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Lrrk2 G2385R is an ancestral risk factor for Parkinson's disease in Asia.

Abstract：

:The goal of genetic association studies is to identify common (>5%) risk factors in complex disease traits. Herein we describe the first replicable 'functional' risk allele for Parkinson's disease. The leucine-rich repeat kinase 2 (Lrrk2) G2385R substitution is associated with familial parkinsonism, late-, and early-onset Parkinson's disease in ethnic Chinese Taiwanese. Crucially, we provide evidence of identity-by-descent and suggest that Lrrk2 G2385R carriers originate from one ancestor some 4800 years ago, at the start of Chinese civilization. Moreover, our findings demonstrate that common genetic coding variants contribute to Parkinson's disease in a population specific manner which may have important implications for future genome-wide association studies.

journal_name

Parkinsonism Relat Disord

journal_title

Parkinsonism & related disorders

authors

Farrer MJ,Stone JT,Lin CH,Dächsel JC,Hulihan MM,Haugarvoll K,Ross OA,Wu RM

doi

10.1016/j.parkreldis.2006.12.001

subject

Has Abstract

pub_date

2007-03-01 00:00:00

pages

89-92

issue

2

eissn

1353-8020

issn

1873-5126

pii

S1353-8020(06)00287-2

journal_volume

13

pub_type

杂志文章

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