Organization of midbrain dopamine systems and the pathophysiology of Parkinson's disease.

abstract：AIM:To clarify the characteristics of hemodynamic responses to exercise and orthostasis in Parkinson's disease patients, especially those with autonomic failure. METHODS:Clinical audit of supine cycling exercise test data (with active standing tests pre- and post-exercise) of Parkinson's patients with autonomic dysfun...

journal_title：Parkinsonism & related disorders

authors： Low DA,Vichayanrat E,Iodice V,Mathias CJ

更新日期：2014-05-01 00:00:00

abstract：:There has been a tremendous development since a regional progression of pathology in subjects with Lewy bodies (LB) was initially proposed 30 years ago. The entity of dementia with Lewy bodies has been acknowledged, the main protein constituent of LBs--aggregated α-synuclein (αS)--has been identified and a stepwise pr...

journal_title：Parkinsonism & related disorders

authors： Alafuzoff I,Parkkinen L

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Non-motor complications of Parkinson's disease (PD), specifically cognitive impairment, sleep disturbances, and fatigue, are recognized as important contributors to poor patient outcomes and quality of life. How sleep problems and fatigue interrelate and impact cognitive function, however, has not systematic...

journal_title：Parkinsonism & related disorders

authors： Goldman JG,Stebbins GT,Leung V,Tilley BC,Goetz CG

更新日期：2014-11-01 00:00:00

abstract：:This preliminary study aimed to analyse the roll-off of the foot during gait before and after implantation of a unilateral pallidal electrode in severely affected patients with Parkinson's disease (PD). Five subjects were tested in a gait laboratory during the "on" phase of the medication cycle. Spatiotemporal variabl...

journal_title：Parkinsonism & related disorders

authors： Nieuwboer A,De Weerdt W,Dom R,Nuttin B,Peeraer L,Pattyn A

更新日期：1998-12-01 00:00:00

abstract：BACKGROUND:Drug-induced Parkinsonism is common, causes significant morbidity, and can be clinically indistinguishable from idiopathic Parkinson's disease. Additionally, drug-induced Parkinsonism may, in some cases, represent "unmasking" of incipient Parkinson's disease. Clinical features or tests that distinguish degen...

journal_title：Parkinsonism & related disorders

authors： Morley JF,Pawlowski SM,Kesari A,Maina I,Pantelyat A,Duda JE

更新日期：2014-07-01 00:00:00

abstract：:The purpose of this preliminary study was to investigate the inter-rater reliability among physician, patient, and caregiver ratings on the Hoehn & Yahr (H & Y) and Schwab & England (S & E) rating instruments. We also examined differences in ratings between patients who attended clinic with and without caregivers (spo...

journal_title：Parkinsonism & related disorders

authors： McRae C,Diem G,Vo A,O'Brien C,Seeberger L

更新日期：2002-01-01 00:00:00

abstract：INTRODUCTION:The reduction of background activity and the increase of low-frequency powers on electroencephalogram (EEG) correlate with cognitive impairment and have been suggested to be underpinned by cholinergic deficit. We aimed to investigate the ratio between α and θ band power (α/θ ratio), as a synoptic index of ...

journal_title：Parkinsonism & related disorders

authors： Massa F,Meli R,Grazzini M,Famà F,De Carli F,Filippi L,Arnaldi D,Pardini M,Morbelli S,Nobili F

更新日期：2020-06-01 00:00:00

abstract：:Involuntary movements are not a known feature of vitamin B12 (vB12) deficiency in adults, though they are a characteristic feature of vB12 deficiency in infants. This case report presents an adult patient with vB12 deficiency in whom, myoclonus-like muscular contractions appeared soon after the initiation of vB12 and ...

journal_title：Parkinsonism & related disorders

authors： Celik M,Barkut IK,Oncel C,Forta H

更新日期：2003-10-01 00:00:00

abstract：INTRODUCTION:PLA2G6-associated neurodegeneration (PLAN) comprises a continuum of three phenotypes with overlapping clinical and radiologic features. METHODS:Observational clinical study in a cohort of infantile and childhood onset PLAN patients and genetic analysis of the PLA2G6 gene. We analysed chronological evoluti...

journal_title：Parkinsonism & related disorders

authors： Darling A,Aguilera-Albesa S,Tello CA,Serrano M,Tomás M,Camino-León R,Fernández-Ramos J,Jiménez-Escrig A,Poó P,O'Callaghan M,Ortez C,Nascimento A,Fernández Mesaque RC,Madruga M,Arrabal L,Roldan S,Gómez-Martín H,Garrido C

更新日期：2019-04-01 00:00:00

abstract：RATIONALE:Cervical dystonia is the most common form of (primary) dystonia. The first line of treatment for cervical dystonia is intramuscular injections with botulinum toxin. To optimise the response to botulinum toxin proper muscles selection is required. Pre-treatment polymyographic EMG in addition to clinical evalua...

journal_title：Parkinsonism & related disorders

authors： Nijmeijer SW,Koelman JH,Standaar TS,Postma M,Tijssen MA

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVE:To describe the long-term outcome in 50 consecutive advanced Parkinson's disease (PD) patients treated with subthalamic nucleus deep brain stimulation (STN-DBS). METHOD:Assessments were carried out at baseline, 6 months, 2 years, and 5 years postoperatively. RESULTS:Compared to baseline scores without medic...

journal_title：Parkinsonism & related disorders

authors： Wider C,Pollo C,Bloch J,Burkhard PR,Vingerhoets FJ

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Germline silencing of the PD-related protein LRRK2 does not alter glutamate or dopamine release in adult mice, but some exploratory abnormalities have been reported with ageing. Contrastingly, high levels of human LRRK2 cause locomotor alterations and cognitive deficits accompanied by reduced striatal dopa...

journal_title：Parkinsonism & related disorders

authors： Volta M,Cataldi S,Beccano-Kelly D,Munsie L,Tatarnikov I,Chou P,Bergeron S,Mitchell E,Lim R,Khinda J,Lloret A,Bennett CF,Paradiso C,Morari M,Farrer MJ,Milnerwood AJ

更新日期：2015-10-01 00:00:00

abstract：INTRODUCTION:Cognitive decline is common in Parkinson's disease (PD), and identifying patients at highest risk for it is essential. We aimed to examine the effect of possible REM sleep behavior disorder (pRBD) on rate of cognitive decline in early PD, for both global cognition and in specific cognitive domains. METHOD...

journal_title：Parkinsonism & related disorders

authors： Chahine LM,Xie SX,Simuni T,Tran B,Postuma R,Amara A,Oertel WH,Iranzo A,Scordia C,Fullard M,Linder C,Purri R,Darin A,Rennert L,Videnovic A,Del Riva P,Weintraub D

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Many patients with advanced Parkinson's disease (PD) are reluctant to undergo the subthalamic nucleus deep brain stimulation (STN-DBS) when surgery is warranted. Reasons for this reluctance have not been examined. We undertook to establish the rate and causes of this reluctance for STN-DBS in patients with a...

journal_title：Parkinsonism & related disorders

authors： Kim MR,Yun JY,Jeon B,Lim YH,Kim KR,Yang HJ,Paek SH

更新日期：2016-02-01 00:00:00

abstract：:Diagnostic biomarkers are measures that detect or confirm the presence of a disease or identify individuals with a subtype of the disease. For Parkinson's disease, unlike other neurodegenerative diseases such as Alzheimer's disease and Creutzfeldt-Jakob disease, diagnostic biomarkers remain elusive as none are yet ava...

journal_title：Parkinsonism & related disorders

authors： Kalia LV

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Multiple system atrophy (MSA) can clinically be divided into the cerebellar (MSA-C) and the parkinsonian (MSA-P) variants. It is unknown whether the variation in clinical expression is also reflected by a different underlying neurochemical profile. METHODS:We analyzed brain specific proteins and neurotransm...

journal_title：Parkinsonism & related disorders

authors： Abdo WF,van de Warrenburg BP,Kremer HP,Bloem BR,Verbeek MM

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:Parkinson's disease is characterized by pathological α-synuclein accumulation and cell death, which has been hypothesized to originate in peripheral nerve terminals and subsequently spread via autonomic nerves. Supporting this, most Parkinson's disease patients experience autonomic non-motor symptoms such as...

journal_title：Parkinsonism & related disorders

authors： Knudsen K,Fedorova TD,Hansen AK,Sommerauer M,Haase AM,Svendsen KB,Otto M,Østergaard K,Krogh K,Borghammer P

更新日期：2019-01-01 00:00:00

abstract：:Spinocerebellar ataxia (SCA) 17 is a dominant neurodegenerative disorder characterized by ataxia, cognitive decline, dystonia, and parkinsonism. The disease is caused by unstable cytosine-adenine-guanine (CAG) trinucleotide expansion mutation coding for polyglutamine tracts in the TATA box-binding protein (TBP), a gen...

journal_title：Parkinsonism & related disorders

authors： Lin IS,Wu RM,Lee-Chen GJ,Shan DE,Gwinn-Hardy K

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:Japan and the United States (US) have different cultures of caregiving including differences in family structure and social programs that may influence caregiver strain. Differences in caregiver strain between regions in Japan and in the US have not been investigated in patient-spouse dyads in PD. OBJECTIVE...

journal_title：Parkinsonism & related disorders

authors： Tanji H,Koyama S,Wada M,Kawanami T,Kurita K,Tamiya G,Saito N,Suzuki K,Kato T,Anderson KE,Gruber-Baldini AL,Fishman PS,Reich SG,Weiner WJ,Shulman LM

更新日期：2013-06-01 00:00:00

abstract：:Excessive daytime sleepiness (EDS) is common in Parkinson's Disease (PD). Actigraphy uses periods of immobility as surrogate markers of nighttime sleep but there are no examples of its use in assessing EDS of PD. A commercial wrist worn system for measuring bradykinesia and dyskinesia also detects 2 min periods of imm...

journal_title：Parkinsonism & related disorders

authors： Kotschet K,Johnson W,McGregor S,Kettlewell J,Kyoong A,O'Driscoll DM,Turton AR,Griffiths RI,Horne MK

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVE:We report a prospective, open label study of 24 h levodopa-carbidopa intestinal gel (LCIG) as treatment for levodopa "unresponsive" freezing of gait (FOG) associated with Parkinson's disease. METHOD:5 patients with disabling FOG, documented as being levodopa "unresponsive", were commenced on continuous 24 h ...

journal_title：Parkinsonism & related disorders

authors： Chang FC,Tsui DS,Mahant N,Wolfe N,Kim SD,Ha AD,Drury M,Griffith JM,Fung VS

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Isolated action tremor (IAT) is the hallmark clinical feature of essential tremor (ET), but it may also be a prominent feature of some individuals with Parkinson's disease (PD) suggesting a pathogenic relationship between these two disorders. OBJECTIVES:We investigated the integrity of the striatal presynap...

journal_title：Parkinsonism & related disorders

authors： Coria F,Gimenez-Garcia M,Samaranch L,Mora FJ,Sampol-Bas C,Pastor P

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND/OBJECTIVE:Essential tremor (ET) can diminish functioning and quality of life (QOL) but generic QOL measures may be relatively insensitive to ET and its therapies. We sought to develop an ET-specific measure that might be more sensitive, acceptable to patients, relatively brief, and easily used. DESIGN/METHO...

journal_title：Parkinsonism & related disorders

authors： Tröster AI,Pahwa R,Fields JA,Tanner CM,Lyons KE

更新日期：2005-09-01 00:00:00

abstract：:We report on two cases who presented with involuntary facial grimacing and frowning. Blepharospasm has never been documented in one, and the other case showed difficulty in lid opening only in the early phase of the disease. Botulinum toxin was effective for both. This is a hitherto unreported presentation of upper fa...

journal_title：Parkinsonism & related disorders

authors： Hirota N,Hirota M,Mezaki T

更新日期：2008-11-01 00:00:00

abstract：:The mild cognitive impairment (MCI) concept was developed to identify the earliest stages of cognitive impairment. MCI and, more specifically, amnestic MCI were initially proposed as transitional states that ultimately progress to full blown Alzheimer's disease (AD). However, MCI subjects do not uniformly progress to ...

journal_title：Parkinsonism & related disorders

authors： Korczyn AD

更新日期：2016-01-01 00:00:00

abstract：:Pathogenic mutations in the EIF4G1 gene were recently reported as a cause of autosomal dominant parkinsonism. To assess the frequency of EIF4G1 mutations in the Japanese population we sequenced the entire gene coding region (31 exons) in 95 patients with an apparent autosomal dominant inherited form of Parkinson's dis...

journal_title：Parkinsonism & related disorders

authors： Nishioka K,Funayama M,Vilariño-Güell C,Ogaki K,Li Y,Sasaki R,Kokubo Y,Kuzuhara S,Kachergus JM,Cobb SA,Takahashi H,Mizuno Y,Farrer MJ,Ross OA,Hattori N

更新日期：2014-06-01 00:00:00

abstract：:In this study we aimed to investigate the effects of bilateral STN HFS in patients with advanced Parkinson disease (PD) at long-term, with a minimum follow-up of 4 years. Twenty patients (15 men, five women) were included, with a mean age of 60.9+/-8.1 years. Surgery was performed under local anesthesia. The target wa...

journal_title：Parkinsonism & related disorders

authors： Visser-Vandewalle V,van der Linden C,Temel Y,Celik H,Ackermans L,Spincemaille G,Caemaert J

更新日期：2005-05-01 00:00:00

abstract：:The stiff-man syndrome (SMS) is characterised by rigidity and spasm of predominantly axial and proximal limb muscles. The cause of the condition is unknown but the finding of antibodies to glutamic acid decarboxylase (GAD) in approximately 60% of patients has suggested an autoimmune basis. Pathological findings are li...

journal_title：Parkinsonism & related disorders

authors： Thompson PD

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND:Motor complications may become major challenges in the management of patients with Parkinson's disease. In this study, we sought to determine the incidence, risk factors, evolution, and treatment of motor fluctuations and dyskinesias in a population-representative, incident Parkinson's disease cohort. METHO...

journal_title：Parkinsonism & related disorders

authors： Bjornestad A,Forsaa EB,Pedersen KF,Tysnes OB,Larsen JP,Alves G

更新日期：2016-01-01 00:00:00

abstract：INTRODUCTION:Cognitive impairment can occur in the early phase of Parkinson's disease and increases the risk of developing dementia. Cognitive deficits were shown to be associated with functional alterations in the dorsolateral prefrontal cortex (DLPFC) and caudate nucleus. Two previous transcranial magnetic stimulatio...

journal_title：Parkinsonism & related disorders

authors： Trung J,Hanganu A,Jobert S,Degroot C,Mejia-Constain B,Kibreab M,Bruneau MA,Lafontaine AL,Strafella A,Monchi O

更新日期：2019-09-01 00:00:00