Wilson's disease with myoclonus and white matter lesions.


:White matter lesions (WML) and epilepsy have been occasionally seen in Wilson's disease. No cases of generalized myoclonus have been reported so far. We present a patient with psychiatric symptoms starting at age 16, followed by tremor, generalized dystonia and severe generalized myoclonus. In addition to classical findings, the MRI showed also extensive WML in temporal, parietal and frontal regions, preserving interhemispheric fibers. Necropsy revealed marked alterations of white matter, cortex and basal ganglia. We subsequently review the literature concerning WML and myoclonus in Wilson's disease.


Barbosa ER,Silveira-Moriyama L,Machado AC,Bacheschi LA,Rosemberg S,Scaff M




Has Abstract


2007-04-01 00:00:00














  • Diagnostic potential of automated tractography in progressive supranuclear palsy variants.

    abstract:BACKGROUND:Microstructural white matter integrity captured by diffusion-tensor imaging (DTI) is significantly more affected in progressive supranuclear palsy-Richardson's syndrome (PSP-RS) compared to PSP-parkinsonism (PSP-P). OBJECTIVES:To characterize the microstructural integrity of large fascicular bundles using s...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章


    authors: Potrusil T,Krismer F,Beliveau V,Seppi K,Müller C,Troger F,Göbel G,Steiger R,Gizewski ER,Poewe W,Scherfler C

    更新日期:2020-03-01 00:00:00

  • Gender and onset age-related features of non-motor symptoms of patients with Parkinson's disease--a study from Southwest China.

    abstract:BACKGROUND:Non-motor symptom (NMS) differences between male Parkinson's disease (PD) and female PD, and between early-onset PD (EOPD) and late-onset PD (LOPD) in Chinese populations remain largely unknown. METHODS:A total of 522 PD patients from Southwest China were included. Patients were assessed using the Non-Motor...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章


    authors: Guo X,Song W,Chen K,Chen X,Zheng Z,Cao B,Huang R,Zhao B,Wu Y,Shang HF

    更新日期:2013-11-01 00:00:00

  • Voxel-wise analysis of diffusion tensor MRI improves the confidence of diagnosis of corticobasal degeneration non-invasively.

    abstract::Corticobasal degeneration (CBD) presents with symptoms that often overlap with other neurological conditions. In many cases, diagnosis, prognosis and consequent clinical management remain uncertain. Structural and functional asymmetric brain changes represent the most consistent imaging findings that may assist in CBD...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章


    authors: Bozzali M,Cercignani M,Baglio F,Scotti G,Farina E,Pugnetti L,Ashburner J,Nemni R,Falini A

    更新日期:2008-01-01 00:00:00

  • The pattern of FP-CIT PET in pure white matter hyperintensities-related vascular parkinsonism.

    abstract:OBJECTIVES:To determine whether vascular parkinsonism (VaP) patients with visually normal dopamine transporter (DAT) scans have presynaptic dopaminergic depletion. METHODS:We enrolled 23 VaP patients who had parkinsonism, relevant diffuse subcortical white matter hyperintensities (WMH), and visually normal DAT scans, ...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章


    authors: Lee YH,Lee S,Chung SJ,Yoo HS,Jung JH,Baik K,Ye BS,Sohn YH,Yun M,Lee PH

    更新日期:2021-01-01 00:00:00

  • Organization of midbrain dopamine systems and the pathophysiology of Parkinson's disease.

    abstract::Understanding of the pathophysiology of Parkinson disease (PD) has advanced rapidly over the last two decades through basic and clinical studies using modern neuroanatomical, clinical assessment, neuropathological and functional brain imaging methods. Two interacting processes determine the development of functional i...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章,评审


    authors: Moore RY

    更新日期:2003-08-01 00:00:00

  • Developing a PD Service.

    abstract::Several changes to society in the last four decades have had implications for people and their families living with Parkinson's disease (PD): (1) The change in the role of voluntary organisations highlighting the importance of listening to the needs of the patients and their families. (2) Demographic changes resulting...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章,评审


    authors: Baker MG

    更新日期:2007-01-01 00:00:00

  • Acute dystonia in a young schizophrenic patient associated with ingestion of a cloperastine containing cough syrup.

    abstract::Acute dystonic reactions are usually observed after exposure to drugs with antidopaminergic actions. We report on one patient with acute dystonia associated with ingestion of a cloperastine containing syrup, who suffered from schizophrenia but had been neuroleptic-free for 6months. Cloperastine has antihistaminic prop...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章


    authors: Linazasoro G,Garmendia MT,Lizaso X

    更新日期:2000-01-01 00:00:00

  • Parkinson's disease, levodopa-use and the risk of melanoma.

    abstract::Since the early 1970s, the literature has suggested an association between Parkinson's Disease (PD) and/or levodopa-use and an increased risk for the development of malignant melanoma. In some countries, this possible association has even led to a warning in the drug insert leaflet of the possible risk. Recently, five...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章,评审


    authors: Vermeij JD,Winogrodzka A,Trip J,Weber WE

    更新日期:2009-09-01 00:00:00

  • Effectiveness of tai chi for Parkinson's disease: a critical review.

    abstract::The objective of this review is to assess the effectiveness of tai chi as a treatment option for Parkinson's disease (PD). We have searched the literature using 21 databases from their inceptions to January 2008, without language restrictions. We included all types of clinical studies regardless of their design. Their...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章,评审


    authors: Lee MS,Lam P,Ernst E

    更新日期:2008-12-01 00:00:00

  • Intertemporal choice in Parkinson's disease and restless legs syndrome.

    abstract:BACKGROUND:Impulse control disorders in Parkinson's disease are a potential consequence of dopaminergic therapy. Impulse control problems might be revealed by intertemporal choice tasks which entail to forgo an immediately available reward in favor of a larger but later reward. The steepness of the discounting curve ca...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章


    authors: Al-Khaled M,Heldmann M,Bolstorff I,Hagenah J,Münte TF

    更新日期:2015-11-01 00:00:00

  • Rotigotine transdermal patch in Chinese patients with early Parkinson's disease: A randomized, double-blind, placebo-controlled pivotal study.

    abstract:INTRODUCTION:Two phase3 studies (SP512; SP513) involving mostly Caucasian patients showed that rotigotine (≤8 mg/24 h) was efficacious and welltolerated in early-stage Parkinson's disease (PD). We report results from a phase 3 study (SP0914/NCT01646268) investigating rotigotine in Chinese patients with early-stage PD. ...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Zhang ZX,Shang HF,Hu X,Chen S,Zhao Z,Du X,Surmann E,Bauer L,Asgharnejad M

    更新日期:2016-07-01 00:00:00

  • Current treatment of tardive dyskinesia.

    abstract::Tardive dyskinesia (TD) is a common, iatrogenic movement disorder affecting many individuals treated with dopamine-receptor blocking agents (DRBAs). Studying treatment of TD can be complex, as the symptoms can be affected by changes in either dosage or type of DRBA, as well as by the variable natural course of the dis...

    journal_title:Parkinsonism & related disorders

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    authors: Margolius A,Fernandez HH

    更新日期:2019-02-01 00:00:00

  • Diagnostic accuracy of the appearance of Nigrosome-1 on magnetic resonance imaging in Parkinson's disease: A systematic review and meta-analysis.

    abstract:INTRODUCTION:There is currently no definitive diagnostic test for Parkinson's disease (PD) and the current diagnostic procedure primarily relies on clinical manifestations. A hypointense appearance of nigrosome-1 (or absence of the "swallow tail" sign) on magnetic resonance imaging (MRI) has been proposed as a biomarke...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章,评审


    authors: Chau MT,Todd G,Wilcox R,Agzarian M,Bezak E

    更新日期:2020-09-01 00:00:00

  • Altered functional network topology correlates with clinical measures in very early-stage, drug-naïve Parkinson's disease.

    abstract:INTRODUCTION:The aim of the study was to identify abnormalities of whole-brain network functional organization and their relation to clinical measures in a well-characterized, multi-site cohort of very early-stage, drug-naïve Parkinson's Disease (PD) patients. METHODS:Functional-MRI data for 16 healthy controls and 20...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章


    authors: Sreenivasan K,Mishra V,Bird C,Zhuang X,Yang Z,Cordes D,Walsh RR

    更新日期:2019-05-01 00:00:00

  • Psychiatric disturbances in patients with progressive supranuclear palsy: a case-control study.

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    journal_title:Parkinsonism & related disorders

    pub_type: 临床试验,杂志文章


    authors: Bloise MC,Berardelli I,Roselli V,Pasquini M,Stirpe P,Colosimo C,Berardelli A,Fabbrini G

    更新日期:2014-09-01 00:00:00

  • Long-duration Parkinson's disease: role of lateralization of motor features.

    abstract:BACKGROUND:A mean of 10 years elapse before patients with Parkinson's disease (PD) reach Hoehn & Yahr (H&Y) stage 4, and 14 years for stage 5. A small proportion of PD patients survive and are ambulatory for ≥ 20 years. We sought to identify features associated with long-duration PD (dPD). METHODS:This five-center, ca...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章


    authors: Munhoz RP,Espay AJ,Morgante F,Li JY,Teive HA,Dunn E,Gallin E,Litvan I

    更新日期:2013-01-01 00:00:00

  • Cardiovascular dysautonomia as a cause of falls in Parkinson's disease.

    abstract::Parkinson's disease (PD) patients have a ninefold increased risk of recurring falls compared to healthy controls. The risk of falling due to cardiovascular dysautonomia (CVD) is not quantifiable. But, CVD is an integral part of the disease and at least 20% of PD patients suffer from orthostatic hypotension, an express...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章,评审


    authors: Martignoni E,Tassorelli C,Nappi G

    更新日期:2006-05-01 00:00:00

  • Effect of light on blinking in patients with idiopathic isolated blepharospasm.

    abstract:OBJECTIVE:Melanopsin may be involved in the pathophysiology of photophobia in idiopathic isolated blepharospasm. We assessed the efficacy of blocking wavelengths of melanopsin absorption to reduce blinking in blepharospasm as a possible surrogate for photophobia. METHODS:Twenty-one participants (11 blepharospasm and 1...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章


    authors: Wu Y,Cho HJ,Panyakaew P,Savant CS,Wu T,Dang N,Hallett M

    更新日期:2019-10-01 00:00:00

  • Phenotype of non-c.907_909delGAG mutations in TOR1A: DYT1 dystonia revisited.

    abstract:BACKGROUND:In addition to the most frequent TOR1A/DYT1 mutation (c.907_909delGAG), a growing number of TOR1A sequence variants are found in dystonia patients. For most, functional characterization has demonstrated pathogenicity at different levels, implying that TOR1A genetic testing should not be limited to screening ...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章


    authors: Dobričić V,Kresojević N,Žarković M,Tomić A,Marjanović A,Westenberger A,Cvetković D,Svetel M,Novaković I,Kostić VS

    更新日期:2015-10-01 00:00:00

  • Cognitive associations with comprehensive gait and static balance measures in Parkinson's disease.

    abstract:INTRODUCTION:Gait and balance impairments are cardinal features of Parkinson's disease (PD) that require cognitive input. However, the extent to which specific gait and balance characteristics relate to cognition in PD is unclear. In addition, independent models of gait and balance have not been developed from the same...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章


    authors: Morris R,Martini DN,Smulders K,Kelly VE,Zabetian CP,Poston K,Hiller A,Chung KA,Yang L,Hu SC,Edwards KL,Cholerton B,Grabowski TJ,Montine TJ,Quinn JF,Horak F

    更新日期:2019-12-01 00:00:00

  • Movement disorders in Latin America.

    abstract::The authors review some particularities of movement disorders (MDs) in the ethnically diverse population of Latin America. Although idiopathic diseases are evenly prevalent, access to treatment encounters difficulties that are worth discussing. Infectious-parasitic diseases observed throughout the continent occasional...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章,评审


    authors: Troiano AR,Micheli FE,Alarcón F,Teive HA

    更新日期:2006-04-01 00:00:00

  • Rhythmic finger tapping reveals cerebellar dysfunction in essential tremor.

    abstract:INTRODUCTION:Cerebellar circuits are hypothesized to play a central role in the pathogenesis of essential tremor. Rhythmic finger tapping is known to strongly engage the cerebellar motor circuitry. We characterize cerebellar and, more specifically, dentate nucleus function, and neural correlates of cerebellar output in...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章,多中心研究


    authors: Buijink AW,Broersma M,van der Stouwe AM,van Wingen GA,Groot PF,Speelman JD,Maurits NM,van Rootselaar AF

    更新日期:2015-04-01 00:00:00

  • Predictors of onset of psychosis in patients with Parkinson's disease: Who gets it early?

    abstract:INTRODUCTION:Psychosis is one of the common non-motor symptoms of PD, which substantially worsens the quality of life. Hence, it is important to identify factors that are associated with early onset of psychosis in PD. In order to identify those factors, the current study aims to compare various demographic and clinica...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章


    authors: Lenka A,George L,Arumugham SS,Hegde S,Reddy V,Kamble N,Yadav R,Pal PK

    更新日期:2017-11-01 00:00:00

  • Bilateral low frequency rTMS of the primary motor cortex may not be a suitable treatment for levodopa-induced dyskinesias in late stage Parkinson's disease.

    abstract:BACKGROUND:In late stage Parkinson patients there is an unmet need for new treatments to adequately control motor complications, especially dyskinesias. In several preliminary studies, it has been suggested that applying unilateral low-frequency repetitive transcranial magnetic stimulation (LF rTMS), delivered at the p...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章


    authors: Flamez A,Cordenier A,De Raedt S,Michiels V,Smetcoren S,Van Merhaegen-Wieleman A,Parys E,De Keyser J,Baeken C

    更新日期:2016-01-01 00:00:00

  • Does the cerebellum intervene in the abnormal somatosensory temporal discrimination in Parkinson's disease?

    abstract:INTRODUCTION:somatosensory temporal discrimination threshold (STDT) measures the ability to perceive two stimuli as being sequential. Altered STDT has been reported in Parkinson's disease (PD). The cerebellum seems to play a role in the pathophysiology of PD, and may consequently be involved in the pathophysiology of S...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章


    authors: Di Biasio F,Conte A,Bologna M,Iezzi E,Rocchi L,Modugno N,Berardelli A

    更新日期:2015-07-01 00:00:00

  • Neurological manifestations and ATP7B mutations in Wilson's disease.

    abstract::Wilson's disease (WD) is a rare inborn metabolic error characterized by deficient biliary copper excretion secondary to ATP7B gene mutations. Neurological presentations are variable in respect to both pattern and age of onset; commonly a movement disorder presents in the second or third decade. The aim of this study w...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章


    authors: Machado AA,Deguti MM,Genschel J,Cançado EL,Bochow B,Schmidt H,Barbosa ER

    更新日期:2008-01-01 00:00:00

  • Salivary alpha-synuclein in the diagnosis of Parkinson's disease and Progressive Supranuclear Palsy.

    abstract:INTRODUCTION:Alpha-synuclein (α-syn) aggregation is the pathological hallmark of Parkinson's Disease (PD). In this study, we measured α-syn total (α-syntotal), oligomeric α-syn (α-synolig) and α-synolig/α-syntotal ratio in the saliva of patients affected by PD and in age and sex-matched healthy subjects. We also compar...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章


    authors: Vivacqua G,Suppa A,Mancinelli R,Belvisi D,Fabbrini A,Costanzo M,Formica A,Onori P,Fabbrini G,Berardelli A

    更新日期:2019-06-01 00:00:00

  • Onset-related subtypes of Parkinson's disease differ in the patterns of striatal dopaminergic dysfunction: A positron emission tomography study.

    abstract:PURPOSE:The young-onset subtype of Parkinson's disease (YOPD) differs from the late-onset subtype (LOPD) in drug responsiveness, incidence of motor complications, and prognosis. The pathophysiology underlying these differences remains largely unknown. This study investigated whether the two subtypes differ in the patte...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章


    authors: Liu SY,Wu JJ,Zhao J,Huang SF,Wang YX,Ge JJ,Wu P,Zuo CT,Ding ZT,Wang J

    更新日期:2015-12-01 00:00:00

  • Optic nerve integrity as a visuospatial cognitive predictor in Parkinson's disease.

    abstract:OBJECTIVE:To explore the microstructural integrity of the optic nerve and its role as a cognitive predictor in patients with de novo Parkinson's disease (PD) using diffusion tensor image-based magnetic resonance scans. METHODS:We enrolled 82 patients with de novo PD, 36 patients with drug-induced parkinsonism (DIP), a...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章


    authors: Lee JJ,Shin NY,Lee Y,Lee SK,Sohn YH,Lee PH

    更新日期:2016-10-01 00:00:00

  • Restless legs syndrome and periodic limb movements after ischemic stroke in the right lenticulostriate region.

    abstract::We report the first instance of restless legs syndrome (RLS) associated with periodic limb movements (PLM) and disruption of sleep architecture occurring in a patient following ischemic infarction in the right lenticulostriate region. Recently, a role for the basal ganglia-brainstem system in the control of motor beha...

    journal_title:Parkinsonism & related disorders

    pub_type: 杂志文章


    authors: Sechi G,Agnetti V,Galistu P,Murgia B,Marrosu F,Puligheddu M,Conti M,Paulus KS

    更新日期:2008-01-01 00:00:00