Positron emission tomography of dopamine pathways in familial Parkinsonian syndromes.

abstract：:The purpose of this preliminary study was to investigate the inter-rater reliability among physician, patient, and caregiver ratings on the Hoehn & Yahr (H & Y) and Schwab & England (S & E) rating instruments. We also examined differences in ratings between patients who attended clinic with and without caregivers (spo...

journal_title：Parkinsonism & related disorders

authors： McRae C,Diem G,Vo A,O'Brien C,Seeberger L

更新日期：2002-01-01 00:00:00

abstract：:It has become increasingly apparent that Parkinson's disease (PD) can no longer be considered purely a motor disease, as numerous sensory alterations accompany this disorder either before or early in its clinical progression. Most notable among such disturbances are decrements in smell function. Such anomalies have be...

journal_title：Parkinsonism & related disorders

authors： Doty RL

更新日期：2007-01-01 00:00:00

abstract：:Serotonin (5-HT) is a monoamine neurotransmitter released throughout the brain. The serotonergic system is implicated in a host of neuropsychiatric disorders including, but not limited to, Parkinson's disease and L-DOPA-induced dyskinesia. These are pathological and drug-induced states that center on dysfunction of th...

journal_title：Parkinsonism & related disorders

authors： Mathur BN,Lovinger DM

更新日期：2012-01-01 00:00:00

abstract：INTRODUCTION:Two phase3 studies (SP512; SP513) involving mostly Caucasian patients showed that rotigotine (≤8 mg/24 h) was efficacious and welltolerated in early-stage Parkinson's disease (PD). We report results from a phase 3 study (SP0914/NCT01646268) investigating rotigotine in Chinese patients with early-stage PD. ...

journal_title：Parkinsonism & related disorders

authors： Zhang ZX,Shang HF,Hu X,Chen S,Zhao Z,Du X,Surmann E,Bauer L,Asgharnejad M

更新日期：2016-07-01 00:00:00

abstract：INTRODUCTION:There is considerable intra- and inter-individual variability in the pharmacokinetics (PK) of levodopa after oral administration. Inter-individual variability in levodopa PK has also been demonstrated in fasting single-dose studies. We examined the factors that affect levodopa PK in patients with Parkinson...

journal_title：Parkinsonism & related disorders

authors： Nishikawa N,Iwaki H,Shiraishi T,Mukai Y,Takahashi Y,Murata M

更新日期：2020-07-01 00:00:00

abstract：:Adenosine derived from the degradation of ATP/AMP functions as a signalling molecule in the nervous system through the occupation of A1, A2, and A3 adenosine receptors. Adenosine A(2A) receptors have a selective localization to the basal ganglia and specifically to the indirect output pathway, and as a consequence off...

journal_title：Parkinsonism & related disorders

authors： Jenner P,Mori A,Hauser R,Morelli M,Fredholm BB,Chen JF

更新日期：2009-07-01 00:00:00

abstract：OBJECTIVES:To determine whether vascular parkinsonism (VaP) patients with visually normal dopamine transporter (DAT) scans have presynaptic dopaminergic depletion. METHODS:We enrolled 23 VaP patients who had parkinsonism, relevant diffuse subcortical white matter hyperintensities (WMH), and visually normal DAT scans, ...

journal_title：Parkinsonism & related disorders

authors： Lee YH,Lee S,Chung SJ,Yoo HS,Jung JH,Baik K,Ye BS,Sohn YH,Yun M,Lee PH

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Quantitative analysis of brain atrophy may be useful in differentiating Parkinson's Disease (PD) from Progressive Supranuclear Palsy (PSP) and parkinsonian variant of Multiple System Atrophy (MSA-P); the aim of this study was to identify the volumetric differences of subcortical structures in pat...

journal_title：Parkinsonism & related disorders

authors： Messina D,Cerasa A,Condino F,Arabia G,Novellino F,Nicoletti G,Salsone M,Morelli M,Lanza PL,Quattrone A

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Drug-induced Parkinsonism is common, causes significant morbidity, and can be clinically indistinguishable from idiopathic Parkinson's disease. Additionally, drug-induced Parkinsonism may, in some cases, represent "unmasking" of incipient Parkinson's disease. Clinical features or tests that distinguish degen...

journal_title：Parkinsonism & related disorders

authors： Morley JF,Pawlowski SM,Kesari A,Maina I,Pantelyat A,Duda JE

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:Mutations in GNAL have recently been identified as responsible for primary dystonia, however, GNAL mutations in Chinese patients with primary dystonia are not well characterized. PATIENTS AND METHODS:Fifty-nine unrelated patients with cervical onset or cervical involved primary dystonia and 120 neurological...

journal_title：Parkinsonism & related disorders

authors： Miao J,Wan XH,Sun Y,Feng JC,Cheng FB

更新日期：2013-10-01 00:00:00

abstract：:Parkinson's disease (PD) is the most common neurodegenerative movement disorder. Currently, no curative treatments or treatments that interdict disease progression are available. Over the past decade, immunization strategies were developed in our laboratories to combat disease progression. These strategies were develo...

journal_title：Parkinsonism & related disorders

authors： Ha D,Stone DK,Mosley RL,Gendelman HE

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:The freezing phenomenon is among the most disabling symptoms of Parkinson's disease (PD) manifesting most commonly as Freezing of Gait with a paroxysmal cessation of effective stepping. Recent studies have suggested that freezing is related to both impairments in conflict resolution as well as the processing...

journal_title：Parkinsonism & related disorders

authors： Matar E,Shine JM,Naismith SL,Lewis SJ

更新日期：2013-11-01 00:00:00

abstract：:Evidence shows that neuronal injury accompanies neuroinflammatory reactions in the brain, and well as in Parkinson's disease (PD) animal models, in which the loss of dopamine neurons is associated with the activation of microglia in the substantia nigra. Activated microglia can be illustrated in vivo using Positron em...

journal_title：Parkinsonism & related disorders

authors： Ouchi Y,Yagi S,Yokokura M,Sakamoto M

更新日期：2009-12-01 00:00:00

abstract：INTRODUCTION:The aim of this study was to examine the association between mild parkinsonian signs (MPS), cerebral small-vessel disease (SVD), and total SVD burden in patients with vascular risk factors. METHODS:We performed a cross-sectional study among 268 patients with vascular risk factors but without parkinsonism ...

journal_title：Parkinsonism & related disorders

authors： Hatate J,Miwa K,Matsumoto M,Sasaki T,Yagita Y,Sakaguchi M,Kitagawa K,Mochizuki H

更新日期：2016-05-01 00:00:00

abstract：:Today's society is changing rapidly and individuals increasingly favor an active role in designing their own lives. Contemporary patients are no exception, but the present health care system-which is organized primarily from the provider's perspective-is not yet prepared for this development. Here, we argue that an al...

journal_title：Parkinsonism & related disorders

authors： van der Eijk M,Nijhuis FA,Faber MJ,Bloem BR

更新日期：2013-11-01 00:00:00

abstract：:Several factors involved in the etiology of Parkinson's disease (PD) have been proposed, including genetic and environmental factors or even a combination of both. Thus, multiple cellular hits are likely to contribute to neurodegeneration in PD. If such a mechanism happens to occur, our therapeutic intervention may pe...

journal_title：Parkinsonism & related disorders

authors： Hirsch EC

更新日期：2007-01-01 00:00:00

abstract：INTRODUCTION:Mutations in GNAL have been associated with adult-onset cranio-cervical dystonia, but a limited number of cases have been reported so far and the clinical spectrum associated with this gene still needs to be fully characterized. METHODS:We identified an Italian family with adult-onset, dominantly-inherite...

journal_title：Parkinsonism & related disorders

authors： Carecchio M,Panteghini C,Reale C,Barzaghi C,Monti V,Romito L,Sasanelli F,Garavaglia B

更新日期：2016-02-01 00:00:00

abstract：:Impulsive personalities are considered to have a general impairment in cognitive flexibility and cortical inhibition. To examine this hypothesis we used a trial by trial Stroop task in impulsive and non impulsive patients with Parkinson's disease (PD) and recorded errors and reaction times (RT). We tested 28 impulsive...

journal_title：Parkinsonism & related disorders

authors： Djamshidian A,O'Sullivan SS,Lees A,Averbeck BB

更新日期：2011-03-01 00:00:00

abstract：:The neuroanatomic substrate for restless legs syndrome (RLS) is not known. We implanted deep brain stimulators into the ventralis intermedius nucleus (VIM) of the thalamus in nine subjects for essential tremor (ET) whom all concurrently had RLS. Although the VIM DBS improved tremor, none of the subjects felt there was...

journal_title：Parkinsonism & related disorders

authors： Ondo W

更新日期：2006-03-01 00:00:00

abstract：INTRODUCTION:Post-operative programming of deep brain stimulation for movement disorders can be both time consuming and difficult, which can delay the optimal symptom control for the patient. Probabilistic maps of stimulation response could improve programming efficiency and optimization. METHODS:The clinically select...

journal_title：Parkinsonism & related disorders

authors： Phibbs FT,Pallavaram S,Tolleson C,D'Haese PF,Dawant BM

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Hyposmia is a common non-motor symptom in Parkinson's disease (PD). However, patients with PD are sometimes unaware of their olfactory dysfunction, resulting in an under-diagnosis of this symptom. To determine whether the loss of awareness of hyposmia results from cognitive impairment in patients with PD, we...

journal_title：Parkinsonism & related disorders

authors： Kawasaki I,Baba T,Takeda A,Mori E

更新日期：2016-01-01 00:00:00

abstract：:Parkinson's disease (PD) studies often measure daily motor function with paper diaries resulting in issues of compliance and reliability. The feasibility and compliance of PD patients using electronic diaries were examined. Twelve patients completed diaries for 7 consecutive days. Diaries recorded motor function, time...

journal_title：Parkinsonism & related disorders

authors： Lyons KE,Pahwa R

更新日期：2007-07-01 00:00:00

abstract：OBJECTIVE:To investigate the association between Apolipoprotein E (APOE) genotype and freezing of gait (FOG) in Parkinson's disease (PD). METHODS:This cohort study included 339 early PD patients who were divided into APOE ε4-positive (n = 88) and ε4-negative (n = 251) groups. They were followed-up for up to 6 years to...

journal_title：Parkinsonism & related disorders

authors： Kim R,Shin JH,Park S,Kim HJ,Jeon B

更新日期：2020-12-01 00:00:00

abstract：:Deep brain stimulation (DBS) is an effective surgical therapy for well-selected patients with medically intractable Parkinson's disease (PD) and essential tremor (ET). The purpose of this review is to describe the success of DBS in these two disorders and its promising application in dystonia, Tourette Syndrome (TS) a...

journal_title：Parkinsonism & related disorders

authors： Halpern C,Hurtig H,Jaggi J,Grossman M,Won M,Baltuch G

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND:We developed a novel secured web-based dystonia video repository for the Dystonia Coalition, part of the Rare Disease Clinical Research network funded by the Office of Rare Diseases Research and the National Institute of Neurological Disorders and Stroke. A critical component of phenotypic data collection fo...

journal_title：Parkinsonism & related disorders

authors： Yan L,Hicks M,Winslow K,Comella C,Ludlow C,Jinnah HA,Rosen AR,Wright L,Galpern WR,Perlmutter JS

更新日期：2015-04-01 00:00:00

abstract：:Recent studies delineate substantial genetic components in Parkinson's disease (PD). However, very few studies were performed in Sub-Saharan African populations. Here, we explore the contribution of known PD-causing genes in patients of indigenous Zambian ancestry. We studied thirty-nine Zambian patients, thirty-eight...

journal_title：Parkinsonism & related disorders

authors： Yonova-Doing E,Atadzhanov M,Quadri M,Kelly P,Shawa N,Musonda ST,Simons EJ,Breedveld GJ,Oostra BA,Bonifati V

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Visual hallucinations (VH) in Parkinson's disease (PD) are associated with PD dementia and have been related to cognitive impairments in non-demented PD patients. Reports on the specific cognitive domains affected are conflicting. The aim of the present study was to investigate the presence of specific cogni...

journal_title：Parkinsonism & related disorders

authors： Hepp DH,da Hora CC,Koene T,Uitdehaag BM,van den Heuvel OA,Klein M,van de Berg WD,Berendse HW,Foncke EM

更新日期：2013-09-01 00:00:00

abstract：:The interactive effects of neonatal iron and adult MPTP treatment groups of C57 Bl/6 mice were studied through adminustration of iron (Fe(2+)) 7.5mg/kg b.w., p.o. or vehicle (saline) on days 10-12 post partum, followed at 3months of age by administration of either MPTP (2x20 or 2x40mg/kg, s.c.) or saline. Neonatal iro...

journal_title：Parkinsonism & related disorders

authors： Fredriksson A,Schröder N,Eriksson P,Izquierdo I,Archer T

更新日期：2001-04-01 00:00:00

abstract：:Current concepts regarding the pathogenesis of Parkinson's disease support a model whereby environmental factors conspire with a permissive genetic background to initiate the disease. The identity of the responsible environmental trigger has remained elusive. There is incontrovertible evidence that aggregation of the ...

journal_title：Parkinsonism & related disorders

authors： Woulfe JM,Gray MT,Gray DA,Munoz DG,Middeldorp JM

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:Parkinson's disease is characterized by pathological α-synuclein accumulation and cell death, which has been hypothesized to originate in peripheral nerve terminals and subsequently spread via autonomic nerves. Supporting this, most Parkinson's disease patients experience autonomic non-motor symptoms such as...

journal_title：Parkinsonism & related disorders

authors： Knudsen K,Fedorova TD,Hansen AK,Sommerauer M,Haase AM,Svendsen KB,Otto M,Østergaard K,Krogh K,Borghammer P

更新日期：2019-01-01 00:00:00