Levodopa therapeutics for Parkinson's disease: new developments.

abstract：:Spinocerebellar ataxia (SCA) 17 is a dominant, progressive, neurodegenerative disorder. The disease is caused by a triplet repeat expansion mutation within TATA-binding protein (TBP). Ataxia, dementia, parkinsonism and dystonia are common features. We have previously shown in several pedigrees that SCA-2 and SCA-3 can...

journal_title：Parkinsonism & related disorders

authors： Hernandez D,Hanson M,Singleton A,Gwinn-Hardy K,Freeman J,Ravina B,Doheny D,Gallardo M,Weiser R,Hardy J,Singleton A

更新日期：2003-08-01 00:00:00

abstract：:Serious adverse effects with antichoreic drugs can occur in patients with acute Sydenham's chorea (SC). The response to conventional treatment in severe SC may also be poor. Thus alternative therapeutic strategies have been developed. We report on four patients with severe acute SC (two with chorea paralytica and two ...

journal_title：Parkinsonism & related disorders

authors： Teixeira AL Jr,Maia DP,Cardoso F

更新日期：2005-08-01 00:00:00

abstract：:Parkinson's disease (PD) is a progressive, disabling, neurodegenerative disease that requires long term care and pharmaceutical treatment. Levodopa remains the gold standard treatment for PD globally, although it is largely unavailable and unaffordable for the majority of patients in many sub-Saharan African and other...

journal_title：Parkinsonism & related disorders

authors： Fothergill-Misbah N,Maroo H,Cham M,Pezzoli G,Walker R,Cilia R

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVE:Our purpose was to determine whether the use of catechol-O-methyltransferase-inhibitors (ICOMT) can reduce the risk of developing levodopa (LD)-induced neuropathy in Parkinson's disease (PD) patients. METHODS:A multicentre study of 197 PD patients was performed. 144 were exposed to LD for more than three yea...

journal_title：Parkinsonism & related disorders

authors： Cossu G,Ceravolo R,Zibetti M,Arca R,Ricchi V,Paribello A,Murgia D,Merola A,Romagnolo A,Nicoletti V,Palermo G,Mereu A,Lopiano L,Melis M,Abbruzzese G,Bonuccelli U

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVE:To investigate the indications and the outcomes of gastrostomy tube insertion in patients with parkinsonian syndromes. METHODS:Consecutive patients with Parkinson's disease or atypical parkinsonism, seen in two French tertiary referral movement disorders centers, that received gastrostomy tube insertion (GTI...

journal_title：Parkinsonism & related disorders

authors： Marois C,Amador MDM,Payan C,Lacomblez L,Bonnet AM,Degos B,Corvol JC,Vidailhet M,Le Forestier N,Mesnage V,Grabli D

更新日期：2017-10-01 00:00:00

abstract：:Antiparkinsonian drugs are thought to act largely through the D2 receptor family that includes the D(2) and D(3) receptors. D(2) and D(3) receptors exhibit both complementary and overlapping expression at the macro and cellular level. The D(3) receptor appears to be a primary target of the mesolimbic dopamine system, ...

journal_title：Parkinsonism & related disorders

authors： Joyce JN,Ryoo H,Gurevich EV,Adler C,Beach T

更新日期：2001-07-01 00:00:00

abstract：:Parkinson's disease (PD) is a common neurodegenerative disorder that produces progressive disability despite symptomatic treatment. Several strategies, including stereotaxic brain lesions, deep brain stimulation, transplants of dopamine cells and administration of neurotrophic factors, have been proposed to improve ef...

journal_title：Parkinsonism & related disorders

authors： Fontan A,Rojo A,Sanchez Pernaute R,Hernández I,López I,Castilla C,Sanchez Albisua J,Perez Higueras A,Al-Rashid I,Rabano A,Gonzalo I,Angeles Mena M,Cools A,Eshuis S,Maguire P,Pruim J,Leenders K,Garcia de Yebenes J

更新日期：2002-06-01 00:00:00

abstract：INTRODUCTION:There is a dearth of studies of spinocerebellar ataxias (SCAs) and diffusion tensor magnetic resonance imaging (DTI). OBJECTIVE:To analyze changes observed in DTI parameters and correlate these to clinical findings in SCA3 and SCA10 patients. METHODS:SCA3 (n = 19) and SCA10 (n = 18) patients were compare...

journal_title：Parkinsonism & related disorders

authors： Meira AT,Arruda WO,Ono SE,Franklin GL,de Carvalho Neto A,Raskin S,Ashizawa T,Camargo CHF,Teive HAG

更新日期：2020-09-01 00:00:00

abstract：:Evidence shows that neuronal injury accompanies neuroinflammatory reactions in the brain, and well as in Parkinson's disease (PD) animal models, in which the loss of dopamine neurons is associated with the activation of microglia in the substantia nigra. Activated microglia can be illustrated in vivo using Positron em...

journal_title：Parkinsonism & related disorders

authors： Ouchi Y,Yagi S,Yokokura M,Sakamoto M

更新日期：2009-12-01 00:00:00

abstract：:The MPTP-treated primate has proved to be a highly predictive model of the effects of dopaminergic drugs in the symptomatic treatment of Parkinson's disease (PD) and for the avoidance of motor complications. Using MPTP-treated primates, new dopaminergic therapies have been devised alongside novel treatment strategies ...

journal_title：Parkinsonism & related disorders

authors： Jenner P

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:Tremor is a common feature of a variety of neurological disorders. In genetic studies of essential tremor (ET), investigators need to screen potential enrollees by mail or telephone to exclude those with other neurological conditions, especially dystonia. In clinical settings, the differentiation of ET and d...

journal_title：Parkinsonism & related disorders

authors： Michalec M,Hernandez N,Clark LN,Louis ED

更新日期：2014-05-01 00:00:00

abstract：:The recently discovered trace amine associated receptors (TAARs) represent attractive potential mediators of certain aspects of movement control. The TAAR that is best characterized, TAAR1, is particularly interesting because it can be activated by a variety of monoaminergic compounds including trace amines, amphetami...

journal_title：Parkinsonism & related disorders

authors： Sotnikova TD,Zorina OI,Ghisi V,Caron MG,Gainetdinov RR

更新日期：2008-01-01 00:00:00

abstract：:The feasibility and efficacy of deep brain stimulation (DBS) has offered new possibilities for treatment of movement disorders. Mechanical failure of the DBS system is a potential complication. Here we report five patients who presented with mechanical failure of the DBS system. Radiographs of the skull and cervical s...

journal_title：Parkinsonism & related disorders

authors： Alex Mohit A,Samii A,Slimp JC,Grady MS,Goodkin R

更新日期：2004-03-01 00:00:00

abstract：:Oxidative stress has been reported as one of the pathogeneses of Parkinson's disease (PD). Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that regulates the expression of the target genes involved in antioxidant pathway. The promoter polymorphisms of the Nrf2-encoding gene, NFE2L2, have b...

journal_title：Parkinsonism & related disorders

authors： Chen YC,Wu YR,Wu YC,Lee-Chen GJ,Chen CM

更新日期：2013-02-01 00:00:00

abstract：:Significant advances in the symptomatic treatment of Parkinson disease (PD) have occurred since the discovery of levodopa (LD). Perhaps as a testament to its unparalleled efficacy, novel formulations aiming to optimize LD delivery to obtain better bioavailability, longer duration of effect and less plasma level fluctu...

journal_title：Parkinsonism & related disorders

authors： Hengartner D,Fernandez HH

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Impulse control disorders in Parkinson's disease are a potential consequence of dopaminergic therapy. Impulse control problems might be revealed by intertemporal choice tasks which entail to forgo an immediately available reward in favor of a larger but later reward. The steepness of the discounting curve ca...

journal_title：Parkinsonism & related disorders

authors： Al-Khaled M,Heldmann M,Bolstorff I,Hagenah J,Münte TF

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:Non-motor symptoms (NMS) are common in Parkinson's disease (PD) and cause significant distress. A high rate of non-declaration of NMS by patients to healthcare providers (HCP) means that many NMS remain untreated. Current understanding of the factors preventing disclosure of NMS to HCPs is limited. The prese...

journal_title：Parkinsonism & related disorders

authors： Hurt CS,Rixon L,Chaudhuri KR,Moss-Morris R,Samuel M,Brown RG

更新日期：2019-07-01 00:00:00

abstract：:This is a short report illustrating the problems of the prescribing of anti-Parkinson's disease (PD) medication in patients with PD who are admitted acutely to hospital for any reason. There were a large number of complications as a result of inappropriate or lack of anti-PD drug administration and poor understanding ...

journal_title：Parkinsonism & related disorders

authors： Magdalinou KN,Martin A,Kessel B

更新日期：2007-12-01 00:00:00

abstract：INTRODUCTION:Recent work suggests that wearables can augment conventional measures of Parkinson's disease (PD). We evaluated the relationship between conventional measures of disease and motor severity (e.g., MDS-UPDRS part III), laboratory-based measures of gait and balance, and daily-living physical activity measures...

journal_title：Parkinsonism & related disorders

authors： Galperin I,Hillel I,Del Din S,Bekkers EMJ,Nieuwboer A,Abbruzzese G,Avanzino L,Nieuwhof F,Bloem BR,Rochester L,Della Croce U,Cereatti A,Giladi N,Mirelman A,Hausdorff JM

更新日期：2019-05-01 00:00:00

abstract：:Involuntary movements are not a known feature of vitamin B12 (vB12) deficiency in adults, though they are a characteristic feature of vB12 deficiency in infants. This case report presents an adult patient with vB12 deficiency in whom, myoclonus-like muscular contractions appeared soon after the initiation of vB12 and ...

journal_title：Parkinsonism & related disorders

authors： Celik M,Barkut IK,Oncel C,Forta H

更新日期：2003-10-01 00:00:00

abstract：:Head drop is characterized by marked anterior flexion of the cervical spine, caused by weakness of the neck extensors or by increased tone of the flexor muscles. We report a woman with Parkinson's disease and head drop not due to cervical dystonia (a common cause of antecollis in parkinsonisms). Clinical, radiological...

journal_title：Parkinsonism & related disorders

authors： Fasano A,Evoli A,Piano C,Tonali PA,Bentivoglio AR

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to compare the short- and long-term outcomes of bilateral subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD) patients with and without probable REM sleep behavior disorder (RBD). METHODS:We retrospectively reviewed 127 patients who underwent bilateral S...

journal_title：Parkinsonism & related disorders

authors： Park S,Kim R,Shin JH,Kim HJ,Paek SH,Jeon B

更新日期：2020-12-01 00:00:00

abstract：:We report a cluster of five cases of Parkinson's disease (PD) among paper mill workers exposed to a fungicide, diphenyl. The cause of PD is still unknown, but epidemiological studies have indicated an elevated risk of developing PD after exposure to pesticides. The five cases of PD were found in a group of 255 dipheny...

journal_title：Parkinsonism & related disorders

authors： Wastensson G,Hagberg S,Andersson E,Johnels B,Barregård L

更新日期：2006-01-01 00:00:00

abstract：:The aim of this study was to assess the middle latency auditory evoked potential (MLAEP) findings in idiopathic Parkinson's disease (IPD) and in patients who are regarded as having atypical parkinsonian disorders (AP) and to determine whether MLAEPs could contribute to the differential diagnosis of IPD and AP.MLAEPs w...

journal_title：Parkinsonism & related disorders

authors： Çelik M,Seleker FK,Sucu H,Forta H

更新日期：2000-04-01 00:00:00

abstract：INTRODUCTION:Early Onset Parkinson's Disease (EOPD) is genetically heterogeneous. PARK2 mutations are the commonest cause of autosomal recessive EOPD followed by PINK1.DJ1 mutations is rare and there is scarce literature on its phenotype and long term outcome. OBJECTIVES:We undertook a retrospective study to determine...

journal_title：Parkinsonism & related disorders

authors： Abbas MM,Govindappa ST,Sudhaman S,Thelma BK,Juyal RC,Behari M,Muthane UB

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVE:Melanopsin may be involved in the pathophysiology of photophobia in idiopathic isolated blepharospasm. We assessed the efficacy of blocking wavelengths of melanopsin absorption to reduce blinking in blepharospasm as a possible surrogate for photophobia. METHODS:Twenty-one participants (11 blepharospasm and 1...

journal_title：Parkinsonism & related disorders

authors： Wu Y,Cho HJ,Panyakaew P,Savant CS,Wu T,Dang N,Hallett M

更新日期：2019-10-01 00:00:00

abstract：:The Behavioural Assessment of the Dysexecutive Syndrome (BADS) is a neuropsychological battery developed with the intent of measuring a wide range of executive impairments. Although the psychometric characteristics of BADS have previously been investigated in distinct neurological disorders, data on its validity in Pa...

journal_title：Parkinsonism & related disorders

authors： Perfetti B,Varanese S,Mercuri P,Mancino E,Saggino A,Onofrj M

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Gait and balance impairments are cardinal features of Parkinson's disease (PD) that require cognitive input. However, the extent to which specific gait and balance characteristics relate to cognition in PD is unclear. In addition, independent models of gait and balance have not been developed from the same...

journal_title：Parkinsonism & related disorders

authors： Morris R,Martini DN,Smulders K,Kelly VE,Zabetian CP,Poston K,Hiller A,Chung KA,Yang L,Hu SC,Edwards KL,Cholerton B,Grabowski TJ,Montine TJ,Quinn JF,Horak F

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:Subthalamic nucleus (STN) deep brain stimulation (DBS) has recently been shown to be an effective treatment for Meige syndrome but efficacy of symptomatic improvement and its relationship to factors in DBS remains to be explored. OBJECTIVES:This study explored the relationship of electrode contact location ...

journal_title：Parkinsonism & related disorders

authors： Yao C,Horn A,Li N,Lu Y,Fu Z,Wang N,Aziz TZ,Wang L,Zhang S

更新日期：2019-01-01 00:00:00

abstract：INTRODUCTION:The patho-physiological basis for finger dexterity deficits in Parkinson's disease (PD) is controversial. Previously, bradykinesia was regarded as the major mechanism. However, recent research suggested limb-kinetic apraxia as an important component of impaired fine motor skills in PD. In contrast to brady...

journal_title：Parkinsonism & related disorders

authors： Foki T,Pirker W,Geißler A,Haubenberger D,Hilbert M,Hoellinger I,Wurnig M,Rath J,Lehrner J,Matt E,Fischmeister F,Trattnig S,Auff E,Beisteiner R

更新日期：2015-03-01 00:00:00