,Hassin-Baer S

    更新日期：2014-10-01 00:00:00

  • Proton magnetic resonance spectroscopy of the striatum in Parkinson's disease patients with motor response fluctuations.

    abstract：:We have performed proton magnetic resonance spectroscopy centred on the putamen contralateral to the worst affected side in 10 patients with idiopathic Parkinson's disease (PD) and motor response fluctuations and seven age matched healthy controls. In PD, there was striking reduction in the N-acetylaspartate (NAA) and...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/1353-8020(96)00007-7

    authors： Chaudhuri KR,Lemmens GM,Williams SC,Ellis C,Lloyd CM,Dawson J,Simmons A,Leigh PN

    更新日期：1996-04-01 00:00:00

  • SNCA-Rep1 polymorphism correlates with susceptibility and iron deficiency in restless legs syndrome.

    abstract：BACKGROUND:Brain iron disequilibrium and dopaminergic dysfunction are key pathophysiological features of Restless Legs Syndrome (RLS). Rep1 polymorphism in the promotor region of SNCA is associated with risk of Parkinson's disease, however its association with RLS and iron status is unclear. OBJECTIVE:To investigate S...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2020.09.015

    authors： Zhu XY,Wang HM,Wu TT,Liu T,Chen YJ,Li X,Chen TJ,Liu Y,Zhang XJ,Wang XX,Zhang Y,Ondo WG,Wu YC

    更新日期：2020-12-01 00:00:00

  • Electronic motor function diary for patients with Parkinson's disease: a feasibility study.

    abstract：:Parkinson's disease (PD) studies often measure daily motor function with paper diaries resulting in issues of compliance and reliability. The feasibility and compliance of PD patients using electronic diaries were examined. Twelve patients completed diaries for 7 consecutive days. Diaries recorded motor function, time...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2006.06.008

    authors： Lyons KE,Pahwa R

    更新日期：2007-07-01 00:00:00

  • Subjective perceived outcome of subthalamic deep brain stimulation in Parkinson's disease one year after surgery.

    abstract：OBJECTIVES:Dissatisfaction with subthalamic deep brain stimulation (STN-DBS) despite motor improvements has been observed in Parkinson's disease (PD). Hence, we compared patient's subjective perceived outcome 12 months after surgery (12mFU) with clinical measures to identify risk factors of dissatisfaction. METHODS:Pa...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2016.01.019

    authors： Maier F,Lewis CJ,Horstkoetter N,Eggers C,Dembek TA,Visser-Vandewalle V,Kuhn J,Zurowski M,Moro E,Woopen C,Timmermann L

    更新日期：2016-03-01 00:00:00

  • The association between objectively measured physical activity, depression, cognition, and health-related quality of life in Parkinson's disease.

    abstract：BACKGROUND:Lower levels of physical activity are associated with lower Health-Related Quality of Life (HRQoL) in Parkinson's disease (PD). We evaluated the influence of quantitative physical activity parameters among other (disease-related) features representing other domains of the WHO International model for classifi...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2017.12.023

    authors： van Uem JMT,Cerff B,Kampmeyer M,Prinzen J,Zuidema M,Hobert MA,Gräber S,Berg D,Maetzler W,Liepelt-Scarfone I

    更新日期：2018-03-01 00:00:00

  • Outcome of gastrostomy in parkinsonism: A retrospective study.

    abstract：OBJECTIVE:To investigate the indications and the outcomes of gastrostomy tube insertion in patients with parkinsonian syndromes. METHODS:Consecutive patients with Parkinson's disease or atypical parkinsonism, seen in two French tertiary referral movement disorders centers, that received gastrostomy tube insertion (GTI...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2017.06.012

    authors： Marois C,Amador MDM,Payan C,Lacomblez L,Bonnet AM,Degos B,Corvol JC,Vidailhet M,Le Forestier N,Mesnage V,Grabli D

    更新日期：2017-10-01 00:00:00

  • Acceleration of syllable repetition in Parkinson's disease is more prominent in the left-side dominant patients.

    abstract：BACKGROUND:In Parkinson's disease (PD), abnormalities of speech rate have been observed in spontaneous speech, reading tasks and syllable repetition tasks. Impaired temporal speech patterns have been contributed to dysfunctional basal ganglia circuits, but little is known about a possible differential role of right and...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2011.11.021

    authors： Flasskamp A,Kotz SA,Schlegel U,Skodda S

    更新日期：2012-05-01 00:00:00

  • Chronic and acute LRRK2 silencing has no long-term behavioral effects, whereas wild-type and mutant LRRK2 overexpression induce motor and cognitive deficits and altered regulation of dopamine release.

    abstract：INTRODUCTION:Germline silencing of the PD-related protein LRRK2 does not alter glutamate or dopamine release in adult mice, but some exploratory abnormalities have been reported with ageing. Contrastingly, high levels of human LRRK2 cause locomotor alterations and cognitive deficits accompanied by reduced striatal dopa...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2015.07.025

    authors： Volta M,Cataldi S,Beccano-Kelly D,Munsie L,Tatarnikov I,Chou P,Bergeron S,Mitchell E,Lim R,Khinda J,Lloret A,Bennett CF,Paradiso C,Morari M,Farrer MJ,Milnerwood AJ

    更新日期：2015-10-01 00:00:00

  • From 1997 to 2007: a decade journey through the H1 haplotype on 17q21 chromosome.

    abstract：:The H1 haplotype was first identified 10 years ago. Initially, a dinucleotide polymorphism was detected in the tau (MAPT) gene and was subsequently found to be in linkage disequilibrium (LD) with other polymorphisms, forming the MAPT H1 haplotype, a risk factor for many neurological diseases, considered as tauopathies...

    journal_title：Parkinsonism & related disorders

    pub_type： 历史文章,杂志文章,评审

    doi：10.1016/j.parkreldis.2008.03.001

    authors： Kalinderi K,Fidani L,Bostantjopoulou S

    更新日期：2009-01-01 00:00:00

  • Which patients discontinue? Issues on Levodopa/carbidopa intestinal gel treatment: Italian multicentre survey of 905 patients with long-term follow-up.

    abstract：OBJECTIVES:To report the results of a national survey aimed at quantifying the current level of diffusion of Levodopa/carbidopa intestinal gel (LCIG) in Italy. METHODS:Sixty Parkinson's Disease (PD) specialists in Italy were invited to complete a survey covering issues on clinical and practical aspects of LCIG therapy...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.parkreldis.2017.02.020

    authors： Sensi M,Cossu G,Mancini F,Pilleri M,Zibetti M,Modugno N,Quatrale R,Tamma F,Antonini A,ITALIAN LEVODOPA CARBIDOPA INTESTINAL GEL WORKING GROUP.

    更新日期：2017-05-01 00:00:00

  • Health-related quality of life and alternative forms of exercise in Parkinson disease.

    abstract：:Parkinson disease (PD) reduces health-related quality of life (HRQoL), but exercise may improve HRQoL. This pilot study compared the effects of Tango, Waltz/Foxtrot, Tai Chi and No Intervention on HRQoL in individuals with PD. Seventy-five persons with PD (Hoehn and Yahr I-III) were assigned to 20 lessons of Tango, Wa...

    journal_title：Parkinsonism & related disorders

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.parkreldis.2009.03.003

    authors： Hackney ME,Earhart GM

    更新日期：2009-11-01 00:00:00