VIM deep brain stimulation does not improve pre-existing restless legs syndrome in patients with essential tremor.

Abstract:

:The neuroanatomic substrate for restless legs syndrome (RLS) is not known. We implanted deep brain stimulators into the ventralis intermedius nucleus (VIM) of the thalamus in nine subjects for essential tremor (ET) whom all concurrently had RLS. Although the VIM DBS improved tremor, none of the subjects felt there was any meaningful effect on their RLS symptoms. The VIM thalamus, which is involved in ET and Parkinson's disease, does not seem to be primarily involved in RLS.

authors

Ondo W

doi

10.1016/j.parkreldis.2004.10.015

subject

Has Abstract

pub_date

2006-03-01 00:00:00

pages

113-4

issue

2

eissn

1353-8020

issn

1873-5126

pii

S1353-8020(05)00240-3

journal_volume

12

pub_type

杂志文章
  • Timely levodopa (LD) administration prolongs survival in Parkinson's disease.

    abstract::Levodopa (LD) is the most effective drug for symptomatic control of Parkinsonism (PS). As prolonged LD therapy leads to response failure; is associated with adverse effects; may accelerate disease process, and its impact on life expectancy is controversial, delaying LD use has been recommended. We studied 934 PS cases...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/s1353-8020(97)00030-8

    authors: Rajput AH,Uitti RJ,Rajput AH,Offord KP

    更新日期:1997-11-01 00:00:00

  • Olfaction in Parkinson's disease.

    abstract::It has become increasingly apparent that Parkinson's disease (PD) can no longer be considered purely a motor disease, as numerous sensory alterations accompany this disorder either before or early in its clinical progression. Most notable among such disturbances are decrements in smell function. Such anomalies have be...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章,评审

    doi:10.1016/S1353-8020(08)70006-3

    authors: Doty RL

    更新日期:2007-01-01 00:00:00

  • The natural history of sex-linked recessive dystonia parkinsonism of Panay, Philippines (XDP).

    abstract::Sex-linked dystonia parkinsonism (XDP) was reported by Lee et al. in 1975 occurring endemically in Panay, Philippines. It is an adult onset, sex-linked, predominantly male, severe, progressive movement disorder with high penetrance and a high frequency of generalization. The movement disorder is characterized by dysto...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章,评审

    doi:10.1016/s1353-8020(02)00042-1

    authors: Lee LV,Maranon E,Demaisip C,Peralta O,Borres-Icasiano R,Arancillo J,Rivera C,Munoz E,Tan K,Reyes MT

    更新日期:2002-10-01 00:00:00

  • Risk and course of motor complications in a population-based incident Parkinson's disease cohort.

    abstract:BACKGROUND:Motor complications may become major challenges in the management of patients with Parkinson's disease. In this study, we sought to determine the incidence, risk factors, evolution, and treatment of motor fluctuations and dyskinesias in a population-representative, incident Parkinson's disease cohort. METHO...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2015.11.007

    authors: Bjornestad A,Forsaa EB,Pedersen KF,Tysnes OB,Larsen JP,Alves G

    更新日期:2016-01-01 00:00:00

  • Revisiting the impact of REM sleep behavior disorder on motor progression in Parkinson's disease.

    abstract:BACKGROUND:Estimation of progression in Parkinson's disease (PD) is useful to guide clinical decisions and to enable patients to plan and manage their life with PD. Rapid eye movement (REM) sleep behavior disorder (RBD) and REM sleep without atonia (RWA) are recognized as early harbingers of neurodegeneration and may p...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2014.01.005

    authors: Sommerauer M,Valko PO,Werth E,Poryazova R,Hauser S,Baumann CR

    更新日期:2014-04-01 00:00:00

  • Behavioural assessment of dysexecutive syndrome in Parkinson's disease without dementia: a comparison with other clinical executive tasks.

    abstract::The Behavioural Assessment of the Dysexecutive Syndrome (BADS) is a neuropsychological battery developed with the intent of measuring a wide range of executive impairments. Although the psychometric characteristics of BADS have previously been investigated in distinct neurological disorders, data on its validity in Pa...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2009.07.011

    authors: Perfetti B,Varanese S,Mercuri P,Mancino E,Saggino A,Onofrj M

    更新日期:2010-01-01 00:00:00

  • Treatment of acute Sydenham's chorea with methyl-prednisolone pulse-therapy.

    abstract::Serious adverse effects with antichoreic drugs can occur in patients with acute Sydenham's chorea (SC). The response to conventional treatment in severe SC may also be poor. Thus alternative therapeutic strategies have been developed. We report on four patients with severe acute SC (two with chorea paralytica and two ...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2005.02.007

    authors: Teixeira AL Jr,Maia DP,Cardoso F

    更新日期:2005-08-01 00:00:00

  • Involuntary movements associated with vitamin B12 deficiency.

    abstract::Involuntary movements are not a known feature of vitamin B12 (vB12) deficiency in adults, though they are a characteristic feature of vB12 deficiency in infants. This case report presents an adult patient with vB12 deficiency in whom, myoclonus-like muscular contractions appeared soon after the initiation of vB12 and ...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/s1353-8020(03)00065-8

    authors: Celik M,Barkut IK,Oncel C,Forta H

    更新日期:2003-10-01 00:00:00

  • Mutations in the Parkinson's disease genes, Leucine Rich Repeat Kinase 2 (LRRK2) and Glucocerebrosidase (GBA), are not associated with essential tremor.

    abstract::We evaluated an association between essential tremor (ET) and the Parkinson's disease (PD) genes, Leucine Rich Repeat Kinase 2 (LRRK2) and Glucocerebrosidase (GBA). Clinical studies demonstrate an association between ET and PD, suggesting possible shared pathophysiologies, yet LRRK2 has rarely been studied in ET, and ...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2009.05.008

    authors: Clark LN,Kisselev S,Park N,Ross B,Verbitsky M,Rios E,Alcalay RN,Lee JH,Louis ED

    更新日期:2010-02-01 00:00:00

  • Diagnostic accuracy of [99mTc]TRODAT-1 SPECT imaging in early Parkinson's disease.

    abstract::We evaluated the diagnostic accuracy of SPECT imaging using [(99m)Tc]TRODAT-1 (TRODAT), a relatively inexpensive technetium-labeled dopamine transporter ligand, in distinguishing 29 patients with early PD from 38 healthy volunteers. Mean TRODAT uptake values were significantly decreased in the caudate (p=0.0097) and a...

    journal_title:Parkinsonism & related disorders

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.parkreldis.2004.04.002

    authors: Chou KL,Hurtig HI,Stern MB,Colcher A,Ravina B,Newberg A,Mozley PD,Siderowf A

    更新日期:2004-08-01 00:00:00

  • Associations between daily-living physical activity and laboratory-based assessments of motor severity in patients with falls and Parkinson's disease.

    abstract:INTRODUCTION:Recent work suggests that wearables can augment conventional measures of Parkinson's disease (PD). We evaluated the relationship between conventional measures of disease and motor severity (e.g., MDS-UPDRS part III), laboratory-based measures of gait and balance, and daily-living physical activity measures...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2019.01.022

    authors: Galperin I,Hillel I,Del Din S,Bekkers EMJ,Nieuwboer A,Abbruzzese G,Avanzino L,Nieuwhof F,Bloem BR,Rochester L,Della Croce U,Cereatti A,Giladi N,Mirelman A,Hausdorff JM

    更新日期:2019-05-01 00:00:00

  • Decreased vesicular storage and aldehyde dehydrogenase activity in multiple system atrophy.

    abstract:BACKGROUND:Parkinson disease (PD) and multiple system atrophy (MSA) share some neuropathologic features (nigrostriatal dopaminergic lesion, alpha-synuclein deposition) but not others (Lewy bodies in PD, glial cytoplasmic inclusions in MSA). In PD evidence has accrued for a vesicular storage defect and decreased aldehyd...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2015.03.006

    authors: Goldstein DS,Sullivan P,Holmes C,Kopin IJ,Sharabi Y,Mash DC

    更新日期:2015-06-01 00:00:00

  • Medical management of myoclonus-dystonia and implications for underlying pathophysiology.

    abstract::Myoclonus-dystonia is an early onset genetic disorder characterised by subcortical myoclonus and less prominent dystonia. Its primary causative gene is the epsilon-sarcoglycan gene but the syndrome of "myoclonic dystonia" has been shown to be a heterogeneous group of genetic disorders. The underlying pathophysiology o...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章,评审

    doi:10.1016/j.parkreldis.2020.06.016

    authors: Fearon C,Peall KJ,Vidailhet M,Fasano A

    更新日期:2020-08-01 00:00:00

  • Validity and reliability of the PDQ-39 and the PDQ-8 in English-speaking Parkinson's disease patients in Singapore.

    abstract::The purpose of the study was to assess the validity and reliability of the Parkinson's disease questionnaire (PDQ-39, UK English version) as well as its briefer version (the PDQ-8) among Asian patients with Parkinson's disease (PD) in Singapore. Eighty-eight patients recruited from movement disorder clinics or patient...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2004.05.007

    authors: Tan LC,Luo N,Nazri M,Li SC,Thumboo J

    更新日期:2004-12-01 00:00:00

  • Randomized, controlled pilot trial of solifenacin succinate for overactive bladder in Parkinson's disease.

    abstract:OBJECTIVE:To evaluate the efficacy of solifenacin succinate in Parkinson's disease (PD) patients suffering from overactive bladder (OAB). BACKGROUND:Urinary dysfunction is a commonly encountered non-motor feature in PD that significantly impacts patient quality of life. DESIGN/METHODS:This was a double-blind, randomi...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.parkreldis.2015.02.025

    authors: Zesiewicz TA,Evatt M,Vaughan CP,Jahan I,Singer C,Ordorica R,Salemi JL,Shaw JD,Sullivan KL,Non-Motor Working Group of the Parkinson Study Group (PSG).

    更新日期:2015-05-01 00:00:00

  • Magnetization transfer and adiabatic R 1ρ MRI in the brainstem of Parkinson's disease.

    abstract:BACKGROUND:In addition to classic midbrain pathology, Parkinson's disease (PD) is accompanied by changes in pontine and medullary brainstem structures. These additional abnormalities may underlie non-motor features as well as play a role in motor disability. METHODS:Using novel magnetic resonance imaging (MRI) methods...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2012.01.003

    authors: Tuite PJ,Mangia S,Tyan AE,Lee MK,Garwood M,Michaeli S

    更新日期:2012-06-01 00:00:00

  • Effects of fibroblast growth factor and glial-derived neurotrophic factor on akinesia, F-DOPA uptake and dopamine cells in parkinsonian primates.

    abstract::Parkinson's disease (PD) is a common neurodegenerative disorder that produces progressive disability despite symptomatic treatment. Several strategies, including stereotaxic brain lesions, deep brain stimulation, transplants of dopamine cells and administration of neurotrophic factors, have been proposed to improve ef...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/s1353-8020(02)00005-6

    authors: Fontan A,Rojo A,Sanchez Pernaute R,Hernández I,López I,Castilla C,Sanchez Albisua J,Perez Higueras A,Al-Rashid I,Rabano A,Gonzalo I,Angeles Mena M,Cools A,Eshuis S,Maguire P,Pruim J,Leenders K,Garcia de Yebenes J

    更新日期:2002-06-01 00:00:00

  • Familial cortical tremor with epilepsy.

    abstract::We report here on a Japanese family in which five members in three generations developed non-progressive adult onset cortical tremor and epilepsy. Other than tremulous movements resembling essential tremor, the neurologic findings were unremarkable. Electrophysiologic studies revealed giant somatosensory evoked potent...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/s1353-8020(97)00001-1

    authors: Okuma Y,Shimo Y,Hatori K,Hattori T,Tanaka S,Mizuno Y

    更新日期:1997-04-01 00:00:00

  • Impairment of cerebral hemodynamic response to the cold pressor test in patients with Parkinson's disease.

    abstract:BACKGROUND AND PURPOSE:Disturbance of the autonomic nervous system (ANS) is frequently encountered in Parkinson's disease (PD). In this study, we examined changes in systemic and cerebral hemodynamics during the cold pressor test (CPT) to determine whether cerebrovascular reactivity, controlled by the sympathetic nervo...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2008.03.007

    authors: Tsai SJ,Chen SC,Leu TM,Chen CM,Chou HH,Peng HY,Liao JM,Lin TB

    更新日期:2009-02-01 00:00:00

  • Functional correlates of cognitive slowing in Parkinson's disease.

    abstract::Although attentional impairments (particularly cognitive slowing) are frequent in Parkinson's disease (PD), the mechanisms underlying these phenomena have not been fully characterized. The MRI-compatible version of the Symbol Digit Modalities Test (SDMT) has been applied to healthy individuals but not previously to pa...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2020.05.006

    authors: Grolez G,Viard R,Lopes R,Kuchcinski G,Defebvre L,Devos D,Dujardin K,Moreau C

    更新日期:2020-07-01 00:00:00

  • Cognitive evaluation of patients with chronic neurolathyrism.

    abstract:OBJECTIVE:The object of the present study was to evaluate whether patients with neurolathyrism (NL) have cognitive abnormalities, and whether the cognitive decline, if found, correlates with the motor deficit. BACKGROUND:NL is a neurological syndrome that develops following ingestion of the grass pea (Lathyrus Sativus...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/s1353-8020(99)00016-4

    authors: Paleacu D,Cohn DF,Rabey JM

    更新日期:1999-04-01 00:00:00

  • The evolving definition of essential tremor: What are we dealing with?

    abstract:BACKGROUND:Although essential tremor (ET) is commonly encountered in clinical practice, historically, there has been considerable disagreement as how to best define it, and now with a growing sense of its clinical complexity, how to best encapsulate it. Here, I draw attention to five issues of current uncertainty. MET...

    journal_title:Parkinsonism & related disorders

    pub_type: 历史文章,杂志文章,评审

    doi:10.1016/j.parkreldis.2017.07.004

    authors: Louis ED

    更新日期:2018-01-01 00:00:00

  • Chronic and acute LRRK2 silencing has no long-term behavioral effects, whereas wild-type and mutant LRRK2 overexpression induce motor and cognitive deficits and altered regulation of dopamine release.

    abstract:INTRODUCTION:Germline silencing of the PD-related protein LRRK2 does not alter glutamate or dopamine release in adult mice, but some exploratory abnormalities have been reported with ageing. Contrastingly, high levels of human LRRK2 cause locomotor alterations and cognitive deficits accompanied by reduced striatal dopa...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2015.07.025

    authors: Volta M,Cataldi S,Beccano-Kelly D,Munsie L,Tatarnikov I,Chou P,Bergeron S,Mitchell E,Lim R,Khinda J,Lloret A,Bennett CF,Paradiso C,Morari M,Farrer MJ,Milnerwood AJ

    更新日期:2015-10-01 00:00:00

  • Early Onset Parkinson's disease due to DJ1 mutations: An Indian study.

    abstract:INTRODUCTION:Early Onset Parkinson's Disease (EOPD) is genetically heterogeneous. PARK2 mutations are the commonest cause of autosomal recessive EOPD followed by PINK1.DJ1 mutations is rare and there is scarce literature on its phenotype and long term outcome. OBJECTIVES:We undertook a retrospective study to determine...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2016.04.024

    authors: Abbas MM,Govindappa ST,Sudhaman S,Thelma BK,Juyal RC,Behari M,Muthane UB

    更新日期:2016-11-01 00:00:00

  • Non-motor symptoms and quality of life in dopa-responsive dystonia patients.

    abstract:BACKGROUND:In patients with GTP-cyclohydrolase deficient dopa-responsive dystonia (DRD) the occurrence of associated non-motor symptoms (NMS) is to be expected. Earlier studies report conflicting results with regard to the nature and severity of NMS. The aim of our study was to investigate the prevalence of psychiatric...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2017.10.005

    authors: Timmers ER,Kuiper A,Smit M,Bartels AL,Kamphuis DJ,Wolf NI,Poll-The BT,Wassenberg T,Peeters EAJ,de Koning TJ,Tijssen MAJ

    更新日期:2017-12-01 00:00:00

  • Task-switching abilities in pre-manifest Huntington's disease subjects.

    abstract:INTRODUCTION:Huntington's Disease (HD) cognitive dysfunction occurs before unequivocal motor signs become apparent. The predominant early cognitive abnormal domains may include deficits in psychomotor speed, negative emotion recognition and executive functioning. Our study is aimed to investigate the executive control ...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2018.09.007

    authors: Migliore S,D'Aurizio G,Curcio G,Squitieri F

    更新日期:2019-03-01 00:00:00

  • Evidence of delayed nigrostriatal dysfunction in corticobasal syndrome: a SPECT follow-up study.

    abstract:OBJECTIVE:To demonstrate that degeneration of substantia nigra neurons may occur at later stages of disease in some patients with corticobasal syndrome (CBS) who evidenced preserved nigrostriatal pathway at a baseline FP-CIT SPECT study. BACKGROUND:Current pathological criteria for the definite diagnosis of corticobas...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2013.01.013

    authors: Ceravolo R,Rossi C,Cilia R,Tognoni G,Antonini A,Volterrani D,Bonuccelli U

    更新日期:2013-05-01 00:00:00

  • Low body mass index and life prognosis in Parkinson's disease.

    abstract:INTRODUCTION:Patients with Parkinson's disease (PD) frequently lose weight, even in the early stages of the disease. Our objective was to clarify the association between low body mass index (BMI) and life prognosis in PD. METHODS:We conducted a retrospective cohort study of 651 PD patients (380 females), with a primar...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2018.05.011

    authors: Park K,Oeda T,Kohsaka M,Tomita S,Umemura A,Sawada H

    更新日期:2018-10-01 00:00:00

  • Imaging executive functions in Parkinson's disease: An activation likelihood estimation meta-analysis.

    abstract:INTRODUCTION:Executive dysfunction is a common and early cognitive symptom in Parkinson's disease (PD) with a detrimental effect on quality of life of patients and their care givers. Thus, a number of neuroimaging studies investigated the underlying neural correlates of such an impairment. Results of individual studies...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.parkreldis.2019.02.015

    authors: Giehl K,Tahmasian M,Eickhoff SB,van Eimeren T

    更新日期:2019-06-01 00:00:00

  • Telemedicine in Parkinson's disease: A patient perspective at a tertiary care centre.

    abstract:INTRODUCTION:To overcome travel distance and lack of local expertise, telemedicine programs have been implemented and are still pilot programs in many jurisdictions. Patient perspectives remain poorly understood. In the largest study to date, we examined user satisfaction and predictors of patient choice to use telemed...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章

    doi:10.1016/j.parkreldis.2015.02.018

    authors: Qiang JK,Marras C

    更新日期:2015-05-01 00:00:00