The pedunculopontine nucleus and movement disorders: anatomy and the role for deep brain stimulation.

abstract：INTRODUCTION:Patients with Parkinson disease (PD) and their partners may experience a worsening of their sexual life. AIM:To assess quality of sexual life (QoSL) in male and female PD patients and their partners. MATERIALS AND METHODS:Medical, demographic and clinical data was collected regarding consecutive PD patie...

journal_title：Parkinsonism & related disorders

authors： Bronner G,Cohen OS,Yahalom G,Kozlova E,Orlev Y,Molshatzki N,Strauss H,Hassin-Baer S

更新日期：2014-10-01 00:00:00

abstract：INTRODUCTION:Cognitive impairment can occur in the early phase of Parkinson's disease and increases the risk of developing dementia. Cognitive deficits were shown to be associated with functional alterations in the dorsolateral prefrontal cortex (DLPFC) and caudate nucleus. Two previous transcranial magnetic stimulatio...

journal_title：Parkinsonism & related disorders

authors： Trung J,Hanganu A,Jobert S,Degroot C,Mejia-Constain B,Kibreab M,Bruneau MA,Lafontaine AL,Strafella A,Monchi O

更新日期：2019-09-01 00:00:00

abstract：:Relatively early seminal investigations on 'mammalian alkaloid biosynthesis'-endogenous Pictet-Spengler condensations of catecholamines or indoleamines with aldehydes (such as acetaldehyde from ethanol metabolism) to form tetrahydroisoquinoline or beta-carboline alkaloids-and the roles of mammalian alkaloids in the CN...

journal_title：Parkinsonism & related disorders

authors： Collins MA

更新日期：2002-09-01 00:00:00

abstract：INTRODUCTION:Physical inactivity in Parkinson disease (PD) has an impact on motor and non-motor symptoms of the disease. It is unclear whether this decline in physical activity occurs early in the disease, in addition to any decline due to aging, and whether commercial activity monitors can be used to self-monitor phys...

journal_title：Parkinsonism & related disorders

authors： Pradhan S,Kelly VE

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Somatosensory abnormalities contribute to the pathophysiology of Parkinson's disease (PD). The goal of this study was to identify abnormalities in the tactile-evoked activation of the somatosensory and motor cortices in PD, and in a sensorimotor circuit that traverses both of these cortical loci. The second ...

journal_title：Parkinsonism & related disorders

authors： Nelson AJ,Hoque T,Gunraj C,Chen R

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Nocturnal hypokinesia is a common symptom in Parkinson's disease (PD), negatively affecting quality of life of both patients and caregivers. However, evidence-based treatment strategies are limited. OBJECTIVE:To evaluate the efficacy of rotigotine transdermal patch, using a wearable sensor, in the managemen...

journal_title：Parkinsonism & related disorders

authors： Bhidayasiri R,Sringean J,Chaiwong S,Anan C,Penkeaw N,Leaknok A,Boonpang K,Saksornchai K,Rattanachaisit W,Thanawattano C,Jagota P

更新日期：2017-11-01 00:00:00

abstract：:Adenosine derived from the degradation of ATP/AMP functions as a signalling molecule in the nervous system through the occupation of A1, A2, and A3 adenosine receptors. Adenosine A(2A) receptors have a selective localization to the basal ganglia and specifically to the indirect output pathway, and as a consequence off...

journal_title：Parkinsonism & related disorders

authors： Jenner P,Mori A,Hauser R,Morelli M,Fredholm BB,Chen JF

更新日期：2009-07-01 00:00:00

abstract：OBJECTIVE:To estimate the frequency and correlates of involuntary emotional expression disorder (IEED) in Parkinson's disease (PD) using the Center for Neurologic Study-Lability Scale (CNS-LS) and recently-proposed diagnostic criteria for IEED. BACKGROUND:IEED is characterized by uncontrollable emotional episodes, typ...

journal_title：Parkinsonism & related disorders

authors： Phuong L,Garg S,Duda JE,Stern MB,Weintraub D

更新日期：2009-08-01 00:00:00

abstract：:There is evidence that astrocytes and microglia can release agents which might have a protective effect on damaged neurons. However the associations of glia with dopaminergic neurons in Parkinson's disease are not defined. Our studies showed that in post mortem parkinsonian nigra healthy neuronal somata were enveloped...

journal_title：Parkinsonism & related disorders

authors： Knott C,Wilkin GP,Stern G

更新日期：1999-09-01 00:00:00

abstract：:The ataxias are a group of progressive neurodegenerative disorders with ataxia as the leading symptom. Current classifications distinguish between hereditary and non-hereditary ataxias. The hereditary ataxias are further divided into the autosomal recessive ataxias, the most frequent of which is Friedreich's ataxia, a...

journal_title：Parkinsonism & related disorders

authors： Klockgether T

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVE:Melanopsin may be involved in the pathophysiology of photophobia in idiopathic isolated blepharospasm. We assessed the efficacy of blocking wavelengths of melanopsin absorption to reduce blinking in blepharospasm as a possible surrogate for photophobia. METHODS:Twenty-one participants (11 blepharospasm and 1...

journal_title：Parkinsonism & related disorders

authors： Wu Y,Cho HJ,Panyakaew P,Savant CS,Wu T,Dang N,Hallett M

更新日期：2019-10-01 00:00:00

abstract：INTRODUCTION:The aim of this study was to examine the association between mild parkinsonian signs (MPS), cerebral small-vessel disease (SVD), and total SVD burden in patients with vascular risk factors. METHODS:We performed a cross-sectional study among 268 patients with vascular risk factors but without parkinsonism ...

journal_title：Parkinsonism & related disorders

authors： Hatate J,Miwa K,Matsumoto M,Sasaki T,Yagita Y,Sakaguchi M,Kitagawa K,Mochizuki H

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Effects on non-motor symptoms, mainly cognitive and psychiatric side effects, could influence the decision for either globus pallidus pars interna (GPi) or subthalamic nucleus (STN) deep brain stimulation (DBS) for patients with Parkinson's disease (PD). OBJECTIVE:1) To compare cognitive and psychiatric out...

journal_title：Parkinsonism & related disorders

authors： Boel JA,Odekerken VJ,Schmand BA,Geurtsen GJ,Cath DC,Figee M,van den Munckhof P,de Haan RJ,Schuurman PR,de Bie RM,NSTAPS study group.

更新日期：2016-12-01 00:00:00

abstract：:Parkinson's disease is a chronic neurological disorder that results in gait and posture impairment. There is increasing evidence that these motor impairments may be partially due to deficits within the sensory system. In this study, the effects of a facilitatory insole that provides increased plantar sensory stimulati...

journal_title：Parkinsonism & related disorders

authors： Jenkins ME,Almeida QJ,Spaulding SJ,van Oostveen RB,Holmes JD,Johnson AM,Perry SD

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:Non-motor symptom (NMS) differences between male Parkinson's disease (PD) and female PD, and between early-onset PD (EOPD) and late-onset PD (LOPD) in Chinese populations remain largely unknown. METHODS:A total of 522 PD patients from Southwest China were included. Patients were assessed using the Non-Motor...

journal_title：Parkinsonism & related disorders

authors： Guo X,Song W,Chen K,Chen X,Zheng Z,Cao B,Huang R,Zhao B,Wu Y,Shang HF

更新日期：2013-11-01 00:00:00

abstract：:Levodopa serves as the gold standard of anti-parkinsonian therapy and nearly every patient with Parkinson's disease eventually receives this drug. To improve upon levodopa therapy, several forms of treatment have been devised to augment its actions, and new delivery systems are under development. This new research off...

journal_title：Parkinsonism & related disorders

authors： LeWitt PA

更新日期：2009-01-01 00:00:00

abstract：:Tardive dyskinesia (TD) is a common, iatrogenic movement disorder affecting many individuals treated with dopamine-receptor blocking agents (DRBAs). Studying treatment of TD can be complex, as the symptoms can be affected by changes in either dosage or type of DRBA, as well as by the variable natural course of the dis...

journal_title：Parkinsonism & related disorders

authors： Margolius A,Fernandez HH

更新日期：2019-02-01 00:00:00

abstract：:Synchronization of neuronal activity within and across distributed brain regions is a fundamental property of cortical and subcortical networks and serves a variety of functions including motor and cognitive processes. Data will be reviewed here from cross-sectional EEG and MEG studies to suggest that Parkinson's dise...

journal_title：Parkinsonism & related disorders

authors： Berendse HW,Stam CJ

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Although essential tremor (ET) is commonly encountered in clinical practice, historically, there has been considerable disagreement as how to best define it, and now with a growing sense of its clinical complexity, how to best encapsulate it. Here, I draw attention to five issues of current uncertainty. MET...

journal_title：Parkinsonism & related disorders

authors： Louis ED

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Tremor-related quality of life is a multi-dimensional concept that reflects the physical, emotional and other health effects of tremor. Curiously, tremor-related quality of life has never been directly compared in patients with the two major tremor disorders, essential tremor (ET) and Parkinson's disease (PD...

journal_title：Parkinsonism & related disorders

authors： Louis ED,Machado DG

更新日期：2015-07-01 00:00:00

abstract：INTRODUCTION:Camptocormia is defined as an involuntary, marked flexion of the thoracolumbar spine appearing during standing or walking and resolving in the supine position or when leaning against a wall. However, there is no established agreement on the minimum degree of forward flexion needed to diagnose camptocormia....

journal_title：Parkinsonism & related disorders

authors： Fasano A,Geroin C,Berardelli A,Bloem BR,Espay AJ,Hallett M,Lang AE,Tinazzi M

更新日期：2018-08-01 00:00:00

abstract：INTRODUCTION:Alzheimer's disease neuropathologies (amyloid-β and tau) frequently co-exist to varying degrees in Lewy body dementias (LBD), which include dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD). OBJECTIVES:To investigate the prevalence of tau in DLB and PDD, and its associations with clin...

journal_title：Parkinsonism & related disorders

authors： Chin KS,Yassi N,Churilov L,Masters CL,Watson R

更新日期：2020-11-01 00:00:00

abstract：:This study presents data on the antemortem evaluations of a cohort of individuals registered in a brain donation program. Clinical evaluation determined that many individuals were unaware they had clinical signs of Parkinson's disease (PD) (rest tremor, bradykinesia, rigidity). Quantitative motor testing (timed tappin...

journal_title：Parkinsonism & related disorders

authors： Adler CH,Hentz JG,Joyce JN,Beach T,Caviness JN

更新日期：2002-12-01 00:00:00

abstract：:The recently discovered trace amine associated receptors (TAARs) represent attractive potential mediators of certain aspects of movement control. The TAAR that is best characterized, TAAR1, is particularly interesting because it can be activated by a variety of monoaminergic compounds including trace amines, amphetami...

journal_title：Parkinsonism & related disorders

authors： Sotnikova TD,Zorina OI,Ghisi V,Caron MG,Gainetdinov RR

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVE:Mutations in the PARK2 (Parkin) gene result in an early-onset autosomal recessive form of Parkinson Disease (EO-PD). Although the frequency of the PARK2 mutations in EO-PD patients according to several studies is high and has been reported in up to 50% in familial and 19% in sporadic cases, these data remain ...

journal_title：Parkinsonism & related disorders

authors： Koziorowski D,Hoffman-Zacharska D,Sławek J,Szirkowiec W,Janik P,Bal J,Friedman A

更新日期：2010-02-01 00:00:00

abstract：OBJECTIVES:Limited data currently exists within the UK addressing the level of Parkinson's disease (PD) healthcare provision. We investigated whether care for PD patients in a UK community met national guidelines, and the determinants of sub-optimal care for this patient group. METHODS:340 PD patients were identified ...

journal_title：Parkinsonism & related disorders

authors： Hu MT,Butterworth R,Kumar V,Cooper J,Jones E,Catterall L,Ben-Shlomo Y

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Apathy is a common neuropsychiatric syndrome in Parkinson's Disease (PD) that affects quality of life. Research into apathy has been hampered by a lack of broadly accepted diagnostic criteria. Recently, diagnostic criteria for apathy in neuropsychiatric disorders have been proposed, which to date have not be...

journal_title：Parkinsonism & related disorders

authors： Drijgers RL,Dujardin K,Reijnders JS,Defebvre L,Leentjens AF

更新日期：2010-12-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy of solifenacin succinate in Parkinson's disease (PD) patients suffering from overactive bladder (OAB). BACKGROUND:Urinary dysfunction is a commonly encountered non-motor feature in PD that significantly impacts patient quality of life. DESIGN/METHODS:This was a double-blind, randomi...

journal_title：Parkinsonism & related disorders

authors： Zesiewicz TA,Evatt M,Vaughan CP,Jahan I,Singer C,Ordorica R,Salemi JL,Shaw JD,Sullivan KL,Non-Motor Working Group of the Parkinson Study Group (PSG).

更新日期：2015-05-01 00:00:00

abstract：RATIONALE:Cervical dystonia is the most common form of (primary) dystonia. The first line of treatment for cervical dystonia is intramuscular injections with botulinum toxin. To optimise the response to botulinum toxin proper muscles selection is required. Pre-treatment polymyographic EMG in addition to clinical evalua...

journal_title：Parkinsonism & related disorders

authors： Nijmeijer SW,Koelman JH,Standaar TS,Postma M,Tijssen MA

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Traditionally the risk of Parkinson's has been considered to increase monotonically with age, although there is evidence that prevalence and incidence may decrease in the oldest old. To examine this further we estimated the national prevalence and incidence of Parkinson's in New Zealand, using drug-tracing m...

journal_title：Parkinsonism & related disorders

authors： Myall DJ,Pitcher TL,Pearson JF,Dalrymple-Alford JC,Anderson TJ,MacAskill MR

更新日期：2017-09-01 00:00:00