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Long-term outcome of 50 consecutive Parkinson's disease patients treated with subthalamic deep brain stimulation.

Abstract：

OBJECTIVE:To describe the long-term outcome in 50 consecutive advanced Parkinson's disease (PD) patients treated with subthalamic nucleus deep brain stimulation (STN-DBS). METHOD:Assessments were carried out at baseline, 6 months, 2 years, and 5 years postoperatively. RESULTS:Compared to baseline scores without medication, we found a highly significant improvement of UPDRS III with stimulation, maintained at 5 years (p<0.001). This improvement, however, tended to diminish over time. Dyskinesia and off periods were also improved (p<0.0001 for both). Seventeen patients died during follow-up, who tended to be older at surgery (p<0.01). CONCLUSIONS:STN-DBS is an effective treatment for advanced PD patients, and the beneficial effect is maintained at 5 years. However, worsening occurs over time due to disease progression.

journal_name

Parkinsonism Relat Disord

journal_title

Parkinsonism & related disorders

authors

Wider C,Pollo C,Bloch J,Burkhard PR,Vingerhoets FJ

doi

10.1016/j.parkreldis.2007.06.012

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

114-9

issue

2

eissn

1353-8020

issn

1873-5126

pii

S1353-8020(07)00113-7

journal_volume

14

pub_type

杂志文章

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