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Thalamic DBS with a constant-current device in essential tremor: A controlled clinical trial.

Abstract：

INTRODUCTION:This study of thalamic deep brain stimulation (DBS) investigated whether a novel constant-current device improves tremor and activities of daily living (ADL) in patients with essential tremor (ET). METHODS:A prospective, controlled, multicenter study was conducted at 12 academic centers. We investigated the safety and efficacy of unilateral and bilateral constant-current DBS of the ventralis intermedius (VIM) nucleus of the thalamus in patients with essential tremor whose tremor was inadequately controlled by medications. The primary outcome measure was a rater-blinded assessment of the change in the target limb tremor score in the stimulation-on versus stimulation-off state six months following surgery. Multiple secondary outcomes were assessed at one-year follow-up, including motor, mood, and quality-of-life measures. RESULTS:127 patients were implanted with VIM DBS. The blinded, primary outcome variable (n = 76) revealed a mean improvement of 1.25 ± 1.26 points in the target limb tremor rating scale (TRS) score in the arm contralateral to DBS (p < 0.001). Secondary outcome variables at one year revealed significant improvements (p ≤ 0.001) in quality of life, depression symptoms, and ADL scores. Forty-seven patients had a second contralateral VIM-DBS, and this group demonstrated reduction in second-sided tremor at 180 days (p < 0.001). Serious adverse events related to the surgery included infection (n = 3), intracranial hemorrhage (n = 3), and device explantation (n = 3). CONCLUSION:Unilateral and bilateral constant-current VIM DBS significantly improves upper extremity tremor, ADL, quality of life, and depression in patients with severe ET.

journal_name

Parkinsonism Relat Disord

journal_title

Parkinsonism & related disorders

authors

Wharen RE Jr,Okun MS,Guthrie BL,Uitti RJ,Larson P,Foote K,Walker H,Marshall FJ,Schwalb J,Ford B,Jankovic J,Simpson R,Dashtipour K,Phibbs F,Neimat JS,Stewart RM,Peichel D,Pahwa R,Ostrem JL,SJM DBS ET Study Group.

doi

10.1016/j.parkreldis.2017.03.017

subject

Has Abstract

pub_date

2017-07-01 00:00:00

pages

18-26

eissn

1353-8020

issn

1873-5126

pii

S1353-8020(17)30112-8

journal_volume

40

pub_type

杂志文章,多中心研究

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