Abstract：
OBJECTIVE:To investigate the indications and the outcomes of gastrostomy tube insertion in patients with parkinsonian syndromes. METHODS:Consecutive patients with Parkinson's disease or atypical parkinsonism, seen in two French tertiary referral movement disorders centers, that received gastrostomy tube insertion (GTI) for feeding between 2008 and 2014 were included in this retrospective study. Data regarding clinical status, indications and outcomes were retrieved from medical files. The main outcome measure was survival duration following gastrostomy insertion according to Kaplan-Meier estimate. Cox analysis was also performed to identify factors associated with survival. Finally, we described short term and long term adverse effects occurring during the follow-up period. RESULTS:We identified 33 patients with Parkinsonism that received GTI during the study period. One patient was excluded from the analysis because of missing data. Among 32 patients, 7 (22%) had Parkinson's disease and 25 (78%) had atypical parkinsonism. The median survival following the procedure was 186 days (CI 95% [62-309]). In Cox model analysis, total dependency was the only factor negatively associated with survival (HR 0.1; 95% CI [0.02-0.4], p = 0.001). Pneumonia was the most frequent adverse event. CONCLUSION:In this sample of patients with parkinsonian syndromes, survival after GTI was short particularly in totally dependent subjects. Aspiration pneumonia was not prevented by GTI. A larger prospective study is warranted to assess the potential benefits of gastrostomy, in order to identify the most appropriate indications and timing for the procedure.
journal_name
Parkinsonism Relat Disordjournal_title
Parkinsonism & related disordersauthors
Marois C,Amador MDM,Payan C,Lacomblez L,Bonnet AM,Degos B,Corvol JC,Vidailhet M,Le Forestier N,Mesnage V,Grabli Ddoi
10.1016/j.parkreldis.2017.06.012subject
Has Abstractpub_date
2017-10-01 00:00:00pages
110-113eissn
1353-8020issn
1873-5126pii
S1353-8020(17)30219-5journal_volume
43pub_type
杂志文章abstract：OBJECTIVE:The aim of this study was to compare the short- and long-term outcomes of bilateral subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD) patients with and without probable REM sleep behavior disorder (RBD). METHODS:We retrospectively reviewed 127 patients who underwent bilateral S...
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journal_title：Parkinsonism & related disorders
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journal_title：Parkinsonism & related disorders
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journal_title：Parkinsonism & related disorders
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abstract：OBJECTIVE:Invasive techniques such as in-vivo microdialysis provide the opportunity to directly assess neurotransmitter levels in subcortical brain areas. METHODS:Five male Filipino patients (mean age 42.4, range 34-52 years) with severe X-linked dystonia-parkinsonism underwent bilateral implantation of deep brain lea...
journal_title：Parkinsonism & related disorders
pub_type： 杂志文章
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abstract：AIM:To clarify the characteristics of hemodynamic responses to exercise and orthostasis in Parkinson's disease patients, especially those with autonomic failure. METHODS:Clinical audit of supine cycling exercise test data (with active standing tests pre- and post-exercise) of Parkinson's patients with autonomic dysfun...
journal_title：Parkinsonism & related disorders
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journal_title：Parkinsonism & related disorders
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journal_title：Parkinsonism & related disorders
pub_type： 杂志文章
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journal_title：Parkinsonism & related disorders
pub_type： 杂志文章,多中心研究
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journal_title：Parkinsonism & related disorders
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journal_title：Parkinsonism & related disorders
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journal_title：Parkinsonism & related disorders
pub_type： 杂志文章,多中心研究,随机对照试验
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journal_title：Parkinsonism & related disorders
pub_type： 杂志文章,评审
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journal_title：Parkinsonism & related disorders
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journal_title：Parkinsonism & related disorders
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journal_title：Parkinsonism & related disorders
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journal_title：Parkinsonism & related disorders
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journal_title：Parkinsonism & related disorders
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journal_title：Parkinsonism & related disorders
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journal_title：Parkinsonism & related disorders
pub_type： 杂志文章
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journal_title：Parkinsonism & related disorders
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journal_title：Parkinsonism & related disorders
pub_type： 杂志文章
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