Treatment of acute Sydenham's chorea with methyl-prednisolone pulse-therapy.

abstract：:We used electrophysiological methods to study the hyperkinetic movement disorders in a pallido-ponto-nigral degeneration (PPND) family, which harbors the N279K tau gene mutation. Our purpose was to: (1). characterize the tremor patterns, (2). characterize the myoclonus physiology, (3). determine whether electrophysiol...

journal_title：Parkinsonism & related disorders

authors： Caviness JN,Tsuboi Y,Wszolek ZK

更新日期：2003-01-01 00:00:00

abstract：INTRODUCTION:Huntington's disease (HD) is the most common hereditary neurodegenerative disorder. Despite the fact that both the gene and the mutation causing this monogenetic disorder were identified more than 20 years ago, disease-modifying therapies for HD have not yet been established. REVIEW:While intense preclini...

journal_title：Parkinsonism & related disorders

authors： Zielonka D,Mielcarek M,Landwehrmeyer GB

更新日期：2015-03-01 00:00:00

abstract：:The recently discovered trace amine associated receptors (TAARs) represent attractive potential mediators of certain aspects of movement control. The TAAR that is best characterized, TAAR1, is particularly interesting because it can be activated by a variety of monoaminergic compounds including trace amines, amphetami...

journal_title：Parkinsonism & related disorders

authors： Sotnikova TD,Zorina OI,Ghisi V,Caron MG,Gainetdinov RR

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Hallucinations are a frequent and severe complication in Parkinson's disease (PD). Minor hallucinations are generally not disturbing, but likely progress to well-structured hallucinations with loss of insight and a great impact on quality of life. Knowledge on the neural bases of minor hallucinations may hel...

journal_title：Parkinsonism & related disorders

authors： Pagonabarraga J,Soriano-Mas C,Llebaria G,López-Solà M,Pujol J,Kulisevsky J

更新日期：2014-03-01 00:00:00

abstract：INTRODUCTION:Fatigue is one of the most common and disabling non-motor symptoms in Parkinson's disease (PD). The objective of this study was to determine prevalence and motor, behavioural, and cognitive correlates of distressing fatigue in early, de novo PD patients. METHODS:Eighty-one consecutive de novo PD patients ...

journal_title：Parkinsonism & related disorders

authors： Siciliano M,Trojano L,De Micco R,De Mase A,Garramone F,Russo A,Tedeschi G,Tessitore A

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:The prevalence and clinical correlates of drooling in Chinese patients with Parkinson disease (PD) are unknown. METHODS:A cross-sectional analysis of 518 Chinese patients with PD was conducted. Assessments included Unified PD Rating Scale (UPDRS), Non-Motor Symptoms Scale (NMSS), Hamilton Depression Scale (...

journal_title：Parkinsonism & related disorders

authors： Ou R,Guo X,Wei Q,Cao B,Yang J,Song W,Shao N,Zhao B,Chen X,Shang H

更新日期：2015-03-01 00:00:00

abstract：:We evaluated an association between essential tremor (ET) and the Parkinson's disease (PD) genes, Leucine Rich Repeat Kinase 2 (LRRK2) and Glucocerebrosidase (GBA). Clinical studies demonstrate an association between ET and PD, suggesting possible shared pathophysiologies, yet LRRK2 has rarely been studied in ET, and ...

journal_title：Parkinsonism & related disorders

authors： Clark LN,Kisselev S,Park N,Ross B,Verbitsky M,Rios E,Alcalay RN,Lee JH,Louis ED

更新日期：2010-02-01 00:00:00

abstract：:Sex-linked dystonia parkinsonism (XDP) was reported by Lee et al. in 1975 occurring endemically in Panay, Philippines. It is an adult onset, sex-linked, predominantly male, severe, progressive movement disorder with high penetrance and a high frequency of generalization. The movement disorder is characterized by dysto...

journal_title：Parkinsonism & related disorders

authors： Lee LV,Maranon E,Demaisip C,Peralta O,Borres-Icasiano R,Arancillo J,Rivera C,Munoz E,Tan K,Reyes MT

更新日期：2002-10-01 00:00:00

abstract：:Impulsive personalities are considered to have a general impairment in cognitive flexibility and cortical inhibition. To examine this hypothesis we used a trial by trial Stroop task in impulsive and non impulsive patients with Parkinson's disease (PD) and recorded errors and reaction times (RT). We tested 28 impulsive...

journal_title：Parkinsonism & related disorders

authors： Djamshidian A,O'Sullivan SS,Lees A,Averbeck BB

更新日期：2011-03-01 00:00:00

abstract：INTRODUCTION:Cognitive impairment and dementia are highly prevalent non-motor complications in Parkinson's disease (PD) with deleterious consequences for patients and caregivers. With no treatment currently available, finding and validating minimally-invasive biomarkers of neurodegeneration in this population represent...

journal_title：Parkinsonism & related disorders

authors： Sampedro F,Pérez-González R,Martínez-Horta S,Marín-Lahoz J,Pagonabarraga J,Kulisevsky J

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Visual hallucinations (VH) in Parkinson's disease (PD) are associated with PD dementia and have been related to cognitive impairments in non-demented PD patients. Reports on the specific cognitive domains affected are conflicting. The aim of the present study was to investigate the presence of specific cogni...

journal_title：Parkinsonism & related disorders

authors： Hepp DH,da Hora CC,Koene T,Uitdehaag BM,van den Heuvel OA,Klein M,van de Berg WD,Berendse HW,Foncke EM

更新日期：2013-09-01 00:00:00

abstract：:Six healthy controls and eighteen patients with Parkinson's disease in different disability stages were studied with SPECT using [(123)I]beta-CIT to label the striatal dopamine transporter. The mean uptake of [(123)I]beta-CIT in the putamen was reduced to 54% of the control mean and to 65% of the average control value...

journal_title：Parkinsonism & related disorders

authors： Rinne JO,Kuikka JT,Bergström KA,Rinne UK

更新日期：1995-07-01 00:00:00

abstract：BACKGROUND:Non-motor symptom (NMS) differences between male Parkinson's disease (PD) and female PD, and between early-onset PD (EOPD) and late-onset PD (LOPD) in Chinese populations remain largely unknown. METHODS:A total of 522 PD patients from Southwest China were included. Patients were assessed using the Non-Motor...

journal_title：Parkinsonism & related disorders

authors： Guo X,Song W,Chen K,Chen X,Zheng Z,Cao B,Huang R,Zhao B,Wu Y,Shang HF

更新日期：2013-11-01 00:00:00

abstract：:Oxidative stress has been reported as one of the pathogeneses of Parkinson's disease (PD). Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that regulates the expression of the target genes involved in antioxidant pathway. The promoter polymorphisms of the Nrf2-encoding gene, NFE2L2, have b...

journal_title：Parkinsonism & related disorders

authors： Chen YC,Wu YR,Wu YC,Lee-Chen GJ,Chen CM

更新日期：2013-02-01 00:00:00

abstract：:Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder. An association with sleep breathing disorder has not previously been established in the literature. We report the case of a 45-year-old woman with HD, presenting with snoring and observed apnea. Polysomnography showed obstructive sleep apne...

journal_title：Parkinsonism & related disorders

authors： Banno K,Hobson DE,Kryger MH

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND:Traditionally the risk of Parkinson's has been considered to increase monotonically with age, although there is evidence that prevalence and incidence may decrease in the oldest old. To examine this further we estimated the national prevalence and incidence of Parkinson's in New Zealand, using drug-tracing m...

journal_title：Parkinsonism & related disorders

authors： Myall DJ,Pitcher TL,Pearson JF,Dalrymple-Alford JC,Anderson TJ,MacAskill MR

更新日期：2017-09-01 00:00:00

abstract：INTRODUCTION:PLA2G6-associated neurodegeneration (PLAN) comprises a continuum of three phenotypes with overlapping clinical and radiologic features. METHODS:Observational clinical study in a cohort of infantile and childhood onset PLAN patients and genetic analysis of the PLA2G6 gene. We analysed chronological evoluti...

journal_title：Parkinsonism & related disorders

authors： Darling A,Aguilera-Albesa S,Tello CA,Serrano M,Tomás M,Camino-León R,Fernández-Ramos J,Jiménez-Escrig A,Poó P,O'Callaghan M,Ortez C,Nascimento A,Fernández Mesaque RC,Madruga M,Arrabal L,Roldan S,Gómez-Martín H,Garrido C

更新日期：2019-04-01 00:00:00

abstract：:We report the first instance of restless legs syndrome (RLS) associated with periodic limb movements (PLM) and disruption of sleep architecture occurring in a patient following ischemic infarction in the right lenticulostriate region. Recently, a role for the basal ganglia-brainstem system in the control of motor beha...

journal_title：Parkinsonism & related disorders

authors： Sechi G,Agnetti V,Galistu P,Murgia B,Marrosu F,Puligheddu M,Conti M,Paulus KS

更新日期：2008-01-01 00:00:00

abstract：:A 68-year-old, normal female volunteer was scanned by positron emission tomography (PET) with [(18)F]6-L-fluorodopa (FD). Striatal FD uptake was in the high normal range. Subsequently, she developed parkinsonism 3.7 years after the scan. A repeat FD PET scan revealed a significant reduction of FD uptake by 20% over th...

journal_title：Parkinsonism & related disorders

authors： Shinotoh H,Vingerhoets FJ,Schulzer M,Snow BJ

更新日期：1996-07-01 00:00:00

abstract：INTRODUCTION:Increasing evidence shows a strong association between idiopathic REM sleep behavior disorder (iRBD) and α-synucleinopathies. Recent studies have indicated an inflammatory mechanism in the pathogenesis of α-synucleinopathies. Whether peripheral inflammatory cytokines are altered in iRBD and can be biomarke...

journal_title：Parkinsonism & related disorders

authors： Zhang H,Wang T,Li Y,Mao W,Hao S,Huang Z,Chan P,Cai Y

更新日期：2020-09-01 00:00:00

abstract：:Abnormally aggregated tau protein is central to the pathophysiology of Alzheimer's disease, frontotemporal dementia variants, progressive supranuclear palsy, corticobasal degeneration and chronic traumatic encephalopathy. The post-mortem cortical density of hyperphosphorylated tau tangles correlates with pre-morbid co...

journal_title：Parkinsonism & related disorders

authors： Dani M,Edison P,Brooks DJ

更新日期：2016-01-01 00:00:00

abstract：INTRODUCTION:Mutations in GNAL have been associated with adult-onset cranio-cervical dystonia, but a limited number of cases have been reported so far and the clinical spectrum associated with this gene still needs to be fully characterized. METHODS:We identified an Italian family with adult-onset, dominantly-inherite...

journal_title：Parkinsonism & related disorders

authors： Carecchio M,Panteghini C,Reale C,Barzaghi C,Monti V,Romito L,Sasanelli F,Garavaglia B

更新日期：2016-02-01 00:00:00

abstract：INTRODUCTION:In addition to neurogenic orthostatic hypotension (nOH), patients with synucleinopathies frequently have hypertension when supine. The long-term consequences of both abnormalities are difficult to disentangle. We aimed to determine if supine hypertension is associated with target organ damage and worse sur...

journal_title：Parkinsonism & related disorders

authors： Palma JA,Redel-Traub G,Porciuncula A,Samaniego-Toro D,Millar Vernetti P,Lui YW,Norcliffe-Kaufmann L,Kaufmann H

更新日期：2020-06-01 00:00:00

abstract：:The goal of genetic association studies is to identify common (>5%) risk factors in complex disease traits. Herein we describe the first replicable 'functional' risk allele for Parkinson's disease. The leucine-rich repeat kinase 2 (Lrrk2) G2385R substitution is associated with familial parkinsonism, late-, and early-o...

journal_title：Parkinsonism & related disorders

authors： Farrer MJ,Stone JT,Lin CH,Dächsel JC,Hulihan MM,Haugarvoll K,Ross OA,Wu RM

更新日期：2007-03-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy of solifenacin succinate in Parkinson's disease (PD) patients suffering from overactive bladder (OAB). BACKGROUND:Urinary dysfunction is a commonly encountered non-motor feature in PD that significantly impacts patient quality of life. DESIGN/METHODS:This was a double-blind, randomi...

journal_title：Parkinsonism & related disorders

authors： Zesiewicz TA,Evatt M,Vaughan CP,Jahan I,Singer C,Ordorica R,Salemi JL,Shaw JD,Sullivan KL,Non-Motor Working Group of the Parkinson Study Group (PSG).

更新日期：2015-05-01 00:00:00

abstract：INTRODUCTION:The reduction of background activity and the increase of low-frequency powers on electroencephalogram (EEG) correlate with cognitive impairment and have been suggested to be underpinned by cholinergic deficit. We aimed to investigate the ratio between α and θ band power (α/θ ratio), as a synoptic index of ...

journal_title：Parkinsonism & related disorders

authors： Massa F,Meli R,Grazzini M,Famà F,De Carli F,Filippi L,Arnaldi D,Pardini M,Morbelli S,Nobili F

更新日期：2020-06-01 00:00:00

abstract：PURPOSE:The young-onset subtype of Parkinson's disease (YOPD) differs from the late-onset subtype (LOPD) in drug responsiveness, incidence of motor complications, and prognosis. The pathophysiology underlying these differences remains largely unknown. This study investigated whether the two subtypes differ in the patte...

journal_title：Parkinsonism & related disorders

authors： Liu SY,Wu JJ,Zhao J,Huang SF,Wang YX,Ge JJ,Wu P,Zuo CT,Ding ZT,Wang J

更新日期：2015-12-01 00:00:00

abstract：:We report a cluster of five cases of Parkinson's disease (PD) among paper mill workers exposed to a fungicide, diphenyl. The cause of PD is still unknown, but epidemiological studies have indicated an elevated risk of developing PD after exposure to pesticides. The five cases of PD were found in a group of 255 dipheny...

journal_title：Parkinsonism & related disorders

authors： Wastensson G,Hagberg S,Andersson E,Johnels B,Barregård L

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:Patients with Parkinson disease (PD) often develop psychosis (P). The association of PDP with death and long-term custodial care (CC) has not been well studied. METHODS:Medicare Parts A, B, and D data, 2007-2015, were used to define cohorts of PD and PDP patients. PD was defined by ≥ 2 ICD-9-CM codes (332...

journal_title：Parkinsonism & related disorders

authors： Wetmore JB,Li S,Yan H,Irfan M,Rashid N,Peng Y,Gilbertson DT,Shim A

更新日期：2019-11-01 00:00:00

abstract：:Serotonin (5-HT) is a monoamine neurotransmitter released throughout the brain. The serotonergic system is implicated in a host of neuropsychiatric disorders including, but not limited to, Parkinson's disease and L-DOPA-induced dyskinesia. These are pathological and drug-induced states that center on dysfunction of th...

journal_title：Parkinsonism & related disorders

authors： Mathur BN,Lovinger DM

更新日期：2012-01-01 00:00:00