当前位置： SCI文献检索 > PARKINSONISM & RELATED DISORDERS期刊下所有文献 > Motor and non-motor features of Parkinson's disease that predict persistent drug-induced Parkinsonism.

Motor and non-motor features of Parkinson's disease that predict persistent drug-induced Parkinsonism.

Abstract：

BACKGROUND:Drug-induced Parkinsonism is common, causes significant morbidity, and can be clinically indistinguishable from idiopathic Parkinson's disease. Additionally, drug-induced Parkinsonism may, in some cases, represent "unmasking" of incipient Parkinson's disease. Clinical features or tests that distinguish degenerative from pharmacologic Parkinsonism are needed. METHODS:We performed a retrospective case-control study of 97 drug-induced Parkinsonism subjects and 97 age-matched patients with Parkinson's disease. We compared the frequency of subjective motor and non-motor complaints, objective motor findings (Unified Parkinson's Disease Rating Scale Part III) and, where available, objective olfactory tests. We also performed a nested case-control study wherein we compared these same features between drug-induced Parkinsonism patients based on whether or not they recovered after changing the offending agent. RESULTS:Non-motor symptoms including constipation and sexual dysfunction were more common in Parkinson's disease than in drug-induced Parkinsonism. While total motor scores were similar between groups, Postural Instability-Gait Difficulty scores were also higher in Parkinson's disease. Features that were significantly different or showed a trend towards significance in both comparisons included subjective loss of facial expression, dream-enactment behavior, autonomic complaints and Postural Instability-Gait Difficulty scores. Hyposmia was more common in Parkinson's disease and was strongly predictive of persistent drug-induced Parkinsonism after therapy change (odds ratio 30.3, 95% confidence interval: 1.5-500, p = 0.03). CONCLUSIONS:A constellation of motor and non-motor features may differentiate unmasked Parkinson's disease from drug-induced Parkinsonism. In particular, olfactory testing may offer a simple and inexpensive method to help predict outcomes in drug-induced Parkinsonism and, potentially, identify a cohort of pre-motor Parkinson's disease.

journal_name

Parkinsonism Relat Disord

journal_title

Parkinsonism & related disorders

authors

Morley JF,Pawlowski SM,Kesari A,Maina I,Pantelyat A,Duda JE

doi

10.1016/j.parkreldis.2014.03.024

subject

Has Abstract

pub_date

2014-07-01 00:00:00

pages

738-42

issue

7

eissn

1353-8020

issn

1873-5126

pii

S1353-8020(14)00134-5

journal_volume

20

pub_type

杂志文章

相关文献

PARKINSONISM & RELATED DISORDERS文献大全
  • Adults with a history of illicit amphetamine use exhibit abnormal substantia nigra morphology and parkinsonism.

    abstract：INTRODUCTION:The sonographic appearance of the substantia nigra is abnormally bright and enlarged (hyperechogenic) in young adults with a history of illicit stimulant use. The abnormality is a risk factor for Parkinson's disease. The aim of the current study was to identify the type of illicit stimulant drug associated...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2016.02.019

    authors： Todd G,Pearson-Dennett V,Wilcox RA,Chau MT,Thoirs K,Thewlis D,Vogel AP,White JM

    更新日期：2016-04-01 00:00:00

  • The evolving definition of essential tremor: What are we dealing with?

    abstract：BACKGROUND:Although essential tremor (ET) is commonly encountered in clinical practice, historically, there has been considerable disagreement as how to best define it, and now with a growing sense of its clinical complexity, how to best encapsulate it. Here, I draw attention to five issues of current uncertainty. MET...

    journal_title：Parkinsonism & related disorders

    pub_type： 历史文章,杂志文章,评审

    doi：10.1016/j.parkreldis.2017.07.004

    authors： Louis ED

    更新日期：2018-01-01 00:00:00

  • Correlation between changes in CSF dopamine turnover and development of dyskinesia in Parkinson's disease.

    abstract：:To assess possible differences in dopamine metabolism that could parallel disease progression in Parkinson's disease (PD), we measured dopamine (DA) and its metabolites in the cerebrospinal fluid (CSF) in PD patients at different stages of disease: de novo (DEN), advanced not showing dyskinesias (ADV), and advanced wi...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2008.10.001

    authors： Lunardi G,Galati S,Tropepi D,Moschella V,Brusa L,Pierantozzi M,Stefani A,Rossi S,Fornai F,Fedele E,Stanzione P,Hainsworth AH,Pisani A

    更新日期：2009-06-01 00:00:00

  • Female, aging, difference formulations of DCI, or lower body weight increases AUC4hr of levodopa in patients with Parkinson's disease.

    abstract：INTRODUCTION:There is considerable intra- and inter-individual variability in the pharmacokinetics (PK) of levodopa after oral administration. Inter-individual variability in levodopa PK has also been demonstrated in fasting single-dose studies. We examined the factors that affect levodopa PK in patients with Parkinson...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2020.05.020

    authors： Nishikawa N,Iwaki H,Shiraishi T,Mukai Y,Takahashi Y,Murata M

    更新日期：2020-07-01 00:00:00

  • Predictors of onset of psychosis in patients with Parkinson's disease: Who gets it early?

    abstract：INTRODUCTION:Psychosis is one of the common non-motor symptoms of PD, which substantially worsens the quality of life. Hence, it is important to identify factors that are associated with early onset of psychosis in PD. In order to identify those factors, the current study aims to compare various demographic and clinica...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2017.09.015

    authors： Lenka A,George L,Arumugham SS,Hegde S,Reddy V,Kamble N,Yadav R,Pal PK

    更新日期：2017-11-01 00:00:00

  • The spiral axis as a clinical tool to distinguish essential tremor from dystonia cases.

    abstract：BACKGROUND:Tremor is a common feature of a variety of neurological disorders. In genetic studies of essential tremor (ET), investigators need to screen potential enrollees by mail or telephone to exclude those with other neurological conditions, especially dystonia. In clinical settings, the differentiation of ET and d...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2014.01.021

    authors： Michalec M,Hernandez N,Clark LN,Louis ED

    更新日期：2014-05-01 00:00:00

  • The effect of tau genotype on clinical features in FTDP-17.

    abstract：:The clinical phenotype of frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17) varies. This variability is seen not only between kindreds with different mutations but also in families sharing the same mutation. Inheritance of tau haplotype (H1) and genotype (H1/H1) has been established as a risk...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2005.01.003

    authors： Baba Y,Tsuboi Y,Baker MC,Uitti RJ,Hutton ML,Dickson DW,Farrer M,Putzke JD,Woodruff BK,Ghetti B,Murrell JR,Boeve BF,Petersen RC,Verpillat P,Brice A,Delisle MB,Rascol O,Arima K,Dysken MW,Yasuda M,Kobayashi T,Sunoh

    更新日期：2005-06-01 00:00:00

  • Phenotype of non-c.907_909delGAG mutations in TOR1A: DYT1 dystonia revisited.

    abstract：BACKGROUND:In addition to the most frequent TOR1A/DYT1 mutation (c.907_909delGAG), a growing number of TOR1A sequence variants are found in dystonia patients. For most, functional characterization has demonstrated pathogenicity at different levels, implying that TOR1A genetic testing should not be limited to screening ...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2015.08.001

    authors： Dobričić V,Kresojević N,Žarković M,Tomić A,Marjanović A,Westenberger A,Cvetković D,Svetel M,Novaković I,Kostić VS

    更新日期：2015-10-01 00:00:00

  • Altered functional network topology correlates with clinical measures in very early-stage, drug-naïve Parkinson's disease.

    abstract：INTRODUCTION:The aim of the study was to identify abnormalities of whole-brain network functional organization and their relation to clinical measures in a well-characterized, multi-site cohort of very early-stage, drug-naïve Parkinson's Disease (PD) patients. METHODS:Functional-MRI data for 16 healthy controls and 20...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2019.02.001

    authors： Sreenivasan K,Mishra V,Bird C,Zhuang X,Yang Z,Cordes D,Walsh RR

    更新日期：2019-05-01 00:00:00

  • Parkinson's disease, levodopa-use and the risk of melanoma.

    abstract：:Since the early 1970s, the literature has suggested an association between Parkinson's Disease (PD) and/or levodopa-use and an increased risk for the development of malignant melanoma. In some countries, this possible association has even led to a warning in the drug insert leaflet of the possible risk. Recently, five...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,评审

    doi：10.1016/j.parkreldis.2009.05.002

    authors： Vermeij JD,Winogrodzka A,Trip J,Weber WE

    更新日期：2009-09-01 00:00:00

  • Involuntary movements associated with vitamin B12 deficiency.

    abstract：:Involuntary movements are not a known feature of vitamin B12 (vB12) deficiency in adults, though they are a characteristic feature of vB12 deficiency in infants. This case report presents an adult patient with vB12 deficiency in whom, myoclonus-like muscular contractions appeared soon after the initiation of vB12 and ...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/s1353-8020(03)00065-8

    authors： Celik M,Barkut IK,Oncel C,Forta H

    更新日期：2003-10-01 00:00:00

  • Effect of light on blinking in patients with idiopathic isolated blepharospasm.

    abstract：OBJECTIVE:Melanopsin may be involved in the pathophysiology of photophobia in idiopathic isolated blepharospasm. We assessed the efficacy of blocking wavelengths of melanopsin absorption to reduce blinking in blepharospasm as a possible surrogate for photophobia. METHODS:Twenty-one participants (11 blepharospasm and 1...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2019.09.010

    authors： Wu Y,Cho HJ,Panyakaew P,Savant CS,Wu T,Dang N,Hallett M

    更新日期：2019-10-01 00:00:00

  • Obstructive sleep apnea, CPAP therapy and Parkinson's disease motor function: A longitudinal study.

    abstract：INTRODUCTION:We aimed to assess, in patients with Parkinson's disease (PD), the association between obstructive sleep apnea (OSA), progression of motor dysfunction and the effect of OSA treatment. METHODS:Data were analysed from a prospective cohort study of idiopathic PD patients from a movement disorders clinic. Pat...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2019.12.001

    authors： Meng L,Benedetti A,Lafontaine AL,Mery V,Robinson AR,Kimoff J,Gros P,Kaminska M

    更新日期：2020-01-01 00:00:00

  • Cognitive evaluation of patients with chronic neurolathyrism.

    abstract：OBJECTIVE:The object of the present study was to evaluate whether patients with neurolathyrism (NL) have cognitive abnormalities, and whether the cognitive decline, if found, correlates with the motor deficit. BACKGROUND:NL is a neurological syndrome that develops following ingestion of the grass pea (Lathyrus Sativus...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/s1353-8020(99)00016-4

    authors： Paleacu D,Cohn DF,Rabey JM

    更新日期：1999-04-01 00:00:00

  • Inpatient rehabilitation after deep brain stimulator placement: a case series.

    abstract：:This case series describes the inpatient rehabilitation of two medically complex patients with Parkinson's disease (PD) who had undergone deep brain stimulator (DBS) placement. Most patients may not require inpatient rehabilitation. However, a short rehabilitation stay might be of use to patients who need to be weaned...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2007.07.002

    authors： Nampiaparampil DE,Kuppy JE,Nampiaparampil GM,Salles SS

    更新日期：2008-01-01 00:00:00

  • Systematic review of apomorphine infusion, levodopa infusion and deep brain stimulation in advanced Parkinson's disease.

    abstract：:The effectiveness of oral levodopa in complex Parkinson's disease (PD) is limited by its short half-life, and the resulting pulsatile dopaminergic stimulation leads to complex motor fluctuations and dyskinesia. Several treatments provide more continuous/less pulsatile dopaminergic stimulation by modifying the pharmaco...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,评审

    doi：10.1016/j.parkreldis.2009.09.005

    authors： Clarke CE,Worth P,Grosset D,Stewart D

    更新日期：2009-12-01 00:00:00

  • Propranolol therapy for Tardive dyskinesia: A retrospective examination.

    abstract：OBJECTIVE:To examine the tolerability and effectiveness of propranolol in treating tardive dyskinesia (TD). BACKGROUND:TD is a disabling, often irreversible, movement disorder that results from chronic therapy with dopamine receptor blocking drugs. There are no treatments currently approved for this disorder. Proprano...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2016.09.004

    authors： Hatcher-Martin JM,Armstrong KA,Scorr LM,Factor SA

    更新日期：2016-11-01 00:00:00

  • Serum uric acid level as a putative biomarker in Parkinson's disease patients carrying GBA1 mutations: 2-Year data from the PPMI study.

    abstract：INTRODUCTION:Blood uric acid represents an important biomarker in sporadic Parkinson's disease (PD). Whether uric acid levels change in genetic forms of PD is beginning to be assessed. The aim of the present study was to evaluate differences in serum uric acid level among PD patients harboring mutations in the glucocer...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2020.12.020

    authors： Koros C,Simitsi AM,Papagiannakis N,Bougea A,Prentakis A,Papadimitriou D,Pachi I,Antonelou R,Angelopoulou E,Beratis I,Bozi M,Papageorgiou SG,Trapali XG,Stamelou M,Stefanis L

    更新日期：2021-01-20 00:00:00

  • Impairment of complex upper limb motor function in de novo Parkinson's disease.

    abstract：:The aim of the present study was to evaluate complex upper limb motor function in newly diagnosed, untreated Parkinson's disease (PD) patients. Four different unimanual upper limb motor tasks were applied to 13 newly diagnosed, untreated PD patients and 13 age- and sex-matched controls. In a handwriting task, PD patie...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2007.07.019

    authors： Ponsen MM,Daffertshofer A,Wolters ECh,Beek PJ,Berendse HW

    更新日期：2008-01-01 00:00:00

  • Low doses of sarizotan reduce dyskinesias and maintain antiparkinsonian efficacy of L-Dopa in parkinsonian monkeys.

    abstract：:Dyskinesia is an important complication of treatment in Parkinson's disease (PD). Sarizotan, a 5-HT(1A) agonist with high affinity for D3 and D4 receptors was investigated on L-Dopa-induced dyskinesia (LID) in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) animal model of PD. Five MPTP female cynomolgus monke...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2008.11.001

    authors： Grégoire L,Samadi P,Graham J,Bédard PJ,Bartoszyk GD,Di Paolo T

    更新日期：2009-07-01 00:00:00

  • Exercise hemodynamics in Parkinson's disease and autonomic dysfunction.

    abstract：AIM:To clarify the characteristics of hemodynamic responses to exercise and orthostasis in Parkinson's disease patients, especially those with autonomic failure. METHODS:Clinical audit of supine cycling exercise test data (with active standing tests pre- and post-exercise) of Parkinson's patients with autonomic dysfun...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2014.02.006

    authors： Low DA,Vichayanrat E,Iodice V,Mathias CJ

    更新日期：2014-05-01 00:00:00

  • Long-term effects of bilateral subthalamic nucleus stimulation in advanced Parkinson disease: a four year follow-up study.

    abstract：:In this study we aimed to investigate the effects of bilateral STN HFS in patients with advanced Parkinson disease (PD) at long-term, with a minimum follow-up of 4 years. Twenty patients (15 men, five women) were included, with a mean age of 60.9+/-8.1 years. Surgery was performed under local anesthesia. The target wa...

    journal_title：Parkinsonism & related disorders

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.parkreldis.2004.10.011

    authors： Visser-Vandewalle V,van der Linden C,Temel Y,Celik H,Ackermans L,Spincemaille G,Caemaert J

    更新日期：2005-05-01 00:00:00

  • Deep brain stimulation of the internal pallidum in multiple system atrophy.

    abstract：:We describe the outcome of deep brain stimulation of the internal pallidum in a 57-year old patient with multiple system atrophy. Although the prominent dystonic features of this patient were markedly attenuated post-operatively, the outcome was to be considered unfavourable. There was a severe increase in akinesia re...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2005.08.004

    authors： Santens P,Vonck K,De Letter M,Van Driessche K,Sieben A,De Reuck J,Van Roost D,Boon P

    更新日期：2006-04-01 00:00:00

  • Barriers to reporting non-motor symptoms to health-care providers in people with Parkinson's.

    abstract：BACKGROUND:Non-motor symptoms (NMS) are common in Parkinson's disease (PD) and cause significant distress. A high rate of non-declaration of NMS by patients to healthcare providers (HCP) means that many NMS remain untreated. Current understanding of the factors preventing disclosure of NMS to HCPs is limited. The prese...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2019.04.014

    authors： Hurt CS,Rixon L,Chaudhuri KR,Moss-Morris R,Samuel M,Brown RG

    更新日期：2019-07-01 00:00:00

  • The pedunculopontine nucleus and movement disorders: anatomy and the role for deep brain stimulation.

    abstract：:The pedunculopontine nucleus (PPN) is a brainstem locomotive center that also processes sensory and behavioral information. Through its connections with basal ganglia structures and the spinal cord, the PPN may play a role in axial motor symptoms in Parkinson's disease (PD). We review the anatomical features of the PP...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,评审

    doi：10.1016/S1353-8020(08)70016-6

    authors： Hamani C,Stone S,Laxton A,Lozano AM

    更新日期：2007-01-01 00:00:00

  • Dopaminergic polymorphisms associated with medication responsiveness of gait in Parkinson's disease.

    abstract：BACKGROUND:Gait dysfunction is a common symptom of Parkinson's disease that can cause significant disability and put patients at risk for falls. These symptoms show variable responsiveness to dopaminergic therapy. OBJECTIVE:To determine whether dopaminergic (rs1076560 DRD2 G > T and rs4680 catechole-o-methyltransphera...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2017.12.010

    authors： Miller NS,Chou KL,Bohnen NI,Müller MLTM,Seidler RD

    更新日期：2018-03-01 00:00:00

  • Levodopa-responsive parkinsonism in hereditary spastic paraplegia with thin corpus callosum.

    abstract：:Hereditary spastic paraplegia with thin corpus callosum is a rare degenerative disease, which is characterized by a progressive weakness of the lower limbs with a hypoplastic corpus callosum, and is often associated with other symptoms such as mental impairment, amyotrophy, sensory disturbances, dysuria, nystagmus and...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2004.05.003

    authors： Kang SY,Lee MH,Lee SK,Sohn YH

    更新日期：2004-10-01 00:00:00

  • Familial cortical tremor with epilepsy.

    abstract：:We report here on a Japanese family in which five members in three generations developed non-progressive adult onset cortical tremor and epilepsy. Other than tremulous movements resembling essential tremor, the neurologic findings were unremarkable. Electrophysiologic studies revealed giant somatosensory evoked potent...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/s1353-8020(97)00001-1

    authors： Okuma Y,Shimo Y,Hatori K,Hattori T,Tanaka S,Mizuno Y

    更新日期：1997-04-01 00:00:00

  • Diagnostic potential of automated tractography in progressive supranuclear palsy variants.

    abstract：BACKGROUND:Microstructural white matter integrity captured by diffusion-tensor imaging (DTI) is significantly more affected in progressive supranuclear palsy-Richardson's syndrome (PSP-RS) compared to PSP-parkinsonism (PSP-P). OBJECTIVES:To characterize the microstructural integrity of large fascicular bundles using s...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2020.02.007

    authors： Potrusil T,Krismer F,Beliveau V,Seppi K,Müller C,Troger F,Göbel G,Steiger R,Gizewski ER,Poewe W,Scherfler C

    更新日期：2020-03-01 00:00:00

  • Hypothesis: a role for EBV-induced molecular mimicry in Parkinson's disease.

    abstract：:Current concepts regarding the pathogenesis of Parkinson's disease support a model whereby environmental factors conspire with a permissive genetic background to initiate the disease. The identity of the responsible environmental trigger has remained elusive. There is incontrovertible evidence that aggregation of the ...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,评审

    doi：10.1016/j.parkreldis.2014.02.031

    authors： Woulfe JM,Gray MT,Gray DA,Munoz DG,Middeldorp JM

    更新日期：2014-07-01 00:00:00