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CSF biomarker profiles do not differentiate between the cerebellar and parkinsonian phenotypes of multiple system atrophy.

Abstract：

BACKGROUND:Multiple system atrophy (MSA) can clinically be divided into the cerebellar (MSA-C) and the parkinsonian (MSA-P) variants. It is unknown whether the variation in clinical expression is also reflected by a different underlying neurochemical profile. METHODS:We analyzed brain specific proteins and neurotransmitter metabolites in cerebrospinal fluid (CSF) of 26 patients with MSA-C and 19 with MSA-P. RESULTS:No differences were found between MSA-C and MSA-P. CONCLUSION:Our results suggest that the clinical and in part pathological distinction between the two clinical MSA phenotypes is not reflected by the neurochemical composition of CSF.

journal_name

Parkinsonism Relat Disord

journal_title

Parkinsonism & related disorders

authors

Abdo WF,van de Warrenburg BP,Kremer HP,Bloem BR,Verbeek MM

doi

10.1016/j.parkreldis.2007.02.002

subject

Has Abstract

pub_date

2007-12-01 00:00:00

pages

480-2

issue

8

eissn

1353-8020

issn

1873-5126

pii

S1353-8020(07)00032-6

journal_volume

13

pub_type

杂志文章

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