当前位置： SCI文献检索 > PARKINSONISM & RELATED DISORDERS期刊下所有文献 > The pimple sign of progressive supranuclear palsy syndrome.

The pimple sign of progressive supranuclear palsy syndrome.

Abstract：

BACKGROUND:Some patients with progressive supranuclear palsy syndrome (PSPS) demonstrate a focal area of midbrain hypometabolism on FDG-PET scans which we call the 'pimple sign'. We assessed its association with midbrain atrophy, its reliability and its ability to differentiate PSPS from corticobasal syndrome (CBS) and multiple system atrophy (MSA). METHODS:We identified 67 patients with PSPS, CBS or MSA who had volumetric MRI as well as FDG-PET imaging. Midbrain volume was measured and expressed as a percentage of total intracranial volume. Two independent, blinded specialists rated the 'pimple sign' on FDG-PET as 'absent', 'possible' or 'definite'. Midbrain volumes were compared across these groups and reliability assessed with the kappa statistic. Sensitivity and specificity were calculated using CBS and MSA patients as controls. RESULTS:Midbrain volume was decreased in the 'definite' group compared to the 'absent' and 'possible' groups (p = 0.0036). Inter-rater reliability for the pimple sign was high (κ = 0.90). A 'definite pimple sign' had a high specificity (100%) but low sensitivity (29%) for PSPS, whilst the presence of a possible or definite sign had a sensitivity of 79%. CONCLUSION:The 'pimple sign' of PSPS is associated with midbrain atrophy, and may be helpful in differentiating PSPS from CBS and MSA.

journal_name

Parkinsonism Relat Disord

journal_title

Parkinsonism & related disorders

authors

Botha H,Whitwell JL,Madhaven A,Senjem ML,Lowe V,Josephs KA

doi

10.1016/j.parkreldis.2013.10.023

subject

Has Abstract

pub_date

2014-02-01 00:00:00

pages

180-5

issue

2

eissn

1353-8020

issn

1873-5126

pii

S1353-8020(13)00386-6

journal_volume

20

pub_type

杂志文章

相关文献

PARKINSONISM & RELATED DISORDERS文献大全
  • Urinary 8-hydroxydeoxyguanosine correlate with hallucinations rather than motor symptoms in Parkinson's disease.

    abstract：BACKGROUND:Oxidative stress is causally associated with the pathogenesis of Parkinson's disease (PD). Oxygen generates a large amount of reactive oxygen species (ROS). ROS including hydroxyl radicals and H(2)O(2) react with guanine residues in DNA and produce 8-hydroxydeoxyguanosine (8-OHdG). 8-OHdG serves as a biomark...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2010.11.004

    authors： Hirayama M,Nakamura T,Watanabe H,Uchida K,Hama T,Hara T,Niimi Y,Ito M,Ohno K,Sobue G

    更新日期：2011-01-01 00:00:00

  • Utility of quantitative EEG in early Lewy body disease.

    abstract：INTRODUCTION:The reduction of background activity and the increase of low-frequency powers on electroencephalogram (EEG) correlate with cognitive impairment and have been suggested to be underpinned by cholinergic deficit. We aimed to investigate the ratio between α and θ band power (α/θ ratio), as a synoptic index of ...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2020.05.007

    authors： Massa F,Meli R,Grazzini M,Famà F,De Carli F,Filippi L,Arnaldi D,Pardini M,Morbelli S,Nobili F

    更新日期：2020-06-01 00:00:00

  • Exercise hemodynamics in Parkinson's disease and autonomic dysfunction.

    abstract：AIM:To clarify the characteristics of hemodynamic responses to exercise and orthostasis in Parkinson's disease patients, especially those with autonomic failure. METHODS:Clinical audit of supine cycling exercise test data (with active standing tests pre- and post-exercise) of Parkinson's patients with autonomic dysfun...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2014.02.006

    authors： Low DA,Vichayanrat E,Iodice V,Mathias CJ

    更新日期：2014-05-01 00:00:00

  • Explosive-aggressive behavior related to bilateral subthalamic stimulation.

    abstract：:We describe a patient with Parkinson's Disease who underwent bilateral subthalamic nucleus deep brain stimulation and later presented with episodes of aggressive behavior disorder with disturbed impulse control and an inability to control anger likely related to the deep brain stimulation "switch-on stimulation". We h...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2004.01.007

    authors： Sensi M,Eleopra R,Cavallo MA,Sette E,Milani P,Quatrale R,Capone JG,Tugnoli V,Tola MR,Granieri E,Data PG

    更新日期：2004-06-01 00:00:00

  • Middle latency auditory evoked potentials in patients with parkinsonism.

    abstract：:The aim of this study was to assess the middle latency auditory evoked potential (MLAEP) findings in idiopathic Parkinson's disease (IPD) and in patients who are regarded as having atypical parkinsonian disorders (AP) and to determine whether MLAEPs could contribute to the differential diagnosis of IPD and AP.MLAEPs w...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/s1353-8020(99)00056-5

    authors： Çelik M,Seleker FK,Sucu H,Forta H

    更新日期：2000-04-01 00:00:00

  • Diaphragmatic myoclonus owing to electrode dislocation of implantable cardioverter defibrillator.

    abstract：:Myoclonus is a sudden and brief involuntary muscle contraction presenting with jerk-like movements that can occasionally involve the trunk muscles or the diaphragm as in the case of spinal myoclonus1. We here present an unusual case with unilateral diaphragmatic myoclonus owing to electrode dislocation of an implantab...

    journal_title：Parkinsonism & related disorders

    pub_type： 信件

    doi：10.1016/j.parkreldis.2019.03.004

    authors： Bedarf JR,Nitsch L,Malotki R,Andrié R,Reimann J

    更新日期：2019-06-01 00:00:00

  • Gender and onset age-related features of non-motor symptoms of patients with Parkinson's disease--a study from Southwest China.

    abstract：BACKGROUND:Non-motor symptom (NMS) differences between male Parkinson's disease (PD) and female PD, and between early-onset PD (EOPD) and late-onset PD (LOPD) in Chinese populations remain largely unknown. METHODS:A total of 522 PD patients from Southwest China were included. Patients were assessed using the Non-Motor...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2013.06.009

    authors： Guo X,Song W,Chen K,Chen X,Zheng Z,Cao B,Huang R,Zhao B,Wu Y,Shang HF

    更新日期：2013-11-01 00:00:00

  • Organization of midbrain dopamine systems and the pathophysiology of Parkinson's disease.

    abstract：:Understanding of the pathophysiology of Parkinson disease (PD) has advanced rapidly over the last two decades through basic and clinical studies using modern neuroanatomical, clinical assessment, neuropathological and functional brain imaging methods. Two interacting processes determine the development of functional i...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,评审

    doi：10.1016/s1353-8020(03)00063-4

    authors： Moore RY

    更新日期：2003-08-01 00:00:00

  • Microstructural changes of normal-appearing white matter in Vascular Parkinsonism.

    abstract：OBJECTIVE:Several evidences demonstrated the role of white matter (WM) lesions in the pathogenesis of Vascular Parkinsonism (VP), a clinical entity characterized by parkinsonism, postural instability, marked gait difficulty and poor response to levodopa. However, the involvement of normal appearing white matter (NAWM) ...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2019.02.046

    authors： Salsone M,Caligiuri ME,Vescio V,Arabia G,Cherubini A,Nicoletti G,Morelli M,Quattrone A,Vescio B,Nisticò R,Novellino F,Cascini GL,Sabatini U,Montilla M,Rektor I,Quattrone A

    更新日期：2019-06-01 00:00:00

  • Effects of augmented visual feedback during balance training in Parkinson's disease: a pilot randomized clinical trial.

    abstract：BACKGROUND:Balance training has been demonstrated to improve postural control in patients with Parkinson's disease (PD). The objective of this pilot randomized clinical trial was to investigate whether a balance training program using augmented visual feedback is feasible, safe, and more effective than conventional bal...

    journal_title：Parkinsonism & related disorders

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.parkreldis.2014.09.022

    authors： van den Heuvel MR,Kwakkel G,Beek PJ,Berendse HW,Daffertshofer A,van Wegen EE

    更新日期：2014-12-01 00:00:00

  • Behavioural assessment of dysexecutive syndrome in Parkinson's disease without dementia: a comparison with other clinical executive tasks.

    abstract：:The Behavioural Assessment of the Dysexecutive Syndrome (BADS) is a neuropsychological battery developed with the intent of measuring a wide range of executive impairments. Although the psychometric characteristics of BADS have previously been investigated in distinct neurological disorders, data on its validity in Pa...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2009.07.011

    authors： Perfetti B,Varanese S,Mercuri P,Mancino E,Saggino A,Onofrj M

    更新日期：2010-01-01 00:00:00

  • Gaba and serotonin molecular neuroimaging in essential tremor: a clinical correlation study.

    abstract：BACKGROUND:Essential tremor is the most common movement disorder in adults, but its exact etiology and pathophysiology are still not fully understood. There is some consensus, however, about the involvement of the cerebellum and accumulating evidence points towards a dysfunction of the gabaergic system. We hypothesize ...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2012.04.024

    authors： Gironell A,Figueiras FP,Pagonabarraga J,Herance JR,Pascual-Sedano B,Trampal C,Gispert JD

    更新日期：2012-08-01 00:00:00

  • Changes in quality of life, burden and mood among spouses of Parkinson's disease patients receiving neurostimulation.

    abstract：BACKGROUND:Deep brain stimulation improves motor function and quality of life in patients with Parkinson's disease. The impact of these changes on patients' spouses is largely unknown. METHODS:Twenty-six spouses of patients undergoing surgery were evaluated before and 12 months after surgery, using the 36-Item Short F...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2011.11.008

    authors： Soulas T,Sultan S,Gurruchaga JM,Palfi S,Fénelon G

    更新日期：2012-06-01 00:00:00

  • Levodopa and neuropathy risk in patients with Parkinson disease: Effect of COMT inhibition.

    abstract：OBJECTIVE:Our purpose was to determine whether the use of catechol-O-methyltransferase-inhibitors (ICOMT) can reduce the risk of developing levodopa (LD)-induced neuropathy in Parkinson's disease (PD) patients. METHODS:A multicentre study of 197 PD patients was performed. 144 were exposed to LD for more than three yea...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.parkreldis.2016.04.016

    authors： Cossu G,Ceravolo R,Zibetti M,Arca R,Ricchi V,Paribello A,Murgia D,Merola A,Romagnolo A,Nicoletti V,Palermo G,Mereu A,Lopiano L,Melis M,Abbruzzese G,Bonuccelli U

    更新日期：2016-06-01 00:00:00

  • Impairment of complex upper limb motor function in de novo Parkinson's disease.

    abstract：:The aim of the present study was to evaluate complex upper limb motor function in newly diagnosed, untreated Parkinson's disease (PD) patients. Four different unimanual upper limb motor tasks were applied to 13 newly diagnosed, untreated PD patients and 13 age- and sex-matched controls. In a handwriting task, PD patie...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2007.07.019

    authors： Ponsen MM,Daffertshofer A,Wolters ECh,Beek PJ,Berendse HW

    更新日期：2008-01-01 00:00:00

  • Astrocytes and microglia in the substantia nigra and caudate-putamen in Parkinson's disease.

    abstract：:There is evidence that astrocytes and microglia can release agents which might have a protective effect on damaged neurons. However the associations of glia with dopaminergic neurons in Parkinson's disease are not defined. Our studies showed that in post mortem parkinsonian nigra healthy neuronal somata were enveloped...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/s1353-8020(99)00022-x

    authors： Knott C,Wilkin GP,Stern G

    更新日期：1999-09-01 00:00:00

  • Diagnostic accuracy of [99mTc]TRODAT-1 SPECT imaging in early Parkinson's disease.

    abstract：:We evaluated the diagnostic accuracy of SPECT imaging using [(99m)Tc]TRODAT-1 (TRODAT), a relatively inexpensive technetium-labeled dopamine transporter ligand, in distinguishing 29 patients with early PD from 38 healthy volunteers. Mean TRODAT uptake values were significantly decreased in the caudate (p=0.0097) and a...

    journal_title：Parkinsonism & related disorders

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.parkreldis.2004.04.002

    authors： Chou KL,Hurtig HI,Stern MB,Colcher A,Ravina B,Newberg A,Mozley PD,Siderowf A

    更新日期：2004-08-01 00:00:00

  • Serum uric acid level as a putative biomarker in Parkinson's disease patients carrying GBA1 mutations: 2-Year data from the PPMI study.

    abstract：INTRODUCTION:Blood uric acid represents an important biomarker in sporadic Parkinson's disease (PD). Whether uric acid levels change in genetic forms of PD is beginning to be assessed. The aim of the present study was to evaluate differences in serum uric acid level among PD patients harboring mutations in the glucocer...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2020.12.020

    authors： Koros C,Simitsi AM,Papagiannakis N,Bougea A,Prentakis A,Papadimitriou D,Pachi I,Antonelou R,Angelopoulou E,Beratis I,Bozi M,Papageorgiou SG,Trapali XG,Stamelou M,Stefanis L

    更新日期：2021-01-20 00:00:00

  • Quality of life outcomes after deep brain stimulation in dystonia: A systematic review.

    abstract：:Dystonia is an incurable movement disorder which can cause not only physical but also mental problems, leading to impaired health-related quality of life (HRQoL). For patients with dystonia refractory to medical treatment, deep brain stimulation (DBS) is a well-established surgical treatment. The objective of this sys...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2019.11.016

    authors： Tsuboi T,Wong JK,Okun MS,Ramirez-Zamora A

    更新日期：2020-01-01 00:00:00

  • The medical treatment of patients with Parkinson's disease receiving subthalamic neurostimulation.

    abstract：INTRODUCTION:Deep brain stimulation of subthalamic nucleus (STN-DBS) for Parkinson's disease allows for a reduction in medication dosage. Changes in total levodopa equivalent daily dose (LEDD) have been frequently reported, there is little information about changes within the drug classes. METHODS:We retrospectively a...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2015.03.003

    authors： Alexoudi A,Shalash A,Knudsen K,Witt K,Mehdorn M,Volkmann J,Deuschl G

    更新日期：2015-06-01 00:00:00

  • Movement disorders in Latin America.

    abstract：:The authors review some particularities of movement disorders (MDs) in the ethnically diverse population of Latin America. Although idiopathic diseases are evenly prevalent, access to treatment encounters difficulties that are worth discussing. Infectious-parasitic diseases observed throughout the continent occasional...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,评审

    doi：10.1016/j.parkreldis.2005.08.009

    authors： Troiano AR,Micheli FE,Alarcón F,Teive HA

    更新日期：2006-04-01 00:00:00

  • Naftazone in advanced Parkinson's disease: An acute L-DOPA challenge randomized controlled trial.

    abstract：INTRODUCTION:There is an unmet need to better control motor complications in Parkinson's disease (PD). Naftazone, which exhibits glutamate release inhibition properties, has shown antiparkinsonian and antidyskinetic activity in preclinical models of PD and in a clinical proof of concept study. METHODS:We conducted a d...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.parkreldis.2018.10.005

    authors： Corvol JC,Durif F,Meissner WG,Azulay JP,Haddad R,Guimarães-Costa R,Mariani LL,Cormier-Dequaire F,Thalamas C,Galitzky M,Boraud T,Debilly B,Eusebio A,Houot M,Dellapina E,Chaigneau V,Salis A,Lacomblez L,Benel L,Rascol

    更新日期：2019-03-01 00:00:00

  • Striatal plasticity and extrapyramidal motor dysfunction.

    abstract：:Knowledge of molecular events contributing to motor dysfunction in Parkinson's disease has advanced rapidly during the past decade. Studies in animal models as well as in patients afflicted by this disorder suggest that the nonphysiologic stimulation of striatal dopamine receptors, first as a result of dopaminergic de...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,评审

    doi：10.1016/j.parkreldis.2004.02.012

    authors： Chase TN

    更新日期：2004-07-01 00:00:00

  • Voxel-wise analysis of diffusion tensor MRI improves the confidence of diagnosis of corticobasal degeneration non-invasively.

    abstract：:Corticobasal degeneration (CBD) presents with symptoms that often overlap with other neurological conditions. In many cases, diagnosis, prognosis and consequent clinical management remain uncertain. Structural and functional asymmetric brain changes represent the most consistent imaging findings that may assist in CBD...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2007.09.011

    authors： Bozzali M,Cercignani M,Baglio F,Scotti G,Farina E,Pugnetti L,Ashburner J,Nemni R,Falini A

    更新日期：2008-01-01 00:00:00

  • Apolipoprotein E ε4 genotype and risk of freezing of gait in Parkinson's disease.

    abstract：OBJECTIVE:To investigate the association between Apolipoprotein E (APOE) genotype and freezing of gait (FOG) in Parkinson's disease (PD). METHODS:This cohort study included 339 early PD patients who were divided into APOE ε4-positive (n = 88) and ε4-negative (n = 251) groups. They were followed-up for up to 6 years to...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2020.10.033

    authors： Kim R,Shin JH,Park S,Kim HJ,Jeon B

    更新日期：2020-12-01 00:00:00

  • Memory perception and strategy use in Parkinson's disease.

    abstract：:Although there is growing support for the existence of memory deficits within Parkinson's disease (PD), little has been done to evaluate the extent to which PD patients demonstrate differences in their use of metacognitive strategies. In the present study, 79 PD patients (46 men and 33 women) and 49 age-matched health...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2004.06.005

    authors： Johnson AM,Pollard CC,Vernon PA,Tomes JL,Jog MS

    更新日期：2005-03-01 00:00:00

  • Levodopa-responsive parkinsonism in hereditary spastic paraplegia with thin corpus callosum.

    abstract：:Hereditary spastic paraplegia with thin corpus callosum is a rare degenerative disease, which is characterized by a progressive weakness of the lower limbs with a hypoplastic corpus callosum, and is often associated with other symptoms such as mental impairment, amyotrophy, sensory disturbances, dysuria, nystagmus and...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2004.05.003

    authors： Kang SY,Lee MH,Lee SK,Sohn YH

    更新日期：2004-10-01 00:00:00

  • Inhibition of dopamine uptake into PC-12 cells by analogues of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

    abstract：:The inhibition of uptake of radioactive dopamine into PC-12 cells by analogues of MPTP with systematic variations of structure was studied in order to assess the steric constraints of the transmembrane dopamine transporter. Of 15 analogues tested, 11 were found to inhibit dopamine uptake, all being competitive inhibit...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/1353-8020(95)00020-8

    authors： Athwal NS,Ramsden DB,Simpson M,Williams AC

    更新日期：1996-01-01 00:00:00

  • Use of efficacy probability maps for the post-operative programming of deep brain stimulation in essential tremor.

    abstract：INTRODUCTION:Post-operative programming of deep brain stimulation for movement disorders can be both time consuming and difficult, which can delay the optimal symptom control for the patient. Probabilistic maps of stimulation response could improve programming efficiency and optimization. METHODS:The clinically select...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2014.09.004

    authors： Phibbs FT,Pallavaram S,Tolleson C,D'Haese PF,Dawant BM

    更新日期：2014-12-01 00:00:00

  • Quantifying physical activity in early Parkinson disease using a commercial activity monitor.

    abstract：INTRODUCTION:Physical inactivity in Parkinson disease (PD) has an impact on motor and non-motor symptoms of the disease. It is unclear whether this decline in physical activity occurs early in the disease, in addition to any decline due to aging, and whether commercial activity monitors can be used to self-monitor phys...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2019.08.001

    authors： Pradhan S,Kelly VE

    更新日期：2019-09-01 00:00:00