Abstract：
BACKGROUND:Impulse control disorders in Parkinson's disease are a potential consequence of dopaminergic therapy. Impulse control problems might be revealed by intertemporal choice tasks which entail to forgo an immediately available reward in favor of a larger but later reward. The steepness of the discounting curve can be quantified by the parameter k. METHODS:Participants (37 Parkinson patients [13 de novo, 24 medicated], 24 patients with restless legs syndrome, and 22 controls) were offered 54 choices between immediate smaller rewards and delayed larger and the k value was estimated from the participants' responses. Participants had the chance of winning one of their decisions. None of the participants had impulse control disorders. RESULTS:Unmedicated Parkinson patients had a higher discounting rate than controls and medicated patients with restless legs syndrome. The k values of medicated Parkinson patients and patients with restless legs syndrome did not differ from those of controls. No correlation was found between the k value and the dopamine agonist dose. CONCLUSION:Impulsive decision making in patients with Parkinson's disease may occur as part of the disease rather than as a consequence of dopamine agonist therapy.
journal_name
Parkinsonism Relat Disordjournal_title
Parkinsonism & related disordersauthors
Al-Khaled M,Heldmann M,Bolstorff I,Hagenah J,Münte TFdoi
10.1016/j.parkreldis.2015.09.026subject
Has Abstractpub_date
2015-11-01 00:00:00pages
1330-5issue
11eissn
1353-8020issn
1873-5126pii
S1353-8020(15)00401-0journal_volume
21pub_type
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journal_title：Parkinsonism & related disorders
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journal_title：Parkinsonism & related disorders
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journal_title：Parkinsonism & related disorders
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journal_title：Parkinsonism & related disorders
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journal_title：Parkinsonism & related disorders
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journal_title：Parkinsonism & related disorders
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journal_title：Parkinsonism & related disorders
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journal_title：Parkinsonism & related disorders
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journal_title：Parkinsonism & related disorders
pub_type： 杂志文章,评审
doi：10.1016/j.parkreldis.2008.04.006
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journal_title：Parkinsonism & related disorders
pub_type： 杂志文章,多中心研究
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更新日期：2016-06-01 00:00:00
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