Trace amine associated receptor 1 and movement control.

abstract：:Oxidative stress has been reported as one of the pathogeneses of Parkinson's disease (PD). Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that regulates the expression of the target genes involved in antioxidant pathway. The promoter polymorphisms of the Nrf2-encoding gene, NFE2L2, have b...

journal_title：Parkinsonism & related disorders

authors： Chen YC,Wu YR,Wu YC,Lee-Chen GJ,Chen CM

更新日期：2013-02-01 00:00:00

abstract：INTRODUCTION:Cognitive impairment can occur in the early phase of Parkinson's disease and increases the risk of developing dementia. Cognitive deficits were shown to be associated with functional alterations in the dorsolateral prefrontal cortex (DLPFC) and caudate nucleus. Two previous transcranial magnetic stimulatio...

journal_title：Parkinsonism & related disorders

authors： Trung J,Hanganu A,Jobert S,Degroot C,Mejia-Constain B,Kibreab M,Bruneau MA,Lafontaine AL,Strafella A,Monchi O

更新日期：2019-09-01 00:00:00

abstract：:Cerebrotendinous xanthomatosis (CTX) is an inborn error of cholesterol and bile acid metabolism, leading to neuropsychiatric and systemic manifestations. Movement disorders have rarely been reported in CTX, while a detailed appreciation of the full phenotypic spectrum is required in order to prevent underdiagnosis of ...

journal_title：Parkinsonism & related disorders

authors： Stelten BML,van de Warrenburg BPC,Wevers RA,Verrips A

更新日期：2019-01-01 00:00:00

abstract：:There is evidence that astrocytes and microglia can release agents which might have a protective effect on damaged neurons. However the associations of glia with dopaminergic neurons in Parkinson's disease are not defined. Our studies showed that in post mortem parkinsonian nigra healthy neuronal somata were enveloped...

journal_title：Parkinsonism & related disorders

authors： Knott C,Wilkin GP,Stern G

更新日期：1999-09-01 00:00:00

abstract：:Patients with idiopathic Parkinson's disease (PD) have impaired sympathetically mediated neurocirculatory innervation. Here we analyzed the correlation between cardiac (123)I-metaiodobenzylguanidine (MIBG) uptake, orthostatic hypotension and heart rate variability in treated patients with PD. Orthostatic hypotension (...

journal_title：Parkinsonism & related disorders

authors： Haensch CA,Lerch H,Jörg J,Isenmann S

更新日期：2009-02-01 00:00:00

abstract：INTRODUCTION:To overcome travel distance and lack of local expertise, telemedicine programs have been implemented and are still pilot programs in many jurisdictions. Patient perspectives remain poorly understood. In the largest study to date, we examined user satisfaction and predictors of patient choice to use telemed...

journal_title：Parkinsonism & related disorders

authors： Qiang JK,Marras C

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Apathy is a common neuropsychiatric syndrome in Parkinson's Disease (PD) that affects quality of life. Research into apathy has been hampered by a lack of broadly accepted diagnostic criteria. Recently, diagnostic criteria for apathy in neuropsychiatric disorders have been proposed, which to date have not be...

journal_title：Parkinsonism & related disorders

authors： Drijgers RL,Dujardin K,Reijnders JS,Defebvre L,Leentjens AF

更新日期：2010-12-01 00:00:00

abstract：INTRODUCTION:Huntington's disease (HD) is the most common hereditary neurodegenerative disorder. Despite the fact that both the gene and the mutation causing this monogenetic disorder were identified more than 20 years ago, disease-modifying therapies for HD have not yet been established. REVIEW:While intense preclini...

journal_title：Parkinsonism & related disorders

authors： Zielonka D,Mielcarek M,Landwehrmeyer GB

更新日期：2015-03-01 00:00:00

abstract：INTRODUCTION:Alzheimer's disease neuropathologies (amyloid-β and tau) frequently co-exist to varying degrees in Lewy body dementias (LBD), which include dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD). OBJECTIVES:To investigate the prevalence of tau in DLB and PDD, and its associations with clin...

journal_title：Parkinsonism & related disorders

authors： Chin KS,Yassi N,Churilov L,Masters CL,Watson R

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Tremor is a common feature of a variety of neurological disorders. In genetic studies of essential tremor (ET), investigators need to screen potential enrollees by mail or telephone to exclude those with other neurological conditions, especially dystonia. In clinical settings, the differentiation of ET and d...

journal_title：Parkinsonism & related disorders

authors： Michalec M,Hernandez N,Clark LN,Louis ED

更新日期：2014-05-01 00:00:00

abstract：INTRODUCTION:Although the hallmark feature of essential tremor (ET) is tremor, there is growing appreciation that cognitive impairment also occurs, including increased prevalence of mild cognitive impairment (MCI) and increased prevalence and incidence of dementia. With emerging knowledge of ET-cognitive impairment, co...

journal_title：Parkinsonism & related disorders

authors： Louis ED,Joyce JL,Cosentino S

更新日期：2019-06-01 00:00:00

abstract：:Mutations in the parkin gene are a common cause of autosomal recessive juvenile parkinsonism (AR-JP) but their role in idiopathic Parkinson's disease (PD) is not clear. Recent studies demonstrate that most young onset PD without family history is not due to mutations in parkin. However, there is less information about...

journal_title：Parkinsonism & related disorders

authors： Sinha R,Racette B,Perlmutter JS,Parsian A

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:Significant efforts have been focused on investigating the contribution of common variants to Parkinson disease (PD) risk. Several independent GWAS and metanalysis studies have shown a genome-wide significant association of single nucleotide polymorphisms (SNPs) in the α-synuclein (SNCA) and microtubule-asso...

journal_title：Parkinsonism & related disorders

authors： Trotta L,Guella I,Soldà G,Sironi F,Tesei S,Canesi M,Pezzoli G,Goldwurm S,Duga S,Asselta R

更新日期：2012-03-01 00:00:00

abstract：:This case series describes the inpatient rehabilitation of two medically complex patients with Parkinson's disease (PD) who had undergone deep brain stimulator (DBS) placement. Most patients may not require inpatient rehabilitation. However, a short rehabilitation stay might be of use to patients who need to be weaned...

journal_title：Parkinsonism & related disorders

authors： Nampiaparampil DE,Kuppy JE,Nampiaparampil GM,Salles SS

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:This study of thalamic deep brain stimulation (DBS) investigated whether a novel constant-current device improves tremor and activities of daily living (ADL) in patients with essential tremor (ET). METHODS:A prospective, controlled, multicenter study was conducted at 12 academic centers. We investigated t...

journal_title：Parkinsonism & related disorders

authors： Wharen RE Jr,Okun MS,Guthrie BL,Uitti RJ,Larson P,Foote K,Walker H,Marshall FJ,Schwalb J,Ford B,Jankovic J,Simpson R,Dashtipour K,Phibbs F,Neimat JS,Stewart RM,Peichel D,Pahwa R,Ostrem JL,SJM DBS ET Study Group.

更新日期：2017-07-01 00:00:00

abstract：OBJECTIVE:Our purpose was to determine whether the use of catechol-O-methyltransferase-inhibitors (ICOMT) can reduce the risk of developing levodopa (LD)-induced neuropathy in Parkinson's disease (PD) patients. METHODS:A multicentre study of 197 PD patients was performed. 144 were exposed to LD for more than three yea...

journal_title：Parkinsonism & related disorders

authors： Cossu G,Ceravolo R,Zibetti M,Arca R,Ricchi V,Paribello A,Murgia D,Merola A,Romagnolo A,Nicoletti V,Palermo G,Mereu A,Lopiano L,Melis M,Abbruzzese G,Bonuccelli U

更新日期：2016-06-01 00:00:00

abstract：:We evaluated the diagnostic accuracy of SPECT imaging using [(99m)Tc]TRODAT-1 (TRODAT), a relatively inexpensive technetium-labeled dopamine transporter ligand, in distinguishing 29 patients with early PD from 38 healthy volunteers. Mean TRODAT uptake values were significantly decreased in the caudate (p=0.0097) and a...

journal_title：Parkinsonism & related disorders

authors： Chou KL,Hurtig HI,Stern MB,Colcher A,Ravina B,Newberg A,Mozley PD,Siderowf A

更新日期：2004-08-01 00:00:00

abstract：PURPOSE:A systematic meta-analysis of published studies on the diagnostic accuracy of presynaptic dopaminergic imaging with ¹²³I-FP-CIT (DaTSCAN) in dementia with Lewy bodies (DLB). METHODS:We included (a) studies in which DaTSCAN was performed in cases of diagnostic uncertainty to differentiate between DLB and non-DL...

journal_title：Parkinsonism & related disorders

authors： Papathanasiou ND,Boutsiadis A,Dickson J,Bomanji JB

更新日期：2012-03-01 00:00:00

abstract：:Parkinson's disease (PD) studies often measure daily motor function with paper diaries resulting in issues of compliance and reliability. The feasibility and compliance of PD patients using electronic diaries were examined. Twelve patients completed diaries for 7 consecutive days. Diaries recorded motor function, time...

journal_title：Parkinsonism & related disorders

authors： Lyons KE,Pahwa R

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:Non-motor symptoms (NMS) are common in Parkinson's disease (PD) and cause significant distress. A high rate of non-declaration of NMS by patients to healthcare providers (HCP) means that many NMS remain untreated. Current understanding of the factors preventing disclosure of NMS to HCPs is limited. The prese...

journal_title：Parkinsonism & related disorders

authors： Hurt CS,Rixon L,Chaudhuri KR,Moss-Morris R,Samuel M,Brown RG

更新日期：2019-07-01 00:00:00

abstract：:Hemifacial spasm (HFS) resulting from Chiari type I malformation (CIM) is rare. We retrospectively evaluated five patients with CIM and HFS among a series of 103 subjects. The frequency of HFS associated to CIM was of 4.85%. The clinical profile did not differ from the classical primary cases except for young-onset de...

journal_title：Parkinsonism & related disorders

authors： Felício AC,de Godeiro C Jr,Borges V,de Azevedo Silva SM,Ferraz HB

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Many patients with Parkinson's disease (PD) suffer from sialorrhea. Sialorrhea is often treated with anticholinergics and botulinum toxin, but some adverse effects have limited the use of these treatments. Dihydroergotoxine mesylate is an α-adrenergic blocking agents as well as some affinities to the dopamin...

journal_title：Parkinsonism & related disorders

authors： Cheng YQ,Ge NN,Zhu HH,Sha ZT,Jiang T,Zhang YD,Tian YY

更新日期：2019-01-01 00:00:00

abstract：:Serotonin (5-HT) is a monoamine neurotransmitter released throughout the brain. The serotonergic system is implicated in a host of neuropsychiatric disorders including, but not limited to, Parkinson's disease and L-DOPA-induced dyskinesia. These are pathological and drug-induced states that center on dysfunction of th...

journal_title：Parkinsonism & related disorders

authors： Mathur BN,Lovinger DM

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Hallucinations are a frequent and severe complication in Parkinson's disease (PD). Minor hallucinations are generally not disturbing, but likely progress to well-structured hallucinations with loss of insight and a great impact on quality of life. Knowledge on the neural bases of minor hallucinations may hel...

journal_title：Parkinsonism & related disorders

authors： Pagonabarraga J,Soriano-Mas C,Llebaria G,López-Solà M,Pujol J,Kulisevsky J

更新日期：2014-03-01 00:00:00

abstract：:Wilson's disease (WD) is a rare inborn metabolic error characterized by deficient biliary copper excretion secondary to ATP7B gene mutations. Neurological presentations are variable in respect to both pattern and age of onset; commonly a movement disorder presents in the second or third decade. The aim of this study w...

journal_title：Parkinsonism & related disorders

authors： Machado AA,Deguti MM,Genschel J,Cançado EL,Bochow B,Schmidt H,Barbosa ER

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Fatigue is one of the most common and disabling non-motor symptoms in Parkinson's disease (PD). The objective of this study was to determine prevalence and motor, behavioural, and cognitive correlates of distressing fatigue in early, de novo PD patients. METHODS:Eighty-one consecutive de novo PD patients ...

journal_title：Parkinsonism & related disorders

authors： Siciliano M,Trojano L,De Micco R,De Mase A,Garramone F,Russo A,Tedeschi G,Tessitore A

更新日期：2017-12-01 00:00:00

abstract：:There has been a tremendous development since a regional progression of pathology in subjects with Lewy bodies (LB) was initially proposed 30 years ago. The entity of dementia with Lewy bodies has been acknowledged, the main protein constituent of LBs--aggregated α-synuclein (αS)--has been identified and a stepwise pr...

journal_title：Parkinsonism & related disorders

authors： Alafuzoff I,Parkkinen L

更新日期：2014-01-01 00:00:00

abstract：:Diagnostic biomarkers are measures that detect or confirm the presence of a disease or identify individuals with a subtype of the disease. For Parkinson's disease, unlike other neurodegenerative diseases such as Alzheimer's disease and Creutzfeldt-Jakob disease, diagnostic biomarkers remain elusive as none are yet ava...

journal_title：Parkinsonism & related disorders

authors： Kalia LV

更新日期：2019-02-01 00:00:00

abstract：:Dystonia is an incurable movement disorder which can cause not only physical but also mental problems, leading to impaired health-related quality of life (HRQoL). For patients with dystonia refractory to medical treatment, deep brain stimulation (DBS) is a well-established surgical treatment. The objective of this sys...

journal_title：Parkinsonism & related disorders

authors： Tsuboi T,Wong JK,Okun MS,Ramirez-Zamora A

更新日期：2020-01-01 00:00:00

abstract：:Autosomal recessive juvenile parkinsonism (ARJP/PARK2) is a distinct clinical and genetic entity characterized by early-onset levodopa-responsive parkinsonism, foot dystonia, sleep benefit, and hyperactive tendon reflexes. We report a patient with genetically confirmed ARJP, who showed mild sensory disturbance and dim...

journal_title：Parkinsonism & related disorders

authors： Okuma Y,Hattori N,Mizuno Y

更新日期：2003-06-01 00:00:00