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Associations between daily-living physical activity and laboratory-based assessments of motor severity in patients with falls and Parkinson's disease.

Abstract：

INTRODUCTION:Recent work suggests that wearables can augment conventional measures of Parkinson's disease (PD). We evaluated the relationship between conventional measures of disease and motor severity (e.g., MDS-UPDRS part III), laboratory-based measures of gait and balance, and daily-living physical activity measures in patients with PD. METHODS:Data from 125 patients (age: 71.7 ± 6.5 years, Hoehn and Yahr: 1-3, 60.5% men) were analyzed. The MDS-UPDRS-part III was used as the gold standard of motor symptom severity. Gait and balance were quantified in the laboratory. Daily-living gait and physical activity metrics were extracted from an accelerometer worn on the lower back for 7 days. RESULTS:In multivariate analyses, daily-living physical activity and gait metrics, laboratory-based balance, demographics and subject characteristics together explained 46% of the variance in MDS-UPDRS-part III scores. Daily-living measures accounted for 62% of the explained variance, laboratory measures 30%, and demographics and subject characteristics 7% of the explained variance. Conversely, demographics and subject characteristics, laboratory-based measures of gait symmetry, and motor symptom severity together explained less than 30% of the variance in total daily-living physical activity. MDS-UPDRS-part III scores accounted for 13% of the explained variance, i.e., <4% of all the variance in total daily-living activity. CONCLUSIONS:Our findings suggest that conventional measures of motor symptom severity do not strongly reflect daily-living activity and that daily-living measures apparently provide important information that is not captured in a conventional one-time, laboratory assessment of gait, balance or the MDS-UPDRS. To provide a more complete evaluation, wearable devices should be considered.

journal_name

Parkinsonism Relat Disord

journal_title

Parkinsonism & related disorders

authors

Galperin I,Hillel I,Del Din S,Bekkers EMJ,Nieuwboer A,Abbruzzese G,Avanzino L,Nieuwhof F,Bloem BR,Rochester L,Della Croce U,Cereatti A,Giladi N,Mirelman A,Hausdorff JM

doi

10.1016/j.parkreldis.2019.01.022

subject

Has Abstract

pub_date

2019-05-01 00:00:00

pages

85-90

eissn

1353-8020

issn

1873-5126

pii

S1353-8020(19)30022-7

journal_volume

pub_type

杂志文章

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Associations between daily-living physical activity and laboratory-based assessments of motor severity in patients with falls and Parkinson's disease.