Explosive-aggressive behavior related to bilateral subthalamic stimulation.

abstract：:In patients with Idiopathic Parkinson's Disease (IPD) without a history of syncope the cardiovascular and cerebrovascular response to orthostatic stress was studied to search for subclinical impairment of autoregulatory mechanisms. Fifteen patients with IPD and 15 healthy age-matched controls were studied at rest and ...

journal_title：Parkinsonism & related disorders

authors： Niehaus L,Böckeler GC,Kupsch A,Meyer BU

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND:Clinical differentiation between parkinsonian syndromes (PS) remains a challenge despite well-established clinical diagnostic criteria. Specific diagnostic biomarkers have yet to be identified, though in recent years, studies have been published on the aid of certain brain related proteins (BRP) in the diagn...

journal_title：Parkinsonism & related disorders

authors： Bech S,Hjermind LE,Salvesen L,Nielsen JE,Heegaard NH,Jørgensen HL,Rosengren L,Blennow K,Zetterberg H,Winge K

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:Mutations in the PARK2 (Parkin) gene result in an early-onset autosomal recessive form of Parkinson Disease (EO-PD). Although the frequency of the PARK2 mutations in EO-PD patients according to several studies is high and has been reported in up to 50% in familial and 19% in sporadic cases, these data remain ...

journal_title：Parkinsonism & related disorders

authors： Koziorowski D,Hoffman-Zacharska D,Sławek J,Szirkowiec W,Janik P,Bal J,Friedman A

更新日期：2010-02-01 00:00:00

abstract：:Deep brain stimulation (DBS) is an effective surgical therapy for well-selected patients with medically intractable Parkinson's disease (PD) and essential tremor (ET). The purpose of this review is to describe the success of DBS in these two disorders and its promising application in dystonia, Tourette Syndrome (TS) a...

journal_title：Parkinsonism & related disorders

authors： Halpern C,Hurtig H,Jaggi J,Grossman M,Won M,Baltuch G

更新日期：2007-02-01 00:00:00

abstract：:Myoclonus-dystonia is an early onset genetic disorder characterised by subcortical myoclonus and less prominent dystonia. Its primary causative gene is the epsilon-sarcoglycan gene but the syndrome of "myoclonic dystonia" has been shown to be a heterogeneous group of genetic disorders. The underlying pathophysiology o...

journal_title：Parkinsonism & related disorders

authors： Fearon C,Peall KJ,Vidailhet M,Fasano A

更新日期：2020-08-01 00:00:00

abstract：:Parkinson disease (PD) reduces health-related quality of life (HRQoL), but exercise may improve HRQoL. This pilot study compared the effects of Tango, Waltz/Foxtrot, Tai Chi and No Intervention on HRQoL in individuals with PD. Seventy-five persons with PD (Hoehn and Yahr I-III) were assigned to 20 lessons of Tango, Wa...

journal_title：Parkinsonism & related disorders

authors： Hackney ME,Earhart GM

更新日期：2009-11-01 00:00:00

abstract：:A 68-year-old, normal female volunteer was scanned by positron emission tomography (PET) with [(18)F]6-L-fluorodopa (FD). Striatal FD uptake was in the high normal range. Subsequently, she developed parkinsonism 3.7 years after the scan. A repeat FD PET scan revealed a significant reduction of FD uptake by 20% over th...

journal_title：Parkinsonism & related disorders

authors： Shinotoh H,Vingerhoets FJ,Schulzer M,Snow BJ

更新日期：1996-07-01 00:00:00

abstract：INTRODUCTION:The sonographic appearance of the substantia nigra is abnormally bright and enlarged (hyperechogenic) in young adults with a history of illicit stimulant use. The abnormality is a risk factor for Parkinson's disease. The aim of the current study was to identify the type of illicit stimulant drug associated...

journal_title：Parkinsonism & related disorders

authors： Todd G,Pearson-Dennett V,Wilcox RA,Chau MT,Thoirs K,Thewlis D,Vogel AP,White JM

更新日期：2016-04-01 00:00:00

abstract：OBJECTIVE:To assess the association between diabetes preceding Parkinson's disease (PD) and PD. METHODS:PD individuals were matched to PD free individuals randomly selected from people in the same municipality as the cases. Occurrence of diabetes preceding PD onset among cases and controls was assessed through a struc...

journal_title：Parkinsonism & related disorders

authors： D'Amelio M,Ragonese P,Callari G,Di Benedetto N,Palmeri B,Terruso V,Salemi G,Famoso G,Aridon P,Savettieri G

更新日期：2009-11-01 00:00:00

abstract：:Dyskinesia is an important complication of treatment in Parkinson's disease (PD). Sarizotan, a 5-HT(1A) agonist with high affinity for D3 and D4 receptors was investigated on L-Dopa-induced dyskinesia (LID) in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) animal model of PD. Five MPTP female cynomolgus monke...

journal_title：Parkinsonism & related disorders

authors： Grégoire L,Samadi P,Graham J,Bédard PJ,Bartoszyk GD,Di Paolo T

更新日期：2009-07-01 00:00:00

abstract：:Levodopa is one of the most effective symptomatic treatment options for Parkinsonism with a favorable safety and tolerability profile. In some patients, particularly those suffering from orthostatic intolerance, the hypotensive effect of levodopa limits its therapeutic use. We used continuous noninvasive cardiovascula...

journal_title：Parkinsonism & related disorders

authors： Noack C,Schroeder C,Heusser K,Lipp A

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:Given the heterogeneity of mild cognitive deficits in non-demented Parkinson's disease (PD), sensitive and anatomically specific behavioural measures are crucial when evaluating cognition in this patient group. Inhibitory dysfunction is one such deficit increasingly being recognised in non-demented PD; howev...

journal_title：Parkinsonism & related disorders

authors： O'Callaghan C,Naismith SL,Shine JM,Bertoux M,Lewis SJ,Hornberger M

更新日期：2013-09-01 00:00:00

abstract：INTRODUCTION:Freezing of gait (FoG) is one of the most disabling gait disorders in Parkinson's disease (PD), reflecting motor and cognitive impairments, mainly related to dopamine deficiency. Recent studies investigating kinematic and kinetic factors affecting gait in these patients showed a postural instability charac...

journal_title：Parkinsonism & related disorders

authors： Mezzarobba S,Grassi M,Pellegrini L,Catalan M,Krüger B,Stragapede L,Manganotti P,Bernardis P

更新日期：2020-11-01 00:00:00

abstract：INTRODUCTION:PLA2G6-associated neurodegeneration (PLAN) comprises a continuum of three phenotypes with overlapping clinical and radiologic features. METHODS:Observational clinical study in a cohort of infantile and childhood onset PLAN patients and genetic analysis of the PLA2G6 gene. We analysed chronological evoluti...

journal_title：Parkinsonism & related disorders

authors： Darling A,Aguilera-Albesa S,Tello CA,Serrano M,Tomás M,Camino-León R,Fernández-Ramos J,Jiménez-Escrig A,Poó P,O'Callaghan M,Ortez C,Nascimento A,Fernández Mesaque RC,Madruga M,Arrabal L,Roldan S,Gómez-Martín H,Garrido C

更新日期：2019-04-01 00:00:00

abstract：:Excessive daytime sleepiness (EDS) is common in Parkinson's Disease (PD). Actigraphy uses periods of immobility as surrogate markers of nighttime sleep but there are no examples of its use in assessing EDS of PD. A commercial wrist worn system for measuring bradykinesia and dyskinesia also detects 2 min periods of imm...

journal_title：Parkinsonism & related disorders

authors： Kotschet K,Johnson W,McGregor S,Kettlewell J,Kyoong A,O'Driscoll DM,Turton AR,Griffiths RI,Horne MK

更新日期：2014-06-01 00:00:00

abstract：:We report the first instance of restless legs syndrome (RLS) associated with periodic limb movements (PLM) and disruption of sleep architecture occurring in a patient following ischemic infarction in the right lenticulostriate region. Recently, a role for the basal ganglia-brainstem system in the control of motor beha...

journal_title：Parkinsonism & related disorders

authors： Sechi G,Agnetti V,Galistu P,Murgia B,Marrosu F,Puligheddu M,Conti M,Paulus KS

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVE:To explore the microstructural integrity of the optic nerve and its role as a cognitive predictor in patients with de novo Parkinson's disease (PD) using diffusion tensor image-based magnetic resonance scans. METHODS:We enrolled 82 patients with de novo PD, 36 patients with drug-induced parkinsonism (DIP), a...

journal_title：Parkinsonism & related disorders

authors： Lee JJ,Shin NY,Lee Y,Lee SK,Sohn YH,Lee PH

更新日期：2016-10-01 00:00:00

abstract：INTRODUCTION:Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common genetic cause of Parkinson's disease (PD). However, only few cases carrying LRRK2 mutations have been reported in Taiwanese PD patients. METHODS:We used targeted next generation sequencing (NGS), covering 24 candidate genes involved in neu...

journal_title：Parkinsonism & related disorders

authors： Fan TS,Wu RM,Chen PL,Chen TF,Li HY,Lin YH,Chen CY,Chen ML,Tai CH,Lin HI,Lin CH

更新日期：2016-12-01 00:00:00

abstract：:The authors review some particularities of movement disorders (MDs) in the ethnically diverse population of Latin America. Although idiopathic diseases are evenly prevalent, access to treatment encounters difficulties that are worth discussing. Infectious-parasitic diseases observed throughout the continent occasional...

journal_title：Parkinsonism & related disorders

authors： Troiano AR,Micheli FE,Alarcón F,Teive HA

更新日期：2006-04-01 00:00:00

abstract：INTRODUCTION:The reduction of background activity and the increase of low-frequency powers on electroencephalogram (EEG) correlate with cognitive impairment and have been suggested to be underpinned by cholinergic deficit. We aimed to investigate the ratio between α and θ band power (α/θ ratio), as a synoptic index of ...

journal_title：Parkinsonism & related disorders

authors： Massa F,Meli R,Grazzini M,Famà F,De Carli F,Filippi L,Arnaldi D,Pardini M,Morbelli S,Nobili F

更新日期：2020-06-01 00:00:00

abstract：PURPOSE:To assess optimism/pessimism and locus of control in a sample of Parkinson's disease patients and to evaluate their impact on disability and health-related quality of life. METHODS:99 patients with Parkinson's disease completed the Life Orientation Test, Multidimensional Health Locus of Control, Older American...

journal_title：Parkinsonism & related disorders

authors： Gruber-Baldini AL,Ye J,Anderson KE,Shulman LM

更新日期：2009-11-01 00:00:00

abstract：:Although attentional impairments (particularly cognitive slowing) are frequent in Parkinson's disease (PD), the mechanisms underlying these phenomena have not been fully characterized. The MRI-compatible version of the Symbol Digit Modalities Test (SDMT) has been applied to healthy individuals but not previously to pa...

journal_title：Parkinsonism & related disorders

authors： Grolez G,Viard R,Lopes R,Kuchcinski G,Defebvre L,Devos D,Dujardin K,Moreau C

更新日期：2020-07-01 00:00:00

abstract：:Patients with advanced Parkinson's Disease (PD) may be eligible for Deep Brain Stimulation (DBS) in case of medication-related motor fluctuations or tremor refractory to oral medication. However, several PD symptoms are unresponsive to DBS and constitute relative contra-indications for DBS. Patients referred for DBS u...

journal_title：Parkinsonism & related disorders

authors： Geraedts VJ,Kuijf ML,van Hilten JJ,Marinus J,Oosterloo M,Contarino MF

更新日期：2019-09-01 00:00:00

abstract：:Clinicogenetic and pathological studies have shown that mutations of the glucocerebrosidase gene (GBA) are a risk factor for Parkinson's disease and Lewy body disorders. In the present study, we have identified GBA mutations in 6.8% (4/59) of cases with a pathological diagnosis of diffuse Lewy body disease. Taken with...

journal_title：Parkinsonism & related disorders

authors： Nishioka K,Ross OA,Vilariño-Güell C,Cobb SA,Kachergus JM,Mann DM,Snowden J,Richardson AM,Neary D,Robinson CA,Rajput A,Papapetropoulos S,Mash DC,Pahwa R,Lyons KE,Wszolek ZK,Dickson DW,Farrer MJ

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND/OBJECTIVE:Essential tremor (ET) can diminish functioning and quality of life (QOL) but generic QOL measures may be relatively insensitive to ET and its therapies. We sought to develop an ET-specific measure that might be more sensitive, acceptable to patients, relatively brief, and easily used. DESIGN/METHO...

journal_title：Parkinsonism & related disorders

authors： Tröster AI,Pahwa R,Fields JA,Tanner CM,Lyons KE

更新日期：2005-09-01 00:00:00

abstract：OBJECTIVE:To investigate the association between Apolipoprotein E (APOE) genotype and freezing of gait (FOG) in Parkinson's disease (PD). METHODS:This cohort study included 339 early PD patients who were divided into APOE ε4-positive (n = 88) and ε4-negative (n = 251) groups. They were followed-up for up to 6 years to...

journal_title：Parkinsonism & related disorders

authors： Kim R,Shin JH,Park S,Kim HJ,Jeon B

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Impulse control disorders in Parkinson's disease are a potential consequence of dopaminergic therapy. Impulse control problems might be revealed by intertemporal choice tasks which entail to forgo an immediately available reward in favor of a larger but later reward. The steepness of the discounting curve ca...

journal_title：Parkinsonism & related disorders

authors： Al-Khaled M,Heldmann M,Bolstorff I,Hagenah J,Münte TF

更新日期：2015-11-01 00:00:00

abstract：:Several forms of autosomal recessive parkinsonism are known. In three forms, caused by mutations in parkin (PARK2), PINK1 (PARK6), or DJ-1 (PARK7), the phenotype is usually characterized by levodopa-responsive parkinsonism without atypical features. Parkin mutations are most frequent, explaining -50% of the cases with...

journal_title：Parkinsonism & related disorders

authors： Bonifati V

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Oxidative stress is causally associated with the pathogenesis of Parkinson's disease (PD). Oxygen generates a large amount of reactive oxygen species (ROS). ROS including hydroxyl radicals and H(2)O(2) react with guanine residues in DNA and produce 8-hydroxydeoxyguanosine (8-OHdG). 8-OHdG serves as a biomark...

journal_title：Parkinsonism & related disorders

authors： Hirayama M,Nakamura T,Watanabe H,Uchida K,Hama T,Hara T,Niimi Y,Ito M,Ohno K,Sobue G

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:Mutations in the GBA gene are associated with Parkinson's disease (PD). A definite description of the clinical characteristics of PD patients who are compound heterozygotes or homozygotes for mutations in the GBA gene (GD-PD) requires further elucidation. METHODS:We assessed motor, cognitive, olfactory and a...

journal_title：Parkinsonism & related disorders

authors： Thaler A,Gurevich T,Bar Shira A,Gana Weisz M,Ash E,Shiner T,Orr-Urtreger A,Giladi N,Mirelman A

更新日期：2017-03-01 00:00:00