Involuntary movements associated with vitamin B12 deficiency.


:Involuntary movements are not a known feature of vitamin B12 (vB12) deficiency in adults, though they are a characteristic feature of vB12 deficiency in infants. This case report presents an adult patient with vB12 deficiency in whom, myoclonus-like muscular contractions appeared soon after the initiation of vB12 and disappeared after the first week of this therapy. To our knowledge, this is the first report of involuntary movements in an adult patient with vB12 deficiency. Although the mechanism remains unknown, involuntary movements similar to myoclonus should be considered as one of the extraordinary neurological manifestations of vB12 deficiency in adults.


Celik M,Barkut IK,Oncel C,Forta H




Has Abstract


2003-10-01 00:00:00














  • Wilson's disease with myoclonus and white matter lesions.

    abstract::White matter lesions (WML) and epilepsy have been occasionally seen in Wilson's disease. No cases of generalized myoclonus have been reported so far. We present a patient with psychiatric symptoms starting at age 16, followed by tremor, generalized dystonia and severe generalized myoclonus. In addition to classical fi...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章


    authors: Barbosa ER,Silveira-Moriyama L,Machado AC,Bacheschi LA,Rosemberg S,Scaff M

    更新日期:2007-04-01 00:00:00

  • Movement disorders in Latin America.

    abstract::The authors review some particularities of movement disorders (MDs) in the ethnically diverse population of Latin America. Although idiopathic diseases are evenly prevalent, access to treatment encounters difficulties that are worth discussing. Infectious-parasitic diseases observed throughout the continent occasional...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章,评审


    authors: Troiano AR,Micheli FE,Alarcón F,Teive HA

    更新日期:2006-04-01 00:00:00

  • A novel bedside task to tap inhibitory dysfunction and fronto-striatal atrophy in Parkinson's disease.

    abstract:BACKGROUND:Given the heterogeneity of mild cognitive deficits in non-demented Parkinson's disease (PD), sensitive and anatomically specific behavioural measures are crucial when evaluating cognition in this patient group. Inhibitory dysfunction is one such deficit increasingly being recognised in non-demented PD; howev...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章


    authors: O'Callaghan C,Naismith SL,Shine JM,Bertoux M,Lewis SJ,Hornberger M

    更新日期:2013-09-01 00:00:00

  • Young onset Hemifacial Spasm in patients with Chiari type I malformation.

    abstract::Hemifacial spasm (HFS) resulting from Chiari type I malformation (CIM) is rare. We retrospectively evaluated five patients with CIM and HFS among a series of 103 subjects. The frequency of HFS associated to CIM was of 4.85%. The clinical profile did not differ from the classical primary cases except for young-onset de...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章


    authors: Felício AC,de Godeiro C Jr,Borges V,de Azevedo Silva SM,Ferraz HB

    更新日期:2008-01-01 00:00:00

  • Factors associated with fall-related fractures in Parkinson's disease.

    abstract:PURPOSE:Fall-related fracture is one of the most disabling features of idiopathic Parkinson's disease (PD). A better understanding of the associated factors is needed to predict PD patients who will require treatment. METHODS:This prospective study enrolled 100 adult idiopathic PD patients. Stepwise logistic regressio...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章


    authors: Cheng KY,Lin WC,Chang WN,Lin TK,Tsai NW,Huang CC,Wang HC,Huang YC,Chang HW,Lin YJ,Lee LH,Cheng BC,Kung CT,Chang YT,Su CM,Chiang YF,Su YJ,Lu CH

    更新日期:2014-01-01 00:00:00

  • The next chapter in symptomatic Parkinson disease treatments.

    abstract::Significant advances in the symptomatic treatment of Parkinson disease (PD) have occurred since the discovery of levodopa (LD). Perhaps as a testament to its unparalleled efficacy, novel formulations aiming to optimize LD delivery to obtain better bioavailability, longer duration of effect and less plasma level fluctu...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章,评审


    authors: Hengartner D,Fernandez HH

    更新日期:2019-02-01 00:00:00

  • Neuropathology of Parkinson disease.

    abstract:INTRODUCTION:Parkinson's disease (PD) is characterized by bradykinesia, rigidity, postural instability and tremor. Several pathologic processes can produce this syndrome, but neurodegeneration accompanied by neuronal inclusions composed of α-synuclein (Lewy bodies) is considered the typical pathologic correlate of PD. ...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章,评审


    authors: Dickson DW

    更新日期:2018-01-01 00:00:00

  • The spiral axis as a clinical tool to distinguish essential tremor from dystonia cases.

    abstract:BACKGROUND:Tremor is a common feature of a variety of neurological disorders. In genetic studies of essential tremor (ET), investigators need to screen potential enrollees by mail or telephone to exclude those with other neurological conditions, especially dystonia. In clinical settings, the differentiation of ET and d...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章


    authors: Michalec M,Hernandez N,Clark LN,Louis ED

    更新日期:2014-05-01 00:00:00

  • Delayed administration of dopaminergic drugs is not associated with prolonged length of stay of hospitalized patients with Parkinson's disease.

    abstract:BACKGROUND:Punctual delivery of dopaminergic medication to Parkinson's disease (PD) patients may be important in optimizing disease control. We tested the hypothesis that prompt delivery of l-dopa medications to emergency hospital inpatients was associated with a decreased length of stay in hospital. METHODS:The study...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章


    authors: Skelly R,Brown L,Fogarty A

    更新日期:2017-02-01 00:00:00

  • Quantifying physical activity in early Parkinson disease using a commercial activity monitor.

    abstract:INTRODUCTION:Physical inactivity in Parkinson disease (PD) has an impact on motor and non-motor symptoms of the disease. It is unclear whether this decline in physical activity occurs early in the disease, in addition to any decline due to aging, and whether commercial activity monitors can be used to self-monitor phys...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章


    authors: Pradhan S,Kelly VE

    更新日期:2019-09-01 00:00:00

  • The effect of tau genotype on clinical features in FTDP-17.

    abstract::The clinical phenotype of frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17) varies. This variability is seen not only between kindreds with different mutations but also in families sharing the same mutation. Inheritance of tau haplotype (H1) and genotype (H1/H1) has been established as a risk...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章


    authors: Baba Y,Tsuboi Y,Baker MC,Uitti RJ,Hutton ML,Dickson DW,Farrer M,Putzke JD,Woodruff BK,Ghetti B,Murrell JR,Boeve BF,Petersen RC,Verpillat P,Brice A,Delisle MB,Rascol O,Arima K,Dysken MW,Yasuda M,Kobayashi T,Sunoh

    更新日期:2005-06-01 00:00:00

  • Predictors of onset of psychosis in patients with Parkinson's disease: Who gets it early?

    abstract:INTRODUCTION:Psychosis is one of the common non-motor symptoms of PD, which substantially worsens the quality of life. Hence, it is important to identify factors that are associated with early onset of psychosis in PD. In order to identify those factors, the current study aims to compare various demographic and clinica...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章


    authors: Lenka A,George L,Arumugham SS,Hegde S,Reddy V,Kamble N,Yadav R,Pal PK

    更新日期:2017-11-01 00:00:00

  • Subthalamic nucleus deep brain stimulation in early stage Parkinson's disease.

    abstract:BACKGROUND:Deep brain stimulation (DBS) is an effective and approved therapy for advanced Parkinson's disease (PD), and a recent study suggests efficacy in mid-stage disease. This manuscript reports the results of a pilot trial investigating preliminary safety and tolerability of DBS in early PD. METHODS:Thirty subjec...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章,随机对照试验


    authors: Charles D,Konrad PE,Neimat JS,Molinari AL,Tramontana MG,Finder SG,Gill CE,Bliton MJ,Kao C,Phibbs FT,Hedera P,Salomon RM,Cannard KR,Wang L,Song Y,Davis TL

    更新日期:2014-07-01 00:00:00

  • How to improve neuroprotection in Parkinson's disease?

    abstract::Several factors involved in the etiology of Parkinson's disease (PD) have been proposed, including genetic and environmental factors or even a combination of both. Thus, multiple cellular hits are likely to contribute to neurodegeneration in PD. If such a mechanism happens to occur, our therapeutic intervention may pe...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章,评审


    authors: Hirsch EC

    更新日期:2007-01-01 00:00:00

  • Gender and onset age-related features of non-motor symptoms of patients with Parkinson's disease--a study from Southwest China.

    abstract:BACKGROUND:Non-motor symptom (NMS) differences between male Parkinson's disease (PD) and female PD, and between early-onset PD (EOPD) and late-onset PD (LOPD) in Chinese populations remain largely unknown. METHODS:A total of 522 PD patients from Southwest China were included. Patients were assessed using the Non-Motor...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章


    authors: Guo X,Song W,Chen K,Chen X,Zheng Z,Cao B,Huang R,Zhao B,Wu Y,Shang HF

    更新日期:2013-11-01 00:00:00

  • Striatal plasticity and extrapyramidal motor dysfunction.

    abstract::Knowledge of molecular events contributing to motor dysfunction in Parkinson's disease has advanced rapidly during the past decade. Studies in animal models as well as in patients afflicted by this disorder suggest that the nonphysiologic stimulation of striatal dopamine receptors, first as a result of dopaminergic de...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章,评审


    authors: Chase TN

    更新日期:2004-07-01 00:00:00

  • The overlap between Essential tremor and Parkinson disease.

    abstract:INTRODUCTION:Essential tremor (ET) and Parkinson's disease (PD) are common disorders especially in the aging population and can have overlapping features that can make it difficult to differentiate between the two. In addition, a possible overlap from a pathophysiological standpoint has been often advocated in the past...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章,评审


    authors: Algarni M,Fasano A

    更新日期:2018-01-01 00:00:00

  • Prevalence and diagnostic challenge of dystonia in Thailand: a service-based study in a tertiary university referral centre.

    abstract::Although the subspeciality of movement disorders was established in neurology more than 20 years ago, it is relatively new in Thailand, and while most physicians are generally aware of Parkinson's disease, they often are not familiar with dystonia. As one of the common movement disorders seen in general practice, a nu...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章


    authors: Bhidayasiri R,Kaewwilai L,Wannachai N,Brenden N,Truong DD,Devahastin R

    更新日期:2011-11-01 00:00:00

  • Proton magnetic resonance spectroscopy of the striatum in Parkinson's disease patients with motor response fluctuations.

    abstract::We have performed proton magnetic resonance spectroscopy centred on the putamen contralateral to the worst affected side in 10 patients with idiopathic Parkinson's disease (PD) and motor response fluctuations and seven age matched healthy controls. In PD, there was striking reduction in the N-acetylaspartate (NAA) and...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章


    authors: Chaudhuri KR,Lemmens GM,Williams SC,Ellis C,Lloyd CM,Dawson J,Simmons A,Leigh PN

    更新日期:1996-04-01 00:00:00

  • Urinary 8-hydroxydeoxyguanosine correlate with hallucinations rather than motor symptoms in Parkinson's disease.

    abstract:BACKGROUND:Oxidative stress is causally associated with the pathogenesis of Parkinson's disease (PD). Oxygen generates a large amount of reactive oxygen species (ROS). ROS including hydroxyl radicals and H(2)O(2) react with guanine residues in DNA and produce 8-hydroxydeoxyguanosine (8-OHdG). 8-OHdG serves as a biomark...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章


    authors: Hirayama M,Nakamura T,Watanabe H,Uchida K,Hama T,Hara T,Niimi Y,Ito M,Ohno K,Sobue G

    更新日期:2011-01-01 00:00:00

  • Dystonia and tremor secondary to a pediatric thalamic stroke.

    abstract::A previously healthy 10-year-old girl developed a right hemiparesis with sensory loss secondary to a posterolateral thalamic infarct. Despite improvement in strength, three weeks later a 4 Hz kinetic tremor appeared in the right hand accompanied by dystonia in the right upper and lower limbs. Basal ganglia vascular le...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章


    authors: Micheli F,Cersósimo G,Palacios C,Scorticati MC,Tenembaum S,Típoli J

    更新日期:1998-10-01 00:00:00

  • From sweet to sweat: Hedonic olfactory range is impaired in Parkinson's disease.

    abstract:INTRODUCTION:Olfactory dysfunction and neuropsychological symptoms like depression and anhedonia are common non-motor symptoms in Parkinson's disease (PD). The assessment of both functional domains includes clinical examination, olfactory testing, and standardized questionnaires. While olfaction is readily assessed by ...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章


    authors: Mrochen A,Marxreiter F,Kohl Z,Schlachetzki J,Renner B,Schenk T,Winkler J,Klucken J

    更新日期:2016-01-01 00:00:00

  • Long-term outcome of 50 consecutive Parkinson's disease patients treated with subthalamic deep brain stimulation.

    abstract:OBJECTIVE:To describe the long-term outcome in 50 consecutive advanced Parkinson's disease (PD) patients treated with subthalamic nucleus deep brain stimulation (STN-DBS). METHOD:Assessments were carried out at baseline, 6 months, 2 years, and 5 years postoperatively. RESULTS:Compared to baseline scores without medic...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章


    authors: Wider C,Pollo C,Bloch J,Burkhard PR,Vingerhoets FJ

    更新日期:2008-01-01 00:00:00

  • Substantia nigra hyperechogenicity correlates with subtle motor dysfunction in tap dancers.

    abstract::Hyperechogenicity of the substantia nigra (SN) detected by transcranial sonography is a typical finding in more than 90% of patients with Parkinson's disease (PD) but may also be visible in about 9% of healthy adults. In this study, we found a correlation between SN hyperechogenicity and subtle motor dysfunction in ot...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章


    authors: Ruprecht-Dörfler P,Klotz P,Becker G,Berg D

    更新日期:2007-08-01 00:00:00

  • Glucocerebrosidase mutations in diffuse Lewy body disease.

    abstract::Clinicogenetic and pathological studies have shown that mutations of the glucocerebrosidase gene (GBA) are a risk factor for Parkinson's disease and Lewy body disorders. In the present study, we have identified GBA mutations in 6.8% (4/59) of cases with a pathological diagnosis of diffuse Lewy body disease. Taken with...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章


    authors: Nishioka K,Ross OA,Vilariño-Güell C,Cobb SA,Kachergus JM,Mann DM,Snowden J,Richardson AM,Neary D,Robinson CA,Rajput A,Papapetropoulos S,Mash DC,Pahwa R,Lyons KE,Wszolek ZK,Dickson DW,Farrer MJ

    更新日期:2011-01-01 00:00:00

  • Mouse models for LRRK2 Parkinson's disease.

    abstract::Parkinson's disease (PD) is the second most common neurodegenerative disease. Mutations in Leucine-rich-repeat-kinase 2 (LRRK2), the causative gene for PARK8 type PD with autosomal dominant inheritance, are the most prevalent genetic causes of both familial and sporadic PD. Animal models are critical tools in the atte...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章,评审


    authors: Xu Q,Shenoy S,Li C

    更新日期:2012-01-01 00:00:00

  • Patterns of brain atrophy in Parkinson's disease, progressive supranuclear palsy and multiple system atrophy.

    abstract:BACKGROUND AND PURPOSE:Quantitative analysis of brain atrophy may be useful in differentiating Parkinson's Disease (PD) from Progressive Supranuclear Palsy (PSP) and parkinsonian variant of Multiple System Atrophy (MSA-P); the aim of this study was to identify the volumetric differences of subcortical structures in pat...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章


    authors: Messina D,Cerasa A,Condino F,Arabia G,Novellino F,Nicoletti G,Salsone M,Morelli M,Lanza PL,Quattrone A

    更新日期:2011-03-01 00:00:00

  • Sensory neuropathy in autosomal recessive juvenile parkinsonism (PARK2).

    abstract::Autosomal recessive juvenile parkinsonism (ARJP/PARK2) is a distinct clinical and genetic entity characterized by early-onset levodopa-responsive parkinsonism, foot dystonia, sleep benefit, and hyperactive tendon reflexes. We report a patient with genetically confirmed ARJP, who showed mild sensory disturbance and dim...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章


    authors: Okuma Y,Hattori N,Mizuno Y

    更新日期:2003-06-01 00:00:00

  • Treatment of depression in Parkinson's disease with moclobemide: A pilot open-label study.

    abstract::Moclobemide, a potent reversible monoamine-oxidase A (MAO-A) inhibitor, is an effective antidepressant that does not cause impairment of cognitive function in elderly patients and might be beneficial to motor deficits in Parkinson's disease (PD). In a 12-week open-label prospective study, we administered moclobemide (...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章


    authors: Giménez-Roldán S,Dobato JL,Mateo D

    更新日期:1997-12-01 00:00:00

  • Prevalence and clinical associations of tau in Lewy body dementias: A systematic review and meta-analysis.

    abstract:INTRODUCTION:Alzheimer's disease neuropathologies (amyloid-β and tau) frequently co-exist to varying degrees in Lewy body dementias (LBD), which include dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD). OBJECTIVES:To investigate the prevalence of tau in DLB and PDD, and its associations with clin...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章,评审


    authors: Chin KS,Yassi N,Churilov L,Masters CL,Watson R

    更新日期:2020-11-01 00:00:00