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Cognitive and psychiatric outcome 3 years after globus pallidus pars interna or subthalamic nucleus deep brain stimulation for Parkinson's disease.

Abstract：

BACKGROUND:Effects on non-motor symptoms, mainly cognitive and psychiatric side effects, could influence the decision for either globus pallidus pars interna (GPi) or subthalamic nucleus (STN) deep brain stimulation (DBS) for patients with Parkinson's disease (PD). OBJECTIVE:1) To compare cognitive and psychiatric outcomes 3 years after GPi DBS versus STN DBS, and 2) to report on occurrence of suicidal ideation, psychiatric diagnoses, social functioning, and marital satisfaction 3 years after DBS. METHODS:Patients were randomized to receive GPi DBS (n = 65) or STN DBS (n = 63). Standardized assessments were performed at baseline, 1 year, and 3 years. We used linear mixed model analyses to investigate between-group differences on the Mattis Dementia Rating Scale (MDRS), neuropsychological tests, and psychiatric questionnaires 3 years after DBS. RESULTS:Eighty-seven patients (68%) completed at least one neuropsychological test after 3 years. No significant between-group differences were found on the MDRS (p = 0.61), neuropsychological tests (p-values between 0.17 and 0.87), and psychiatric questionnaires (p-values between 0.23 and 0.88) 3 years after DBS. The Mini International Neuropsychiatric Interview did not indicate a substantial number of psychiatric diagnoses after 3 years. Social functioning and marital satisfaction were comparable in both groups. CONCLUSIONS:Three years after GPi DBS and STN DBS no pronounced between-group differences on measures of cognitive and psychiatric functioning could be demonstrated. Overall, cognitive and psychiatric outcome 3 years after DBS do not provide a clear direction for clinicians when considering which of these two surgical targets to choose.

journal_name

Parkinsonism Relat Disord

journal_title

Parkinsonism & related disorders

authors

Boel JA,Odekerken VJ,Schmand BA,Geurtsen GJ,Cath DC,Figee M,van den Munckhof P,de Haan RJ,Schuurman PR,de Bie RM,NSTAPS study group.

doi

10.1016/j.parkreldis.2016.09.018

subject

Has Abstract

pub_date

2016-12-01 00:00:00

pages

90-95

eissn

1353-8020

issn

1873-5126

pii

S1353-8020(16)30369-8

journal_volume

33

pub_type

杂志文章,多中心研究

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