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Subject-investigator reproducibility of the Unified Parkinson's Disease Rating Scale.

Abstract：

OBJECTIVE:To evaluate the subject-investigator agreement on the Unified Parkinson's Disease Rating Scale (UPDRS) subsections I and II. METHODS:Subject-investigator agreement was estimated at baseline and endpoint by Kappa statistics for individual items and concordance correlations for subscale totals using data from two NIH Exploratory Trials in Parkinson's Disease studies. RESULTS:All but two questions had moderate subject-investigator agreement at baseline and endpoint. Participants consistently rated their disease activity worse that investigators. CONCLUSION:UPDRS self-administration produces similar results to investigator-administration. Although slightly elevated, UPDRS self-administration can be accommodated in a clinical trial setting.

journal_name

Parkinsonism Relat Disord

journal_title

Parkinsonism & related disorders

authors

Seidel SE,Tilley BC,Huang P,Palesch YY,Bergmann KJ,Goetz CG,Swearingen CJ

doi

10.1016/j.parkreldis.2011.10.006

subject

Has Abstract

pub_date

2012-03-01 00:00:00

pages

230-3

issue

3

eissn

1353-8020

issn

1873-5126

pii

S1353-8020(11)00328-2

journal_volume

18

pub_type

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