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Cardiovascular effects of levodopa in Parkinson's disease.

Abstract：

:Levodopa is one of the most effective symptomatic treatment options for Parkinsonism with a favorable safety and tolerability profile. In some patients, particularly those suffering from orthostatic intolerance, the hypotensive effect of levodopa limits its therapeutic use. We used continuous noninvasive cardiovascular and ventilatory monitoring in 17 patients suffering from moderate Parkinson's disease to quantify the hypotensive effect of levodopa and to determine whether this effect is rather vasodepressor or cardioinhibitory. Oral administration of 200 mg levodopa/50 mg benserazide induced a significant decrease in mean arterial pressure (-15%, p < 0.001), cardiac stroke volume (-13%, p < 0.01) and measures of cardiac contractility (dP/dt: -18%, p < 0.001). Systemic vascular resistance, heart rate and ventilatory parameters remained preserved. Our data indicate that the hypotensive blood pressure response to levodopa is caused primarily by a negative inotropic mechanism rather than peripheral vasodilation. Whether this effect is triggered peripherally at the level of the heart or is mediated via central sympathoinhibition remains unsolved.

journal_name

Parkinsonism Relat Disord

journal_title

Parkinsonism & related disorders

authors

Noack C,Schroeder C,Heusser K,Lipp A

doi

10.1016/j.parkreldis.2014.04.007

subject

Has Abstract

pub_date

2014-08-01 00:00:00

pages

815-8

issue

8

eissn

1353-8020

issn

1873-5126

pii

S1353-8020(14)00148-5

journal_volume

20

pub_type

临床试验,杂志文章

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