Young onset Hemifacial Spasm in patients with Chiari type I malformation.

abstract：:The objective of this review is to assess the effectiveness of tai chi as a treatment option for Parkinson's disease (PD). We have searched the literature using 21 databases from their inceptions to January 2008, without language restrictions. We included all types of clinical studies regardless of their design. Their...

journal_title：Parkinsonism & related disorders

authors： Lee MS,Lam P,Ernst E

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:In Parkinson's disease (PD), abnormalities of speech rate have been observed in spontaneous speech, reading tasks and syllable repetition tasks. Impaired temporal speech patterns have been contributed to dysfunctional basal ganglia circuits, but little is known about a possible differential role of right and...

journal_title：Parkinsonism & related disorders

authors： Flasskamp A,Kotz SA,Schlegel U,Skodda S

更新日期：2012-05-01 00:00:00

abstract：INTRODUCTION:Mutations in the LRRK2 and alpha-synuclein (SNCA) genes are well-established causes of autosomal dominant Parkinson's disease (PD). However, their frequency differs widely between ethnic groups. Only three studies have screened all coding regions of LRRK2 and SNCA in European samples so far. In Turkey, the...

journal_title：Parkinsonism & related disorders

authors： Kessler C,Atasu B,Hanagasi H,Simón-Sánchez J,Hauser AK,Pak M,Bilgic B,Erginel-Unaltuna N,Gurvit H,Gasser T,Lohmann E

更新日期：2018-03-01 00:00:00

abstract：:Pathogenic mutations in the EIF4G1 gene were recently reported as a cause of autosomal dominant parkinsonism. To assess the frequency of EIF4G1 mutations in the Japanese population we sequenced the entire gene coding region (31 exons) in 95 patients with an apparent autosomal dominant inherited form of Parkinson's dis...

journal_title：Parkinsonism & related disorders

authors： Nishioka K,Funayama M,Vilariño-Güell C,Ogaki K,Li Y,Sasaki R,Kokubo Y,Kuzuhara S,Kachergus JM,Cobb SA,Takahashi H,Mizuno Y,Farrer MJ,Ross OA,Hattori N

更新日期：2014-06-01 00:00:00

abstract：:Most patients with tremor-dominant Parkinson's disease (PD) have impaired smell function but it is unclear whether this is true for subjects with essential tremor (ET). If ET patients do not exhibit meaningful smell loss, then olfactory testing may help to distinguish PD from ET. We assessed olfactory function in 59 E...

journal_title：Parkinsonism & related disorders

authors： Shah M,Muhammed N,Findley LJ,Hawkes CH

更新日期：2008-11-01 00:00:00

abstract：INTRODUCTION:Cerebellar circuits are hypothesized to play a central role in the pathogenesis of essential tremor. Rhythmic finger tapping is known to strongly engage the cerebellar motor circuitry. We characterize cerebellar and, more specifically, dentate nucleus function, and neural correlates of cerebellar output in...

journal_title：Parkinsonism & related disorders

authors： Buijink AW,Broersma M,van der Stouwe AM,van Wingen GA,Groot PF,Speelman JD,Maurits NM,van Rootselaar AF

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Parkinson disease (PD) and multiple system atrophy (MSA) share some neuropathologic features (nigrostriatal dopaminergic lesion, alpha-synuclein deposition) but not others (Lewy bodies in PD, glial cytoplasmic inclusions in MSA). In PD evidence has accrued for a vesicular storage defect and decreased aldehyd...

journal_title：Parkinsonism & related disorders

authors： Goldstein DS,Sullivan P,Holmes C,Kopin IJ,Sharabi Y,Mash DC

更新日期：2015-06-01 00:00:00

abstract：INTRODUCTION:Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common genetic cause of Parkinson's disease (PD). However, only few cases carrying LRRK2 mutations have been reported in Taiwanese PD patients. METHODS:We used targeted next generation sequencing (NGS), covering 24 candidate genes involved in neu...

journal_title：Parkinsonism & related disorders

authors： Fan TS,Wu RM,Chen PL,Chen TF,Li HY,Lin YH,Chen CY,Chen ML,Tai CH,Lin HI,Lin CH

更新日期：2016-12-01 00:00:00

abstract：OBJECTIVE:To examine the tolerability and effectiveness of propranolol in treating tardive dyskinesia (TD). BACKGROUND:TD is a disabling, often irreversible, movement disorder that results from chronic therapy with dopamine receptor blocking drugs. There are no treatments currently approved for this disorder. Proprano...

journal_title：Parkinsonism & related disorders

authors： Hatcher-Martin JM,Armstrong KA,Scorr LM,Factor SA

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Effects on non-motor symptoms, mainly cognitive and psychiatric side effects, could influence the decision for either globus pallidus pars interna (GPi) or subthalamic nucleus (STN) deep brain stimulation (DBS) for patients with Parkinson's disease (PD). OBJECTIVE:1) To compare cognitive and psychiatric out...

journal_title：Parkinsonism & related disorders

authors： Boel JA,Odekerken VJ,Schmand BA,Geurtsen GJ,Cath DC,Figee M,van den Munckhof P,de Haan RJ,Schuurman PR,de Bie RM,NSTAPS study group.

更新日期：2016-12-01 00:00:00

abstract：INTRODUCTION:Executive dysfunction is a common and early cognitive symptom in Parkinson's disease (PD) with a detrimental effect on quality of life of patients and their care givers. Thus, a number of neuroimaging studies investigated the underlying neural correlates of such an impairment. Results of individual studies...

journal_title：Parkinsonism & related disorders

authors： Giehl K,Tahmasian M,Eickhoff SB,van Eimeren T

更新日期：2019-06-01 00:00:00

abstract：:We examined the autopsied brains of two parkinsonian patients who had malignant syndrome (MS). Neopterin and biopterin contents, and GTP cyclohydrolase I activity were measured in various region of the brain. We found relatively higher GTP cyclohydrolase I activities in the hypothalamus compared with other regions of ...

journal_title：Parkinsonism & related disorders

authors： Ichinose H,Ohye T,Shinotoh H,Arai K,Yamazaki S,Mizuta E,Kuno S,Nagatsu T

更新日期：2003-04-01 00:00:00

abstract：PURPOSE:The young-onset subtype of Parkinson's disease (YOPD) differs from the late-onset subtype (LOPD) in drug responsiveness, incidence of motor complications, and prognosis. The pathophysiology underlying these differences remains largely unknown. This study investigated whether the two subtypes differ in the patte...

journal_title：Parkinsonism & related disorders

authors： Liu SY,Wu JJ,Zhao J,Huang SF,Wang YX,Ge JJ,Wu P,Zuo CT,Ding ZT,Wang J

更新日期：2015-12-01 00:00:00

abstract：INTRODUCTION:The deep brain stimulation (DBS) withdrawal syndrome (DBS-WDS) is a rare, life-threatening complication in Parkinson's disease (PD) patients with long disease duration and stimulation when stimulation is terminated for extended periods mostly due to infection of the DBS-hardware. METHODS, RESULTS:In five ...

journal_title：Parkinsonism & related disorders

authors： Reuter S,Deuschl G,Berg D,Helmers A,Falk D,Witt K

更新日期：2018-11-01 00:00:00

abstract：:We report on two cases who presented with involuntary facial grimacing and frowning. Blepharospasm has never been documented in one, and the other case showed difficulty in lid opening only in the early phase of the disease. Botulinum toxin was effective for both. This is a hitherto unreported presentation of upper fa...

journal_title：Parkinsonism & related disorders

authors： Hirota N,Hirota M,Mezaki T

更新日期：2008-11-01 00:00:00

abstract：INTRODUCTION:We performed a systematic review and Bayesian network meta-analysis to clarify the relative efficacy and safety of pimavanserin compared to atypical antipsychotics for psychosis in Parkinson's disease (PD). METHODS:PubMed, Embase, Cochrane Central Register of Controlled Trials, and Japana Centra Revuo Med...

journal_title：Parkinsonism & related disorders

authors： Iketani R,Furushima D,Imai S,Yamada H

更新日期：2020-09-01 00:00:00

abstract：:The goal of genetic association studies is to identify common (>5%) risk factors in complex disease traits. Herein we describe the first replicable 'functional' risk allele for Parkinson's disease. The leucine-rich repeat kinase 2 (Lrrk2) G2385R substitution is associated with familial parkinsonism, late-, and early-o...

journal_title：Parkinsonism & related disorders

authors： Farrer MJ,Stone JT,Lin CH,Dächsel JC,Hulihan MM,Haugarvoll K,Ross OA,Wu RM

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:Punctual delivery of dopaminergic medication to Parkinson's disease (PD) patients may be important in optimizing disease control. We tested the hypothesis that prompt delivery of l-dopa medications to emergency hospital inpatients was associated with a decreased length of stay in hospital. METHODS:The study...

journal_title：Parkinsonism & related disorders

authors： Skelly R,Brown L,Fogarty A

更新日期：2017-02-01 00:00:00

abstract：OBJECTIVE:Several evidences demonstrated the role of white matter (WM) lesions in the pathogenesis of Vascular Parkinsonism (VP), a clinical entity characterized by parkinsonism, postural instability, marked gait difficulty and poor response to levodopa. However, the involvement of normal appearing white matter (NAWM) ...

journal_title：Parkinsonism & related disorders

authors： Salsone M,Caligiuri ME,Vescio V,Arabia G,Cherubini A,Nicoletti G,Morelli M,Quattrone A,Vescio B,Nisticò R,Novellino F,Cascini GL,Sabatini U,Montilla M,Rektor I,Quattrone A

更新日期：2019-06-01 00:00:00

abstract：:Laryngeal hypokinesia is a common symptom in Parkinson's disease (PD) that affects quality of life. Deep brain stimulation (DBS) is well recognized as a complementary method for treatment of motor symptoms in PD but the outcomes on patients' control over phonatory alternation have yet not been clearly elucidated. The ...

journal_title：Parkinsonism & related disorders

authors： Karlsson F,Blomstedt P,Olofsson K,Linder J,Nordh E,van Doorn J

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:Clinical differentiation between parkinsonian syndromes (PS) remains a challenge despite well-established clinical diagnostic criteria. Specific diagnostic biomarkers have yet to be identified, though in recent years, studies have been published on the aid of certain brain related proteins (BRP) in the diagn...

journal_title：Parkinsonism & related disorders

authors： Bech S,Hjermind LE,Salvesen L,Nielsen JE,Heegaard NH,Jørgensen HL,Rosengren L,Blennow K,Zetterberg H,Winge K

更新日期：2012-01-01 00:00:00

abstract：:Recent studies delineate substantial genetic components in Parkinson's disease (PD). However, very few studies were performed in Sub-Saharan African populations. Here, we explore the contribution of known PD-causing genes in patients of indigenous Zambian ancestry. We studied thirty-nine Zambian patients, thirty-eight...

journal_title：Parkinsonism & related disorders

authors： Yonova-Doing E,Atadzhanov M,Quadri M,Kelly P,Shawa N,Musonda ST,Simons EJ,Breedveld GJ,Oostra BA,Bonifati V

更新日期：2012-06-01 00:00:00

abstract：INTRODUCTION:Physical inactivity in Parkinson disease (PD) has an impact on motor and non-motor symptoms of the disease. It is unclear whether this decline in physical activity occurs early in the disease, in addition to any decline due to aging, and whether commercial activity monitors can be used to self-monitor phys...

journal_title：Parkinsonism & related disorders

authors： Pradhan S,Kelly VE

更新日期：2019-09-01 00:00:00

abstract：:Parkinson's disease (PD) is characterized by a dramatic loss of dopamine that underlies complex structural and functional changes in striatal projection neurons. A key alteration that has been reported in various rodent models and PD patients is a significant reduction in striatal dendritic spine density. Our recent f...

journal_title：Parkinsonism & related disorders

authors： Smith Y,Villalba RM,Raju DV

更新日期：2009-12-01 00:00:00

abstract：:Benign hereditary chorea (BHC, MIM 118700) is a rare autosomal dominant disorder manifesting with chorea in conjunction with hypothyroidism and respiratory problems, a triad also named "brain-lung-thyroid syndrome". BHC is characterized by childhood onset with minimal or no progression into adult life and normal cogni...

journal_title：Parkinsonism & related disorders

authors： Inzelberg R,Weinberger M,Gak E

更新日期：2011-06-01 00:00:00

abstract：:Knowledge of molecular events contributing to motor dysfunction in Parkinson's disease has advanced rapidly during the past decade. Studies in animal models as well as in patients afflicted by this disorder suggest that the nonphysiologic stimulation of striatal dopamine receptors, first as a result of dopaminergic de...

journal_title：Parkinsonism & related disorders

authors： Chase TN

更新日期：2004-07-01 00:00:00

abstract：OBJECTIVE:To explore the microstructural integrity of the optic nerve and its role as a cognitive predictor in patients with de novo Parkinson's disease (PD) using diffusion tensor image-based magnetic resonance scans. METHODS:We enrolled 82 patients with de novo PD, 36 patients with drug-induced parkinsonism (DIP), a...

journal_title：Parkinsonism & related disorders

authors： Lee JJ,Shin NY,Lee Y,Lee SK,Sohn YH,Lee PH

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:No effective treatment for tardive dystonia (TD) has been well established. Deep brain stimulation (DBS) can ameliorate motor manifestations in primary dystonia, and may also be an effective approach for TD. OBJECTIVES:This study aimed to illuminate the long-term efficacy and safety of subthalamic nucleus (...

journal_title：Parkinsonism & related disorders

authors： Deng ZD,Li DY,Zhang CC,Pan YX,Zhang J,Jin H,Zeljec K,Zhan SK,Sun BM

更新日期：2017-08-01 00:00:00

abstract：:Clinicogenetic and pathological studies have shown that mutations of the glucocerebrosidase gene (GBA) are a risk factor for Parkinson's disease and Lewy body disorders. In the present study, we have identified GBA mutations in 6.8% (4/59) of cases with a pathological diagnosis of diffuse Lewy body disease. Taken with...

journal_title：Parkinsonism & related disorders

authors： Nishioka K,Ross OA,Vilariño-Güell C,Cobb SA,Kachergus JM,Mann DM,Snowden J,Richardson AM,Neary D,Robinson CA,Rajput A,Papapetropoulos S,Mash DC,Pahwa R,Lyons KE,Wszolek ZK,Dickson DW,Farrer MJ

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy of solifenacin succinate in Parkinson's disease (PD) patients suffering from overactive bladder (OAB). BACKGROUND:Urinary dysfunction is a commonly encountered non-motor feature in PD that significantly impacts patient quality of life. DESIGN/METHODS:This was a double-blind, randomi...

journal_title：Parkinsonism & related disorders

authors： Zesiewicz TA,Evatt M,Vaughan CP,Jahan I,Singer C,Ordorica R,Salemi JL,Shaw JD,Sullivan KL,Non-Motor Working Group of the Parkinson Study Group (PSG).

更新日期：2015-05-01 00:00:00