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The presymptomatic period in a patient with idiopathic parkinsonism.

Abstract：

:A 68-year-old, normal female volunteer was scanned by positron emission tomography (PET) with [(18)F]6-L-fluorodopa (FD). Striatal FD uptake was in the high normal range. Subsequently, she developed parkinsonism 3.7 years after the scan. A repeat FD PET scan revealed a significant reduction of FD uptake by 20% over the 5.2 year interval. Our observations suggest a relatively short presymptomatic period with fast initial losses of nigral neurons in idiopathic parkinsonism.

journal_name

Parkinsonism Relat Disord

journal_title

Parkinsonism & related disorders

authors

Shinotoh H,Vingerhoets FJ,Schulzer M,Snow BJ

doi

10.1016/1353-8020(96)00010-7

subject

Has Abstract

pub_date

1996-07-01 00:00:00

pages

127-30

issue

3

eissn

1353-8020

issn

1873-5126

pii

1353-8020(96)00010-7

journal_volume

2

pub_type

杂志文章

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