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Loss of awareness of hyposmia is associated with mild cognitive impairment in Parkinson's disease.

Abstract：

BACKGROUND:Hyposmia is a common non-motor symptom in Parkinson's disease (PD). However, patients with PD are sometimes unaware of their olfactory dysfunction, resulting in an under-diagnosis of this symptom. To determine whether the loss of awareness of hyposmia results from cognitive impairment in patients with PD, we investigated the relationship between the degree of hyposmia self-awareness and the cognitive status of non-demented PD patients. METHODS:Thirty-one non-demented patients with PD and 20 healthy controls (HC) were assessed via a self-reported olfactory questionnaire and an odor identification test. PD patients were sub-classified as having mild cognitive impairment (PD-MCI) or as cognitively normal (PD-CN) (according to the current PD-MCI criteria). We compared the degree of hyposmia self-awareness between the PD-MCI and PD-CN groups. RESULTS:The PD-MCI group scored the lowest on the odor identification test among all groups, whereas PD-MCI patients tended to rate their olfactory function higher on the self-reported olfactory questionnaire than PD-CN patients. Differences in the scores of subjective and objective olfactory measures between the PD-MCI and PD-CN groups were significant (p = 0.0069). CONCLUSIONS:The loss of awareness of hyposmia is closely associated with mild cognitive impairment (MCI) in PD patients.

journal_name

Parkinsonism Relat Disord

journal_title

Parkinsonism & related disorders

authors

Kawasaki I,Baba T,Takeda A,Mori E

doi

10.1016/j.parkreldis.2015.11.015

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

74-9

eissn

1353-8020

issn

1873-5126

pii

S1353-8020(15)30039-0

journal_volume

22

pub_type

杂志文章

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