Non motor subtypes and Parkinson's disease.

abstract：BACKGROUND:Deep brain stimulation improves motor function and quality of life in patients with Parkinson's disease. The impact of these changes on patients' spouses is largely unknown. METHODS:Twenty-six spouses of patients undergoing surgery were evaluated before and 12 months after surgery, using the 36-Item Short F...

journal_title：Parkinsonism & related disorders

authors： Soulas T,Sultan S,Gurruchaga JM,Palfi S,Fénelon G

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Deep brain stimulation of the subthalamic nucleus (STN-DBS) reduces motor fluctuations in Parkinson's disease (PD) but its effect on non-motor fluctuations (NMF) is not well known. In this study we assess the efficacy of STN-DBS on NMF two years after surgery. METHODS:Autonomic, cognitive, psychiatric and s...

journal_title：Parkinsonism & related disorders

authors： Ortega-Cubero S,Clavero P,Irurzun C,Gonzalez-Redondo R,Guridi J,Obeso JA,Rodriguez-Oroz MC

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVE:Our purpose was to determine whether the use of catechol-O-methyltransferase-inhibitors (ICOMT) can reduce the risk of developing levodopa (LD)-induced neuropathy in Parkinson's disease (PD) patients. METHODS:A multicentre study of 197 PD patients was performed. 144 were exposed to LD for more than three yea...

journal_title：Parkinsonism & related disorders

authors： Cossu G,Ceravolo R,Zibetti M,Arca R,Ricchi V,Paribello A,Murgia D,Merola A,Romagnolo A,Nicoletti V,Palermo G,Mereu A,Lopiano L,Melis M,Abbruzzese G,Bonuccelli U

更新日期：2016-06-01 00:00:00

abstract：:Pathogenic mutations in the EIF4G1 gene were recently reported as a cause of autosomal dominant parkinsonism. To assess the frequency of EIF4G1 mutations in the Japanese population we sequenced the entire gene coding region (31 exons) in 95 patients with an apparent autosomal dominant inherited form of Parkinson's dis...

journal_title：Parkinsonism & related disorders

authors： Nishioka K,Funayama M,Vilariño-Güell C,Ogaki K,Li Y,Sasaki R,Kokubo Y,Kuzuhara S,Kachergus JM,Cobb SA,Takahashi H,Mizuno Y,Farrer MJ,Ross OA,Hattori N

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy of solifenacin succinate in Parkinson's disease (PD) patients suffering from overactive bladder (OAB). BACKGROUND:Urinary dysfunction is a commonly encountered non-motor feature in PD that significantly impacts patient quality of life. DESIGN/METHODS:This was a double-blind, randomi...

journal_title：Parkinsonism & related disorders

authors： Zesiewicz TA,Evatt M,Vaughan CP,Jahan I,Singer C,Ordorica R,Salemi JL,Shaw JD,Sullivan KL,Non-Motor Working Group of the Parkinson Study Group (PSG).

更新日期：2015-05-01 00:00:00

abstract：INTRODUCTION:Alpha-synuclein (α-syn) aggregation is the pathological hallmark of Parkinson's Disease (PD). In this study, we measured α-syn total (α-syntotal), oligomeric α-syn (α-synolig) and α-synolig/α-syntotal ratio in the saliva of patients affected by PD and in age and sex-matched healthy subjects. We also compar...

journal_title：Parkinsonism & related disorders

authors： Vivacqua G,Suppa A,Mancinelli R,Belvisi D,Fabbrini A,Costanzo M,Formica A,Onori P,Fabbrini G,Berardelli A

更新日期：2019-06-01 00:00:00

abstract：:Parkinson's disease (PD) is a common neurodegenerative disorder that produces progressive disability despite symptomatic treatment. Several strategies, including stereotaxic brain lesions, deep brain stimulation, transplants of dopamine cells and administration of neurotrophic factors, have been proposed to improve ef...

journal_title：Parkinsonism & related disorders

authors： Fontan A,Rojo A,Sanchez Pernaute R,Hernández I,López I,Castilla C,Sanchez Albisua J,Perez Higueras A,Al-Rashid I,Rabano A,Gonzalo I,Angeles Mena M,Cools A,Eshuis S,Maguire P,Pruim J,Leenders K,Garcia de Yebenes J

更新日期：2002-06-01 00:00:00

abstract：BACKGROUND:IPX066, an investigational extended-release carbidopa-levodopa (CD-LD) preparation, has demonstrated a rapid attainment and prolonged maintenance of therapeutic LD plasma concentrations in advanced Parkinson's disease (PD). This phase-3 crossover study assessed its efficacy and safety vs. CD-LD plus entacapo...

journal_title：Parkinsonism & related disorders

authors： Stocchi F,Hsu A,Khanna S,Ellenbogen A,Mahler A,Liang G,Dillmann U,Rubens R,Kell S,Gupta S

更新日期：2014-12-01 00:00:00

abstract：INTRODUCTION:Cognitive decline is common in Parkinson's disease (PD), and identifying patients at highest risk for it is essential. We aimed to examine the effect of possible REM sleep behavior disorder (pRBD) on rate of cognitive decline in early PD, for both global cognition and in specific cognitive domains. METHOD...

journal_title：Parkinsonism & related disorders

authors： Chahine LM,Xie SX,Simuni T,Tran B,Postuma R,Amara A,Oertel WH,Iranzo A,Scordia C,Fullard M,Linder C,Purri R,Darin A,Rennert L,Videnovic A,Del Riva P,Weintraub D

更新日期：2016-06-01 00:00:00

abstract：:Anterograde tract-tracing and immunohistochemical methods were used to study projections from the pedunculopontine tegmental nucleus (PPN) to midbrain dopaminergic neurons in the squirrel monkey (Saimiri sciureus). The PPN harbored numerous cholinergic and glutamatergic neurons, as well as neurons that displayed both ...

journal_title：Parkinsonism & related disorders

authors： Parent A,Parent M,Charara A

更新日期：1999-12-01 00:00:00

abstract：BACKGROUND:Deep brain stimulation surgery (DBS) for movement disorders has become commonplace and patients are beginning to present to specialized centers for second opinions. We aimed to uncover reasons for referral by analyzing a large single center cohort of DBS patients referred for management. METHODS:Data were c...

journal_title：Parkinsonism & related disorders

authors： Kluger BM,Foote KD,Jacobson CE,Okun MS

更新日期：2011-05-01 00:00:00

abstract：INTRODUCTION:Psychosis is one of the common non-motor symptoms of PD, which substantially worsens the quality of life. Hence, it is important to identify factors that are associated with early onset of psychosis in PD. In order to identify those factors, the current study aims to compare various demographic and clinica...

journal_title：Parkinsonism & related disorders

authors： Lenka A,George L,Arumugham SS,Hegde S,Reddy V,Kamble N,Yadav R,Pal PK

更新日期：2017-11-01 00:00:00

abstract：:Spinocerebellar ataxia (SCA) 17 is a dominant, progressive, neurodegenerative disorder. The disease is caused by a triplet repeat expansion mutation within TATA-binding protein (TBP). Ataxia, dementia, parkinsonism and dystonia are common features. We have previously shown in several pedigrees that SCA-2 and SCA-3 can...

journal_title：Parkinsonism & related disorders

authors： Hernandez D,Hanson M,Singleton A,Gwinn-Hardy K,Freeman J,Ravina B,Doheny D,Gallardo M,Weiser R,Hardy J,Singleton A

更新日期：2003-08-01 00:00:00

abstract：:Hemifacial spasm (HFS) resulting from Chiari type I malformation (CIM) is rare. We retrospectively evaluated five patients with CIM and HFS among a series of 103 subjects. The frequency of HFS associated to CIM was of 4.85%. The clinical profile did not differ from the classical primary cases except for young-onset de...

journal_title：Parkinsonism & related disorders

authors： Felício AC,de Godeiro C Jr,Borges V,de Azevedo Silva SM,Ferraz HB

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:There is an unmet need to better control motor complications in Parkinson's disease (PD). Naftazone, which exhibits glutamate release inhibition properties, has shown antiparkinsonian and antidyskinetic activity in preclinical models of PD and in a clinical proof of concept study. METHODS:We conducted a d...

journal_title：Parkinsonism & related disorders

authors： Corvol JC,Durif F,Meissner WG,Azulay JP,Haddad R,Guimarães-Costa R,Mariani LL,Cormier-Dequaire F,Thalamas C,Galitzky M,Boraud T,Debilly B,Eusebio A,Houot M,Dellapina E,Chaigneau V,Salis A,Lacomblez L,Benel L,Rascol

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Motor complications may become major challenges in the management of patients with Parkinson's disease. In this study, we sought to determine the incidence, risk factors, evolution, and treatment of motor fluctuations and dyskinesias in a population-representative, incident Parkinson's disease cohort. METHO...

journal_title：Parkinsonism & related disorders

authors： Bjornestad A,Forsaa EB,Pedersen KF,Tysnes OB,Larsen JP,Alves G

更新日期：2016-01-01 00:00:00

abstract：INTRODUCTION:The age of diagnosis of Huntington's disease (HD) varies among individuals with the same HTT CAG-repeat expansion size. We investigated whether early-life events, like perinatal insults or neurodevelopmental disorders, influence the diagnosis age. METHODS:We used data from 13,856 participants from REGISTR...

journal_title：Parkinsonism & related disorders

authors： Barkhuizen M,Rodrigues FB,Anderson DG,Winkens B,REGISTRY Investigators of the European Huntington's Disease Network.,Wild EJ,Kramer BW,Gavilanes AWD

更新日期：2018-10-01 00:00:00

abstract：:Parkinson's disease (PD) patients have a ninefold increased risk of recurring falls compared to healthy controls. The risk of falling due to cardiovascular dysautonomia (CVD) is not quantifiable. But, CVD is an integral part of the disease and at least 20% of PD patients suffer from orthostatic hypotension, an express...

journal_title：Parkinsonism & related disorders

authors： Martignoni E,Tassorelli C,Nappi G

更新日期：2006-05-01 00:00:00

abstract：:Parkinson's disease (PD) is the most common neurodegenerative movement disorder. Currently, no curative treatments or treatments that interdict disease progression are available. Over the past decade, immunization strategies were developed in our laboratories to combat disease progression. These strategies were develo...

journal_title：Parkinsonism & related disorders

authors： Ha D,Stone DK,Mosley RL,Gendelman HE

更新日期：2012-01-01 00:00:00

abstract：:Evidence shows that neuronal injury accompanies neuroinflammatory reactions in the brain, and well as in Parkinson's disease (PD) animal models, in which the loss of dopamine neurons is associated with the activation of microglia in the substantia nigra. Activated microglia can be illustrated in vivo using Positron em...

journal_title：Parkinsonism & related disorders

authors： Ouchi Y,Yagi S,Yokokura M,Sakamoto M

更新日期：2009-12-01 00:00:00

abstract：INTRODUCTION:Continuous infusion of levodopa/carbidopa intestinal gel (LCIG) is an effective treatment for patients with advanced Parkinson Disease (PD) that cannot be further improved by oral therapy. METHODS:We conducted an observational, prospective, and multicenter study to collect, in a large sample of PD treated...

journal_title：Parkinsonism & related disorders

authors： Buongiorno M,Antonelli F,Cámara A,Puente V,de Fabregues-Nebot O,Hernandez-Vara J,Calopa M,Pascual-Sedano B,Campolongo A,Valldeoriola F,Tolosa E,Kulisevsky J,Martí MJ

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Japan and the United States (US) have different cultures of caregiving including differences in family structure and social programs that may influence caregiver strain. Differences in caregiver strain between regions in Japan and in the US have not been investigated in patient-spouse dyads in PD. OBJECTIVE...

journal_title：Parkinsonism & related disorders

authors： Tanji H,Koyama S,Wada M,Kawanami T,Kurita K,Tamiya G,Saito N,Suzuki K,Kato T,Anderson KE,Gruber-Baldini AL,Fishman PS,Reich SG,Weiner WJ,Shulman LM

更新日期：2013-06-01 00:00:00

abstract：INTRODUCTION:The aim of the study was to identify abnormalities of whole-brain network functional organization and their relation to clinical measures in a well-characterized, multi-site cohort of very early-stage, drug-naïve Parkinson's Disease (PD) patients. METHODS:Functional-MRI data for 16 healthy controls and 20...

journal_title：Parkinsonism & related disorders

authors： Sreenivasan K,Mishra V,Bird C,Zhuang X,Yang Z,Cordes D,Walsh RR

更新日期：2019-05-01 00:00:00

abstract：INTRODUCTION:Cognitive impairment and dementia are highly prevalent non-motor complications in Parkinson's disease (PD) with deleterious consequences for patients and caregivers. With no treatment currently available, finding and validating minimally-invasive biomarkers of neurodegeneration in this population represent...

journal_title：Parkinsonism & related disorders

authors： Sampedro F,Pérez-González R,Martínez-Horta S,Marín-Lahoz J,Pagonabarraga J,Kulisevsky J

更新日期：2020-05-01 00:00:00

abstract：:In patients with Idiopathic Parkinson's Disease (IPD) without a history of syncope the cardiovascular and cerebrovascular response to orthostatic stress was studied to search for subclinical impairment of autoregulatory mechanisms. Fifteen patients with IPD and 15 healthy age-matched controls were studied at rest and ...

journal_title：Parkinsonism & related disorders

authors： Niehaus L,Böckeler GC,Kupsch A,Meyer BU

更新日期：2002-03-01 00:00:00

abstract：:We studied daytime sleepiness in 160 patients with Parkinson's disease and 40 normal subjects. We compared the prevalence of daytime sleepiness in patients who were taking levodopa alone, levodopa with bromocriptine, levodopa with ropinirole, and levodopa with pramipexole. We found that (1) all these anti-Parkinson dr...

journal_title：Parkinsonism & related disorders

authors： Sanjiv CC,Schulzer M,Mak E,Fleming J,Martin WR,Brown T,Calne SM,Tsui J,Stoessl AJ,Lee CS,Calne DB

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND:Non-motor symptoms (NMS) are common in Parkinson's disease (PD) and cause significant distress. A high rate of non-declaration of NMS by patients to healthcare providers (HCP) means that many NMS remain untreated. Current understanding of the factors preventing disclosure of NMS to HCPs is limited. The prese...

journal_title：Parkinsonism & related disorders

authors： Hurt CS,Rixon L,Chaudhuri KR,Moss-Morris R,Samuel M,Brown RG

更新日期：2019-07-01 00:00:00

abstract：:The feasibility and efficacy of deep brain stimulation (DBS) has offered new possibilities for treatment of movement disorders. Mechanical failure of the DBS system is a potential complication. Here we report five patients who presented with mechanical failure of the DBS system. Radiographs of the skull and cervical s...

journal_title：Parkinsonism & related disorders

authors： Alex Mohit A,Samii A,Slimp JC,Grady MS,Goodkin R

更新日期：2004-03-01 00:00:00

abstract：OBJECTIVE:To describe the long-term outcome in 50 consecutive advanced Parkinson's disease (PD) patients treated with subthalamic nucleus deep brain stimulation (STN-DBS). METHOD:Assessments were carried out at baseline, 6 months, 2 years, and 5 years postoperatively. RESULTS:Compared to baseline scores without medic...

journal_title：Parkinsonism & related disorders

authors： Wider C,Pollo C,Bloch J,Burkhard PR,Vingerhoets FJ

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Impulse control disorders in Parkinson's disease are a potential consequence of dopaminergic therapy. Impulse control problems might be revealed by intertemporal choice tasks which entail to forgo an immediately available reward in favor of a larger but later reward. The steepness of the discounting curve ca...

journal_title：Parkinsonism & related disorders

authors： Al-Khaled M,Heldmann M,Bolstorff I,Hagenah J,Münte TF

更新日期：2015-11-01 00:00:00