Daytime somnolence in patients with Parkinson's disease.

abstract：:Parkinson's disease (PD) is characterized by a dramatic loss of dopamine that underlies complex structural and functional changes in striatal projection neurons. A key alteration that has been reported in various rodent models and PD patients is a significant reduction in striatal dendritic spine density. Our recent f...

journal_title：Parkinsonism & related disorders

authors： Smith Y,Villalba RM,Raju DV

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:Hallucinations are a frequent and severe complication in Parkinson's disease (PD). Minor hallucinations are generally not disturbing, but likely progress to well-structured hallucinations with loss of insight and a great impact on quality of life. Knowledge on the neural bases of minor hallucinations may hel...

journal_title：Parkinsonism & related disorders

authors： Pagonabarraga J,Soriano-Mas C,Llebaria G,López-Solà M,Pujol J,Kulisevsky J

更新日期：2014-03-01 00:00:00

abstract：:Patients with Parkinson's disease (PD) experience progressive disability and reduced quality of life due to both motor and non-motor complications. The cost of illness escalates as PD progresses, placing an economic burden on the healthcare system, society and patients themselves. Overall cost estimates vary from coun...

journal_title：Parkinsonism & related disorders

authors： Findley LJ

更新日期：2007-09-01 00:00:00

abstract：OBJECTIVES:Longitudinal assessment of a Parkinson's disease (PD) cohort, to investigate the evolution or REM sleep behavior symptoms (RBD) over time and to test the relation between RBD at onset and motor dysfunction progression. METHODS:An early stage PD cohort (n = 61) was assessed at two time points, separated by a...

journal_title：Parkinsonism & related disorders

authors： Bugalho P,Viana-Baptista M

更新日期：2013-12-01 00:00:00

abstract：:The H1 haplotype was first identified 10 years ago. Initially, a dinucleotide polymorphism was detected in the tau (MAPT) gene and was subsequently found to be in linkage disequilibrium (LD) with other polymorphisms, forming the MAPT H1 haplotype, a risk factor for many neurological diseases, considered as tauopathies...

journal_title：Parkinsonism & related disorders

authors： Kalinderi K,Fidani L,Bostantjopoulou S

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:Essential tremor (ET) and Parkinson's disease (PD) are common disorders especially in the aging population and can have overlapping features that can make it difficult to differentiate between the two. In addition, a possible overlap from a pathophysiological standpoint has been often advocated in the past...

journal_title：Parkinsonism & related disorders

authors： Algarni M,Fasano A

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Parkinson's disease patients may be at increased risk of delirium and developing adverse outcomes, such as cognitive decline and increased mortality. Delirium is an acute state of confusion that has overlapping symptoms with Parkinson's dementia, making it difficult to identify. This study aimed to determine...

journal_title：Parkinsonism & related disorders

authors： Lawson RA,McDonald C,Burn DJ

更新日期：2019-07-01 00:00:00

abstract：PURPOSE:The young-onset subtype of Parkinson's disease (YOPD) differs from the late-onset subtype (LOPD) in drug responsiveness, incidence of motor complications, and prognosis. The pathophysiology underlying these differences remains largely unknown. This study investigated whether the two subtypes differ in the patte...

journal_title：Parkinsonism & related disorders

authors： Liu SY,Wu JJ,Zhao J,Huang SF,Wang YX,Ge JJ,Wu P,Zuo CT,Ding ZT,Wang J

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Deep brain stimulation improves motor function and quality of life in patients with Parkinson's disease. The impact of these changes on patients' spouses is largely unknown. METHODS:Twenty-six spouses of patients undergoing surgery were evaluated before and 12 months after surgery, using the 36-Item Short F...

journal_title：Parkinsonism & related disorders

authors： Soulas T,Sultan S,Gurruchaga JM,Palfi S,Fénelon G

更新日期：2012-06-01 00:00:00

abstract：:We evaluated an association between essential tremor (ET) and the Parkinson's disease (PD) genes, Leucine Rich Repeat Kinase 2 (LRRK2) and Glucocerebrosidase (GBA). Clinical studies demonstrate an association between ET and PD, suggesting possible shared pathophysiologies, yet LRRK2 has rarely been studied in ET, and ...

journal_title：Parkinsonism & related disorders

authors： Clark LN,Kisselev S,Park N,Ross B,Verbitsky M,Rios E,Alcalay RN,Lee JH,Louis ED

更新日期：2010-02-01 00:00:00

abstract：:Forty patients with Parkinson's disease (PD) were studied to explore the relationship between aspects of psychological functioning (depression, problems in motoric, cognitive and psychological areas) and physical illness (stage and duration of illness, functional disability, global cognitive status). Depression, motor...

journal_title：Parkinsonism & related disorders

authors： Gupta A,Bhatia S

更新日期：2000-07-01 00:00:00

abstract：INTRODUCTION:Glucocerebrosidase (GBA) gene variants are associated with the development of the Lewy body disorders (LBD) Parkinson disease (PD) and dementia with Lewy bodies (DLB). Idiopathic REM sleep behavior disorder (IRBD) represents prodromal LBD in most instances. We investigated whether GBA variants are overrepr...

journal_title：Parkinsonism & related disorders

authors： Gámez-Valero A,Iranzo A,Serradell M,Vilas D,Santamaria J,Gaig C,Álvarez R,Ariza A,Tolosa E,Beyer K

更新日期：2018-05-01 00:00:00

abstract：INTRODUCTION:The DUALITY trial recently showed that both integrated and consecutive dual-task training improve dual-task gait velocity, without increasing fall risks in patients with Parkinson's disease (PD). Gait velocity was the primary outcome; not reported, however, were important gait measures related to the risk ...

journal_title：Parkinsonism & related disorders

authors： Geroin C,Nonnekes J,de Vries NM,Strouwen C,Smania N,Tinazzi M,Nieuwboer A,Bloem BR

更新日期：2018-10-01 00:00:00

abstract：:We report the first instance of restless legs syndrome (RLS) associated with periodic limb movements (PLM) and disruption of sleep architecture occurring in a patient following ischemic infarction in the right lenticulostriate region. Recently, a role for the basal ganglia-brainstem system in the control of motor beha...

journal_title：Parkinsonism & related disorders

authors： Sechi G,Agnetti V,Galistu P,Murgia B,Marrosu F,Puligheddu M,Conti M,Paulus KS

更新日期：2008-01-01 00:00:00

abstract：:Although attentional impairments (particularly cognitive slowing) are frequent in Parkinson's disease (PD), the mechanisms underlying these phenomena have not been fully characterized. The MRI-compatible version of the Symbol Digit Modalities Test (SDMT) has been applied to healthy individuals but not previously to pa...

journal_title：Parkinsonism & related disorders

authors： Grolez G,Viard R,Lopes R,Kuchcinski G,Defebvre L,Devos D,Dujardin K,Moreau C

更新日期：2020-07-01 00:00:00

abstract：INTRODUCTION:Psychosis is one of the common non-motor symptoms of PD, which substantially worsens the quality of life. Hence, it is important to identify factors that are associated with early onset of psychosis in PD. In order to identify those factors, the current study aims to compare various demographic and clinica...

journal_title：Parkinsonism & related disorders

authors： Lenka A,George L,Arumugham SS,Hegde S,Reddy V,Kamble N,Yadav R,Pal PK

更新日期：2017-11-01 00:00:00

abstract：INTRODUCTION:The diagnosis of progressive supranuclear palsy is often challenging early in the course of the disease, when clinical signs of the condition may be less apparent and patients do not clearly meet diagnostic criteria. In this study, we examine a potential radiographic marker in progressive supranuclear pals...

journal_title：Parkinsonism & related disorders

authors： Owens E,Krecke K,Ahlskog JE,Fealey R,Hassan A,Josephs KA,Klassen B,Matsumoto J,Bower J

更新日期：2016-07-01 00:00:00

abstract：OBJECTIVE:The primary objective was to evaluate the efficacy and safety of droxidopa as add-on therapy in improving stiffness, tremors and other motor functions and activities of daily living for moderate-to-severe Parkinson's disease (PD). METHODS:PD patients, above Hoehn-Yahr III (including Hoehn-Yahr III), were ran...

journal_title：Parkinsonism & related disorders

authors： Zhao S,Cheng R,Zheng J,Li Q,Wang J,Fan W,Zhang L,Zhang Y,Li H,Liu S

更新日期：2015-10-01 00:00:00

abstract：:Excessive daytime sleepiness (EDS) is common in Parkinson's Disease (PD). Actigraphy uses periods of immobility as surrogate markers of nighttime sleep but there are no examples of its use in assessing EDS of PD. A commercial wrist worn system for measuring bradykinesia and dyskinesia also detects 2 min periods of imm...

journal_title：Parkinsonism & related disorders

authors： Kotschet K,Johnson W,McGregor S,Kettlewell J,Kyoong A,O'Driscoll DM,Turton AR,Griffiths RI,Horne MK

更新日期：2014-06-01 00:00:00

abstract：INTRODUCTION:The aim of this study was to examine the association between mild parkinsonian signs (MPS), cerebral small-vessel disease (SVD), and total SVD burden in patients with vascular risk factors. METHODS:We performed a cross-sectional study among 268 patients with vascular risk factors but without parkinsonism ...

journal_title：Parkinsonism & related disorders

authors： Hatate J,Miwa K,Matsumoto M,Sasaki T,Yagita Y,Sakaguchi M,Kitagawa K,Mochizuki H

更新日期：2016-05-01 00:00:00

abstract：:The recently discovered trace amine associated receptors (TAARs) represent attractive potential mediators of certain aspects of movement control. The TAAR that is best characterized, TAAR1, is particularly interesting because it can be activated by a variety of monoaminergic compounds including trace amines, amphetami...

journal_title：Parkinsonism & related disorders

authors： Sotnikova TD,Zorina OI,Ghisi V,Caron MG,Gainetdinov RR

更新日期：2008-01-01 00:00:00

abstract：:We used electrophysiological methods to study the hyperkinetic movement disorders in a pallido-ponto-nigral degeneration (PPND) family, which harbors the N279K tau gene mutation. Our purpose was to: (1). characterize the tremor patterns, (2). characterize the myoclonus physiology, (3). determine whether electrophysiol...

journal_title：Parkinsonism & related disorders

authors： Caviness JN,Tsuboi Y,Wszolek ZK

更新日期：2003-01-01 00:00:00

abstract：:This case series describes the inpatient rehabilitation of two medically complex patients with Parkinson's disease (PD) who had undergone deep brain stimulator (DBS) placement. Most patients may not require inpatient rehabilitation. However, a short rehabilitation stay might be of use to patients who need to be weaned...

journal_title：Parkinsonism & related disorders

authors： Nampiaparampil DE,Kuppy JE,Nampiaparampil GM,Salles SS

更新日期：2008-01-01 00:00:00

abstract：:Oxidative stress has been reported as one of the pathogeneses of Parkinson's disease (PD). Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that regulates the expression of the target genes involved in antioxidant pathway. The promoter polymorphisms of the Nrf2-encoding gene, NFE2L2, have b...

journal_title：Parkinsonism & related disorders

authors： Chen YC,Wu YR,Wu YC,Lee-Chen GJ,Chen CM

更新日期：2013-02-01 00:00:00

abstract：:Parkinson's disease (PD) patients have a ninefold increased risk of recurring falls compared to healthy controls. The risk of falling due to cardiovascular dysautonomia (CVD) is not quantifiable. But, CVD is an integral part of the disease and at least 20% of PD patients suffer from orthostatic hypotension, an express...

journal_title：Parkinsonism & related disorders

authors： Martignoni E,Tassorelli C,Nappi G

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND:Microstructural white matter integrity captured by diffusion-tensor imaging (DTI) is significantly more affected in progressive supranuclear palsy-Richardson's syndrome (PSP-RS) compared to PSP-parkinsonism (PSP-P). OBJECTIVES:To characterize the microstructural integrity of large fascicular bundles using s...

journal_title：Parkinsonism & related disorders

authors： Potrusil T,Krismer F,Beliveau V,Seppi K,Müller C,Troger F,Göbel G,Steiger R,Gizewski ER,Poewe W,Scherfler C

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Subthalamic nucleus (STN) deep brain stimulation (DBS) has recently been shown to be an effective treatment for Meige syndrome but efficacy of symptomatic improvement and its relationship to factors in DBS remains to be explored. OBJECTIVES:This study explored the relationship of electrode contact location ...

journal_title：Parkinsonism & related disorders

authors： Yao C,Horn A,Li N,Lu Y,Fu Z,Wang N,Aziz TZ,Wang L,Zhang S

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:Our purpose was to determine whether the use of catechol-O-methyltransferase-inhibitors (ICOMT) can reduce the risk of developing levodopa (LD)-induced neuropathy in Parkinson's disease (PD) patients. METHODS:A multicentre study of 197 PD patients was performed. 144 were exposed to LD for more than three yea...

journal_title：Parkinsonism & related disorders

authors： Cossu G,Ceravolo R,Zibetti M,Arca R,Ricchi V,Paribello A,Murgia D,Merola A,Romagnolo A,Nicoletti V,Palermo G,Mereu A,Lopiano L,Melis M,Abbruzzese G,Bonuccelli U

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Tremor is a common feature of a variety of neurological disorders. In genetic studies of essential tremor (ET), investigators need to screen potential enrollees by mail or telephone to exclude those with other neurological conditions, especially dystonia. In clinical settings, the differentiation of ET and d...

journal_title：Parkinsonism & related disorders

authors： Michalec M,Hernandez N,Clark LN,Louis ED

更新日期：2014-05-01 00:00:00

abstract：PURPOSE:Fall-related fracture is one of the most disabling features of idiopathic Parkinson's disease (PD). A better understanding of the associated factors is needed to predict PD patients who will require treatment. METHODS:This prospective study enrolled 100 adult idiopathic PD patients. Stepwise logistic regressio...

journal_title：Parkinsonism & related disorders

authors： Cheng KY,Lin WC,Chang WN,Lin TK,Tsai NW,Huang CC,Wang HC,Huang YC,Chang HW,Lin YJ,Lee LH,Cheng BC,Kung CT,Chang YT,Su CM,Chiang YF,Su YJ,Lu CH

更新日期：2014-01-01 00:00:00