当前位置： SCI文献检索 > PARKINSONISM & RELATED DISORDERS期刊下所有文献 > Effect of light on blinking in patients with idiopathic isolated blepharospasm.

Effect of light on blinking in patients with idiopathic isolated blepharospasm.

Abstract：

OBJECTIVE:Melanopsin may be involved in the pathophysiology of photophobia in idiopathic isolated blepharospasm. We assessed the efficacy of blocking wavelengths of melanopsin absorption to reduce blinking in blepharospasm as a possible surrogate for photophobia. METHODS:Twenty-one participants (11 blepharospasm and 10 healthy controls) were studied. There were three sessions: (1) a baseline condition to measure the blink rate (BR) without intervention; (2) two conditions where the participants received intermittent light stimuli with high or low intensity without wearing study lenses; (3) four conditions in which the participants received intermittent light stimuli with high intensity while wearing one of four different lenses: tinted lenses with neutral gray or FL-41, or coated lenses that block 480-nm or 590-nm wavelength. The primary outcome measure was the BR. RESULTS:The blepharospasm group blinked more frequently than controls in dim room conditions. Patients reported greater photosensitivity compared to controls based on the questionnaire and exhibited a higher BR with intermittent light stimuli. The BR decreased for both groups when using 480-nm and 590-nm blocking lenses. In the patients, 480-nm and 590-nm blocking lenses reduced the mean BR by 9.6 blink/min and 10.3 blink/min, respectively, while in the control group, the mean BR decreased by 4.4 blink/min and 4.3 blink/min, respectively. CONCLUSIONS:Blepharospasm patients had increased BR with light stimuli which decreased with 590-nm and 480-nm blocking lenses. The 480-nm- and 590-nm- coated lenses might have therapeutic potential in treating photophobia although BR does not appear to be an optimal biomarker for photophobia.

journal_name

Parkinsonism Relat Disord

journal_title

Parkinsonism & related disorders

authors

Wu Y,Cho HJ,Panyakaew P,Savant CS,Wu T,Dang N,Hallett M

doi

10.1016/j.parkreldis.2019.09.010

subject

Has Abstract

pub_date

2019-10-01 00:00:00

pages

66-71

eissn

1353-8020

issn

1873-5126

pii

S1353-8020(19)30387-6

journal_volume

67

pub_type

杂志文章

相关文献

PARKINSONISM & RELATED DISORDERS文献大全
  • Prospective study on the components of metabolic syndrome and the incidence of Parkinson's disease.

    abstract：INTRODUCTION:Inconsistent results regarding the association between the components of metabolic syndrome and Parkinson's disease (PD) have been reported. We investigated whether the metabolic syndrome or its components, or serum total cholesterol, predict PD incidence in a prospective cohort study design. METHODS:The ...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2015.07.017

    authors： Sääksjärvi K,Knekt P,Männistö S,Lyytinen J,Heliövaara M

    更新日期：2015-10-01 00:00:00

  • Sensory neuropathy in autosomal recessive juvenile parkinsonism (PARK2).

    abstract：:Autosomal recessive juvenile parkinsonism (ARJP/PARK2) is a distinct clinical and genetic entity characterized by early-onset levodopa-responsive parkinsonism, foot dystonia, sleep benefit, and hyperactive tendon reflexes. We report a patient with genetically confirmed ARJP, who showed mild sensory disturbance and dim...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/s1353-8020(02)00114-1

    authors： Okuma Y,Hattori N,Mizuno Y

    更新日期：2003-06-01 00:00:00

  • Serum uric acid level as a putative biomarker in Parkinson's disease patients carrying GBA1 mutations: 2-Year data from the PPMI study.

    abstract：INTRODUCTION:Blood uric acid represents an important biomarker in sporadic Parkinson's disease (PD). Whether uric acid levels change in genetic forms of PD is beginning to be assessed. The aim of the present study was to evaluate differences in serum uric acid level among PD patients harboring mutations in the glucocer...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2020.12.020

    authors： Koros C,Simitsi AM,Papagiannakis N,Bougea A,Prentakis A,Papadimitriou D,Pachi I,Antonelou R,Angelopoulou E,Beratis I,Bozi M,Papageorgiou SG,Trapali XG,Stamelou M,Stefanis L

    更新日期：2021-01-20 00:00:00

  • Dihydroergotoxine mesylate for the treatment of sialorrhea in Parkinson's disease.

    abstract：BACKGROUND:Many patients with Parkinson's disease (PD) suffer from sialorrhea. Sialorrhea is often treated with anticholinergics and botulinum toxin, but some adverse effects have limited the use of these treatments. Dihydroergotoxine mesylate is an α-adrenergic blocking agents as well as some affinities to the dopamin...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.parkreldis.2018.08.022

    authors： Cheng YQ,Ge NN,Zhu HH,Sha ZT,Jiang T,Zhang YD,Tian YY

    更新日期：2019-01-01 00:00:00

  • Delayed-onset dystonia in patients with antecedents of perinatal asphyxia.

    abstract：:We report 27 cases of delayed-onset dystonia in patients with antecendents of perinatal asphyxia after excluding other possible causes of dystonia. The patients were 16 males and 11 females (mean +/- SD age at onset of dystonia = 13.0 +/- 9.4 yr). Adverse obstetric and/or perinatal events were presented by 20 patients...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/s1353-8020(96)00035-1

    authors： Jiménez-Jiménez FJ,Burguera J,Catalán MJ,Vázquez A,Vaamonde J,Vela-Desojo L,Martínez-Martín P,Balseiro J,Pondal-Sordo M,Domingo J,García-Ruiz PJ,Muñoz-Vázquez A,Molina J,Ceballos-Hernánsont MA,Arcaya J,Duarte J

    更新日期：1997-01-01 00:00:00

  • Neurological manifestations and ATP7B mutations in Wilson's disease.

    abstract：:Wilson's disease (WD) is a rare inborn metabolic error characterized by deficient biliary copper excretion secondary to ATP7B gene mutations. Neurological presentations are variable in respect to both pattern and age of onset; commonly a movement disorder presents in the second or third decade. The aim of this study w...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2007.08.002

    authors： Machado AA,Deguti MM,Genschel J,Cançado EL,Bochow B,Schmidt H,Barbosa ER

    更新日期：2008-01-01 00:00:00

  • Increases in institutionalization, healthcare resource utilization, and mortality risk associated with Parkinson disease psychosis: Retrospective cohort study.

    abstract：INTRODUCTION:Patients with Parkinson disease (PD) often develop psychosis (P). The association of PDP with death and long-term custodial care (CC) has not been well studied. METHODS:Medicare Parts A, B, and D data, 2007-2015, were used to define cohorts of PD and PDP patients. PD was defined by ≥ 2 ICD-9-CM codes (332...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2019.10.018

    authors： Wetmore JB,Li S,Yan H,Irfan M,Rashid N,Peng Y,Gilbertson DT,Shim A

    更新日期：2019-11-01 00:00:00

  • Pareidolias and cognition in isolated REM sleep behavior disorder.

    abstract：BACKGROUND:Though visual illusions and hallucinations are common in dementia with Lewy bodies (DLB) and Parkinson's disease (PD), they are not typically observed clinically in prodromal stages, including isolated REM sleep behavior disorder (iRBD). False-noise errors on the pareidolia test (seeing faces when none are p...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2020.05.017

    authors： Honeycutt L,Gagnon JF,Pelletier A,De Roy J,Montplaisir JY,Postuma RB

    更新日期：2020-06-01 00:00:00

  • Diagnostic accuracy of [99mTc]TRODAT-1 SPECT imaging in early Parkinson's disease.

    abstract：:We evaluated the diagnostic accuracy of SPECT imaging using [(99m)Tc]TRODAT-1 (TRODAT), a relatively inexpensive technetium-labeled dopamine transporter ligand, in distinguishing 29 patients with early PD from 38 healthy volunteers. Mean TRODAT uptake values were significantly decreased in the caudate (p=0.0097) and a...

    journal_title：Parkinsonism & related disorders

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.parkreldis.2004.04.002

    authors： Chou KL,Hurtig HI,Stern MB,Colcher A,Ravina B,Newberg A,Mozley PD,Siderowf A

    更新日期：2004-08-01 00:00:00

  • Tremor-related quality of life: A comparison of essential tremor vs. Parkinson's disease patients.

    abstract：BACKGROUND:Tremor-related quality of life is a multi-dimensional concept that reflects the physical, emotional and other health effects of tremor. Curiously, tremor-related quality of life has never been directly compared in patients with the two major tremor disorders, essential tremor (ET) and Parkinson's disease (PD...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2015.04.019

    authors： Louis ED,Machado DG

    更新日期：2015-07-01 00:00:00

  • Significance of cerebellar Purkinje cell loss to pathogenesis of essential tremor.

    abstract：UNLABELLED:Some recent studies indicate that most essential tremor (ET) cases have cerebellar pathology characterized by Purkinje cell (PC) loss and its sequelae. OBJECTIVE:To assess the role of PC degeneration in ET symptomatology. METHODS:We studied seven ET, six tremor dominant Parkinson's disease controls and two...

    journal_title：Parkinsonism & related disorders

    pub_type： 评论,杂志文章

    doi：10.1016/j.parkreldis.2011.05.008

    authors： Rajput AH,Rajput A

    更新日期：2011-07-01 00:00:00

  • Diagnostic accuracy of ¹²³I-FP-CIT (DaTSCAN) in dementia with Lewy bodies: a meta-analysis of published studies.

    abstract：PURPOSE:A systematic meta-analysis of published studies on the diagnostic accuracy of presynaptic dopaminergic imaging with ¹²³I-FP-CIT (DaTSCAN) in dementia with Lewy bodies (DLB). METHODS:We included (a) studies in which DaTSCAN was performed in cases of diagnostic uncertainty to differentiate between DLB and non-DL...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.parkreldis.2011.09.015

    authors： Papathanasiou ND,Boutsiadis A,Dickson J,Bomanji JB

    更新日期：2012-03-01 00:00:00

  • Olfactory tests in the diagnosis of essential tremor.

    abstract：:Most patients with tremor-dominant Parkinson's disease (PD) have impaired smell function but it is unclear whether this is true for subjects with essential tremor (ET). If ET patients do not exhibit meaningful smell loss, then olfactory testing may help to distinguish PD from ET. We assessed olfactory function in 59 E...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2007.12.006

    authors： Shah M,Muhammed N,Findley LJ,Hawkes CH

    更新日期：2008-11-01 00:00:00

  • Noninvasive functional neurosurgery using transcranial MR imaging-guided focused ultrasound.

    abstract：UNLABELLED:Transcranial magnetic resonance imaging-guided focused ultrasound (tcMRgFUS) is a novel technique to supplement the spectrum of established neurosurgical interventions. In contrast to traditional ablative procedures, tcMRgFUS is noninvasive and entirely imaging-guided with continuous temperature measurements...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,评审

    doi：10.1016/S1353-8020(13)70046-4

    authors： Bauer R,Martin E,Haegele-Link S,Kaegi G,von Specht M,Werner B

    更新日期：2014-01-01 00:00:00

  • From 1997 to 2007: a decade journey through the H1 haplotype on 17q21 chromosome.

    abstract：:The H1 haplotype was first identified 10 years ago. Initially, a dinucleotide polymorphism was detected in the tau (MAPT) gene and was subsequently found to be in linkage disequilibrium (LD) with other polymorphisms, forming the MAPT H1 haplotype, a risk factor for many neurological diseases, considered as tauopathies...

    journal_title：Parkinsonism & related disorders

    pub_type： 历史文章,杂志文章,评审

    doi：10.1016/j.parkreldis.2008.03.001

    authors： Kalinderi K,Fidani L,Bostantjopoulou S

    更新日期：2009-01-01 00:00:00

  • PLA2G6-associated neurodegeneration: New insights into brain abnormalities and disease progression.

    abstract：INTRODUCTION:PLA2G6-associated neurodegeneration (PLAN) comprises a continuum of three phenotypes with overlapping clinical and radiologic features. METHODS:Observational clinical study in a cohort of infantile and childhood onset PLAN patients and genetic analysis of the PLA2G6 gene. We analysed chronological evoluti...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.parkreldis.2018.10.013

    authors： Darling A,Aguilera-Albesa S,Tello CA,Serrano M,Tomás M,Camino-León R,Fernández-Ramos J,Jiménez-Escrig A,Poó P,O'Callaghan M,Ortez C,Nascimento A,Fernández Mesaque RC,Madruga M,Arrabal L,Roldan S,Gómez-Martín H,Garrido C

    更新日期：2019-04-01 00:00:00

  • Hypertrophic olivary degeneration: A clinico-radiologic study.

    abstract：INTRODUCTION:The frequency and causes of hypertrophic olivary degeneration (HOD) are unknown. We compared the clinical and radiological characteristics of unilateral HOD and bilateral HOD. METHODS:We performed a search of a radiologic report database for patients who were radiologically diagnosed as having HOD. This d...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2016.04.008

    authors： Konno T,Broderick DF,Tacik P,Caviness JN,Wszolek ZK

    更新日期：2016-07-01 00:00:00

  • Altered body composition, sarcopenia, frailty, and their clinico-biological correlates, in Parkinson's disease.

    abstract：INTRODUCTION:Low body weight in Parkinson's disease (PD) is poorly understood despite the associated risks of malnutrition, fractures, and death. Sarcopenia (loss of muscle bulk and strength) and frailty are geriatric syndromes that are likewise associated with adverse health outcomes, yet have received scant attention...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2018.06.020

    authors： Tan AH,Hew YC,Lim SY,Ramli NM,Kamaruzzaman SB,Tan MP,Grossmann M,Ang BH,Tan JY,Manap MAAA,Tay TK,Tan SL,New RP,Fadzli F,Yee EJ,Moy FM,Mahadeva S,Lang AE

    更新日期：2018-11-01 00:00:00

  • Transcranial magnetic stimulation improves cognition over time in Parkinson's disease.

    abstract：INTRODUCTION:Cognitive impairment can occur in the early phase of Parkinson's disease and increases the risk of developing dementia. Cognitive deficits were shown to be associated with functional alterations in the dorsolateral prefrontal cortex (DLPFC) and caudate nucleus. Two previous transcranial magnetic stimulatio...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.parkreldis.2019.07.006

    authors： Trung J,Hanganu A,Jobert S,Degroot C,Mejia-Constain B,Kibreab M,Bruneau MA,Lafontaine AL,Strafella A,Monchi O

    更新日期：2019-09-01 00:00:00

  • Movement disorders in Latin America.

    abstract：:The authors review some particularities of movement disorders (MDs) in the ethnically diverse population of Latin America. Although idiopathic diseases are evenly prevalent, access to treatment encounters difficulties that are worth discussing. Infectious-parasitic diseases observed throughout the continent occasional...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,评审

    doi：10.1016/j.parkreldis.2005.08.009

    authors： Troiano AR,Micheli FE,Alarcón F,Teive HA

    更新日期：2006-04-01 00:00:00

  • Long-term response to continuous duodenal infusion of levodopa/carbidopa gel in patients with advanced Parkinson disease: The Barcelona registry.

    abstract：INTRODUCTION:Continuous infusion of levodopa/carbidopa intestinal gel (LCIG) is an effective treatment for patients with advanced Parkinson Disease (PD) that cannot be further improved by oral therapy. METHODS:We conducted an observational, prospective, and multicenter study to collect, in a large sample of PD treated...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.parkreldis.2015.05.014

    authors： Buongiorno M,Antonelli F,Cámara A,Puente V,de Fabregues-Nebot O,Hernandez-Vara J,Calopa M,Pascual-Sedano B,Campolongo A,Valldeoriola F,Tolosa E,Kulisevsky J,Martí MJ

    更新日期：2015-08-01 00:00:00

  • Is there a pathogenic role for mitochondria in Parkinson's disease?

    abstract：:Parkinson's disease (PD) is a common neurodegenerative disorder of unknown cause. For decades, a deficit in mitochondrial respiration was thought to be a key factor in PD neurodegeneration. However, excluding a few exceptions where a clinical picture of parkinsonism is associated with a mitochondrial DNA mutation, pre...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/S1353-8020(09)70823-5

    authors： Vives-Bauza C,de Vries RL,Tocilescu MA,Przedborski S

    更新日期：2009-12-01 00:00:00

  • Diaphragmatic myoclonus owing to electrode dislocation of implantable cardioverter defibrillator.

    abstract：:Myoclonus is a sudden and brief involuntary muscle contraction presenting with jerk-like movements that can occasionally involve the trunk muscles or the diaphragm as in the case of spinal myoclonus1. We here present an unusual case with unilateral diaphragmatic myoclonus owing to electrode dislocation of an implantab...

    journal_title：Parkinsonism & related disorders

    pub_type： 信件

    doi：10.1016/j.parkreldis.2019.03.004

    authors： Bedarf JR,Nitsch L,Malotki R,Andrié R,Reimann J

    更新日期：2019-06-01 00:00:00

  • A randomized, double-blind, controlled trial of add-on therapy in moderate-to-severe Parkinson's disease.

    abstract：OBJECTIVE:The primary objective was to evaluate the efficacy and safety of droxidopa as add-on therapy in improving stiffness, tremors and other motor functions and activities of daily living for moderate-to-severe Parkinson's disease (PD). METHODS:PD patients, above Hoehn-Yahr III (including Hoehn-Yahr III), were ran...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.parkreldis.2015.08.023

    authors： Zhao S,Cheng R,Zheng J,Li Q,Wang J,Fan W,Zhang L,Zhang Y,Li H,Liu S

    更新日期：2015-10-01 00:00:00

  • Immunization strategies for Parkinson's disease.

    abstract：:Parkinson's disease (PD) is the most common neurodegenerative movement disorder. Currently, no curative treatments or treatments that interdict disease progression are available. Over the past decade, immunization strategies were developed in our laboratories to combat disease progression. These strategies were develo...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,评审

    doi：10.1016/S1353-8020(11)70067-0

    authors： Ha D,Stone DK,Mosley RL,Gendelman HE

    更新日期：2012-01-01 00:00:00

  • Subjective perceived outcome of subthalamic deep brain stimulation in Parkinson's disease one year after surgery.

    abstract：OBJECTIVES:Dissatisfaction with subthalamic deep brain stimulation (STN-DBS) despite motor improvements has been observed in Parkinson's disease (PD). Hence, we compared patient's subjective perceived outcome 12 months after surgery (12mFU) with clinical measures to identify risk factors of dissatisfaction. METHODS:Pa...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2016.01.019

    authors： Maier F,Lewis CJ,Horstkoetter N,Eggers C,Dembek TA,Visser-Vandewalle V,Kuhn J,Zurowski M,Moro E,Woopen C,Timmermann L

    更新日期：2016-03-01 00:00:00

  • The impact of ropinirole on blood pressure and noradrenaline concentration after active orthostasis in Parkinsonian patients.

    abstract：:Orthostatic hypotension is common in Parkinsonian patients. It is probably caused by reduced noradrenaline (NA) release. This effect is further enhanced by therapeutic use of ergot alkaloid dopamine agonists. In this trial we studied the impact of the non-ergot dopamine agonist ropinirole on blood pressure and noradre...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/s1353-8020(98)00014-5

    authors： Jost WH,Bellon AK,Kaiser T,Schrank B

    更新日期：1998-08-01 00:00:00

  • Plasma immune markers in an idiopathic REM sleep behavior disorder cohort.

    abstract：INTRODUCTION:Increasing evidence shows a strong association between idiopathic REM sleep behavior disorder (iRBD) and α-synucleinopathies. Recent studies have indicated an inflammatory mechanism in the pathogenesis of α-synucleinopathies. Whether peripheral inflammatory cytokines are altered in iRBD and can be biomarke...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2020.07.017

    authors： Zhang H,Wang T,Li Y,Mao W,Hao S,Huang Z,Chan P,Cai Y

    更新日期：2020-09-01 00:00:00

  • Bilateral pallidal stimulation improves cervical dystonia for more than a decade.

    abstract：INTRODUCTION:Deep brain stimulation (DBS) is an effective treatment in medically resistant cervical dystonia (CD) with a documented therapeutic effect. Long term outcome beyond a decade, however, has not been studied systematically. METHODS:To investigate the impact of pallidal DBS beyond 10 years in CD we followed a ...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2020.10.028

    authors： Kaelin-Lang A,You H,Burgunder JM,Lönnfors-Weitze T,Loher TJ,Taub E,Isaias IU,Krauss JK,Michael Schüpbach WM

    更新日期：2020-12-01 00:00:00

  • Familial cortical tremor with epilepsy.

    abstract：:We report here on a Japanese family in which five members in three generations developed non-progressive adult onset cortical tremor and epilepsy. Other than tremulous movements resembling essential tremor, the neurologic findings were unremarkable. Electrophysiologic studies revealed giant somatosensory evoked potent...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/s1353-8020(97)00001-1

    authors： Okuma Y,Shimo Y,Hatori K,Hattori T,Tanaka S,Mizuno Y

    更新日期：1997-04-01 00:00:00